|  | Turrin, Cedric-Olivier / Laurent, Regis / Ouali, Arnelle / Delavaux-Nicot, Beatrice
Dendrimers
Towards Catalytic, Material and Biomedical Uses
 1. Edition September 2011
155.- Euro
2011. 566 Pages, Hardcover
ISBN 978-0-470-74881-7 - John Wiley & Sons
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| Short description
The definitive reference book on the subject, Dendrimers: Towards Catalytic, Material and Biomedical Uses focuses on the properties and uses of dendrimers and dendrons. Providing a unique overview of existing research, with numerous references and illustrations, it emphasizes the role of nanometric size and multiple functions of dendrimers. Divided into four main parts: Generalities, syntheses, characterizations and properties; Applications in catalysis; Applications for the elaboration or modification of materials; and Applications in biology/medicine, the book is aimed at academic and industrial researchers in the field.
From the contents
Preface xv
Part 1 Generalities, Syntheses, Characterizations, and Physicochemical Properties 1
1 Syntheses of Dendrimers and Dendrons 3
Anne-Marie Caminade
1.1 Introduction: What Are Dendrimers and Dendrons? 3
1.2 Syntheses of Poly(propyleneimine) Dendrimers (PPI) 5
1.3 Synthesis of Poly(amidoamine) Dendrimers (PAMAM) 5
1.4 Syntheses of Poly(ether) Dendrimers 7
1.5 Syntheses of Poly(ester) Dendrimers 10
1.6 Synthesis of Poly(lysine) Dendrimers 14
1.7 Syntheses of Silicon-Containing Dendrimers 15
1.8 Syntheses of Phosphorus-Containing Dendrimers 16
1.9 Syntheses of Carbon-Based Dendrimers 17
1.10 Syntheses of Dendrimers Constituted of Nitrogen Heterocycles 19
1.11 Syntheses by Self-Assembly 21
1.12 Accelerated Syntheses 26
1.13 Conclusion 30
References 30
2 Methods of Characterization of Dendrimers 35
Anne-Marie Caminade
2.1 Introduction 35
2.2 Spectroscopy and Spectrometry 36
2.3 Scattering Techniques 47
Wide-Angle X-ray Scattering (WAXS) 48
2.4 Microscopy 48
2.5 Rheology and Physical Characterizations 50
2.6 Separation Techniques 52
2.7 Conclusion 53
References 54
3 Luminescent Dendrimers 67
Anne-Marie Caminade
3.1 Introduction 67
3.2 Dendrimers with Fluorescent Terminal Groups 68
3.3 Luminescent Group at the Core of Dendrimers and Energy/Light-Harvesting Properties 74
3.4 Fluorescent Groups inside the Structure of Dendrimers 79
3.5 Intrinsically Fluorescent Dendrimers 81
3.6 Two-Photon-Excited Fluorescence of Dendrimers 86
3.7 Conclusion 89
References 90
4 Stimuli-Responsive Dendrimers 99
Anne-Marie Caminade
4.1 Introduction 99
4.2 Photoresponsive Dendrimeric Structures 100
4.3 Thermoresponsive Dendrimeric Structures 110
4.4 Dendrimers Responsive to Solution Media Changes 114
4.5 Conclusion 117
References 118
5 Liquid Crystalline Dendrimers 125
Anne-Marie Caminade
5.1 Introduction 125
5.2 Mesogenic Groups as Terminal Functions of Dendrons 126
5.3 Mesogenic Groups as Terminal Functions of Dendrimers 131
5.4 Mesogenic Groups as Branches of Dendrimers 134
5.5 Conclusion 135
References 136
6 Dendrimers and Nanoparticles 141
Cédric-Olivier Turrin and Anne-Marie Caminade
6.1 Introduction 141
6.2 Dendrimers or Dendrons for Coating Nanoparticles 142
6.3 Dendrimers as Templates for the Synthesis of
Dendrimer-Encapsulated Nanoparticles (DENs) 152
6.4 Conclusion and Perspectives 154
References 155
Part 2 Applications in Catalysis 163
7 Terminal Groups of Dendrimers as Catalysts for Homogeneous Catalysis 165
Armelle Ouali and Anne-Marie Caminade
7.1 General Introduction 165
7.2 Catalytic Organometallic Sites as Catalysts for Homogeneous Catalysis 167
7.3 Organocatalysis with Dendrimers 178
7.4 Conclusion 178
References 179
8 Catalytic Sites inside the Dendrimeric Structure for Homogeneous Catalysis 183
Armelle Ouali and Anne-Marie Caminade
8.1 Introduction 183
8.2 Catalytic Sites as the Core of Dendrimers 184
8.3 Catalytic Sites inside the Branches of Dendrimers 191
8.4 Conclusion 192
References 193
9 Dendrimers as Homogeneous Enantioselective Catalysts 197
Armelle Ouali and Anne-Marie Caminade
9.1 Introduction 197
9.2 Catalytic Organometallic Sites as Catalysts for Homogeneous Catalysis 198
9.3 Organocatalysis with Dendrimers 209
9.4 Conclusion 210
References 210
10 Catalysis with Dendrimers in Particular Media 215
Régis Laurent and Anne-Marie Caminade
10.1 Introduction 215
10.2 Two-Phase (Liquid-Liquid) Media 216
10.3 Catalysis in Ionic Liquids 219
10.4 Catalysis in Supercritical Media 220
10.5 Catalysis in Aqueous Media 221
10.6 Conclusion 234
References 234
11 Heterogeneous Catalysis with Dendrimers 239
Régis Laurent and Anne-Marie Caminade
11.1 Introduction 239
11.2 Catalysis with Dendrons Synthesized from a Solid Material 240
11.3 Catalysis with Dendrons or Dendrimers Grafted on to a Solid Surface 254
11.4 Catalysis with Insoluble Dendrimers 257
11.5 Conclusion 260
References 261
Part 3 Applications for the Elaboration or Modification of Materials 267
12 Dendrimers inside Materials 269
Régis Laurent and Anne-Marie Caminade
12.1 Introduction 269
12.2 Dendrimers for the Elaboration of Gels 270
12.3 Dendrimers inside Silica Gels 280
12.4 Dendrimers inside Other Types of Materials 285
12.5 Dendrimers for the Elaboration of OLEDs 288
12.6 Conclusion 298
References 299
13 Self-Assembly of Dendrimers in Layers 313
Béatrice Delavaux-Nicot and Anne-Marie Caminade
13.1 Introduction 313
13.2 Langmuir-Blodgett Films of Dendrons and Dendrimers 314
13.3 Assemblies of Dendrons and Dendrimers on Solid Surfaces 326
13.4 Several Routes for the Formation of Dendron or Dendrimer Multilayers 334
13.5 Nanoimprinting with Dendrons and Dendrimers on Solid Surfaces 342
13.6 Conclusion 350
References 351
14 Dendrimers as Chemical Sensors 361
Anne-Marie Caminade
14.1 Introduction 361
14.2 Dendrimers as Chemical Sensors in Solution 362
14.3 Dendrimers as Electrochemical Sensors 365
14.4 Dendrimers on Modifi ed Surfaces as Chemical Sensors 367
14.5 Conclusion 370
References 370
15 Dendrimers as Biological Sensors 375
Anne-Marie Caminade
15.1 Introduction 375
15.2 Dendrimers as Sensors in Solutions of Biological Media 375
15.3 Detection by Electrochemical Methods 378
15.4 Dendrimers or Dendrons for DNA Microarrays 380
15.5 Dendrimers for Other Types of Biomicroarrays 383
15.6 Dendrimers on Other Types of Support 384
15.7 Dendrimers as Multiply Labeled Entities Connected to the Target 385
15.8 Conclusion 386
References 387
Part 4 Applications in Biology/Medicine 393
16 Dendrimers for Imaging 395
Cédric-Olivier Turrin and Anne-Marie Caminade
16.1 Introduction 395
16.2 Magnetic Resonance Imaging with Dendrimers 395
16.3 Other Types of Imaging with Dendrimers 403
16.4 Conclusion and Perspectives 407
References 407
17 Dendrimers as Transfection Agents 413
Cédric-Olivier Turrin and Anne-Marie Caminade
17.1 Introduction 413
17.2 Gene Transfection with PAMAM Dendrimers 415
17.3 Gene Transfection with Other Dendrimers 421
17.4 Conclusion and Perspective 426
References 426
18 Dendrimer Conjugates for Drug Delivery 437
Cédric-Olivier Turrin and Anne-Marie Caminade
18.1 Introduction 437
18.2 Improving Bioavailability with Dendrimers 438
18.3 Passive Targeting in Tumors with Dendrimer-Drug Conjugates 440
18.4 Active Targeting with Site-Specifi c Dendrimer-Drug Conjugates 446
18.5 Dendrimers for Photodynamic Therapy (PDT) 449
18.6 Dendrimers for Boron Neutron Capture Therapy (BNCT) 451
18.7 Conclusion and Perspectives 452
References 453
19 Encapsulation of Drugs inside Dendrimers 463
Cédric-Olivier Turrin and Anne-Marie Caminade
19.1 Introduction 463
19.2 From Dendritic Boxes to Dendrimer-Based Formulations 464
19.3 Improving Bioavailability with Dendrimers? 464
19.4 Toxicological Issues 465
19.5 Dendrimer-Based Formulations for Drug Delivery 466
19.6 Conclusion and Perspectives 477
References 477
20 Unexpected Biological Applications of Dendrimers and Specifi c Multivalency Activities 485
Cédric-Olivier Turrin and Anne-Marie Caminade
20.1 Introduction 485
20.2 Dendrimers and Multivalency 486
20.3 Antimicrobial Dendrimers 488
20.4 From Immunomodulation to Regenerative Medicine 494
20.5 Conclusion and Perspectives 501
References 502
21 General Conclusions and Perspectives 511
Anne-Marie Caminade
Index 515
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