Carbohydrate-based Drug Discovery
1. Edition August 2003
XXXII, 948 Pages, Hardcover
296 Pictures (15 Colored Figures)
Wong, Chi-Huey (tables)
A premier resource for carbohydrate chemists and drug developers, this two-volume handbook presents the latest developments in carbohydrate chemistry and biochemistry. Although it is unique in its comprehensive coverage, particular emphasis is placed on carbohydrates with pharmaceutical potential.
Contains contributions by more than 50 of the world's leading carbohydrate chemists, backed by an extensive bibliography and index.
To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential.
Topics include the following:
> Chemical Synthesis of Carbohydrates
> Carbohydrate Biosynthesis and Metabolism
> Carbohydrate Analysis
> Cellular Functions of Carbohydrates
> Development of Carbohydrate-based Drugs
A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.
The Chemistry of Sialic Acid
Solid-Phase Oligosaccharide Synthesis
Solution and Polymer-supported Synthesis of Carbohydrates
Enzymatic Synthesis of Oligosaccharides
Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology
Chemistry and Biochemistry of Asparagine-linked Protein Glycosylation
Conformational Analysis of C-Glycosides and Related Compounds
Synthetic Lipid A Analogs for Sepsis Treatment
Polysialic Acid Vaccines
Synthetic Carbohydrate-based Vaccines
Antithrombotics Based on Synthetic Oligosaccharides
Sequencing of Oligosaccharides and Glycoproteins
Analytical Techniques for the Characterization and Sequencing of Glycosaminoglycans
Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes
Glycosylated Natural Products
Small Molecule Inhibitors of the Sulfotransferases
Carbohydrate-based Treatment of Cancer Metastasis
N-Acetylneuraminic Acid Derivatives and Mimetics as Anti-influenza Agents
Carbohydrate-based Drug Discovery in the Battle Against Bacterial Infections
Francesco Nicotra, Università di Milano-Bicocca (Italy)
"To summarize, the work provides a comprehensive and excellent survey of the present situation in carbohydrate research, in which many interesting details can be spotted. Because of the wide range of topics covered, the reader will refer to it again and again. It is likely to become a standard work on the subject, not exclusively for carbohydrate chemistry enthusiasts."
Oliver Plettenburg, Ulrich Stilz
Angewandte Chemie + IE 2004-43/31
Professor Wong is a member of the U.S. National Academy of Sciences and the American Academy of Arts and Sciences. He is a recipient of The Searle Scholar Award in Biomedical Sciences (1985), the Presidential Young Investigator Award in Chemistry (1986), the American Chemical Society A.C. Cope Scholar Award (1993), the Roy Whistler Award of the International Carbohydrate Organization (1994), the American Chemical Society Harrison Howe Award in Chemistry (1998) and the Claude S. Hudson Award in Carbohydrate Chemistry (1999), the International Enzyme Engineering Award (1999) and the Presidential Green Chemistry Challenge Award (2000). He is a member of Academia Sinica, Taipei (1994), the American Academy of Arts and Sciences (1996) and the US National Academy of Sciences (2002). He serves as editor-in-chief of Bioorganic and Medicinal Chemistry and is an executive board member of the Tetrahedron Publications. He was head of the Frontier Research Program on Glycotechnology at RIKEN (Institute of Physical and Chemical Research, Japan) (1991-1999) and is currently a scientific advisor of the Max-Planck Institute, a board member of the U.S. National Research Council on Chemical Sciences and Technology, and is a founding scientist of Optimer Pharmaceuticals, Inc. He is author and co-author of over 450 publications, 60 patents and several books.
His current interests are in the areas of bioorganic and synthetic chemistry and biocatalysis, including development of new synthetic chemistry based on enzymatic and chemo-enzymatic reactions, synthetic approach to carbohydrate-mediated biological recognition, design and synthesis of mechanism-based inhibitors of enzymes, RNA and carbohydrate receptors, development of oligosaccharide and aminoglycoside microarrays for high-throughput screening and the study of reaction mechanisms.