1. Edition - October 2009
175.- Euro
2009. 532 Pages, Hardcover
- Practical Approach Book -
ISBN-10: 0-470-72361-0
ISBN-13: 978-0-470-72361-6 - John Wiley & Sons






Sample Chapter

Short description
The Pulmonary Endothelium is a uniquely comprehensive compendium of current knowledge and is the first book dedicated specifically to the subject, offering insights into current and future approaches to management. The text provides the clinician with the most up-to-date information on one of the core physiological processes in airway disease and is an ideal point of reference for both postgraduates and professionals - specialist physicians in pulmonology and allergy and workers in biomedical and pharmaceutical research.

From the contents
List of Contributors


Introduction, Sharon Rounds and Norbert Voelkel



SECTION I: NORMAL PULMONARY ENDOTHELIUM. STRUCTURE, FUNCTION, CELL BIOLOGY



1: Development of the Pulmonary Endothelium in Development of the Pulmonary

Circulation: Vasculogenesis and Angiogenesis, Margaret A. Schwarz and Ondine B. Cleaver


2: Anatomy of the Pulmonary Endothelium, Radu V. Stan


3: Cadherins and Connexins in Pulmonary Endothelial Function, Kaushik Parthasarathi

and Sadiqa K. Quadri


4: Pulmonary Endothelial Cell Interactions with the Extracellular Matrix,

Katie L. Grinnell and Elizabeth O. Harrington


5: Pulmonary Endothelial Cell Calcium Signaling and Regulation of Lung Vascular

Barrier Function, Nebojsa Knezevic, Mohammad Tauseef and Dolly Mehta


6: Pulmonary Endothelium and Nitric Oxide, Yunchao Su and Edward R. Block


7: Pulmonary Endothelial Cell Surface Metabolic Functions, Usamah S. Kayyali and

Barry L. Fanburg


8: Cell Biology of Lung Endothelial Permeability, Guochang Hu and Richard D. Minshall


9: Lung Endothelial Phenotypes: Insights Derived from the Systematic Study

of Calcium Channels, Donna L. Cioffi, Songwei Wu and Troy Stevens


10: Pulmonary Endothelial Interactions with Leukocytes and Platelets, Rosana Souza

Rodrigues and Guy A. Zimmerman


11: Mesenchymal-Endothelial Interactions in the Control of Angiogenic, Inflammatory,

and Fibrotic Responses in the Pulmonary Circulation, Kurt R. Stenmark, Evgenia V.

Gerasimovskaya, Neil Davie and Maria Frid


12: Pulmonary Endothelium and Vasomotor Control, Nikki L. Jernigan, Benjimen R. Walker and Thomas C. Resta


13: Pulmonary Endothelial Progenitor Cells, Bernard Thébaud and Mervin C. Yoder


14: Bronchial Vasculature: The Other Pulmonary Circulation, Elizabeth Wagner


15: Mapping Protein Expression on Pulmonary Vascular Endothelium,

Kerri A. Massey and Jan E. Schnitzer



SECTION II: MECHANISMS AND CONSEQUENCES OF PULMONARY ENDOTHELIAL CELL

INJURY


16: Pulmonary Endothelial Cell Death: Implications for Lung Disease Pathogenesis,

Qing Lu and Sharon Rounds


17: Oxidant-Mediated Signaling and Injury in Pulmonary Endothelium, Kenneth E.

Chapman, Shampa Chatterjee and Aron B. Fisher


18: Hypoxia and the Pulmonary Endothelium, Matthew Jankowich, Gaurav Choudhary, and Sharon Rounds


19: Viral Infection and Pulmonary Endothelial Cells, Norbert F. Voelkel


20: Effects of Pressure and Flow on the Pulmonary Endothelium, Wolfgang M. Kuebler


21: Therapeutic Strategies to Limit Lung Endothelial Cell Permeability,

Rachel K. Wolfson, Gabriel Lang, Jeff Jacobson and Joe G. N. Garcia


22: Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium, Vladimir R.

Muzykantov



SECTION III: PULMONARY ENDOTHELIUM IN DISEASE


23: Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn,

Yuansheng Gao and J. Usha Raj


24: Genetic Insights into Endothelial Barrier Regulation in the Acutely Inflamed Lung,

Sumegha Mitra, Daniel Turner Lloveras, Shwu-Fan Ma and Joe G. N. Garcia


25: Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets:

Implications for Disease Pathogenesis, Mark R. Nicolls, Rasa Tamosiuniene, Ashok N. Babu and Norbert F. Voelkel


26: Role of the Endothelium in Emphysema: Emphysema - A Lung Microvascular Disease,

Norbert F. Voelkel and Ramesh Natarajan


27: Pulmonary Endothelium and Pulmonary Hypertension, Rubin M. Tuder and Serpil C.

Erzurum


28: Collagen Vascular Diseases and Pulmonary Endothelium, Pradeep R. Rai and

Carlyne D. Cool


29: Pulmonary Endothelium in Thromboembolism, Irene M. Lang


30: Pulmonary Endothelium and Malignancies, Abu-Bakr Al-Mehdi



Epilogue, Norbert F. Voelkel


Index