|  | Triggle, David J. / Gopalakrishnan, Murali / Rampe, David / Zheng, Wei (eds.)
Voltage-Gated Ion Channels as Drug Targets
Methods and Principles in Medicinal Chemistry (Volume 29)
Edited by Mannhold, Raimund / Kubinyi, Hugo / Folkers, Gerd
 1. Edition - February 2006
185.- Euro
2006. XII, 480 Pages, Hardcover
121 Fig., 48 Tab.
- Monograph -
ISBN-10: 3-527-31258-7
ISBN-13: 978-3-527-31258-0 - Wiley-VCH, Weinheim
Sample Chapter
List of Contributors
Short description
Edited by prominent researchers in the field, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology.
From the contents
Introduction
Structure and Function of Ion Channels
Drug Interaction at Ion Channels
Assay Technologies
Binding Studies
Ion Fluxes
Fluorescence Studies
Patch Clamping
Calcium Channels
Overview
T-type Channels
L-type Channels
N-type Channels
Sodium Channels
Overview
Channel Subtype Selectivity
Potassium Channels
Overview
Kv1.3
Kv1.5
Ca-activated channels
K(ATP)
KCNQ
Genetic and Acquired Channelopathies
Overview
HERG
Long QT Syndrome
Safety Issues in Ion Channel Drug Development
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