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Hilfiker, Rolf (ed.)
Polymorphism
in the Pharmaceutical Industry

1. Edition - February 2006
179.- Euro
2006. XIX, 414 Pages, Hardcover
156 Fig. (8 Colored Fig.), 19 Tab. 
- Handbook/Reference Book -
ISBN-10: 3-527-31146-7
ISBN-13: 978-3-527-31146-0 - Wiley-VCH, Weinheim


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Short description
This handbook emphasizes why solid-state issues are important, what approaches should be taken to avoid problems and exploits opportunities of solid state properties in the field of pharma-, agro- and fine chemical industry.

From the contents
Relevance of Solid-state Properties for Pharmaceutical Products
Thermodynamics of Polymorphs
Characterization of Polymorphic Systems using Thermal Analysis
Solid-state NMR Spectroscopy
Vibrational Spectroscopic Methods in Pharmaceutical Solid-state Characterization
Crystallography for Polymorphs
Light Microscopy
The Importance of Solvates
Physical Characterization of Hygroscopicity in Pharmaceutical Solids
The Amorphous State
Approaches to Polymorphism Screening
Salt Selection
Processing-induced Phase Transformations and their Implications on Pharmaceutical Product Quality
Polymorphism and Patents from A Chemist's Point of View
Scientific Considerations of Pharmaceutical Solid Polymorphism in Regulatory Applications


 
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