4. Edition - August 2008
112.- Euro
2008. 944 Pages, Hardcover
- Textbook -
ISBN-10: 0-470-10211-X
ISBN-13: 978-0-470-10211-4 - John Wiley & Sons






Sample Chapter

Short description
This book is an important resource for academic and industrial toxicologists in toxicology, chemistry, biochemistry, pharmacology. New chapters on the molecular topics of proteomics, toxicogenomics, metabolomics, bioinformatics, and pharmaco(toxico)genetics complement the updated coverage of biochemical toxicology.

From the contents
Preface.

Contributors.

1. Molecular and Biochemical Toxicology: Definition and Scope (Ernest Hodgson and Robert C. Smart).

Suggested Reading.

2. Overview of Molecular Techniques in Toxicology: Genes and Transgenes (Robert C. Smart).

3. Toxicogenomics (Marjorie F. Oleksiak).

4. Proteomics (B. Alex Merrick).

5. Metabolomics (Nigel Deighton).

6. Bioinformatics (Eric A. Stone and Dahlia M. Nielsen).

7 Immunochemical Techniques in Toxicology (Gerald A. LeBlanc).

8. Cellular Techniques (Sharon A. Meyer).

9. Structure, Mechanism and Regulation of Cytochromes P450 (Darryl C. Zeldin and John M. Seubert).

10. Phase I Metabolism of Toxicants and Metabolic Interactions (Ernest Hodgson, Parikshit C. Das, Taehyeon M. Cho and Randy L. Rose).

11. Phase I Pharmacogenetics (Ernest Hodgson and Edward L. Croom).

12. Phase II - Conjugation of Toxicants (Gerald A. LeBlanc).

13. Regulation and Polymorphisms in Phase II Genes (Yoshiaki Tsuji).

14. Developmental Effects on Xenobiotic Metabolism (Martin J. J. Ronis and Helen C. Cunny).

15. Cellular Transport and Elimination (David S. Miller).

16. Mechanisms of Cell Death (Mac Law and Susan Elmore).

17. Mitochondrial Dysfunction (Jun Ninomiya-Tsuji).

18. Glutathione-Dependent Mechanisms in Chemically Induced Cell Injury and Cellular Protection Mechanisms (Donald J. Reed).

19. Toxicant-Receptor Interactions: Fundamental Principles (Richard B. Mailman).

20. Reactive Oxygen/Metabolites and Toxicity (Elizabeth L. MacKenzie).

21. Metals (David B. Buchwalter).

22. DNA Damage and Mutagenesis (Zhigang Wang).

23. DNA Repair (Isabel Mellon).

24. Carcinogenesis (Robert C. Smart, Sarah J. Ewing and Kari D. Loomis).

25. Genetic Toxicology (R. Julian Preston).

26. Molecular Epidemiology and Genetic Susceptibility (Ruth M. Lunn and Marianna Stern).

27. Respiratory Toxicology (James C. Bonner).

28. Hepatotoxicity (Andrew D. Wallace and Sharon A. Meyer).

29. Biochemical Mechanisms of Renal Toxicity (Joan B. Tarloff and Andrew D. Wallace).

30. Biochemical Toxicology of the Peripheral Nervous System (Jeffry F. Goodrum, Arrel D. Toews and Thomas W. Bouldin).

31. Biochemical Toxicology of the Central Nervous System (Bonita L. Blake).

32. Immunotoxicology (MaryJane K. Selgrade, Dori R. Germolec, Robert W. Luebke, Ralph J. Smialowicz, Marsha D. Ward and Christal C. Bowman).

33. Reproductive Toxicology (John F. Couse).

34. Developmental Toxicology (John F. Couse).

35. Dermatotoxicology (Nancy A. Monteiro-Riviere).

Index.