|  | Patnaik, Ranjan
Engineering Complex Phenotypes in Industrial Strains
 1. Edition December 2012
87.90 Euro
2012. 280 Pages, Hardcover
ISBN 978-0-470-61075-6 - John Wiley & Sons
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Sample Chapter
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| Short description
This book details the current and future tools used in the production of bulk chemicals and biofuels developed from renewable biomass using green technologies. It describes in depth the technology used to unravel the complexity of microbial metabolism in order to produce engineering strains at time scales much faster than would occur naturally. It also highlights the advantages and drawbacks of all methods and tools used in multiple disciplines for genome engineering of complex phenotypes. Case-study examples on applying the tools reinforce the fundamental concepts. A must for research and development biochemists and engineers.
From the contents
Foreword vii
John Pierce
Preface ix
Contributors xi
1 Classical Strain Improvement 1
Nathan Crook and Hal S. Alper
2 Tracer-Based Analysis of Metabolic Flux Networks 35
Michael Dauner
3 Integration of "Omics" Data with Genome-Scale Metabolic Models 77
Stephen Van Dien, Priti Pharkya, and Robin Osterhout
4 Strain Improvement via Evolutionary Engineering 111
Byoungjin Kim, Jing Du, and Huimin Zhao
5 Rapid Fermentation Process Development and Optimization 133
Jun Sun and Lawrence Chew
6 The Clavulanic Acid Strain Improvement Program at DSM Anti-Infectives 169
Bert Koekman and Marcus Hans
7 Metabolic Engineering of Recombinant E. coli for the Production of 3-Hydroxypropionate 185
Tanya Warnecke Lipscomb, Matthew L. Lipscomb, Ryan T. Gill, and Michael D. Lynch
8 Complex System Engineering: A Case Study for an Unsequenced Microalga 201
Michael T. Guarnieri, Lieve M.L. Laurens, Eric P. Knoshaug, Yat-Chen Chou, Bryon S. Donohoe, and Philip T. Pienkos
9 Meiotic Recombination-Based Genome Shuffling of Saccharomyces Cerevisiae and Schefferomyces Stiptis for Increased Inhibitor Tolerance to Lignocellulosic Substrate Toxicity 233
Dominic Pinel and Vincent J.J. Martin
Index 251
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