1. Edition - June 2003
185.- Euro
2003. XX, 780 Pages, Hardcover
- Monograph -
ISBN-10: 3-906390-25-X
ISBN-13: 978-3-906390-25-3 - Verlag Helvetica Chimica Acta, Zürich









Short description
In this volume, Bernard Testa and Joachim M. Mayer discuss the molecular and biochemical aspects of metabolic reactions of hydrolysis and hydration. While an encyclopaedic treatment is avoided, the topics covered include biochemical properties of the enzymes/isozymes, drug-enzyme interactions, the various chemical reactions catalyzed by enzymes, reaction mechanisms and catalytic cycles, regio- and stereoselectivities, structure-metabolism relationships, molecular aspects of toxification and detoxification, as well as enzyme inhibition. The classification of materials is based mainly on the types of target groups and compounds being transformed, with carefully selected examples to illustrate the reactions under discussion. Such a treatment has heuristic value since it renders the reader capable of educated guesses on the metabolism of other or novel drugs.

From the contents
Introduction
The Nature and Function of Hydrolytic Enzymes
Classification, Localization and Physiological Roles of Hydrolytic Enzymes
The Hydrolysis of Amides
The Hydrolysis of Lactams
The Hydrolysis of Peptides
The Hydrolysis of Carboxylic Esters
The Hydrolysis of Carboxylic Ester Prodrugs
The Hydrolysis of Esters of Inorganic Acids
Epoxide Hydratase and Epoxide Hydration
Various Reactions of Hydration or Dehydration