|  | Langer, Thierry / Hoffmann, Rémy D. (eds.)
Pharmacophores and Pharmacophore Searches
Methods and Principles in Medicinal Chemistry (Volume 32)
Edited by Mannhold, Raimund / Kubinyi, Hugo / Folkers, Gerd
 1. Edition - July 2006
175.- Euro
2006. XX, 375 Pages, Hardcover
121 Fig. (63 Colored Fig.), 26 Tab.
- Monograph -
ISBN-10: 3-527-31250-1
ISBN-13: 978-3-527-31250-4 - Wiley-VCH, Weinheim
Sample Chapter
Short description
The first handbook to address the practical aspects of this novel method, providing a complete overview and progressing from general considerations to real life drug discovery scenarios. A valuable aid for bench scientists and project leaders in pharmaceutical industry.
From the contents
INTRODUCTION
Historical Overview
LIGAND-BASED APPROACHES
Pharmacophore Model Generation Software Tools
Alignment-free Pharmacophore Patterns
Theory and Applications from Large-scale Virtual Screening to Data Analysis
Concept and Application of Pseudoreceptors
Pharmacophores from Macromolecular Complexes with LigandScout
GRID-based Pharmacophore Models
"Hot Spot" Analysis of Protein-binding Sites as a Prerequisite for Structure-based Virtual Screening and Lead Optimization
Application of Pharmacophore Fingerprints to Structure-based Design and Data Mining
SIFt: analysis, Organization and Database Mining for Protein-Inhibitor Complexes
Application of Structure-based Alignment Methods for 3D QSAR Analyses
PHARMACOPHORES FOR HIT IDENTIFCATION AND LEAD PROFILING: APPLICATIONS AND VALIDATION
Application of Pharmacophore Models in Clinical Chemistry
GPCR Anti-target Modeling: Pharmacophore Models to Avoid GPCR-mediated Side-effects
Pharmacophores for Human ADME/Tox-related Proteins
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