1. Edition - September 2008
122.- Euro
2008. 392 Pages, Hardcover
- Practical Approach Book -
ISBN-10: 0-470-51172-9
ISBN-13: 978-0-470-51172-5 - John Wiley & Sons






Sample Chapter

Short description
Taking a "bottom up" approach to studying skin toxicology, this basic introduction to the principles and practice of dermal toxicology explores skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity, and in vitro alternatives. Coverage of global legislation and regulatory aspects, a user-friendly layout with learning boxes, and summaries of each chapter round out the coverage and will appeal to practitioners of toxicology, clinical researchers, researchers in industry and academia as well as MSc and PhD students of toxicology.

From the contents
Contents

Foreword

Preface

Acknowledgements

List of contributors

PART I Introduction

1 Cutaneous anatomy and function

Robert P. Chilcott

Summary

References

2 Biochemistry of the skin

Simon C. Wilkinson

Summary

References

3 Skin photobiology

Mark A. Birch-Machin and Simon C. Wilkinson

Summary

References

PART II Skin Absorption

4 Skin as a route of entry

Simon C. Wilkinson

Summary

References

5 Physicochemical Factors Affecting Skin Absorption

Keith R. Brain and Robert P. Chilcott

Summary

References

6 Principles of Diffusion and Thermodynamics

W. John Pugh and Robert P. Chilcott

Summary

References

7 In vivo measurements of skin absorption

James C. Wakefield and Robert P. Chilcott

Summary

References

8 In vitro percutaneous absorption measurements

Ruth U. Pendlington

Summary

References

PART III Toxicological Assessment

9 Skin immunology and sensitisation

David A. Basketter

Summary

References

10 In vitro phototoxicity assays

Penny Jones

Summary

References

11 In vitro alternatives for irritation and corrosion assessment

Penny Jones

Summary

References

12 Instruments for measuring skin toxicity

Helen Taylor

Summary

References

PART IV Clinical Aspects

13 Introduction to dermatology

Manjunatha Kalavala and Alex Anstey

Summary

14 Clinical aspects of phototoxicity

Anthony D. Pearse and Alex Anstey

Summary

References

15 Occupational skin diseases

Jon Spiro

Summary

References

16 Prevention of occupational skin disease

Chris Packham

Summary

References

PART V Regulatory

17 Occupational skin exposures: legal aspects

Chris Packham

Summary

References

18 Safety assessment of cosmetics: an EU perspective

Jo Larner

Summary

References

Appendix 18.1 Additional obligations for cosmetic suppliers

19 Regulatory dermatotoxicology and international guidelines

Adam Woolley

Summary

References

20 Glossary of main terms and abbreviations

James C. Wakefield

Index