1. Edition - December 1992
272.- Euro
1992. 388 Pages, Hardcover
62 Fig., 25 Tab. 
- Monograph -
ISBN-10: 0-471-18794-1
ISBN-13: 978-0-471-18794-3 - John Wiley & Sons








Detailed description
The rapidly growing interest in cation transport phenomena has captured the attention of chemists, biologists and medical scientists. Amiloride and certain of its analogs possess unique Na+-channel, Na+/H+-antiport, Na+/Ca2+-exchange and/or voltage-dependent Ca+-channel inhibitory activity. This book reviews the extensive literature on the subject, puts the concepts in perspective, reveals the applications, and regards the future of cation regulating agents in biological sciences and medicine.

From the contents
Contributors

Section A Introduction

1. Historical Perspective

Edward J. Cragoe, Jr.

2. An Overview of the Structure-Activity Relations in the Amiloride Series

Louis Simchowitz, Thomas R. Kleyman, and Edward J. Cragoe, Jr.

3. The Synthesis of Amiloride and Its Analogs

Edward J. Cragoe, Jr.

Section B Transport Systems Affected by Amiloride Analogs

4. Amiloride-Sensitive Sodium Channels

Young S. Oh and Dale J. Benos

5. Na+/H+ Exchange in Epithelia

Robert F. Reilly and Peter S. Aronson

6. Na+/H+ Exchange in Blood Cells

William E. Dale and Louis Simchowitz

7. Na+/H+ Exchange in an Excitable Tissue

Peter J. Little

8. Na+/Ca2+ Exchange

Gregory J. Kaczorowski

9. Voltage-Dependent Ca2+ Channels

Gregory J. Kaczorowski and Maria L. Garcia

10. Inhibition of Sodium-Dependent Solute Cotransport in Renal Brush Border Membrane Vesicles by Amiloride

Julian L. Seifter, Robert A. Lufburrow III, and Raymond C. Harris

11. Cellular Systems: Enzymes, Receptors, and Metabolic Pathways

Jeffrey M. Besterman

Section C Biologic Applications and Immunologic Approaches

12. Radiolabeled Analogs

Paul Vigne and Christian Frelin

13. Photoreactive Amiloride Analogs

Chaomei Lin and Thomas R. Kleyman

14. Generation, Characterization, and Utilization of Anti-Amiloride Antibodies

Thomas R. Kleyman

15. Generation of Antibodies Directed Against the Amiloride-Binding Site on Specific Transport Proteins by an Antiidiotypic Approach

Brigitte Coupaye-Gerard and Thomas R. Kleyman

Section D Molecular Biology

16. Molecular Organization of the Human Amiloride-Sensitive Na+/H+ Antiporter Gene

Gilles Pagès, Claude Sardet, and Jacques Pouysségur

17. Molecular Biology of the Na+/H+ Exchanger Amiloride-Binding Site

Laurent Counillon, Claude Sardet, and Jacques Pouysségur

Section E Clinical Applications

18. K+ Sparing Diuretics

George M. Feldman and Krystyna Drewnowska

19. Antihypertensive Agents

Francis J. Haddy and Motilal B. Pamnani

20. Amiloride in Cystic Fibrosis: Safety, Pharmacokinetics, and Efficacy in the Treatment of Pulmonary Disease

Michael R. Knowles, Nina L. Church, William E. Waltner, John T. Gatzy, and Richard C. Boucher

21. The Use of Na+/H+ Antiporter Inhibitors as a Novel Approach to Cancer Treatment

Salvador Harguindey

22. Other Potential Medical Uses and Summary

Edward J. Cragoe, Jr.

Index