|  | Dinges, Jürgen / Lamberth, Clemens (Hrsg.)
Bioactive Heterocyclic Compound Classes
Pharmaceuticals
 1. Auflage September 2012
139,- Euro
2012. XVI, 356 Seiten, Hardcover
123 Abb., 16 Tab.
- Handbuch/Nachschlagewerk -
ISBN 978-3-527-33395-0 - Wiley-VCH, Weinheim
Preis inkl. Mehrwertsteuer zzgl. Versandkosten.
|
Inhalt
Probekapitel
Index
| Jetzt kaufen   
E-Books sind auch über alle bekannten E-Book Shops erhältlich.
|
| Kurzbeschreibung
This book provides researchers in academia and industry with first-hand information on the chemistry and mode of action of important pharmaceuticals.
Aus dem Inhalt
IINTRODUCTION
THE SIGNIFICANCE OF HETEROCYCLES FOR PHARMACEUTICALS AND AGROCHEMICALS
Introduction
Heterocycles as Framework of Biologically Active Compounds
Fine-Tuning the Physicochemical Properties with Heterocycles
Heterocycles as Prodrugs
Heterocycles as Peptidomimetics
Heterocycles as Isosteric Replacement of Functional Groups
Heterocycles as Isosteric Replacement of Alicyclic Rings
Heterocycles as Isosteric Replacement of other Heterocyclic Rings
PART I: Neurological Disorders
TROPANE-BASED ALKALOIDS AS MUSCARINIC ANTAGONISTS FOR THE TREATMENT OF ASTHMA, OBSTRUCTIVE PULMONARY DISEASE, AND MOTION SICKNESS
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationships
MORPHINONE-BASED OPIOID RECEPTOR AGONIST ANALGESICS
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
BARBITURIC ACID-BASED GABA(A) RECEPTOR MODULATORS FOR THE TREATMENT OF SLEEP DISORDER AND EPILEPSY AND AS ANESTHETICS
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
PHENOTHIAZINE-BASED DOPAMINE D2 ANTAGONISTS FOR THE TREATMENT OF SCHIZOPHRENIA
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationships
ARYLPIPERAZINE-BASED 5-HT1A RECEPTOR PARTIAL AGONISTS AND 5-HT2A ANTAGONISTS FOR THE TREATMENT OF AUTISM, DEPRESSION, ANXIETY, PSYCHOSIS, AND SCHIZOPHRENIA
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
ARYLPIPERIDINE-BASED DOPAMINE D2 ANTAGONISTS/5-HT2A ANTAGONISTS FOR THE TREATMENT OF AUTISM, DEPRESSION, SCHIZOPHRENIA, AND BIPOLAR DISORDER
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
DIBENZAZEPINE-BASED SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROPATHIC PAIN
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationships
PART II: Cardiovascular Diseases
DIHYDROPYRIDINE-BASED CALCIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ANGINA PECTORIS AND HYPERTENSION
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
TETRAZOLE-BASED ANGIOTENSIN II TYPE 1 (AT1) ANTAGONISTS FOR THE TREATMENT OF HEART FAILURE AND CONGESTIVE HYPERTENSION
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
THIAZIDE-BASED DIURETICS FOR THE TREATMENT OF HYPERTENSION AND GENITOURINARY DISORDERS
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
TETRAHYDROPYRANONE-BASED HMG-COA REDUCTASE INHIBITORS FOR THE TREATMENT OF ARTERIAL HYPERCHOLESTEROLEMIA
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
PART III: Infectious Diseases
ADENINE-BASED REVERSE TRANSCRIPTASE INHIBITORS AS ANTI-HIV AGENTS
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
GUANINE-BASED NUCLEOSIDE ANALOGS AS ANTIVIRAL AGENTS
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
PENICILLIN AND CEPHALOSPORIN ANTIBIOTICS
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationships
PART IV: Oncology
PYRIMIDINE-BASED KINASE INHIBITORS IN CANCER CHEMOTHERAPY
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
BENZYL TRIAZOLE-BASED AROMATASE INHIBITORS FOR THE TREATMENT OF BREAST CANCER
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
PART V: Inflammation and Gastrointestinal Diseases
ACETONIDE-BASED GLUCOCORTICOIDS FOR THE TREATMENT OF ASTHMA, SKIN INFLAMMATION AND DISEASES OF THE EYE
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
BENZIMIDAZOLE-BASED H+/K+-ATPASE INHIBITORS FOR THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationships
PART VI: Metabolic Diseases
THIAZOLIDINEDIONE-BASED INSULIN SENSITIZERS:PPAR-G AGONISTS FOR THE TREATMENT OF TYPE 2 DIABETES
Introduction
History
Synthesis
Mode of Action
Structure?Activity Relationship
INDEX
|
|
|
|
