1. Auflage - Juli 2004
165,- Euro
2004. 218 Seiten, Hardcover
ISBN-10: 0-471-66737-4
ISBN-13: 978-0-471-66737-7 - John Wiley & Sons

Preis inkl. Mehrwertsteuer zzgl. Versandkosten.





Probekapitel

Kurzbeschreibung
Metal and metalloid-containing compounds exhibit a wide range of biological and biocidal activities, some of which have been employed in medicines and drugs. Polymers containing metal or metalloid functions become a natural extension of this effort; just as organic compound drugs have been chemically bound to polymers or physically imbibed into polymer matrices in order to provide a variety of useful advantages, the same opportunities exist for using metal and metalloid species. This volume will cover important biomedical applications of organometallic compounds, including metal-labeled DNA on surfaces, artificial metallo-DNA, organotin molecules as anti-cancer drugs, and much more.

Aus dem Inhalt
Preface

Series Preface

1. Organometallic Compounds in Biomedical Applications (Charles E. Carraher Jr. and Charles U. Pittman Jr.)

I. Introduction

II. Case for Metal-Containing Bioactive Agents

A. Tin-Containing Biocidal Polymers

B. Ferrocene: A Therapeutic Role in Polymeric Systems?

C. Polymeric Moderation of OsO4 Toxicity

III. Miscellaneous Polymers

A. Metal Chelation Polymers

B. Condensation Polymers

IV. Small-Molecule Analogs

V. Summary

VI. References

2. Metal-Labeled DNA on Surfaces (Heinz-Bernhard Kraatz, Yitao Long, and Todd C. Sutherland)

I. Introduction

II. Ferrocene Nucleotides

III. Ferrocene-DNA Conjugates

IV. Other Metal-DNA Conjugates

V. Metallated DNA

A. Cu-DNA

B. M-DNA

VI. Summary

VII. Acknowledgments

VIII. References

3. Artificial DNA through Metal-Mediated Base Pairing: Structural Control and Discrete Metal Assembly (Mitsuhiko Shionoya)

I. Introduction

II. Alternative Hydrogen-Bonding Schemes for DNA Base Pairing

III. Non-Hydrogen-Bonding Basepairs in DNA

IV. Metal-Mediated Base Pairing in DNA

A. Basic Concept

B. Artificial Nucleosides Designed for Metal-Mediated Base Pairs

C. Incorporation of a Metallo-Base Pair in DNA and Its Effect on Thermal Stability

D. Discrete Self-Assembled Metal Arrays in DNA

V. Future Prospects for Artificial Metallo-DNA

VI. Summary

VII. References

4. Organotin Macromolecules as Anticancer Drugs (Charles E. Carraher Jr. and Deborah Siegmann-Louda)

I. General

II. Anticancer Activity of Small Organotin Compounds

III. Molecule-Level Studies on Monomeric Organotin Compounds

IV. Anticancer Activity of Organotin Polymers

V. Future Work

VI. References

5. Organotin Oligomeric Drugs Containing the Antivirial Agent Acyclovir (Charles E. Carraher Jr. and Robert E. Bleicher)

I. Early History of Organotin Compounds

II. Mechanisms and Reactions

III. General Structures

IV. Acyclovir

V. Bioactivity of Related Compounds

VI. Experimental Work

VII. Results and Discussion

VIII. References

6. Polymeric Ferrocene Conjugates as Antiproliferative Agents (Eberhard W. Neuse)

I. Introduction

II. The Ferrocene-Ferricenium System in the Biological Environment

III. Polymer-Drug Conjugation as a Pharmaceutical Tool for Drug Delivery

IV. Polymer-Ferrocene Conjugates: Synthesis and Structure

A. The Carrier Component: Structural Considerations

B. Conjugates of Amide-Linked Ferrocene

C. Conjugates of Ester-Linked Ferrocene

V. Bioactivity Screening

VI. Summary and Conclusions

VII. Acknowledgments

VIII.References

7. Polymeric Platinum-Containing Drugs in the Treatment of Cancer (Deborah W. Siegmann-Louda and Charles E. Carraher Jr)

I. Introduction

II. Basic Mechanisms of Pt(II) Complex Formation

III. Nomenclature

IV. Currently Approved Platinum-Containing Compounds

V. Properties of Cisplatin

VI. Structure-Activity Relationships

VII. Polymer-Drug Conjugation Strategy and Possible Benefits

A. Polymers as Carriers

B. Polymers as Drugs

C. General

VIII. Mainchain-Incorporated cis-Diamine-Coordinated Platinum

A. Simple Amine Derivatives

B. Amino Acid Derivatives

C. Other Nitrogen-Platinum Products

D. Solution Stability

E. Thermal Stability

F. Antiviral Activity

IX. Platinum Carrier-Bound Complexes via Nitrogen Donor Ligands

A. Pt-Polyphosphazenes

B. Slowly Biofissionable PtN Complexes Anchored through Primary and Secondary Amines

C. Biofissionable PtN Complexes Anchored through Primary and Secondary Amines

X. Pt-O-Bound Polymers

XI. Mixed Pt-O/Pt-N-Bound Polymers

XII. Future Work

XIII. Acknowledgments

XIV. References

8. New Organic Polyacid-Inorganic Compounds for Improved Dental Materials (Bill M. Culbertson, Minhhoa H. Dotrong, and Scott R. Schricker)

I. Introduction

II. Glass Ionomer Technology

A. Amino Acid-Modified Glass Ionomers

B. N-Vinylpyrrolidone (NVP)-Modified Glass Ionomers

III. New NVP-Modified Glass Ionomers: Experimental Work

A. Materials

B. Polymer Synthesis

C. Characterization

D. Physical Properties

IV. Results and Discussion

V. Conclusions

VI. References

Index.