1. Edition - December 2010
59.- Euro
2010. XXVI, 472 Pages, Softcover
129 Fig. (18 Colored Fig.), 24 Tab. 
- Textbook -
ISBN-10: 3-527-31766-X
ISBN-13: 978-3-527-31766-0 - Wiley-VCH, Weinheim






Content

Sample Chapter



Short description
A book like no other existing textbook. Looking behind the curtains, it provides a thorough analysis of the foundations of the present day biotech industry for students and professionals alike: its history, its tools and processes, its markets and products.

From the contents
Preface

PART ONE: History

INTRODUCTION
THE EARLY PERIOD TO 1850
Introduction
Experimental Scientific Findings
Application
Theoretical Approaches

THE PERIOD FROM 1850 TO 1890
Introduction
Experimental Findings
Practical Application, Technical Progress and Institutional Development
Theoretical Approaches

THE PERIOD FROM 1890 TO 1950
Introduction
Research - Advances in the Basics of Biotechnology: Experimental Findings
Technological Development, Progress and Application
Theoretical Approaches

OUTLOOK, FROM 1950 ONWARDS: BIOTECHNOLOGY - SCIENCE OR WHAT?
Introduction
Traditional Biotechnology and the Dechema Report
The Changing Focus in BT in the USA in the Early 1980s
Conclusions

PART TWO: The New Paradigm Based on Molecular Biology and Genetics

BROADENING OF BIOTECHNOLOGY THROUGH UNDERSTANDING LIFE, GENETICS AND EVOLUTION

THE BEGINNINGS OF THE NEW BIOTECHNOLOGY
Introduction
The Beginnings of Evolution Theory and Genetics
The Origin of Recombinant DNA Technology
Oligonucleotide Synthesis Leads to Protein Engineering
Synthetic DNA, Reverse Transcriptase: Isolating Genes
Biodiversity and Gene Mining
Creating New Diversity by Design or Empirically
'Genetic Fingerprinting'
Inherited Predisposition to Disease

ETHICAL ASPECTS RELATED TO GENOME RESEARCH, AND REPRODUCTIVE MEDICINE
Negative Public Reaction to Gene Technology
Ethical Aspects: Animal Cloning and Fertility Research

ELUCIDATING PROTEIN STRUCTURE: THE BEGINNINGS OF RATIONAL PROTEIN DESIGN
Cambridge England, the Cradle of Structural Analysis of Macromolecules
Redesigning the Protein Core
Redesigning the Protein by Altering Primary Sequence
Post Translational Modifications
Total Chemical Synthesis
Validation of Drug Design Based on the known Structure of the Target
General Considerations in Drug Development

THE DEVELOPMENT OF ANTIBODIES AS PHARMACEUTICAL PRODUCTS
An Introduction to the Immune System
The Beginnings of Applied Immunology
Monoclonal Antibodies
Producing Antibodies via rDNA and Combinatorial Biology
Affinity Enrichment on Surfaces of Immobilized Target Molecules
Mice with Human Antibody Gene Repertoires
Two Severe Setbacks during Clinical Testing
A Survey of Therapeutic Antibodies

HEREDITARY DISEASE AND HUMAN GENOME ANALYSIS
Introduction
Heredity Studies and Family Counselling
Early Attempts to Analyse the Human Genome
The Personalized Genome and Personal Medicine
Analysing the Effect of the Environment on the Human Genome: Epigenetics

TRANSGENIC ANIMALS AND PLANTS
Introduction
Stem Cells and Gene Targeting

EXTRAPOLATING TO THE FUTURE
Summary of the Status Quo
Insect Control Through 'Sterile' Males (SIT)
The Future of Gene Therapy
Stem Cell Therapy
Flash Sequencing DNA: A Human Genome Sequence in Minutes?
Systems Biology and Looking for 'Druggable' Targets
Synthetic Biology

BIOTECHNOLOGY AND INTELLECTUAL PROPERTY
Introduction
Patents Ensure Growth and Rapid Dissemination of Knowledge
Owning a Patent does not simply Mean that it can be Implemented: 'Freedom to Operate' (FTO)
Life-Forms as 'Novel Subject Matter' for Patents?
Technology 'State of the Art': Precedence/Directives, not Fixed by Law
Who can make Decisions about Public Morality?
Biotechnology-Oriented Directives Guide Patenting Decisions

PART THREE: Applications

BIOPROCESS ENGINEERING
Introduction
Aspects of Applied Microbiology
Biocatalysis
Biochemical Engineering
Process Sustainability and Ecological Considerations
Biosystems Engineering, Including Omics Technologies
Outlook and Perspectives

INDUSTRIAL BIOTECHNOLOGY
Introduction
General Aspects
Commodities
Chemicals
Food Processing and Products
Environmental Processes
Summary, Trends and Perspectives

PHARMACEUTICAL BIOTECHNOLOGY
Introduction
Drug Targeting, Discovery Strategies and Development
Pharmaceuticals Production
Products, Pharmaceuticals Made by Biotechnology
Medicinal Techniques, Diagnostics
Business: Companies and Economic Aspects

PLANT BIOTECHNOLOGY
Introduction
Political, Ethical and Biosafety Aspects
Research and Development
Application of Modified Plants and Products
Economic Aspects
Summary and Outlook