|  | Benson, Heather A. E. / Watkinson, Adam C.
Topical and Transdermal Drug Delivery
Principles and Practice
 1. Auflage Januar 2012
109,- Euro
2012. 464 Seiten, Hardcover
- Praktikerbuch -
ISBN 978-0-470-45029-1 - John Wiley & Sons
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| Kurzbeschreibung
By understanding the mechanisms by which compounds cross the skin, it becomes possible to devise means for improving drug delivery. Providing an overview of the current science in drug and cosmetic application to and through the skin, Topical and Transdermal Drug Delivery includes treatment of skin conditions, skin permeation, and enhancement and measurement of skin permeation. The book provides pharmaceutical scientists, skin product development experts, and those in the cosmetic and personal care industry with practical knowledge and insight into future product development.
Aus dem Inhalt
Preface ix
About the Editors xi
Contributors xiii
Part One Current Science, Skin Permeation, and Enhancement Approaches
1. Skin Structure, Function, and Permeation 3
Heather A.E. Benson
2. Passive Skin Permeation Enhancement 23
Majella E. Lane, Paulo Santos, Adam C. Watkinson, and Jonathan Hadgraft
3. Electrical and Physical Methods of Skin Penetration Enhancement 43
Jeffrey E. Grice, Tarl W. Prow, Mark A.F. Kendall, and Michael S. Roberts
4. Clinical Applications of Transdermal Iontophoresis 67
Dhaval R. Kalaria, Sachin Dubey, and Yogeshvar N. Kalia
5. In Vitro Skin Permeation Methodology 85
Barrie Finnin, Kenneth A. Walters, and Thomas J. Franz
6. Skin Permeation Assessment: Tape Stripping 109
Sandra Wiedersberg and Sara Nicoli
7. Skin Permeation Assessment: Microdialysis 131
Rikke Holmgaard, Jesper B. Nielsen, and Eva Benfeldt
8. Skin Permeation: Spectroscopic Methods 155
Jonathan Hadgraft and Majella E. Lane
9. Skin Permeation Assessment in Man: In Vitro-In Vivo Correlation 167
Paul A. Lehman, Sam G. Raney, and Thomas J. Franz
10. Risk Assessment 183
Jon R. Heylings
Part Two Topical and Transdermal Product Development
11. An Overview of Product Development from Concept to Approval 203
Adam C. Watkinson
12. Regulatory Aspects of Drug Development for Dermal Products 217
William K. Sietsema
13. Toxicological and Pre-clinical Considerations for Novel Excipients and New Chemical Entities 233
Andrew Makin and Jens Thing Mortensen
14. Topical Product Formulation Development 255
Marc B. Brown, Robert Turner, and Sian T. Lim
15. Transdermal Product Formulation Development 287
Kenneth J. Miller
16. Sensitivity and Irritation Testing 309
Belum Viswanath Reddy, Geetanjali Sethi, and Howard I. Maibach
17. New Product Development for Transdermal Drug Delivery: Understanding the Market Opportunity 345
Hugh Alsop
18. Transdermal and Topical Drug Delivery Today 357
Adam C. Watkinson
19. Current and Future Trends: Skin Diseases and Treatment 367
Simon G. Danby, Gordon W. Duff, and Michael J. Cork
Index 409
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