1. Edition - April 2008
135.- Euro
2008. 432 Pages, Hardcover
- Handbook/Reference Book -
ISBN-10: 0-470-01922-0
ISBN-13: 978-0-470-01922-1 - John Wiley & Sons






Sample Chapter

Detailed description
In the last decade there has been an explosion of interest in viral therapies for cancer. Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy.

This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient's bedside, they give an up-to-date and realistic evaluation of a therapy's potential utility for the cancer patient.
* Presents state-of-the-art knowledge on how viruses can be, and have been,used in novel therapeutic approaches for the treatment of cancer
* Describes the use of viruses as oncolytic agents, killing cells directly
* Editors are experts in the field, with experience of both laboratory and clinical research

Viral Therapy of Cancer is essential reading for both basic scientists and clinicians with an interest in viral therapy and gene therapy.

From the contents
Foreword.

Preface.

Contributors.

1. Adenoviruses (Kate Relph, Kevin J. Harrington, Alan Melcher and Hardev S. Pandha).

References.

2. Application of HSV-1 Vectors to the treatment of cancer (Paola Grandi, Kiflai Bein, Costas G. Hadjipanayis, Darren Wolfe, Xandra O. Breakefield and Joseph C. Glorioso).

Acknowledgements.

References.

3. Adeno-associated virus (Selvarangan Ponnazhagan).

Acknowledgements.

References.

4. Retroviruses (Simon Chowdhury and Yasuhiro Ikeda).

4/6 Safety of retroviral vectors: insertional mutagenesis.

References.

5. Lentiviral vectors for cancer gene therapy (Antonia Follenzi and Elisa Vigna).

References.

6. Poxviruses as immunomodulatory cancer therapeutics (Kevin J. Harrington, Hardev S. Pandha and Richard G. Vile).

References.

7. Oncolytic herpes simplex viruses (Guy R. Simpson and Robert S. Coffin).

Acknowledgement.

References.

8. Selective tumour cell cytotoxicity by reoviridae - preclinical evidence and clinical trial results (Laura Vidal, Matt Coffey and Johann de Bono).

References.

9. Oncolytic vaccinia (M. Firdos Ziauddin and David L. Bartlett).

References.

10. Newcastle Disease virus: a promising vector for viral therapy of cancer (Volker Schirrmacher and Philippe Fournier).

References.

11. Vesicular stomatitis virus (John Bell, Kelly Parato and Harold Atkins).

References.

12. Measles as an oncolytic virus (Adele Fielding).

References.

13. Alphaviruses (Ryuya Yamanaka).

References.

14. Tumour-suppressor gene therapy (Bingliang Fang and Jack A. Roth).

Acknowledgements.

References.

15. RNA interference and dominant negative approaches (Charlotte Moss and Nick Lemoine).

References.

16. Gene-directed enzyme prodrug therapy (Silke Schepelmann, Douglas Hedley, Lesley M. Ogilvie and Caroline J. Springer).

References.

17. Immunomodulatory gene therapy (Denise Boulanger and Andrew Bateman).

References.

18. Antiangiogenic gene delivery (Anita T. Tandle and Steven K. Libutti).

References.

19. Radiosensitization in viral gene therapy (Jula Veerapong, Kai A. Bickenbach and Ralph R. Weichselbaum).

References.

20. Radioisotope delivery (Inge D.L. Peerlinck and Georges Vassaux).

References.

21. Radioprotective gene therapy: current status and future goals (Joel S. Greenberger and Michael W. Epperly).

References.

22. Chemoprotective gene delivery (Michael Milsom, Axel Schambach, David Williams and Christopher Baum).

Acknowledgements.

References.

Index.