|  | Dunn, Peter / Wells, Andrew / Williams, Michael T. (Hrsg.)
Green Chemistry in the Pharmaceutical Industry
 1. Auflage März 2010
132,- Euro
2010. XVIII, 370 Seiten, Hardcover
187 Abb. (18 Farbabb.)
- Handbuch/Nachschlagewerk -
ISBN 978-3-527-32418-7 - Wiley-VCH, Weinheim
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Von drei weltbekannten Pharmazeuten herausgegeben, widmet sich dieser Band erstmals der "grünen" Chemie im Umfeld der pharmazeutischen Industrie. Dabei geht es um einfache kleine Moleküle genauso wie um komplexe Proteine, um pharmazeutische Grundlagenforschung und um das Schicksal von Wirkstoffen in der Umwelt. Die handliche Monographie enthält zahlreiche bisher nicht publizierte Informationen, dazu überzeugende Fallstudien aus der Industrie (Taxol, Pregabalin, Crestor etc.), die zeigen, inwieweit ein multidisziplinärer Ansatz Effizienz und Umweltfreundlichkeit der Prozesse befördern kann. Ein abschließendes Kapitel befasst sich mit eindrucksvollen Technologien und technischen Hilfsmitteln.
Aus dem Inhalt
INTRODUCTION TO GREEN CHEMISTRY, ORGANIC SYNTHESIS AND PHARMACEUTICALS
The Development of Organic Synthesis
The Environmental Factor
The Role of Catalysis
Green Chemistry: Benign by Design
Ibuprofen Manufacture
The Question of Solvents: Alternative Reaction Media
Biocatalysis: Green Chemistry Meets White Biotechnology
Conclusions and Prospects
GREEN CHEMISTRY METRICS
Introduction
Measuring Resource Usage
Life Cycle Assessment (LCA)
Measuring Chemistry and Process Efficiency
Measuring Process Parameters and Emissions
Real Time Analysis
Operational Efficiency
Measuring Energy
Measuring the Toxicity of All the Substrates
Measuring Degradation Potential
Measuring the Inherent Safety of Lack of Inherent Safety
Conclusions
SOLVENT USE AND WASTE ISSUES
Introduction to Solvent Use and Waste Issues
Solvent and Process Greenness Scoring and Selection Tools
Waste Minimization and Solvent Recovery
ENVIRONMENTAL AND REGULATORY ASPECTS
Historical Perspective
Pharmaceuticals in the Environment
Environmental Regulations
A Look to the Future
SYNTHESIS OF SITAGLIPTIN, THE ACTIVE INGREDIENT IN JANUVIA AND JANUMET
Introduction
First-Generation Route
Sitagliptin through Diastereoselective Hydrogenation of an Enamine. The PGA Enamine-Ester Route
The Triazole Fragment
Direct Preparation of Beta-Keto Amides
Second-Generation Chiral Auxiliary Route. The PGA Enamine-Amide Route
Prufication and Isolation of Sitagliptin (Pharmaceutical Form)
The Final Manufacturing Route
THE DEVELOPMENT OF SHORT, EFFICIENT, ECONOMIC, AND SUSTAINABLE CHEMOENZYMATIC PROCESSES FOR STATIN SIDE CHAINS
Introduction: Biocatalysis
The Relevance of Statins
Biocatalytic Routes to Statin Side Chains
2-Deoxy-D-Ribose 5-Phosphate Aldolase (DERA)-Based Routes to Statin Intermediates
Conclusions
THE TAXOL STORY-DEVELOPMENT OF A GREEN SYNTHESIS VIA PLANT CELL FERMENTATION
Introduction
Discovery and Early Development
From Extraction of Taxol from Pacific Yew Tree Bark to Semi-Synthetic Taxol
Taxol from Plant Cell Fermentation
Comparison of Semi-Synthetic versus PCF Taxol Processes: The Environmental Impact
Comparison of Semi-Synthetic versus PCF Taxol: Green Chemistry Principles
Final Words
THE DEVELOPMENT OF A GREEN, ENERGY EFFICIENT, CHEMOENZYMATIC MANUFACTURING PROCESS OF PREGABALIN
Introduction
Process Routes to Pregabalin
Biocatalytic Route to Pregabalin
Green Chemistry Considerations
Conclusions
GREEN PROCESSES FOR PEPTIDE MIMETIC DIABETIC DRUGS
Introduction
Green Chemistry Considerations in Peptide-like API manufacture
Purification Process to Manufacture Amorphous API
Preparation of Unnatural Amino Acids
Summary
THE DEVELOPMENT OF AN ENVIRONMENTALLY SUSTAINABLE PROCESS FOR RADAFAXINE
Introduction
Chemistry Process and the Dynamic Kinetic Resolution (DKR)
Multicolumn Chromatography - Development of Route 4
Environmental Assessment
Summary
CONTINUOUS PROCESSING IN THE PHARMACEUTICAL INDUSTRY
Introduction
Continuous Production of a Key Intermediate for Atorvastatin
Continuous Process to Prepare Celecoxib
Continuous Oxidation of Alcohols to Aldehydes
Continuous Production of Bromonitromethane
Continuous Production and Use of Diazomehtane
A Snapshot of Some Further Continuous Processes Used in the Preparation of Pharmaceutical Agents
Conclusions
PREPARATIVE AND INDUSTRIAL SCALE CHROMATOGRAPHY: GREEN AND INTEGRATED PROCESSES
Introduction
Basic Principles of Chromatography
Process Optimization to Reduce Eluent Consumption
Use of a Green Solvent: Supercritical Carbon Dioxide
Solvent Recycling Technologies
Application Examples
Conclusion: An Environmentally Friendly Solution for Each Separation
DYNAMIC RESOLUTION OF CHIRAL AMINE PHARMACEUTICALS: TURNING WASTE ISOMERS INTO USEFUL PRODUCT
Background
Integration of Chiral Amine Resolution and Racemization
Case Studies
Conclusions
GREEN TECHNOLOGIES IN THE GENERIC PHARMACEUTICAL INDUSTRY
Introduction
'Waste': Definition and Remedy
Amidation
Synthesis of Galanthamine
Synthesis of Solefinacin
Synthesis of Levetiracetam
Synthesis of a Finasteride Intermediate
Bromination
Sulfoxidation in the Synthesis of Rabeprazole
Conclusions
ENVIRONMENTAL CONSIDERATIONS IN BIOLOGICS MANUFACTURE
Introduction
Therapeutic Biologics
Environmental Impact Considerations
Overall Comparison
Environmental Indices for Therapeutic Protein Manufacture
Technologies with Potential Environmental Impact
Single-Use Biologics Manufacture
Summary
FUTURE TRENDS FOR GREEN CHEMISTRY IN THE PHARMACEUTICAL INDUSTRY
Introduction
Waste Minimization in Drug Discovery
Greener Synthetic Methods in Primary Manufacturing
Alternative Solvents in the Pharmaceutical Industry
Green Chemistry in Secondary Pharmaceutical Operations
Global Cooperation in Green Chemistry
Conclusions
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