|Lesk, Arthur M. (ed.)|
Database Annotation in Molecular Biology
Principles and Practice
1. Edition November 2004
2004. 266 Pages, Hardcover
- Handbook/Reference Book -
ISBN 978-0-470-85681-9 - John Wiley & Sons
E-Books are also available on all known E-Book shops.
The amount of data generated in molecular biology using high-throughput genomics and proteomics technologies is vast and proliferating rapidly. The successful application of such data in biomedical research requires carefully, continuously curated and accurately annotated databanks. Annotations often depend on features inferred rather than directly observed or measured: for instance, the identification of genes in genome sequences. Annotation is emerging as a specialist field within bioinformatics with its own set of techniques and associated skills. Database Annotation in Molecular Biology is the first book to address the vital and emerging field of biological database curation and annotation.
From the contents
List of Contributors.
1. Annotation and Databases: Status and Prospects (M. Hoebeke, H. Chiapello, J.-F. Gibrat, Ph. Bessieres and J. Garnier).
I: THE DATABANKS.
2. Survey of Sequence Databases: Archival Projects (M. Magrane, M. Garcia-Pastor and R. Apweiler).
3. Survey of Sequence Databases: Derived Databases (M. Pruess, N. Mulder and R. Apweiler).
4. Databanks of Macromolecular Structure (H.J. Bernstein and F.C. Bernstein).
5. Gene Expression Databases (H. Parkinson).
II: THE BASIS OF ANNOTATION.
6. Taxonomy: a Moving Target for Sequence Data (M.I. Krichevsky).
7. Genomics and Proteomics: Design and Sources of Annotation (K. Mayer and G. Mannhaupt).
8. Annotation of Protein Sequences (W.C. Barker and C.H. Wu).
9. Issues in the Annotation of Protein Structures (G.J. Swaminathan, J. Tate, R. Newman, A. Hussain, J. Ionides, K. Henrick and S. Velankar).
10. Classification of Protein Function (A.M. Lesk, H. Parkinson and J.C. Whisstock).
III: DATABASE DESIGN AND INTEGRATION.
11. Information Flow and Data Integration of Databanks (C.H. Wu and W.C. Barker).
12. Models of Database Interconnectivity (G.J.L.Kemp).
13. The European Bioinformatics Institute Macromolecular Structure Relational Database Technology (H. Boutselakis, D. Dimitriopoulos, K. Henrick, J. Ionides, M. John, P.A. Keller, P. McNeil, J. Pineda and A. Suarez-Uruena).
IV: CONCLUSIONS AND PROSPECTS.
14. Looking Around, Looking Ahead (A.M. Lesk).