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Short description A plasmid is a DNA molecule separate from chromosomal DNA and capable of autonomous replication. Plasmid Biopharmaceuticals helps pharmaceutical scientists and engineers understand the basic characteristics of therapeutic DNA plasmids, their potential utilization in drug development, and the issues and solutions for large-scale GMP production. Bringing together information on plasmid basics and applications, the book also addresses a range of manufacturing-related issues. It is an essential guide for academic and industrial researchers concerned with plasmid DNA manufacturing for pharmaceutical applications.
From the contents Preface.
Part I Basics.
1 Historical Perspective.
2 Gene Transfer with Plasmid Biopharmaceuticals.
3 Product and Process Development.
5 Analytical Characterization.
Part II Applications.
7 Ethical and Safety Issues.
8 Human and Veterinary Markets.
9 Human Case Studies: Pandemic Infl uenza and Critical Limb Ischemia.
10 Veterinary Case Studies: West Nile, Infectious Hematopoietic Necrosis, and Melanoma.