 The use of natural and synthetic anabolic steroids by professional, amateur and adolescent athletes has reached epidemic rates in some sports. Imperlini et al. apply proteomic tools, starting with 2-D DIGE, to examine the effects of hyper physiological levels of androgens and testosterones on selected cell types. They found ~30 cases of differential expression. Functionally, roughly half were involved in apoptosis, both negative and positive regulation. Disturbed genes responsible for actin remodeling may also enhance cell survival and invasiveness rather than cell death (apoptosis) which may allow the cells to bypass a potential cancer checkpoint and continue growing. From the number of genes that are functionally disrupted in vitro in primary lymphocytes, there can be little doubt that the problem is worse in vivo. /tl
To appear in PROTEOMICS Issue 17.
Androgen receptor signaling induced by supraphysiological doses of dihydrotestosterone in human peripheral blood lymphocytes
Imperlini, E. et al., Proteomics 2010, 10, DOI: 10.1002/pmic.201000079
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