2. Edition - November 2005
155.- Euro
2005. XII, 356 Pages, Hardcover
255 Fig., 23 Tab. 
- Monograph -
ISBN-10: 3-527-31029-0
ISBN-13: 978-3-527-31029-6 - Wiley-VCH, Weinheim






Sample Chapter



Short description
This second edition reflects recent developments in the use of hydrolases for organic synthesis, providing an overview of the stereoselective reactions of hydrolases and helping to solve synthetic challenges. Contains over one thousand chemical structures and 1,800 references.

From the contents
INTRODUCTION
DESIGNING ENANTIOSELECTIVE REACTIONS
Kinetic Resolutions
Asymmetric Syntheses
CHOOSING REACTION MEDIA: WATER AND ORGANIC SOLVENTS
Hydrolysis in Water
Transesterifications and Condensations in Organic Solvents
Other Reaction Media
Immobilization
PROTEIN SOURCES AND OPTIMIZATION OF BIOCATALYST PERFORMANCE
Accessing Biodiversity
Creating Improved Biocatalysts
Catalytic Promiscuity in Hydrolases
LIPASES AND ESTERASES
Availability, Structures and Properties
Survey of Enantioselective Lipase-Catalyzed Reactions
Chemo- and Regioselective Lipase-Catalyzed Reactions
Reactions Catalyzed by Esterases
PROTEASES AND AMIDASES
Occurrence and Availability of Proteases and Amidases
General Features of Subtilisin, Chymotrypsin, and Other Proteases and Amidases
Structures of Proteases and Amidases
Survey of Enantioselective Protease- and Amidase-Catalyzed Reactions
PHOSPHOLIPASES
Phospholipase A1
Phospholipase A2
Phospholipase C
Phospholipase D
EPOXIDE HYDROLASES
Introduction
Mammalian Epoxide Hydrolases
Microbial Epoxide Hydrolases
HYDROLYSIS OF NITRILES
Introduction
Mild Conditions
Regioselective Reactions of Dinitriles
Enantioselective Reactions
OTHER HYDROLASES
Glycosidases
Haloalcohol Dehalogenases
Phosphotriesterases