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Quin, Louis D. / Tyrell, John A.
Fundamentals of Heterocyclic Chemistry
Importance in Nature and in the Synthesis of Pharmaceuticals

1. Edition July 2010
91.90 Euro
2010. 344 Pages, Hardcover
ISBN 978-0-470-56669-5 - John Wiley & Sons

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Short description
Heterocyclic chemistry - a sub-discipline of organic chemistry - is a vast and, sometimes, complicated field. Providing practical examples of applied methodology, as well as problem sets, Fundamentals of Heterocyclic Chemistry: Importance in Nature and in the Synthesis of Pharmaceuticals introduces both students and researchers to heterocyclic chemistry and synthesis, while emphasizing biological uses of heterocyclic compounds in natural product and pharmaceutical applications. Professional chemists and organic chemistry students will not want to miss this opportunity to learn the fundamentals of working with the largest and most varied family of organic compounds.

From the contents
PREFACE.ACKNOWLEDGMENT.Chapter 1 THE SCOPE OF THE FIELD OF HETEROCYCLIC CHEMISTRY.References.Appendix.Chapter 2 COMMON RING SYSTEMS AND THE NAMING OF HETEROCYCLIC COMPOUNDS.2.1. General.2.2. Naming Simple Monocyclic Compounds.2.3. Handling the "Extra Hydrogen".2.4. Substituted Monocyclic Compounds.2.5. Rings With More Than One Heteroatom.2.6. Bicyclic Compounds.2.7. Multicyclic Systems.2.8. The Replacement Nomenclature System.2.9. Saturated Bridged Ring Systems.References.Review Exercises.Chapter 3 NATURE AS A SOURCE OF HETEROCYCLIC COMPOUNDS.3.1. General.3.2. Naturally Occurring Nitrogen Heterocyclic Compounds.3.3. Oxygen Compounds.3.4. Sulfur and Phosphorus Heterocyclic Compounds in Nature.References.Chapter 4 PRINCIPLES OF SYNTHESIS OF AROMATIC HETEROCYCLES BY INTRAMOLECULAR CYCLIZATION.4.1. General.4.2. Some of the Classic Synthetic Methods.4.3. Cyclizations Involving Metallic Complexes as Catalysts.4.4. Cyclizations with Radical Intermediates.4.5. Cyclizations by Intramolecular Wittig Reactions.4.6. Synthesis of Heterocycles by the Alkene Metathesis Reaction.References.Review Exercises.Chapter 5 SYNTHESIS OF HETEROCYCLIC SYSTEMS BY CYCLOADDITION REACTIONS.5.1. The Diels-Alder Reaction.5.2. Dipolar Cycloadditions.5.3. [2 + 2] Cycloadditions.References.Review Exercises.Chapter 6 AROMATICITY AND OTHER SPECIAL PROPERTIES OF HETEROCYCLES: PI-DEFICIENT RING SYSTEMS.6.1. General.6.2. Review of the Aromaticity of Benzene.6.3. Pi-Deficient Aromatic Heterocycles.References.Review Exercises.Chapter 7 AROMATICITY AND OTHER SPECIAL PROPERTIES OF HETEROCYCLES: PI-EXCESSIVE RING SYSTEMS AND MESOIONIC RING SYSTEMS.7.1. Pi-Excessive Aromatic Heterocycles.7.2. Mesoionic Heterocycles.References.Review Exercises.Chapter 8 THE IMPORTANCE OF HETEROCYCLES IN MEDICINE.8.1. General.8.2. Historical.8.3. Pyridines.8.4. Indoles.8.5. Quinolines.8.6. Azepines.8.7. Pyrimidines.8.8. Concluding Remarks.References.Chapter 9 SYNTHETIC METHODS FOR SOME PROMINENT HETEROCYCLIC FAMILIES: EXAMPLES OF PHARMACEUTICALS SYNTHESIS.9.1. Scope of the Chapter.9.2. Pyrroles.9.3. Furans.9.4. Thiophenes.9.5. 1,3-Thiazoles.9.6. 1,3-Oxazoles.9.7. Imidazoles.9.8. Pyrazoles.9.9. 1,2,4-Triazoles.9.10. Tetrazoles.9.11. 1,3,4-Thiadiazoles and other 5-Membered Systems.9.12. Indole.9.13. Pyridines.9.14. Quinolines and Isoquinolines.9.15. Benzodiazepines.9.16. Pyrimidines.9.17. Fused Pyrimidines: Purines and Pteridines.9.18. 1,3,5-Triazines.9.19. Multicyclic Compounds.References.Review Exercises.Chapter 10 GEOMETRIC AND STEREOCHEMICAL ASPECTS OF NONAROMATIC HETEROCYCLES.10.1. General.10.2. Special Properties of Three-Membered Rings.10.3. Closing Heterocyclic Rings: Baldwin's Rules.10.4. Conformations of Heterocyclic Rings.10.5. Chirality Effects on Biological Properties of Heterocycles.References.Review Exercises.Chapter 11 SYNTHETIC HETEROCYCLIC COMPOUNDS IN AGRICULTURAL AND OTHER APPLICATIONS.11.1. Heterocyclic Agrochemicals.11.2. Applications of Heterocyclic Compounds in Commercial Fields.References.Appendix UNIFIED AROMATICITY INDICES (IA) OF BIRD.INDEX.



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