|  | Francotte, Eric / Lindner, Wolfgang (eds.)
Chirality in Drug Research
Methods and Principles in Medicinal Chemistry (Volume 33)
Edited by Mannhold, Raimund / Kubinyi, Hugo / Folkers, Gerd
 1. Edition - September 2006
169.- Euro
2006. XIX, 351 Pages, Hardcover
146 Fig. (6 Colored Fig.), 22 Tab.
- Monograph -
ISBN-10: 3-527-31076-2
ISBN-13: 978-3-527-31076-0 - Wiley-VCH, Weinheim
Sample Chapter
Short description
Synthesis, purification, analysis and pharmacology of chiral drugs: Current strategies for mastering the challenge of chirality in drug development. Required reading for medicinal and pharmaceutical chemists.
From the contents
INTRODUCTION
Chiral drugs from a historical point of view (J. Gal)
SYNTHESIS
Stereoselective synthesis of chiral drugs (H. Federsel)
Chiral drugs from natural source (F. Petersen)
Biotransformation methods for preparing chiral drugs and drug intermediates (M. Müller, M. Wubbolts)
SEPARATIONS
Resolution of chiral drugs and drug intermediates by crystallisation (K. Saigo)
Resolution of chiral drugs by preparative chromatography (E. Francotte)
ANALYSIS
Stereoselective chromatographic methods for drug analysis (W. Lindner)
CE-MS for the quantitative analysis of chiral drugs (J. Veuthey)
Spectrosopic methods for chiral drug analysis (N. Harada)
Modeling of chiral drug-receptor interactions (G. Folkers)
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