Wiley-VCH - Biomedizintechnik

Primary and Stem Cells

Lakshmipathy, Uma / Thyagarajan, Bhaskar — 29 Dec 2011 08:17:27 +0100

This book describes basic cell engineering methods, emphasizing stem cell applications, and use of the genetically modified stem cells in cell therapy and drug discovery. Together, the chapters introduce and offer insights on new techniques for engineering of stem cells and the delivery of transgenes into stem cells via various viral and non-viral systems. The book offers a guide to the types of manipulations currently available to create genetically engineered stem cells that suit any investigator's purpose, whether it's basic science investigation, creation of disease models and screens, or cells for therapeutic applications. [296 Seiten, Hardcover]

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Renewable Polymers

Mittal, Vikas (ed.) — 5 Dec 2011 08:19:34 +0100

This book describes advances in synthesis, processing, and technology of environmentally friendly polymers generated from renewable resources. With contents based on a wide range of functional monomers and contributions from eminent researchers, this volume demonstrates the design, synthesis, properties and applications of plant oil based polymers, presenting an elaborate review of acid mediated polymerization techniques for the generation of green polymers. Chemical engineers are provided with state-of-the-art information that acts to further progress research in this direction. [502 Seiten, Hardcover]

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Ceramic Integration and Joining Technologies

Singh, Mrityunjay / Ohji, Tatsuki / Asthana, Rajiv / Mathur, Sanjay (eds.) — 21 Nov 2011 08:17:14 +0100

This is the only book that addresses the integration of advanced ceramics and ceramic-base materials in a single resource. Written by acknowledged experts representing industry, government, and academia, the book addresses integration issues in such areas as space power and propulsion, thermoelectric power generation, solar energy, micro-electro-mechanical systems (MEMS), solid oxide fuel cells (SOFC), multi-chip modules, prosthetic devices, and implanted biosensors and stimulators. The text presents science and engineering design data, facts, cases, and industrial and research insights, balancing engineering and scientific information to serve the needs of practitioners and researchers alike. [830 Seiten, Hardcover]

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Tribology of Ceramics and Composites

Basu, Bikramjit / Kalin, Mitjan — 14 Nov 2011 08:17:17 +0100

This book helps students and practicing scientists alike understand that a comprehensive knowledge about the friction and wear properties of advanced materials is essential to further design and development of new materials. With important introductory chapters on the fundamentals, processing, and applications of tribology, the book then examines in detail the nature and properties of materials, the friction and wear of structural ceramics, bioceramics, biocomposites, and nanoceramics, as well as lightweight composites and the friction and wear of ceramics in a cryogenic environment. [550 Seiten, Hardcover]

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Advanced Structural Ceramics

Basu, Bikramjit / Balani, Kantesh — 14 Nov 2011 08:17:14 +0100

This book covers the area of advanced ceramic composites broadly, providing important introductory chapters to fundamentals, processing, and applications of advanced ceramic composites. Within each section, specific topics covered highlight the state of the art research within one of the above sections. The organization of the book is designed to provide easy understanding by students as well as professionals interested in advanced ceramic composites. The various sections discuss fundamentals of nature and characteristics of ceramics, processing of ceramics, processing and properties of toughened ceramics, high temperature ceramics, nanoceramics and nanoceramic composites, and bioceramics and biocomposites. [504 Seiten, Hardcover]

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Susceptibility Weighted Imaging in MRI

Haacke, Mark E. / Reichenbach, Jürgen — 4 Nov 2011 08:17:09 +0100

This is the first reference and textbook to discuss the exciting and very promising new MRI technique called Susceptibility Weighted Imaging or SWI, which is a powerful tool for the diagnosis and treatment of acute stroke, allowing earlier detection of acute stroke hemorrhage and easier detection of microbleeds in acute ischemia. Edited by the originators of SWI with contributions from the top leaders in the science and use of the modality. [760 Seiten, Hardcover]

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Biopolymers

Kalia, Susheel / Avérous, Luc — 24 Oct 2011 08:18:36 +0200

There is currently a huge focus on polymer related materials. Because of the deteriorating environmental conditions, researchers are concentrating their attention on biopolymers. Featuring unique contributions from renowned experts of this area of research, this handbook comprehensively covers material structures, characterization, processing, properties, and applications. A very useful tool for scientists, academicians, research scholars, polymer engineers and those in the pharmaceutical, biotechnology, environmental, medical, packaging, and chemical engineering industries, this volume is an important resource for all those researching in green chemistry. [642 Seiten, Hardcover]

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Handbook of Biophotonics

Popp, Jürgen / Tuchin, Valery V. / Chiou, Arthur / Heinemann, Stefan H. (eds.) — 20 Oct 2011 08:17:20 +0200

Adopting an application-related approach, these three volumes provide both the physics basics as well as the biological and medical background. This handbook collects interdisciplinary contributions, serving as a unique base of common knowledge and mutual understanding. [LII, 1132 Seiten, Hardcover]

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Biohybrid Systems

Jung, Ranu (ed.) — 20 Oct 2011 08:17:17 +0200

Accessible for engineers and physicists alike, this high-level work on this hot topic in medical physics covers the issue from principles of neuroscience to in-vivo use. Backed by extensive data tables and software samples on the Web. [XIV, 210 Seiten, Hardcover]

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Plasmid Biopharmaceuticals

Prazeres, Duarte Miguel F. — 29 Aug 2011 08:17:11 +0200

A plasmid is a DNA molecule separate from chromosomal DNA and capable of autonomous replication. Plasmid Biopharmaceuticals helps pharmaceutical scientists and engineers understand the basic characteristics of therapeutic DNA plasmids, their potential utilization in drug development, and the issues and solutions for large-scale GMP production. Bringing together information on plasmid basics and applications, the book also addresses a range of manufacturing-related issues. It is an essential guide for academic and industrial researchers concerned with plasmid DNA manufacturing for pharmaceutical applications. [616 Seiten, Hardcover]

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Epistemology of the Cell

Dougherty, Edward R. / Bittner, Michael L. — 22 Aug 2011 08:18:35 +0200

An examination of how the cell should be described in order to effectively process biological data The fruitful pursuit of biological knowledge requires one to take Einstein's admonition [on science without epistemology] as a practical demand for scientific research, to recognize Waddington's characterization of the subject matter of biology, and to embrace Wiener's conception of the form of biological knowledge in response to its subject matter. It is from this vantage point that we consider the epistemology of the cell. --from the Preface In the era of high biological data throughput, biomedical engineers need a more systematic knowledge of the cell in order to perform more effective data handling. Epistemology of the Cell is the first authored book to break down this knowledge. This text examines the place of biological knowledge within the framework of science as a whole and addresses issues focused on the specific nature of biology, how biology is studied, and how biological knowledge is translated into applications, in particular with regard to medicine. The book opens with a general discussion of the historical development of human understanding of scientific knowledge, the scientific method, and the manner in which scientific knowledge is represented in mathematics. The narrative then gets specific for biology, focusing on knowledge of the cell, the basic unit of life. The salient point is the analogy between a systems-based analysis of factory regulation and the regulation of the cell. Each chapter represents a key topic of current interest, including: * Causality and randomness * Translational science * Stochastic validation: classification * Stochastic validation: networks * Model-based experimentation in biology Epistemology of the Cell is written for biomedical researchers whose interests include bioinformatics, biological modeling, biostatistics, and biological signal processing. [216 Seiten, Hardcover]

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Mathematical and Computational Methods and Algorithms in Biomechanics

Nedoma, Jirí / Stehlik, Jiri — 22 Aug 2011 08:17:23 +0200

Despite the current successful methods and achievement of good joint implantation results, it is essential to further optimize the implants' shapes, enabling them to better resist extreme long-term mechanical demands. This book provides the orthopedic, biomechanical, and mathematical basis for the mathematical simulation of surgical techniques in orthopedics, as well as the numerical modeling of human joint replacements and simulation of their functions. It is a highly useful tool for designers, researchers, scientists, and manufacturers of joint implants who require the results of suggested experiments to improve existing shapes or to design the new shapes. [592 Seiten, Hardcover]

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Biomechatronic Design in Biotechnology

Mandenius, Carl-Fredrik / Björkman, Mats — 15 Aug 2011 08:17:26 +0200

Bio-mechatronics integrates mechanical parts with a human being. Illustrating how the general engineering design science theory can be applied when designing a technical system where biological species or components are integrated, Mechatronic Design for Biotechnology provides the fundamentals, theory, and applications of bio-mechatronic design principles. This cutting-edge book present professionals in the industrial biotech sector with a unifying approach to the many fields of engineering sciences and biotechnology used in the product development of protein purification systems, artificial human organs, and stem-cell technology. [304 Seiten, Hardcover]

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Collaborative Computational Technologies for Biomedical Research

Ekins, Sean / Hupcey, Maggie A. Z. / Williams, Antony J. (eds.) — 29 Jul 2011 08:17:26 +0200

Covering a neglected but important topic of management and information technology collaborations in drug discovery and development, this book discusses the state-of-the-art collaborative and computing techniques for the pharmaceutical industry. Tackling problems thoroughly, from both the human collaborative and the data and informatics side, this volume is relevant to the day-to-day activities of running a laboratory or a collaborative R&D project. Researchers will appreciate this how-to guide for new laboratories, new companies, and new partnerships, as well as a user manual for how to troubleshoot existing collaborations. [576 Seiten, Hardcover]

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Computed Tomography

Kalender, Willi A. — 21 Jul 2011 08:17:31 +0200

Das Buch bietet eine verständliche Darstellung der theoretischen und technischen Grundlagen der Computertomographie mit allen notwendigen Parametern. Die dritte Auflage beschreibt zusätzlich aktuellste Themen wie Dual-Source-, Dual-Energy- und Flachdetektoren-CT. [372 Seiten, Hardcover]

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Biodegradable Polymers in Clinical Use and Clinical Development

Domb, Abraham J. / Kumar, Neeraj (eds.) — 18 Jul 2011 08:22:31 +0200

Biodegradable polymers used in clinical applications, such as absorbable sutures, are implantable polymers that degrade and eliminate from the body within a set time period. Here is the first comprehensive review of all biodegradable polymers that are currently in use in clinical application or development, with coverage of such applications as absorbable implants, orthopedic plates, nanoparticles, and drug delivery. The book covers the chemistry of each polymer (including synthesis, characterization, biodegradability, and mechanical properties), toxicity and safety aspects, and clinical applications. [752 Seiten, Hardcover]

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CMOS Biomicrosystems

Iniewski, Krzysztof — 4 Jul 2011 08:17:24 +0200

The book will address the-state-of-the-art in integrated bio-microsystems that integrate microelectronics with fluidics, photonics, and mechanics. Written by top industrial experts and key academic professors, it is the only book on the market that covers bio-microsystems from an integration point of view. Revealed are new, exciting opportunities in emerging applications that will take system performance beyond what is offered by traditional CMOS based circuits. It is a must for practicing engineers with an electronics background; it will also be used as a recommended reading and supplementary material in a graduate course curriculum. [520 Seiten, Hardcover]

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Medical Imagery

Fanet, Hervé — 13 Jun 2011 08:18:14 +0200

This book describes the different principles and equipments used in medical imaging. Importance of medical imaging for diagnostic is strongly increasing and it is now necessary to have a good knowledge of the different physical possible principles. Researchers, clinicians, engineers and professionals in this area, along with postgraduate students in the signal and image processing field, will find this book of great interest. [352 Seiten, Hardcover]

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Advanced Methods of Biomedical Signal Processing

Cerutti, Sergio / Marchesi, Carlo (eds.) — 31 May 2011 08:17:11 +0200

This book grew out of the IEEE-EMBS Summer Schools on Biomedical Signal Processing, which have been held annually since 2002 to provide the participants state-of-the-art knowledge on emerging areas in biomedical engineering. The book provides an overview of a compelling group of advanced biomedical signal processing techniques, such as multisource and multiscale integration of information for physiology and clinical decision; the impact of advanced methods of signal processing in cardiology and neurology; and classification and parameter enhancement. Graduate and PhD students in engineering and physics courses and research professionals in biological sciences will highly benefit. [608 Seiten, Hardcover]

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Modeling and Simulation in the Medical and Health Sciences

Sokolowski, John A. / Banks, Catherine M. (eds.) — 24 May 2011 08:17:44 +0200

This edited book is divided into three parts: Fundamentals of Medical and Health Sciences Modeling and Simulation introduces modeling and simulation in the medical and health sciences; Medical and Health Sciences Models provides the theoretical underpinnings of medical and health sciences modeling; and Modeling and Simulation Applications in Medical and Health Sciences focuses on teaching, training, and research applications. The book begins with a general discussion of modeling and simulation from the modeling and simulation discipline perspective. This discussion grounds the reader in common terminology. It also relates this terminology to concepts found in the medical and health care (MHC) area to help bridge the gap between developers and MHC practitioners. Three distinct modes of modeling and simulation are described: live, constructive, and virtual. The live approach explains the concept of using real (live) people employing real equipment for training purposes. The constructive mode is a means of engaging medical modeling and simulation. In constructive simulation, simulated people and simulated equipment are developed to augment real-world conditions for training or experimentation purposes. The virtual mode is perhaps the most fascinating as virtual operating rooms and synthetic training environments are being produced for practitioners and educators at break-neck speed. In this mode, real people are employing simulated equipment to improve physical skills and decision-making ability. [304 Seiten, Hardcover]

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Handbook of Biophotonics

Popp, Jürgen / Tuchin, Valery V. / Chiou, Arthur / Heinemann, Stefan H. (eds.) — 21 Apr 2011 08:17:22 +0200

Nanotechnologies for the Life Sciences

Kumar, Challa S. S. R. (ed.) — 21 Apr 2011 08:17:17 +0200

Maßgeschneiderte Nanowerkstoffe für Medizin, Biotechnik und verwandte Einsatzgebiete sind ein Milliardenmarkt. Diese zehnbändige Reihe kann als das erste wirklich umfassende, interdisziplinäre Werk gelten, das Nanofabrikation und Nanotechnologie im Zusammenhang mit Biomolekülen, Biomaterialien und medizinischen Anwendungen diskutiert. Sie bietet einen detailreichen Einblick in alle Facetten des Forschungsgebiets und stellt gleichzeitig aktuelle Erkenntnisse in einen breiteren Kontext. Existierende Technologien werden ebenso tiefgründig behandelt wie Verfahren, die sich noch in der Entwicklung befinden. Jeder einzelne Band befasst sich mit einem speziellen Thema. [4680 Seiten, Softcover]

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Analyzing the Large Number of Variables in Biomedical and Satellite Imagery

Good, Phillip I. — 20 Apr 2011 08:18:45 +0200

Written by a well-known author in the fields of permutation and bootstrap methods, this book fills a gap in the literature by discussing both the biological context as well as the specialized statistical methods needed to handle large arrays. Topical coverage includes: very large arrays; applying permutation tests; gathering and preparing data for analysis; multiple tests; applying the bootstrap; classification methods; decision trees; and applying decision trees. It balances statistical and data mining methods at a level that is appropriate for researchers, statisticians, meteorologists, physicians, neurologists, and other biological research workers. [200 Seiten, Softcover]

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Solid State Characterization of Pharmaceuticals

Storey, Richard A. / Ymen, Ingvar (eds.) — 19 Apr 2011 08:18:40 +0200

The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties. This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. The following topics are included: * Physical properties and processes * Thermodynamics * Intellectual guidance * X-ray diffraction * Spectroscopy Microscopy * Particle sizing * Mechanical properties * Vapour sorption * Thermal analysis & Calorimetry * Polymorph prediction * Form selection [526 Seiten, Hardcover]

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Multifrequency Electron Paramagnetic Resonance

Misra, Sushil K. (ed.) — 14 Apr 2011 08:17:44 +0200

Filling the gap for a systematic, authoritative, and up-to-date review of this hot topic, this book covers both low and high frequency EPR, providing readers with knowledge of the underlying theory, fundamentals, and applications. [XXXIV, 1022 Seiten, Hardcover]

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Gene Discovery for Disease Models

Gu, W. — 13 Apr 2011 08:17:20 +0200

The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. Gene Discovery for Disease Models provides readers with new paradigms on the mutation discovery in the post-genome era with detailed description of positional cloning and genomic cloning with identification of genes found in human disease and animal models. Backed by sound scientific findings, this informational guide advances the promising possibilities of genetic research. [552 Seiten, Hardcover]

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Advanced Optical Flow Cytometry

Tuchin, Valery V. (ed.) — 7 Apr 2011 08:17:19 +0200

A detailed look at the latest research in non-invasive in vivo cytometry and its applications, with particular emphasis on novel biophotonic methods, disease diagnosis, and monitoring of disease treatment at single cell level in stationary and flow conditions. [XXXVIII, 702 Seiten, Hardcover]

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Engineered Carbohydrate-Based Materials for Biomedical Applications

Narain, Ravin (ed.) — 28 Mar 2011 08:17:12 +0200

This comprehensive book covers the design, synthesis, and characterization of synthetic carbohydrate-based polymeric materials along with their biological applications. The first two chapters cover the synthesis and self-assembly of glycopolymers and different techniques for creating these synthetic polymers. Subsequent chapters account for the preparation of block copolymers, branched glycopolymers, glycosurfaces, glycodendrimers, cationic glycopolymers, bioconjugates, glyconanoparticles, and hydrogels. The book details the synthetic and characterization methods of those carbohydrate-based materials, and their biological applications are also discussed. This book is ideal for polymer scientists, material scientists, and organic and carbohydrate chemists. [416 Seiten, Hardcover]

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Organic Materials for Sustainable Civil Engineering

Mouton, Yves — 14 Mar 2011 08:18:54 +0100

This book provides an inventory of organic materials and products, the major components of all civil engineering projects, in terms of their scientific and technical background, including the regulations that cover their use and their predicted useful life. Such materials include: bitumen on the roads; geotextiles for retaining walls; membranes for bridges; tunnel and reservoir waterproofing; paint binders to protect metallic and concrete structures or to realize road markings; injection resins; gluing products; concrete admixtures; and composite materials. The presentation is based on a physicochemical approach, which is essential if these products are to be considered as part of sustainable development: as such, those studying or working in these fields will find this an invaluable source of information. [688 Seiten, Hardcover]

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Medical Image Analysis

Dhawan, Atam P. — 16 Feb 2011 08:17:23 +0100

The last two decades have witnessed revolutionary progress in medical imaging and computerized medical image processing. This unique book describes complex medical imaging modalities in simple terms and explains medical image analysis methods that are useful in research and clinical application. Thoroughly expanded and revised, it features new chapters on Optical Imaging Modalities, Simultaneous Multi-Modality Medical Imaging, and Computer-Aided Diagnosis and image guided surgery, as well as updates on 3-D dynamic contrast ultrasound imaging, 3-D fast statistical estimation-based reconstruction methods, and 3-D image fusion and visualization. This new edition is must reading for students in medical imaging & image processing, electrical engineers, biomedical engineers, physicians, medical physicists, and researchers. [400 Seiten, Hardcover]

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Advances in Optical Imaging for Clinical Medicine

Iftimia, Nicusor / Brugge, William R. / Hammer, Daniel X. — 31 Jan 2011 08:18:19 +0100

This book provides students, teachers, researchers, and clinicians with a strong and established source of information on advanced optical technologies that show real promise of being translated to clinical use. [556 Seiten, Hardcover]

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Electronic Health Records For Dummies

Williams, Trenor / Samarth, Anita — 20 Dec 2010 08:17:35 +0100

The straight scoop on choosing and implementing an electronic health records (EHR) system Doctors, nurses, and hospital and clinic administrators are interested in learning the best ways to implement and use an electronic health records system so that they can be shared across different health care settings via a network-connected information system. This helpful, plain-English guide provides need-to-know information on how to choose the right system, assure patients of the security of their records, and implement an EHR in such a way that it causes minimal disruption to the daily demands of a hospital or clinic. * Offers a plain-English guide to the many electronic health records (EHR) systems from which to choose * Authors are a duo of EHR experts who provide clear, easy-to-understand information on how to choose the right EHR system an implement it effectively * Addresses the benefits of implementing an EHR system so that critical information (such as medication, allergies, medical history, lab results, radiology images, etc.) can be shared across different health care settings * Discusses ways to talk to patients about the security of their electronic health records Electronic Health Records For Dummies walks you through all the necessary steps to successfully choose the right EHR system, keep it current, and use it effectively. [384 Seiten, Softcover]

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Advanced Biomedical Image Analysis

Haidekker, Mark — 6 Dec 2010 08:17:22 +0100

This text provides readers with a comprehensive reference of cutting-edge advanced techniques of quantitative image analysis with a focus on biomedical applications. It offers both theory and practical examples for immediate application of the topics covered as well as for in-depth study. The bonus live DVD includes the algorithm software presented in the book, which other image analysis programs do not offer. Members of the academic community doing image-related research as well as members of the professional R&D sector and graduate educators and students will rely on this text. [540 Seiten, Hardcover]

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Biomechanics of Hard Tissues

Öchsner, Andreas / Ahmed, Waqar (eds.) — 25 Nov 2010 08:17:09 +0100

1 BONE AND CARTILAGE, ITS STRUCTURE AND PHYSICAL PROPERTIES Introduction The Structure of Living Organisms Growth of Living Organisms Ring-Shaped Grain Boundary Planarity of Biological Structures Microscopie Structure of the Bone Growth of the Bone Structure of the Body Macroscopic Structure of Skeleton Apatite in the Bone Structure of the Bone Microscopic Structure of the Bone General Osteon Bone Innervation Anatomy of Bone Innervation Bone Cells Cells Cell Membrane Membrane Transport Bone Cell Types Osteoclasts Cellular Image - OPG/RANK/RANKL Signaling System Osteoprotegerin RANK/RANKL TACE Bone Modeling and Remodeling Proteins and Amino Acids Collagen and Its Properties Molecular Structure Geometry of Triple Helix Polymer Thermodynamics Thermodynamics Ideal Chain Wormlike Chain Architecture of Biological Fibers Architecture of Collagen Fibers in Human Osteon Collagen Elasticity References Further Reading 2 NUMERICAL SIMULATION OF BONE REMODELING PROCESS CONSIDERING INTERFACE TISSUE DIFFERENTIATION IN TOTAL HIP REPLACEMENTS Introduction Mechanical Adaptation of Bone Constitutive Models Bone Constitutive Model Model of Preprosthetic Adaptation Model of Interfacial Adaptation Numerical Examples Final Remarks Acknowledgments References 3 BONE AS A COMPOSITE MATERIAL Introduction Bone Phases Organic Mineral Physical Structure of Bone Material Water Bone Phase Material Properties Organic Matrix Mineral Phase Water Elastic Modulus of Composite Materials Bone as a Composite: Macroscopic Effects Bone as a Composite: Microscale Effects Bone as a Composite: Anisotropy Effects Bone as a Composite: Implications References 4 MECHANOBIOLOGICAL MODELS FOR BONE TISSUE. APPLICATIONS TO IMPLANT DESIGN Introduction Biological and Mechanobiological Factores in Bone Remodeling and Bone Fracture Healing Bone Remodeling Bone Fracture Healing Phenomenological Models of Bone Remodeling Mechanistic Models of Bone Remodeling Models to Implant Design Models of Tissue Differentiation Application to Bone Fracture Healing Mechanistic Models of Bone Fracture Healing Models to Implant Design Concluding Remarks References 5 BIOMECHANICAL TESTING OF ORTHOPEDIC IMPLANTS; ASPECTS OF TRIBOLOGY AND SIMULATION Introduction Tribological Testing of Orthopedic Implants Tribological Testing of Tissue from a Living Body Theoretical Analysis for Tribological Issues References 6 CONSTITUTIVE MODELING OF THE MECHANICAL BEHAVIOR FOR TRABECULAR BONE - CONTINUUM MECHANICAL APPROACHES Introduction Summy of Elasticity Theory and Continuum Mechanics Stress Tensor and Decomposition Invariants Constitutive Equations Linear Elastic Behavior: Generalized Hooke´s Law for Isotropic Materials Linear Elastic Behavior: Generalized Hooke´s Law for Orthotropic Materials Linear Elastic Behaivor: Generalized Hooke´s Law for Orthotropic Materials with Cubic Structure Linear Elastic Behaivor: Generalized Hooke´s Law for Transverse Isotropic Materials Plastic Behavior, Failure and Limit Surface The Structure of Trabecular Bone and Modeling Approaches Structural Analogies: Cellular Plastics and Materials Conclusions References 7 MECHANICAL AND MAGNETIC STIMULATION ON CELLS FOR BONE REGENERATION Introduction Mechanical Stimulation on Cells Various Mechanical Stimulations Techniques for Applying Mechanical Loading Mechanotransduction Mechanical Influences on Stem Cell Magnetic Stimulation on Cells Magnetic Nanoparticles for Cell Stimulation Properties of Magnetic Nanoparticles Functionalization of Magnetic Nanoparticles Magnetic Stimulation Magnetic Pulling Magnetic Twisting Limitation of Using Magnetic Nanoparticles for Cell Stimulation Magnetic Stimulation and Cell Conditioning for Tissue Regeneration Summary References 8 Joint Replacement Implants Introduction Biomaterials for Joint Replacement Implants Joint Replacement Implants for Weight-Bearing Joints Introduction Hip Joint Replacement Knee Joint Replacement Ankle Joint Replacemen Methods of Fication for Weight-Bearing Joint Replacement Implants Joint Replacement Implants for Joints of the Hand and Wrist Introduction Finger Joint Replacement Wrist Joint Replacement Design of Joint Replacement Implants Introduction Feasibility Design Verification Manufacture Validation Design Transfer Design Changes Conlusions References 9 INTERSTITIAL FLUID MOVEMENT IN CORTICAL BONE TISSUE Introduction Arterial Supply Overview of the Arterial System in Bone Dynamics of the Arterial System Transcortical Arterial Hemodynamics The Arterial System in Small Animals May Be Different from That in Humans Microvascular Network of Cortical Bone Microvascular Network of Cortical Bone Venous Drainage of Bone Bone Lymphatics and Blood Vessel Trans-Wall Transport The Levels of Bone Porosity and Their Bone Interfaces The Vascular Porosity The Lacunar - Canalicular Porosity The Collagen - Hydroxyapatite Porosity Cancellous Bone Porosity The Interfaces between the Levels of Bone Porosity Interstitial Fluid Flow The Different Fluid Pressures in Long Bones (Blood Pressure, Interstitial Fluid Pressure, and Intramedullary Pressure) Interstitial Flow and Mechanosensation Electrokinetic Effects in Bone The Poroelastic Model for the Cortical Bone Interchange of Interstitial Fluid between the Vascular and Lacunar - Canalicular Porosites Implications for the Determination of the Permeabilites References 10 Bone Implant Design Using Optimization Methods Introduction Optimization Methods for Implant Desing Cemented Stems Uncemented Stems Design Requirements for a Cementless Hip Stem Implant Stability Stress Shielding Effect Multicriteria Formulation for Hip Stem Design Design Variables and Geometry Objective Function for Interface Displacement Objective Function for Interface Stress Objective Function for Bone Remodeling Multicriteria Objective Function Computational Model Optimization Algorithm Finite Element Model Optimal Geometries Analysis Optimal Geometry for Tangential Interfacial Displacement Optimal Geometry for Normal Contact Stress Optimal Geometry for Remodeling Multicriteria Optimal Geometries Long-Term Performance of Optimized Implants Concluding Remarks References INDEX [XVI, 306 Seiten, Hardcover]

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Genetic and Evolutionary Computation

Smith, Stephen / Cagnoni, Stefano (eds.) — 15 Nov 2010 08:17:24 +0100

Genetic and Evolutionary Computation: Medical Applications provides an overview of the range of GEC techniques being applied to medicine and healthcare in a context that is relevant not only for existing GEC practitioners but also those from other disciplines, particularly health professionals. There is rapidly increasing interest in applying evolutionary computation to problems in medicine, but to date no text that introduces evolutionary computation in a medical context. By explaining the basic introductory theory, typical application areas and detailed implementation in one coherent volume, this book will appeal to a wide audience from software developers to medical scientists. Centred around a set of nine case studies on the application of GEC to different areas of medicine, the book offers an overview of applications of GEC to medicine, describes applications in which GEC is used to analyse medical images and data sets, derive advanced models, and suggest diagnoses and treatments, finally providing hints about possible future advancements of genetic and evolutionary computation in medicine. * Explores the rapidly growing area of genetic and evolutionary computation in context of its viable and exciting payoffs in the field of medical applications. * Explains the underlying theory, typical applications and detailed implementation. * Includes general sections about the applications of GEC to medicine and their expected future developments, as well as specific sections on applications of GEC to medical imaging, analysis of medical data sets, advanced modelling, diagnosis and treatment. * Features a wide range of tables, illustrations diagrams and photographs. [250 Seiten, Hardcover]

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