Wiley-VCH - Lamberth, Clemens / Dinges, Jürgen (eds.) - Bioactive Heterocyclic Compound Classes

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Ernst & Sohn

Lamberth, Clemens / Dinges, Jürgen (eds.) Bioactive Heterocyclic Compound Classes Pharmaceuticals and Agrochemicals, 2 Volume Set 1. Edition September 2012 229.- Euro 2012. 670 Pages, 2 Volumes, Hardcover - Handbook/Reference Book - ISBN 978-3-527-32993-9 - Wiley-VCH, Weinheim
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Short description Filling a gap in the market, this one-stop reference is the first to present important pharmaceuticals as well as agrochemical pesticides in two handy volumes. Each of the around 40 chapters concisely covers one class of heterocycles, strictly structured for ease of use. From the contents AGROCHEMICALS THE SIGNIFICANCE OF HETEROCYCLES FOR PHARMACEUTICALS AND AGROCHEMICALS Introduction Heterocycles as Framework of Biologically Active Compounds Fine-Tuning the Physicochemical Properties with Heterocycles Heterocycles as Prodrugs Heterocycles as Peptidomimetics Heterocycles as Isosteric Replacement of Functional Groups Heterocycles as Isosteric Replacement of Alicyclic Rings Heterocycles as Isosteric Replacement of other Heterocyclic Rings PART I: Herbicides TRIAZINE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationships PYRIMIDINYL AND TRIAZINYLSULFONYLUREA HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship ACETOHYDROXYACID SYNTHASE INHIBITING TRIAZOLOPYRIMIDINE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship HPPD-INHIBITING BENZOYLPYRAZOLE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship PYRIDYLOXYPHENOXYPROPIONATE HERBICIDES: INHIBITORS OF ACETYL-COACARBOXYLASE Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationships IMIDAZOLINONE HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship PROTOPORPHYRINOGEN-IX-OXIDASE-INHIBITING URACIL HERBICIDES Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship PART II: Fungicides BENZIMIDAZOLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship MORPHOLINE FUNGICIDES FOR THE TREATMENT OF POWDERY MILDEW Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship STEROL BIOSYNTHESIS INHIBITING TRIAZOLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship METHIONINE BIOSYNTHESIS-INHIBITING ANILINOPYRIMIDINE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship PHENYLPYRROLE FUNGICIDES Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship BROAD-SPECTRUM FUNGICIDALLY ACTIVE PYRIMIDINYLDIOXY STROBILURINS INHIBITING THE RESPIRATORY CHAIN Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship PYRAZOLE CARBOXAMIDE FUNGICIDES INHIBITING SUCCINATE DEHYDROGENASE Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationships PART III: Insecticides AVERMECTIN INSECTICIDES AND ACARICIDES Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship PYRIDINE AND THIAZOLE-CONTAINING INSECTICIDES AS POTENT AGONISTS ON INSECT NICOTINIC ACETYLCHOLINE RECEPTORS Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship PYRAZOLE AND PYRIMIDINE ACARICIDES AND INSECTICIDES ACTING AS INHIBITORS OF MITOCHONDRIAL ELECTRON TRANSPORT AT COMPLEX I Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship PHENYLPYRAZOLE-CONTAINING FIPROLE INSECTICIDES Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship PYRAZOLYLPYRIDINE ACTIVATORS OF THE INSECT RYANODINE RECEPTOR Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationships TETRONIC ACID INSECTICIDES AND ACARICIDES INHIBITING ACETYL-COACARBOXYLASE Introduction History Synthesis Mode of Action Biological Activity Structure - Activity Relationship PHARMACEUTICALS THE SIGNIFICANCE OF HETEROCYCLES FOR PHARMACEUTICALS AND AGROCHEMICALS Introduction Heterocycles as Framework of Biologically Active Compounds Fine-Tuning the Physicochemical Properties with Heterocycles Heterocycles as Prodrugs Heterocycles as Peptidomimetics Heterocycles as Isosteric Replacement of Functional Groups Heterocycles as Isosteric Replacement of Alicyclic Rings Heterocycles as Isosteric Replacement of other Heterocyclic Rings PART I: Neurological Disorders TROPANE-BASED ALKALOIDS AS MUSCARINIC ANTAGONISTS FOR THE TREATMENT OF ASTHMA, OBSTRUCTIVE PULMONARY DISEASE, AND MOTION SICKNESS Introduction History Synthesis Mode of Action Structure - Activity Relationships MORPHINONE-BASED OPIOID RECEPTOR AGONIST ANALGESICS Introduction History Synthesis Mode of Action Structure - Activity Relationship BARBITURIC ACID-BASED GABA(A) RECEPTOR MODULATORS FOR THE TREATMENT OF SLEEP DISORDER AND EPILEPSY AND AS ANESTHETICS Introduction History Synthesis Mode of Action Structure - Activity Relationship PHENOTHIAZINE-BASED DOPAMINE D2 ANTAGONISTS FOR THE TREATMENT OF SCHIZOPHRENIA Introduction History Synthesis Mode of Action Structure - Activity Relationships ARYLPIPERAZINE-BASED 5-HT1A RECEPTOR PARTIAL AGONISTS AND 5-HT2A ANTAGONISTS FOR THE TREATMENT OF AUTISM, DEPRESSION, ANXIETY, PSYCHOSIS, AND SCHIZOPHRENIA Introduction History Synthesis Mode of Action Structure - Activity Relationship ARYLPIPERIDINE-BASED DOPAMINE D2 ANTAGONISTS/5-HT2A ANTAGONISTS FOR THE TREATMENT OF AUTISM, DEPRESSION, SCHIZOPHRENIA, AND BIPOLAR DISORDER Introduction History Synthesis Mode of Action Structure - Activity Relationship DIBENZAZEPINE-BASED SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROPATHIC PAIN Introduction History Synthesis Mode of Action Structure - Activity Relationships PART II: Cardiovascular Diseases DIHYDROPYRIDINE-BASED CALCIUM CHANNEL BLOCKERS FOR THE TREATMENT OF ANGINA PECTORIS AND HYPERTENSION Introduction History Synthesis Mode of Action Structure - Activity Relationship TETRAZOLE-BASED ANGIOTENSIN II TYPE 1 (AT1) ANTAGONISTS FOR THE TREATMENT OF HEART FAILURE AND CONGESTIVE HYPERTENSION Introduction History Synthesis Mode of Action Structure - Activity Relationship THIAZIDE-BASED DIURETICS FOR THE TREATMENT OF HYPERTENSION AND GENITOURINARY DISORDERS Introduction History Synthesis Mode of Action Structure - Activity Relationship TETRAHYDROPYRANONE-BASED HMG-COA REDUCTASE INHIBITORS FOR THE TREATMENT OF ARTERIAL HYPERCHOLESTEROLEMIA Introduction History Synthesis Mode of Action Structure - Activity Relationship PART III: Infectious Diseases ADENINE-BASED REVERSE TRANSCRIPTASE INHIBITORS AS ANTI-HIV AGENTS Introduction History Synthesis Mode of Action Structure - Activity Relationship GUANINE-BASED NUCLEOSIDE ANALOGS AS ANTIVIRAL AGENTS Introduction History Synthesis Mode of Action Structure - Activity Relationship PENICILLIN AND CEPHALOSPORIN ANTIBIOTICS Introduction History Synthesis Mode of Action Structure - Activity Relationships PART IV: Oncology PYRIMIDINE-BASED KINASE INHIBITORS IN CANCER CHEMOTHERAPY Introduction History Synthesis Mode of Action Structure - Activity Relationship BENZYL TRIAZOLE-BASED AROMATASE INHIBITORS FOR THE TREATMENT OF BREAST CANCER Introduction History Synthesis Mode of Action Structure - Activity Relationship PART V: Inflammation and Gastrointestinal Diseases ACETONIDE-BASED GLUCOCORTICOIDS FOR THE TREATMENT OF ASTHMA, SKIN INFLAMMATION, AND DISEASES OF THE EYE Introduction History Synthesis Mode of Action Structure - Activity Relationship BENZIMIDAZOLE-BASED H+/K+-ATPASE INHIBITORS FOR THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE Introduction History Synthesis Mode of Action Structure - Activity Relationships PART VI: Metabolic Diseases THIAZOLIDINEDIONE-BASED INSULIN SENSITIZERS:PPAR-G AGONISTS FOR THE TREATMENT OF TYPE 2 DIABETES Introduction History Synthesis Mode of Action Structure - Activity Relationship

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