|  | Rognan, Didier (ed.)
Ligand Design for G Protein-coupled Receptors
Methods and Principles in Medicinal Chemistry (Volume 30)
Edited by Mannhold, Raimund / Kubinyi, Hugo / Folkers, Gerd
 1. Edition - January 2006
175.- Euro
2006. XX, 264 Pages, Hardcover
80 Fig. (23 Colored Fig.), 13 Tab.
- Monograph -
ISBN-10: 3-527-31284-6
ISBN-13: 978-3-527-31284-9 - Wiley-VCH, Weinheim
Sample Chapter
Short description
This is an introduction to the structure-based approach for developing drugs that target G protein-coupled receptors, based on existing examples from academia and the pharmaceutical industry.
From the contents
GPCRs in the human genome
GPCR Three-dimensional structures: from bovine rhodopsin to homology models
Orphan GPCRs and ligand design
GPCR databases: From genes to proteins, from proteins to ligands
Druggability of human GPCRs
Molecular Mechanisms of GPCR activation & Oligomerisation
Allosteric regulation of GPCRs
Ligand-Based rational design
Receptor-based rational design
Chemogenomics approaches to ligand design and target priorisation
GPCR targeted libraries and privileged structures
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