Mayer, R. John / Ciechanover, Aaron J. / Rechsteiner, Martin (eds.) Protein Degradation Vol. 4: The Ubiquitin-Proteasome System and Disease Protein Degradation (Volume 4)
1. Edition - October 2007 175.- Euro 2007. XVI, 242 Pages, Hardcover 28 Fig. (15 Colored Fig.), 7 Tab. - Handbook/Reference Book - ISBN-10: 3-527-31436-9 ISBN-13: 978-3-527-31436-2 - Wiley-VCH, Weinheim
Short description The final volume in the series focuses on malfunctions of the ubiquitin-proteasome system and their role in human disease. Required reading for molecular biologists, cell biologists and physiologists with an interest in the topic.
From the contents Ubiquitin signaling and cancer pathogenesis Regulation of the p53 tumor-suppressor protein by ubiquitin and ubiquitin-like molecules The ubiquitin-proteasome system in Epstein-Barr virus infection and oncogenesis HECT ubiquitin-protein ligases in human disease Ubiquitin-independent mechanisms of substrate recognition and degradation by the proteasome Endoplasmic reticulum protein quality control and degradation Interactions between viruses and the ubiquitin-proteasome system The ubiquitin-proteasome system in Parkinson's disease The molecular pathway to neurodegeneration in parkin-related Parkinsonism Parkin and neurodegeneration
