Formulation and Delivery in Gene Therapy, DNA Vaccination and Immunotherapy
1. Edition August 2005
XXII, 253 Pages, Hardcover
37 Pictures (6 Colored Figures)
Practical Approach Book
Schleef, Martin (tables)
Focusing on a completely new class of pharmaceuticals, this book collates the hitherto scarce literature on DNA drug formulation much desired by biotechnologists, molecular biologists and pharmacists, as well as those working in the biotechnological and pharmaceutical industries.
With its focus on a completely novel class of pharmaceuticals, this book collates the hitherto scarce literature about DNA drug formulation keenly desired by biotechnologists, molecular biologists and pharmacists, as well as those working in the biotechnological and pharmaceutical industries.
As such, this volume presents a wide range of gene delivery systems needed for different therapeutic applications. It fills the gap between research and clinical trials and describes pharmaceutical fundamentals for the development of efficient DNA pharmaceuticals.
DNA Vaccines: an Overview
DNA as a Pharmaceutical: Regulatory Aspects
From Bulk to Delivery: Plasmid Manufacturing and Delivery
Minimized, CpG-Depleted and Methylated DNA Vectors: Towards Perfection in Nonviral Gene Therapy
Localized Nucleic Acid Delivery: a Discussion of Selected Methods
DNA Needle Injection
Needleless Jet Injection of Naked DNA von Nonviral in vivo Gene Transfer
Plasmid Inhalation: Delivery to the Airways
Hydrodynamic Gene Delivery
DNA Pharmaceuticals for Skin Diseases
Electrotransfection: an Overview
Electrogenetransfer in Clinical Applications
Cancer Inhibition in Mice after Systematic Application of Plasmid Driven Expression of Small Interfering RNAs
Martin Schleef received post-doctoral training from the Institut Pasteur Paris, France. He joined QIAGEN GmbH, Hilden, Germany in 1994 and is co-founder and CEO of PlasmidFactory in Bielefeld since 2000.