1. Edition - May 2009
112.- Euro
2009. 336 Pages, Hardcover
- Monograph -
ISBN-10: 0-470-82314-3
ISBN-13: 978-0-470-82314-9 - John Wiley & Sons






Sample Chapter

Short description
Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for Pharmaceutical Industry discusses modern application of biocatalysis in drug discovery, development and manufacturing. Written by leading experts, coverage includes enzyme discovery, applications of enzymatic transformations for development of pharmaceutically active compounds, biocatalysis in synthesizing, screening, identifying and characterizing human drug metabolites, combinatorial biosynthesis of active natural products for drug discovery, application of metabolic engineering, optimization of production hosts for efficient development of biopharmaceuticals and applying biocatalysis in green chemistry.

From the contents
1. Enzymes and Their Synthetic Applications: An Overview

2. Expression Hosts for Enzyme Discovery and Production

3. Directed Enzyme Evolution and High Throughput Screening

4. Applications of Reaction Engineering to Industrial Biotransformations

5. Chiral Synthesis of Pharmaceutical Intermediates Using Oxynitrilases

6. Expanding the Scope of Aldolases as Tools for Organic Synthesis

7. Synthetic Applications of Ketoreductases and Alcohol Oxidases

8. Applications of Nitrile Hydratases and Nitrilases

9. Biosynthesis of Drug Metabolites

10. Application of Whole Cell Biotransformation in Pharmaceutical Industry

11. Combinatorial Biosynthesis of Pharmaceutical Natural Products

12. Metabolic Engineering for the Development and Manufacturing of Pharmaceuticals

13. Multimodular Synthases and Supporting Enzymes for Chemical Production

14. Green Chemistry with Biocatalysis for Production of Pharmaceuticals