Walsh, Gary Pharmaceutical Biotechnology Concepts and Applications
1. Edition - July 2007 51.90 Euro 2007. 498 Pages, Softcover - Practical Approach Book - ISBN-10: 0-470-01245-5 ISBN-13: 978-0-470-01245-1 - John Wiley & Sons
Short description Pharmaceutical Biotechnology: Concepts and Applications provides a comprehensive introduction to the fast-moving area of biopharmaceuticals. With a particular focus on the subject taken from a pharmaceutical perspective, this book offers a broad introduction to protein science and recombinant DNA technology - key areas that underpin the whole subject.
From the contents 1 Pharmaceuticals, Biologics and Biopharmaceuticals
1.1 Introduction to pharmaceutical products
1.2 Biopharmaceuticals and pharmaceutical biotechnology
1.3 History of the pharmaceutical industry
1.4 The age of biopharmaceuticals
1.5 Biopharmaceuticals: current status and future prospects
Further reading 2 Protein Structure
2.1 Introduction
2.2 Overview of protein structure
2.3 Higher level structure
2.4 Protein stability and folding
2.5 Protein post-translational modification
Further reading 3 Gene Manipulation and Recombinant DNA Technology
3.1 Introduction
3.2 Nucleic acids: function and structure
3.3 Recombinant production of therapeutic proteins
3.4 Classical gene cloning and identification
Further reading 4 The Drug Development Process
4.1 Introduction
4.2 Discovery of biopharmaceuticals
4.3 The impact of genomics and related technologies upon drug discovery
4.4 Gene chips
4.5 Proteomics
4.6 Structural genomics
4.7 Pharmacogenetics
4.8 Initial product characterization
4.9 Patenting
4.10 Delivery of biopharmaceuticals
4.11 Preclinical studies
4.12 Pharmacokinetics and pharmacodynamics
4.13 Toxicity studies
4.14 The role and remit of regulatory authorities
4.14 Conclusion
Further reading 5 Sources and Upstream Processing
5.1 Introduction
5.2 Sources of biopharmaceuticals
5.3 Upstream processing
Further reading 6 Downstream Processing
6.1 Introduction
6.2 Initial product recovery
6.3 Cell disruption
6.4 Removal of nucleic acid
6.5 Initial product concentration
6.6 Chromatographic purification
6.7 High-performance liquid chromatography of proteins
6.8 Purification of recombinant proteins
6.9 Final product formulation
Further reading 7 Product Analysis
7.1 Introduction
7.2 Protein-based contaminants
7.3 Removal of altered forms of the protein of interest from the product stream
7.4 Detection of protein-based product impurities
7.5 Immunological approaches to detection of contaminants
7.6 Endotoxin and other pyrogenic contaminants
Further reading 8 The Cytokines: The Interferon Family
8.1 Cytokines
8.2 The interferons
8.3 Interferon biotechnology
8.4 Conclusion
Further reading 9 Cytokines: Interleukins and Tumour Necrosis Factor
9.1 Introduction
9.2 Interleukin-2
9.3 Interleukin-1
9.4 Interleukin-11
9.5 Tumour necrosis factors
Further reading 10 Growth Factors
10.1 Introduction
10.2 Haematopoietic growth factors
10.3 Growth factors and wound healing
Further reading 11 Therapeutic Hormones
11.1 Introduction
11.2 Insulin
11.3 Glucagon
11.4 Human growth hormone
11.5 The gonadotrophins
11.6 Medical and veterinary applications of gonadotrophins
11.7 Additional recombinant hormones now approved
11.8 Conclusion
Further reading 12 Recombinant Blood Products and Therapeutic Enzymes
12.1 Introduction
12.2 Haemostasis
12.3 Anticoagulants
12.4 Thrombolytic agents
12.5 Enzymes of therapeutic value
Further reading 13 Antibodies, Vaccines and Adjuvants
13.1 Introduction
13.2 Traditional polyclonal antibody preparations
13.3 Monoclonal antibodies
13.4 Vaccine technology
13.5 Adjuvant technology
Further reading 14 Nucleic-Acid- and Cell-Based Therapeutics
14.1 Introduction
14.2 Gene therapy
14.3 Vectors used in gene therapy
14.4 Gene therapy and genetic disease
14.5 Gene therapy and cancer
14.6 Gene therapy and AIDS
14.7 Antisense technology
14.8 Oligonucleotide pharmacokinetics and delivery
