1. Edition - September 2006
155.- Euro
2006. XXII, 404 Pages, Hardcover
121 Fig., 45 Tab. 
- Practical Approach Book -
ISBN-10: 3-527-31408-3
ISBN-13: 978-3-527-31408-9 - Wiley-VCH, Weinheim






Sample Chapter



Short description
First ever comprehensive coverage of the pharmacokinetic and pharmacodynamic characteristics of highly important class of biology-based drugs. Spans all topics from lead identification right up to final-stage clinical trials -- a must for all pharmaceutical researchers.

From the contents
The Role of Pharmacokinetics and Pharmacodynamics in the Development of Biotech Drugs

Pharmacokinetics of Peptides and Proteins

Pharmacokinetics of Monoclonal Antibodies

Pharmacokinetics and Pharmacodynamics of Antisense Oligonucleotides

Pharmacokinetics of Viral and Non-Viral Gene Delivery Vectors

Bioanalytical Methods used for Pharmacokinetic Evaluations of Biotech Macromolecule Drugs: Issues, Assay Approaches, and Limitations

Limitations of Noncompartmental Pharmacokinetic Analysis of Biotech Drugs

Bioequivalence of Biologics

Biopharmaceutical Challenges in Pulmonary Delivery of Proteins and Peptides

Biopharmaceutical Challenges: Delivery of Oligonucleotides

Custom-Tailored Pharmacokinetics and Pharmacodynamics via Chemical Modifications of Biotech Drugs

Exposure-Response Relationships for Therapeutic Biologic Products

Preclinical and Clinical Drug Development of Tasidotin, a Depsi-Pentapeptide Oncolytic Agent

Clinical Drug Development of Cetuximab, a Monoclonal Antibody

Integration of Pharmacokinetics and Pharmacodynamics into the Drug Development of Pegfilgrastim, a Pegylated Protein