|  | Mascher, Hermann
HPLC Methods for Clinical Pharmaceutical Analysis
A User's Guide
 1. Auflage Januar 2012
59,90 Euro
2012. IX, 247 Seiten, Hardcover
- Praktikerbuch -
ISBN 978-3-527-33129-1 - Wiley-VCH, Weinheim
Preis inkl. Mehrwertsteuer zzgl. Versandkosten.
|
Inhalt
Probekapitel
Index
| Jetzt kaufen
|
| Kurzbeschreibung
The author describes all steps of a routine pharmaceutical analysis in an intuitive fashion and explains how to develop robust and efficient methods for any clinical compound. A reference appendix contains tried and tested methods for 100 freqently encountered pharmaceuticals.
Aus dem Inhalt
Preface
INTRODUCTION
First Question: Determination of Ibuprofen in Plasma
Second Question: Determination of Tryptophan in Urine
Third Question: Determination of Paclitaxel in Tissue
PLANNING OF ANALYSES
Introduction
Limit of Detection (LOD) and Determination (LLOQ)
Detectors
Structure of the Analyte
Solubility of an Analyte
Selection of the Detector
SAMPLE PREPARATION
Dilution
Protein Precipitation, Overview
Extraction
HPLC SEPARATION
HPLC Pumps
Degassers
Injector
HPLC Columns
DETECTION
Detection in the Pharmaceutical/Bioanalytical Area
Detection in the "Clinical Area" (Therapy Control/Compliance)
CHEMICAL DERIVATISATION FOR DETECTION ENHANCEMENT
VALIDATION CONCEPTS
Introduction
Realisation of the FDA Guideline
PRACTICAL HINTS CONCERNING STABILITY, DESTRUCTION AND DEGRADATION PRODUCTS
METABOLITES
INTERNAL STANDARDS
CASE STUDIES WITH INTENSIVE DISCUSSION FOR EACH SUBSTANCE
Acetylcarnitine in Plasma
Acetylcysteine in Plasma
Acyclovir in Plasma and Urine
Caffeine in Plasma
Diazepam in Plasma
Diclofenac in Plasma
Dihydralazine in Plasma
Duramycin (Moli1901) in Plasma
Fluticasone Propionate in Plasma
Hydroxytriamterene Sulfate and Triamterene in Plasma and Urine
Ibuprofen in Plasma (also Enantiomeric Separation)
Minocycline in plasma
Norfloxacine in Plasma and Urine
Paclitaxel in Plasma, Urine, and Tissue
Paracetamol (Acetaminophen) in Plasma
Pimelic Acid in Plasma and Urine
8-Prenylnaringenin in Plasma and in Different Types of Tissues
Silibinin in Plasma
Valnemulin in Plasma, Different Tissue Types and Animal Feed
Vitamin B1 (Total Thiamine) in Plasma
APPENDIX
Short Description of Determination for about 100 Substances
Substances listed in the Appendix
A Short Explanation of Tables Presented in the Appendix
|
|
|
|
