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Kurzbeschreibung Human Population Genetics will provide an introduction to mathematical population genetics, along with relevant examples from human (and some non-human primate) populations, and will also present concepts and methods of population genetics that are specific to the study of human populations. The purpose of this book is to provide a basic background text for advanced undergraduate and graduate students interesting in the mechanisms of human microevolution.
Aus dem Inhalt Foreword vii
Preface ix
1 GENETIC, MATHEMATICAL, AND ANTHROPOLOGICAL BACKGROUND 1
I. The Scope of Population Genetics 2
II. Genetics Background 5
III. Principles of Probability 14
IV. The Anthropological Connection 17
V. A Closing Thought 21
2 HARDY-WEINBERG EQUILIBRIUM 23
I. Genotype and Allele Frequencies 24
II. What is Hardy-Weinberg Equilibrium? 30
III. The Mathematics of Hardy-Weinberg Equilibrium 31
IV. Using Hardy-Weinberg Equilibrium 37
V. Extensions of Hardy-Weinberg Equilibrium 40
VI. Hardy-Weinberg Equilibrium and Evolution 44
VII. Summary 45
3 INBREEDING 49
I. Quantifying Inbreeding 51
II. Population Genetics and Inbreeding 62
III. Inbreeding in Human Populations 65
IV. Summary 75
4 MUTATION 77
I. The Nature of Mutations 77
II. Models of Mutation 81
III. Mutational History and Anthropological Questions 88
IV. Summary 96
5 GENETIC DRIFT 101
I. What is Genetic Drift? 102
II. Genetic Drift and Population Size 112
III. Effects on Genetic Variation 120
IV. Mutation and Genetic Drift 121
V. Coalescent Theory 125
VI. Summary 131
6 MODELS OF NATURAL SELECTION 139
I. How Does Natural Selection Work? 140
II. A General Model of Natural Selection 145
III. Types of Natural Selection 147
IV. Other Aspects of Selection 160
V. Summary 167
7 NATURAL SELECTION IN HUMAN POPULATIONS 181
I. Case Studies of Natural Selection in Human Populations 182
