Evidence-Based Evolutionary Medicine

Torday, John S. / Blackstone, Neil W. / Rehan, Virender K.

1. Auflage Juli 2018
256 Seiten, Hardcover
Wiley & Sons Ltd

ISBN: 978-1-118-83837-2

John Wiley & Sons

Probekapitel

Jetzt kaufen

Preis: 135,00 €

Preis inkl. MwSt, zzgl. Versand

Weitere Versionen

A groundbreaking, evidence-based text to the growing field of evolutionary medicine

Evidence-Based Evolutionary Medicine offers a comprehensive review of the burgeoning field of evolutionary medicine and explores vital topics such as evolution, ecology, and aging as they relate to mainstream medicine. The text integrates Darwinian principles and evidence-based medicine in order to offer a clear picture of the underlying principles that reflect how and why organisms have evolved on a cellular level.

The authors--noted authorities in their respective fields--address evolutionary medicine from a developmental cell-molecular perspective. They explore the first principles of physiology that explain the generation of existing tissues, organs, and organ systems. The text offers an understanding of the overall biology as a vertically integrated whole, from unicellular to multicellular organisms. In addition, it addresses clinical diagnostic and therapeutic approaches, both traditional and cell-homeostatic. This groundbreaking text:

* Offers a much-needed, logical, and fundamental approach to biology and medicine
* Provides a clear explanation of complex physiology and pathophysiology
* Integrates topics like evolution, ecology and aging into mainstream medicine, making them more relevant
* Contains the first evidence-based text on evolutionary medicine

Written for medical and graduate students in biology, physiology, anatomy, endocrinology, reproductive biology, medicine, pathology, systems biology, this vital resource offers a unique text of both biology as an integrated whole with universal properties; and of medicine seeing the individual as a whole, not an inventory of parts and diseases.

We will base the Chapters of the proposed book on EvolutionaryMedicine on standard textbooks of Medicine, physiology andpathophysiology so that the medical student will be able to see howthe evolutionary approach provides a 'logic' for thedescriptive parts lists for health and disease. In examiningHarrison's Principles of Internal Medicine, McCance andHuether's Pathophysiology, and Guyton and Hall'sPhysiology as standard textbooks for medical and graduate schooleducation in biology and medicine, none of them provide anintegrated perspective for the processes of physiology, how theyevolved for homeostasis, how pathophysiology can be viewed as acontinuum from health to disease (and back) as 'failedevolution', regeneration/repair as the recapitulation ofontogeny, and aging as a logical consequence of the evolutionaryphysiologic strategy.

One illustration-related thought would be to have standardschematics for medicine, physiology, and pathophysiology withtransparent overlays of the evolutionary approach so that thestudent can literally 'see' how the descriptive andmechanistic evolutionary approaches are at the same time one andthe same and different.

Working Table of Contents or Outline of contents

1. The Cell as the smallest Unit of Biology/Physiology

2. Development of tissues and organs

3. Mechanisms of Development as the Basis for Homeostasis

4. Cell Communication as the Universal Language of Biology andMedicine

5. Integrated Regulation of Homeostasis- vascular, nervous,endocrine, neuroendocrine, autonomic

6. When Homeostasis Fails

7. Endogenous Mechanisms for Healing

8. Exogenous Mechanisms for Healing- Pharmacologics

9. Exogenous Mechanisms for Healing- Biologics

10. Repair as Ontogeny

11. Regeneration as Phylogeny

12. Systems Biology as Recapitulation of Ontogeny andPhylogeny

13. Bioethics Based on First Principles of Physiology

14. Man's Place in the Universe Redux

About the Authors

John S. Torday is a Professor of Pediatrics at UCLA, USA.

Neil W. Blackstone is a Professor in the Department of Biological Sciences at Northern Illinois University, USA.

Virender K. Rehan is a Professor of Pediatrics at UCLA, USA.