|  | Dingermann, Theodor / Steinhilber, Dieter / Folkers, Gerd (eds.)
Molecular Biology in Medicinal Chemistry
Methods and Principles in Medicinal Chemistry (Volume 21)
Edited by Mannhold, Raimund / Kubinyi, Hugo / Folkers, Gerd
 1. Edition - November 2003
155.- Euro
2003. XXII, 413 Pages, Hardcover
113 Fig. (9 Colored Fig.), 32 Tab.
- Monograph -
ISBN-10: 3-527-30431-2
ISBN-13: 978-3-527-30431-8 - Wiley-VCH, Weinheim
Short description
Using a diverse range of examples from drug development, synthesis, analysis and pharmacokinetics, this volume describes the successful application of molecular biology methods in pharmaceutical research.
Essential reading for all pharmaceutical chemists, molecular biologists and medical researchers using molecular methods to study drugs and their action.
From the contents
MOLECULAR TARGETS
Cellular Assays in Drug Discovery
Gene Knockout Models
Reporter Gene Assay Systems for the Investigation of GPCRs
From the Human Genome to New Drugs: The Potential of Orphan GPCRs
SYNTHESIS
Stereoselective Synthesis with the Help of Recombinant Enzymes
Nucleic Acid Drugs
ANALYSIS
Recent Trends in Enantioseparation of Chiral Drugs
Affinity Chromatography
NMR-based Drug Discovery
13C- and 15N-Isotopic Labeling of Proteins
Antibody Fragments as Crystallization Enhancers
KINETICS, METABOLISM AND TOXICOLOGY
Pharmacogenetics: The Effect of Inherited Genetic Variation on Drug Disposition and Drug Response
Pharmacogenomics of Bioavaliability and Elimination
Toxicogenomics: Integration of New Molecular Biological Tools in Toxicology
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