Otzen, Daniel Erik (ed.) Amyloid Fibrils and Prefibrillar Aggregates Molecular and Biological Properties
1. Edition February 2013 139.- Euro 2013. XVI, 448 Pages, Hardcover 112 Fig. (82 Colored Fig.), 25 Tab. - Handbook/Reference Book - ISBN 978-3-527-33200-7 - Wiley-VCH, Weinheim
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Short description A modern view of amyloid proteins that focuses on their structural biology and physiological roles in health and disease. This comprehensive handbook is targeted at basic and applied researchers in the biochemical, biomedical and pharmaceutical sectors.
From the contents PREFACE
THE AMYLOID PHENOMENON AND ITS SIGNIFICANCE Introduction The Nature of the Amyloid State of Proteins The Structure and Properties of Amyloid Species The Kinetics and Mechanism of Amyloid Formation The Link between Amyloid Formation and Disease Strategies for Therapeutic Intervention Looking to the Future Summary
AMYLOID STRUCTURES AT THE ATOMIC LEVEL: INSIGHTS FROM CRYSTALLOGRAPHY Atomic Structures of Segments of Amyloid-Forming Proteins Stability of Amyloid Fibers Which Proteins Enter the Amyloid State? Molecular Basis of Amyloid Polymorphism and Prion Strains Atomic Structures of Steric Zippers Suggest Models for Amyloid Fibers of Parent Proteins Atomic Structures of Steric Zippers Offer Approaches for Chemical Interventions against Amyloid Formation Summary
WHAT DOES SOLID-STATE NMR TELL US ABOUT AMYLOID STRUCTURES? Introduction Principles of Solid-State NMR Spectroscopy and Experiments for Structural Constraints Amyloid Fibrils Investigated by Solid-State NMR Spectroscopy Summary
FROM MOLECULAR TO SUPRAMOLECULAR AMYLOID STRUCTURES: CONTRIBUTIONS FROM FIBER DIFFRACTION AND ELECTRON MICROSCOPY Introduction History Methodology Recent Advances in Amyloid Structure Determination Summary
STRUCTURES OF AGGREGATING SPECIES BY SMALL-ANGLE X-RAY SCATTERING Introduction Theoretical and Experimental Aspects Data Analysis and Modeling Methods Studying Protein Aggregation and Fibrillation Using SAXS General Strategies for Modeling SAXS Data from Protein Complexes Summary and Final Remarks
STRUCTURAL AND COMPOSITIONAL INFORMATION ABOUT PRE-AMYLOID OLIGOMERS General Introduction Biophysical Techniques to Study Amyloid Oligomers The Structure and Composition of Amyloid Oligomers Concluding Remarks
THE OLIGOMER SPECIES: MECHANISTICS AND BIOCHEMISTRY Introduction The Structure - Toxicity Relation of Early Amyloids The Oligomer - Membrane Complex Biochemical Modifications Underlying Amyloid Toxicity Summary
PATHWAYS OF AMYLOID FORMATION Introduction Nomenclature of the Various Conformational States Graphical Representations of the Mechanisms Leading to Amyloid Pathways of Amyloid Fibril Formation Nucleation Growth versus Nucleated Conformational Conversion Summary
SEQUENCE-BASED PREDICTION OF PROTEIN BEHAVIOR Introduction The Strategy of the Zyggregator Predictions Aggregation Under Other Conditions Prediction of the Cellular Toxicity of Protein Aggregates Relationship to Other Methods of Predicting Protein Aggregation Propensities Competition between Folding and Aggregation of Proteins Prediction of Protein Solubility from the Competition between Folding and Aggregation Sequence-Based Prediction of Protein Interactions with Molecular Chaperones Summary
THE KINETICS AND MECHANISMS OF AMYLOID FORMATION Introduction Classical Theory of Nucleated Polymerization The Theory of Filamentous Growth with Secondary Pathways Self-Consistent Solutions for the Complete Reaction Time Course Summary
FLUORESCENCE SPECTROSCOPY AS A TOOL TO CHARACTERIZE AMYLOID OLIGOMERS AND FIBRILS Introduction Fluorescence Spectroscopy for Studies of Amyloid Reactions In vitro Cysteine-Reactive Fluorescent Probes Amyloidotropic Probes for Amyloid Fibrils and Oligomeric States Luminescent Conjugated Poly and Oligothiophenes LCPs and LCOs Summary
ANIMAL MODELS OF AMYLOID DISEASES Introduction Some Big Questions Regarding Amyloid Diseases and Some Answers from Animal Models Identifying the Toxic Species in the Systemic Amyloidoses Identifying the Toxic Species in Alzheimer's Disease Infectious Protein Misfolding Conclusions
THE ROLE OF AB IN ALZHEIMER'S DISEASE History of Amyloidosis Biochemistry of Aß Amyloid Fibrils The Soluble Oligomer Theory of AD Other Factors Involved in Amyloid Plaque Formation in AD Metal Ions in AD Other Potential Aß Interactions Other Neurodegenerative Diseases Conclusion
EXPERIMENTAL APPROACHES TO INDUCING AMYLOID AGGREGATES The Need for Reproducible Fibrillation Assays Setting Up an Assay to Monitor Fibrillation Conditions That Promote Protein Aggregation Processing and Batch Differences Toward High-Throughput Assays Summary
FIBRILLAR POLYMORPHISM Detection of Fibrillar Polymorphism The Structural Definition of Fibril Polymorphism The Two Classes of Fibril Polymorphism How Does Fibrillar Polymorphism Arise? The Interconversion of Fibril Polymorphs The Biological Implications of Fibril Polymorphism Summary
INHIBITORS OF AMYLOID AND OLIGOMER FORMATION Introduction: Amyloidoses versus Neurodegenerative Diseases Summary
DEVELOPMENT OF THERAPEUTIC STRATEGIES FOR THE TRANSTHYRETIN AMYLOIDOSES Introduction to Transthyretin Structure and Function Introduction to Amyloid Diseases in General Mechanism of Transthyretin Amyloidogenesis Kinetic Stabilization of the Transthyretin Tetramer through Small-Molecule Binding Assessment of Diflunisal for Treatment of Transthyretin Amyloidosis Tafamidis, the First Approved Drug for Treatment of a Transthyretin Amyloidosis Summary
HORMONE AMYLOIDS IN SICKNESS AND IN HEALTH Introduction Constitutive vs. Regulated Secretory Pathways Secretory Granules Contain Aggregated Cargo Secretory Granule Aggregation by Functional Amyloid Formation Hormone Amyloids in Disease: Diabetes Insipidus Conclusions
FUNCTIONAL AMYLOIDS IN BACTERIA Introduction Functional Amyloids are Common in Nature Identification and Characterization of Functional Amyloids Functional Bacterial Amyloids Play Many Roles Biogenesis and Regulation of Functional Bacterial Amyloids Structural Composition of Functional Amyloids Assembly Properties of Functional Amyloid In Vitro Diversity and Distribution of Functional Amyloid Genes Summary
STRUCTURAL PROPERTIES AND APPLICATIONS OF SELF-ASSEMBLING PEPTIDES Introduction to Self-Assembling Peptides The Principles of Self-Assembling Peptides Self-Assembling Peptide Nanofibers Diverse Applications of Self-Assembling Peptide Nanofibers Scaffolds Summary
HARNESSING THE SELF-ASSEMBLING PROPERTIES OF PROTEINS IN SPIDER SILK AND LUNG SURFACTANT Introduction Amino Acid Sequences and Amyloid Formation Spider Silk and How the Spiders Make It Harnessing the Properties of Spider Silk and Its Constituent Proteins Biosynthesis of an a-Helix from One of the Most ß-Prone Sequences Known Anti-Amyloid Properties of the BRICHOS Domain Summary
Thomas, Sabu / Durand, Dominique / Chassenieux, Christophe / Jyotishkumar, P. (eds.) Handbook of Biopolymer-Based Materials 269.- Euro valid until 31 July 2013
