|Lee, Mike S. / Zhu, Mingshe|
Mass Spectrometry in Drug Metabolism and Disposition
Basic Principles and Applications
Wiley Series on Pharmaceutical Science
1. Auflage April 2011
2011. 800 Seiten, Hardcover
ISBN 978-0-470-40196-5 - John Wiley & Sons
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In drug development and research, it is crucial to analyze and monitor the metabolism of drugs, as the process may lead to the creation of metabolites that are either helpful or harmful. Mass spectrometry has emerged as an ideal technique for the identification of almost all structurally diverse metabolites, due to its superb speed, high selectivity, and high sensitivity. This important reference provides a background in metabolite identification and discusses how to solve real-world problems in drug metabolism using mass spectrometry. An ideal resource for scientists in drug research and discovery as well as students and professors in analytical chemistry and pharmaceutics.
Aus dem Inhalt
Foreword (Tom Baillie).
Preface (Mike Lee and Mingshe Zhu).
Part I. Basic Concepts of Drug Metabolism and Disposition.
1. Progression of Drug Metabolism (Ronald E. White).
2. Common Biotransformation Reactions (Bo Wen and Sidney D. Nelson).
3. Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry (Amit S. Kalgutkar).
4. Drug-Metabolizing Enzymes, Transporters, and Drug-Drug Interactions (Steven W. Louie and Magang Shou).
5. Experimental Models of Drug Metabolism and Disposition (Gang Luo, Chuang Lu, Xinxin Ding, and Donglu Zhang).
6. Principles of Pharmacokinetics: Predicting Human Pharmacokinetics in Drug Discovery (Takehito Yamamoto, Akihiro Hisaka, and Hiroshi Suzuki).
7. Drug Metabolism Research as Integral Part of Drug Discovery and Development Processes (W. Griffith Humphereys).
Part II. Mass Spectrometry in Drug Metabolism: Principles and Common Practice.
8. Theory and Instrumentation of Mass Spectrometry (Gérard Hopfgartner).
9. Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification (Lin Xu, Lewis J. Klunk, and Chandra Prakash).
10. Mass Spectral Interpretation (Li-Kang Zhang and Birendra N. Pramanik).
11. Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography, and Non-Mass-Spectrometric Detection (Mark Hayward, Maria D. Bacolod, Qing Ping Han, Manuel Cajina, and Zack Zou).
Part III. Applications of New LC-MS Techniques in Drug Metabolism and Disposition.
12. Quantitative In Vitro ADME Assays Using LC-MS as a Part of Early Drug Metabolism Screening (Walter Korfmacher).
13. High-Resolution Mass Spectrometry and Drug Metabolite Identification (Russell J. Mortishire-Smith, Haiying Zhang, and Kevin P. Bateman).
14. Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging (Richard F. Reich, Daniel P. Magparangalan, Timothy J. Garrett, and Richard A. Yost).
15. Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC-MS Platform in Drug Metabolism and Pharmacokinetics (Wenying Jian, Ming Yao, Bo Wen, Elliott B. Jones, and Mingshe Zhu).
16. Quantitative Drug Metabolism with Accelerator Mass Spectrometry (John S. Vogel, Peter Lohstroh, Brad Keck, and Stephen R. Dueker).
17. Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions (Jing-Tao Wu).
18. Profiling and Characterization of Herbal Medicine and Its Metabolites Using LC-MS (Zeper Abliz, Ruiping Zhang, Ping Geng, Dongmei Dai, Jiuming He, and Jian Liu).
19. Liquid Chromatography Mass Spectrometry Bioanalysis of Protein Therapeutics and Biomarkers in Biological Matrices (Fumin Li and Qin C. Ji).
20. Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress (Stacy L. Gelhaus and Ian A. Blair).
21. LC-MS in Endogenous Metabolite Profiling and Small-Molecule Biomarker Discovery (Michael D. Reily, Petia Shipkova, and Serhiy Hnatyshyn).