1. Edition - April 2010
119.- Euro
2010. 272 Pages, Hardcover
ISBN-10: 1-4443-3064-0
ISBN-13: 978-1-4443-3064-9 - John Wiley & Sons






Sample Chapter

Short description
Clinical Pathways to Success in CNS Drug Development provides a thorough overview of the critical early CNS drug development process for clinical scientists and reviews the latest models, technologies and regulations designed to improve and expedite the drug development process on each of the major CNS disorders. It includes a critical analysis of the lack of CNS specific drugs successfully brought to market and the steps required to remedy this problem. The book covers all of the initial stages of CNS drug development, from pre-clinical to early clinical trials, and includes all the latest technologies, methods, biomarkers, models and regulations designed to accelerate the early CNS drug development process, reduce overall costs, and improve drug safety and efficacy. It also discusses the many inherent difficulties in developing CNS-specific drugs, and describes the many technical and methodological advances used to circumvent these difficulties.

From the contents
Acknowledgements.

Foreword.

1 The Impending Crisis in CNS Drug Development.

2 Animal Models and Procedures for CNS Disorders.

3 Pre-Clinical Antecedents to Early Human Clinical Trials.

4 Biomarkers and Surrogate Markers in Drug Development.

5 Neuroimaging and Cognitive Assessments in Early Drug Development.

6 Bridging and CSF Studies.

7 A Case Study from Pre-Clinical to Early Clinical Trials.

Index.