|  | Becker, Katja (ed.)
Apicomplexan Parasites
Molecular Approaches toward Targeted Drug Development
Drug Discovery in Infectious Diseases (Volume 2)
Edited by Selzer, Paul M.
 1. Edition February 2011
169.- Euro
2011. XXII, 528 Pages, Hardcover
99 Fig. (46 Colored Fig.), 31 Tab.
- Handbook/Reference Book -
ISBN 978-3-527-32731-7 - Wiley-VCH, Weinheim
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Content
Sample Chapter
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| Short description
This title is the first dealing with drug discovery for apicomplexan parasites, which cause prominent diseases like Malaria, Toxoplasmosis and Babesiosis. Focusing on current approaches for drug development for all apicomplexan diseases it is appealing to a large audience.
From the contents
SCREENING, BIOINFORMATICS, CHEMOINFORMATICS, AND DRUG DESIGN
Drug Discovery Approaches towards Anti-Parasitic Agents
(Andreas Rohwer, Richard J. Marhöfer, Conor R. Caffrey and Paul M. Selzer)
New Bioinformatic Strategies against Apicomplexan Parasites
(Thomas Dandekar and Ke Xiao)
Sorting Potential Therapeutic Targets in Apicomplexa
(Jan A. Hiss and Gisbert Schneider)
Alternatives to Drug Development in Apicomplexa
(Prof. Dr. Theo P.M. Schetters)
METABOLIC PATHWAYS AND PROCESSES ADDRESSED BY CURRENT DRUG DISCOVERY APPROACHES
The Energy Metabolism as an Antimalarial Drug Target
(Esther Jortzik and Katja Becker)
Polyamines in Apicomplexan Parasites
(Ingrid B. Müller, Robin Das Gupta, Kai Lüersen, Carsten Wrenger and Rolf D. Walter)
The Reducing Milieu of Parasitized Cells as a Target of Antimalarial Agents. Methylene Blue as an Ethical Drug
(Peter Meissner, Heike Adler, Karin Fritz-Wolf and R. Heiner Schirmer)
Lipids as Drug Targets for Malaria Therapy
(Henri J. Vial, Diana Penarete, Sharon Wein, Sergio Caldarelli, Laurent Fraisse and Suzanne Peyrottes)
Targeting Apicoplast Pathways in Plasmodium
(Snober S. Mir, Subir Biswas and Saman Habib)
Lipoic Acid Acquisition and Glutathione Biosynthesis in Apicomplexan Parasites
(Janet Storm, Eva-Maria Patzewitz and Sylke Müller)
Antimalarial Drugs and Molecules Inhibiting Hemozoin formation
(Uday Bandyopadhyay and Sumanta Dey)
Exploiting the Vitamin Metabolism of Apicomplexa as Drug Targets
(Carsten Wrenger and Ingrid B. Müller)
Vitamin Biosynthetic Pathways, the PLP Synthase Complex, and the Potential for Drugging Protein-Protein Interaction
(Ivo Tews and Irmgard Sinning)
Targeting Prokaryotic Enzymes in the Eukaryotic Pathogen Cryptosporidium
(Suresh Kumar Gorla, Corey Johnson, Jihan Khan, Xin Sun, Lisa Sharling,
Boris Striepen and Lizbeth Hedstrom)
DRUG TARGETS IN APICOMPLEXAN PARASITES
Novel Apicomplexan Phosphatases and Immunophilins
as Domain-Specific Drug Targets
(Sailen Barik)
Dehydrogenases and enzymes of the mitochondrial electron transport chain as antiapicomplexan drug targets
(Kathleen Zocher, Stefan Rahlfs and Katja Becker)
Calcium-dependent protein kinases as drug targets in apicomplexan parasites
(Dominik Kugelstadt, Bianca Derrer, and Barbara Kappes)
Protein Acylation:
New Potential Targets for Intervention against Apicomplexa
(Joana M. Santos, Christian Hedberg and Dominique Soldati-Favre)
Drugs and Drug Targets in Neospora Caninum and Related Apicomplexans
(Joachim Müller, Norbert Müller and Andrew Hemphill)
COMPOUNDS
Subversive Substrates of Glutathione Reductases from P. Falciparum-infected Red Blood Cells as Antimalarial Agents
(Elisabeth Davioud-Charvet and Don Antoine Lanfranchi)
Ferroquine: a Concealed Weapon (Christophe Biota, Bruno Pradinesb and Daniel Divec)
Current Aspects of Endoperoxides in Antiparasitic Chemotherapy
(Denis Matovu Kasozi, Stefan Rahlfs and Katja Becker)
Plasmodium Hsp90 as an Antimalarial Target
(G. Sridhar Prasad and Sailen Barik)
Drug Discovery against Babesia and Toxoplasma
(Mohamad Alaa Terkawi and Ikuo Igarashi)
Search for Drugs and Drug Targets against Babesia bovis, Babesia bigemina, Babesia caballi, and Babesia (Theileria) equi
(Sabine Bork-Mimm)
Orlistat: A Repositioning Opportunity as a Growth Inhibitor of Apicomplexan Parasites?
(Christian Miculka, Hon Tran, Thorsten Meyer, Anja R. Heckeroth, Stefan Baumeister, Frank Seeber and Paul M. Selzer)
Recent drug discovery against Cryptosporidium
(Jean-François Rossignol, Gilles Gargala, J. Edward Semple and Andrew V. Stachulski)
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