Asymmetric Synthesis of Non-Proteinogenic Amino Acids
1. Auflage Oktober 2016
XIV, 359 Seiten, Hardcover
343 Abbildungen
Monographie
Kurzbeschreibung
Aimed at further stimulating research in this rapidly developing field, this much-needed reference provides an up-to-date review of catalytic and stoichiometric strategies for the synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin.
Authored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology.
Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.
1. NON-PROTEIN ALPHA-AMINO ACIDS, ASPECTS OF THEIR APPLICATION
1.1. Natural Origin, Biological Functions
1.2. Amino Acids as Radiopharmaceuticals in PET Diagnostics
2. NATURAL SYNTHESIS OF AMINO ACIDS, MECHANISMS AND MODELING
2.1. Regularity of Mechanisms for the Natural Synthesis of Amino Acids
2.2. Systems for Modeling Some Aspects of Pyridoxal Enzyme Action
2.3. Modeling of Processes Associated with Cleavage of C-alpha-H and C-alpha-C-beta Bonds
2.4. Modelling of alpha. beta-Elimination Processes of PP-Catalysis, Kinetics and Stereochemistry
2.5. Biomimetic Addition Reaction of Nucleophiles to Co(III) Complexes Of Dehydroaminobutyric Acid
3. ASYMMETRIC SYNTHESIS OF NON-PROTEIN ALPHA-AMINO ACIDS
3.1. The Main Rules of Asymmetric Synthesis
3.2. Catalytic Asymmetric Synthesis
3.3. Stoichiometric Asymmetric Synthesis of Alpha-Amino Acids
Peter Langer studied chemistry at the University of Hannover and at the Massachusetts Institute of Technology (MIT, USA). In February 1997 he obtained his Dr. rer. nat. at the University of Hannover. During a postdoctoral period in Cambridge (UK) he worked on the synthesis of oligosaccharides. In 1998 he moved to the University of Göttingen where he completed his habilitation in July 2001. In April 2002 he took a permanent position as a full professor (C4) at
the University of Greifswald. In December 2004 Peter Langer moved to a new position as a full professor (C4) at the University of Rostock. Since July 2005 he is
also affiliated to the Leibniz-Institute of Catalysis e. V. at the University of Rostock (LIKAT) as the head of the division `organic synthesis'. Prof. Langer is coauthor
of more than 600 research papers and reviews. His research is focused on the development of new synthetic methods and their application to the synthesis of biologically relevant ring systems. Professor Langer received several prestigious scholarships (Studienstiftung des Deutschen Volkes, Feodor-Lynen-scholarship, Liebig scholarship, Heisenberg-scholarship), international awards, and honorary doctorates of several universities. In 2015 Peter Langer has been elected foreign member of the National Academy of Science of Armenia.