Veterinary Pharmacology and Therapeutics
10. Edition February 2018
1552 Pages, Hardcover
Practical Approach Book
ISBN:
978-1-118-85582-9
John Wiley & Sons
Further versions
Veterinary Pharmacology and Therapeutics, Tenth Edition is a fully updated and revised version of the gold-standard reference on the use of drug therapy in all major veterinary species.
* Provides current, detailed information on using drug therapies in all major domestic animal species
* Organized logically by drug class and treatment indication, with exhaustive information on the rational use of drugs in veterinary medicine
* Includes extensive tables of pharmacokinetic data, products available, and dosage regimens
* Adds new chapters on pharmaceutics, ophthalmic pharmacology, food animal pharmacology, and aquatic animal pharmacology
* Includes access to a companion website with the figures from the book in PowerPoint
Contributors xiii
Preface xix
About the Companion Website xxi
Section ?I Principles of Pharmacology 1
Veterinary Pharmacology: An Introduction to the Discipline 3
Jim E. Riviere and Mark G. Papich
Absorption, Distribution, Metabolism, and Elimination 8
Jim E. Riviere
Pharmacokinetics 41
Jim E. Riviere
Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine 65
Pierre-Louis Toutain
Principles of Pharmaceutics and Veterinary Dosage Forms 87
Raafat M. Fahmy and Marilyn N. Martinez
Section ?f Drugs Acting on the Autonomic Nervous System 111
Introduction to the Autonomic Nervous Systemand Autonomic Pharmacology 113
Joshua A. Rowe, RoseM.McMurphy, Barbara J. Lutjemeier, andMichael J. Kenney
Adrenergic Receptor Agonists and Antagonists 131
Rose M.McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and Michael J. Kenney
Cholinergic Pharmacology: Autonomic Drugs 151
RoseM.McMurphy, Elizabeth G. Davis, Amy J. Rankin,Marjory A. Artzer, Barbara J. Lutjemeier, andMichael J. Kenney
Section ?g Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System 165
Introduction to Drugs Acting on the Central Nervous Systemand Principles of Anesthesiology 167
Peter J. Pascoe and Eugene P. Steffey
Neuromuscular Blocking Agents 194
Diane E.Mason and Christopher L. Norkus
Inhalation Anesthetics 216
Robert J. Brosnan and Eugene P. Steffey
Injectable Anesthetic Agents 247
Lysa P. Posner
Opioid Analgesic Drugs 281
Butch KuKanich andMark G. Papich
Sedatives and Tranquilizers 324
Lysa P. Posner
Local Anesthetics 369
Thomas W. Vickroy
Euthanizing Agents 387
Anna Hampton
Anticonvulsant Drugs 395
Mark G. Papich
Drugs Affecting Animal Behavior 416
Margaret E. Gruen, Barbara L. Sherman, and Mark G. Papich
Section ?h Autacoids and Antiinflammatory Drugs 449
Histamine, Serotonin, and their Antagonists 451
Wolfgang B¨aumer
Analgesic, Antiinflammatory, Antipyretic Drugs 467
Peter Lees
Section ?i Drugs Acting on the Cardiovascular System 501
Digitalis, Positive Inotropes, and Vasodilators 503
Clarke E. Atkins and Marisa K. Ames
Antiarrhythmic Agents 537
Kathryn M. Meurs and Jim E. Riviere
Section ?j Drugs Affecting Renal Function and Fluid-Electrolyte Balance 553
Principles of Acid-Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes 555
Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar
Diuretics and Renal Pharmacology 593
Butch Kukanich and Deborah T. Kochevar
Section ?k Drugs Acting on Blood and Blood Elements 623
Anticoagulant, Antiplatelet, and Hemostatic Drugs 625
Mark G. Papich
Section ?l Endocrine Pharmacology 647
Hypothalamic and Pituitary Hormones 649
Srujana Rayalam,Margarethe Hoenig, and Duncan C. Ferguson
Hormones Affecting Reproduction 674
Wolfgang B¨aumer, C. Scott Bailey, and John Gadsby
Thyroid Hormone and Antithyroid Drugs 691
Duncan C. Ferguson
Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs 729
Duncan C. Ferguson and Margarethe Hoenig
Drugs Influencing Glucose Metabolism 763
Margarethe Hoenig
Chemotherapy of Microbial Diseases 779
Antiseptics and Disinfectants 781
Megan E. Jacob
Sulfonamides and Potentiated Sulfonamides 796
Mark G. Papich
beta-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs 826
Mark G. Papich
Tetracycline Antibiotics 858
Mark G. Papich and Jim E. Riviere
Aminoglycoside Antibiotics 877
Mark G. Papich and Jim E. Riviere
Chloramphenicol and Derivatives, Macrolides, Lincosamides, andMiscellaneous Antimicrobials 903
Mark G. Papich
Fluoroquinolone Antimicrobial Drugs 953
Mark G. Papich
Antifungal and Antiviral Drugs 988
Jennifer L. Davis and LaraMaxwell
Section ?I?e Chemotherapy of Parasitic Diseases 1033
Antinematodal Drugs 1035
Carlos E. Lanusse, JuanM. Sallovitz, Sergio F. Sanchez Bruni, and Luis I. Alvarez
Anticestodal and Antitrematodal Drugs 1081
Carlos E. Lanusse, Luis I. Alvarez, and Guillermo L. Virkel
Macrocyclic Lactones: Endectocide Compounds 1102
Carlos E. Lanusse, Fernanda A. Imperiale, and Adrian L. Lifschitz
Antiprotozoan Drugs 1128
Jennifer L. Davis and Jody L. Gookin
Ectoparasiticides 1166
Ronald E. Baynes
Section ?I?I Specialty Areas of Pharmacology 1189
Chemotherapy of Neoplastic Diseases 1191
Luke A.Wittenburg and Daniel L. Gustafson
Immunosuppressive Drugs 1226
Mark G. Papich
Drugs for Treating Gastrointestinal Diseases 1245
Mark G. Papich
Dermatopharmacology: Drugs Acting Locally on the Skin 1278
Jim E. Riviere and Rosanna Marsella
Drugs that Affect the Respiratory System 1302
Mark G. Papich
Ophthalmic Pharmacology 1321
Alison Clode
Pharmacogenomics 1332
Katrina L.Mealey
Considerations for TreatingMinor Food-Producing Animals with Veterinary Pharmaceuticals 1345
Lisa A. Tell, Margaret Oeller, Tara Marmulak, and Ronette Gehring
Unique Considerations Pertaining to the Use of Drugs in Food Animals 1358
Michael D. Apley
Pharmacology in Aquatic Animals 1373
Ron A.Miller
Zoological Pharmacology 1395
Robert P. Hunter
Section ?I?f Regulatory and Other Considerations 1405
The Regulation of Animal Drugs 1407
Steven D. Vaughn andMarilyn N. Martinez
Veterinary Pharmacy 1427
Gigi Davidson andMark G. Papich
Medication Control Programs in Performance Animals 1439
Cynthia A. Cole
Pharmacovigilance 1448
John D. Baker, Susan J. Bright-Ponte, and Lee Anne M. Palmer
Dosage Forms And Veterinary Feed Directives 1459
Geof Smith and Jim E. Riviere
Evidence-Based Pharmacotherapy 1465
Ronette Gehring
Chemical Residues In Tissues Of Food Animals 1469
Jim E. Riviere
Index 1481
Preface xix
About the Companion Website xxi
Section ?I Principles of Pharmacology 1
Veterinary Pharmacology: An Introduction to the Discipline 3
Jim E. Riviere and Mark G. Papich
Absorption, Distribution, Metabolism, and Elimination 8
Jim E. Riviere
Pharmacokinetics 41
Jim E. Riviere
Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine 65
Pierre-Louis Toutain
Principles of Pharmaceutics and Veterinary Dosage Forms 87
Raafat M. Fahmy and Marilyn N. Martinez
Section ?f Drugs Acting on the Autonomic Nervous System 111
Introduction to the Autonomic Nervous Systemand Autonomic Pharmacology 113
Joshua A. Rowe, RoseM.McMurphy, Barbara J. Lutjemeier, andMichael J. Kenney
Adrenergic Receptor Agonists and Antagonists 131
Rose M.McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and Michael J. Kenney
Cholinergic Pharmacology: Autonomic Drugs 151
RoseM.McMurphy, Elizabeth G. Davis, Amy J. Rankin,Marjory A. Artzer, Barbara J. Lutjemeier, andMichael J. Kenney
Section ?g Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System 165
Introduction to Drugs Acting on the Central Nervous Systemand Principles of Anesthesiology 167
Peter J. Pascoe and Eugene P. Steffey
Neuromuscular Blocking Agents 194
Diane E.Mason and Christopher L. Norkus
Inhalation Anesthetics 216
Robert J. Brosnan and Eugene P. Steffey
Injectable Anesthetic Agents 247
Lysa P. Posner
Opioid Analgesic Drugs 281
Butch KuKanich andMark G. Papich
Sedatives and Tranquilizers 324
Lysa P. Posner
Local Anesthetics 369
Thomas W. Vickroy
Euthanizing Agents 387
Anna Hampton
Anticonvulsant Drugs 395
Mark G. Papich
Drugs Affecting Animal Behavior 416
Margaret E. Gruen, Barbara L. Sherman, and Mark G. Papich
Section ?h Autacoids and Antiinflammatory Drugs 449
Histamine, Serotonin, and their Antagonists 451
Wolfgang B¨aumer
Analgesic, Antiinflammatory, Antipyretic Drugs 467
Peter Lees
Section ?i Drugs Acting on the Cardiovascular System 501
Digitalis, Positive Inotropes, and Vasodilators 503
Clarke E. Atkins and Marisa K. Ames
Antiarrhythmic Agents 537
Kathryn M. Meurs and Jim E. Riviere
Section ?j Drugs Affecting Renal Function and Fluid-Electrolyte Balance 553
Principles of Acid-Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes 555
Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar
Diuretics and Renal Pharmacology 593
Butch Kukanich and Deborah T. Kochevar
Section ?k Drugs Acting on Blood and Blood Elements 623
Anticoagulant, Antiplatelet, and Hemostatic Drugs 625
Mark G. Papich
Section ?l Endocrine Pharmacology 647
Hypothalamic and Pituitary Hormones 649
Srujana Rayalam,Margarethe Hoenig, and Duncan C. Ferguson
Hormones Affecting Reproduction 674
Wolfgang B¨aumer, C. Scott Bailey, and John Gadsby
Thyroid Hormone and Antithyroid Drugs 691
Duncan C. Ferguson
Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs 729
Duncan C. Ferguson and Margarethe Hoenig
Drugs Influencing Glucose Metabolism 763
Margarethe Hoenig
Chemotherapy of Microbial Diseases 779
Antiseptics and Disinfectants 781
Megan E. Jacob
Sulfonamides and Potentiated Sulfonamides 796
Mark G. Papich
beta-Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs 826
Mark G. Papich
Tetracycline Antibiotics 858
Mark G. Papich and Jim E. Riviere
Aminoglycoside Antibiotics 877
Mark G. Papich and Jim E. Riviere
Chloramphenicol and Derivatives, Macrolides, Lincosamides, andMiscellaneous Antimicrobials 903
Mark G. Papich
Fluoroquinolone Antimicrobial Drugs 953
Mark G. Papich
Antifungal and Antiviral Drugs 988
Jennifer L. Davis and LaraMaxwell
Section ?I?e Chemotherapy of Parasitic Diseases 1033
Antinematodal Drugs 1035
Carlos E. Lanusse, JuanM. Sallovitz, Sergio F. Sanchez Bruni, and Luis I. Alvarez
Anticestodal and Antitrematodal Drugs 1081
Carlos E. Lanusse, Luis I. Alvarez, and Guillermo L. Virkel
Macrocyclic Lactones: Endectocide Compounds 1102
Carlos E. Lanusse, Fernanda A. Imperiale, and Adrian L. Lifschitz
Antiprotozoan Drugs 1128
Jennifer L. Davis and Jody L. Gookin
Ectoparasiticides 1166
Ronald E. Baynes
Section ?I?I Specialty Areas of Pharmacology 1189
Chemotherapy of Neoplastic Diseases 1191
Luke A.Wittenburg and Daniel L. Gustafson
Immunosuppressive Drugs 1226
Mark G. Papich
Drugs for Treating Gastrointestinal Diseases 1245
Mark G. Papich
Dermatopharmacology: Drugs Acting Locally on the Skin 1278
Jim E. Riviere and Rosanna Marsella
Drugs that Affect the Respiratory System 1302
Mark G. Papich
Ophthalmic Pharmacology 1321
Alison Clode
Pharmacogenomics 1332
Katrina L.Mealey
Considerations for TreatingMinor Food-Producing Animals with Veterinary Pharmaceuticals 1345
Lisa A. Tell, Margaret Oeller, Tara Marmulak, and Ronette Gehring
Unique Considerations Pertaining to the Use of Drugs in Food Animals 1358
Michael D. Apley
Pharmacology in Aquatic Animals 1373
Ron A.Miller
Zoological Pharmacology 1395
Robert P. Hunter
Section ?I?f Regulatory and Other Considerations 1405
The Regulation of Animal Drugs 1407
Steven D. Vaughn andMarilyn N. Martinez
Veterinary Pharmacy 1427
Gigi Davidson andMark G. Papich
Medication Control Programs in Performance Animals 1439
Cynthia A. Cole
Pharmacovigilance 1448
John D. Baker, Susan J. Bright-Ponte, and Lee Anne M. Palmer
Dosage Forms And Veterinary Feed Directives 1459
Geof Smith and Jim E. Riviere
Evidence-Based Pharmacotherapy 1465
Ronette Gehring
Chemical Residues In Tissues Of Food Animals 1469
Jim E. Riviere
Index 1481
The editors
Jim E. Riviere, DVM, PhD, DSc (hon), ATS, is The MacDonald Chair in Veterinary Medicine, University Distinguished Professor, Kansas Bioscience Eminent Scholar, and Director, Institute of Computational Comparative Medicine at Kansas State University in Manhattan, Kansas, USA. He is also a Distinguished Professor Emeritus at North Carolina State University in Raleigh, North Carolina, USA.
Mark G. Papich, DVM, MS, Diplomate ACVCP, has the Burroughs Wellcome Professorship in Veterinary Pharmacology and is a Professor of Clinical Pharmacology, Department of Molecular Biomedical Sciences, College of Veterinary Medicine at North Carolina State University in Raleigh, North Carolina, USA
Jim E. Riviere, DVM, PhD, DSc (hon), ATS, is The MacDonald Chair in Veterinary Medicine, University Distinguished Professor, Kansas Bioscience Eminent Scholar, and Director, Institute of Computational Comparative Medicine at Kansas State University in Manhattan, Kansas, USA. He is also a Distinguished Professor Emeritus at North Carolina State University in Raleigh, North Carolina, USA.
Mark G. Papich, DVM, MS, Diplomate ACVCP, has the Burroughs Wellcome Professorship in Veterinary Pharmacology and is a Professor of Clinical Pharmacology, Department of Molecular Biomedical Sciences, College of Veterinary Medicine at North Carolina State University in Raleigh, North Carolina, USA
