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Prasad, Paras N.
Introduction to Nanomedicine and Nanobioengineering
Wiley Series in Biomedical Engineering
(Volume 1)

1. Edition June 2012
145.- Euro
2012. 608 Pages, Hardcover
ISBN 978-1-118-09343-6 - John Wiley & Sons




Sample Chapter


Short description
This book is an introduction to the emerging field of nanomedicine and its applications to health care. It describes the many multidisciplinary challenges facing nanomedicine and discusses the required collaboration between chemists, physicists, engineers and clinicians. The book introduces the reader to nanomedicine's vast potential to improve and extend human life through the application of nanomaterials in diagnosis and treatment of disease.

From the contents
PREFACE xiiiACKNOWLEDGMENTS xv1 INTRODUCTION 11.1. Nanomedicine: A Global Vision 11.2. The Nanotechnology Revolution: Realization of Asimov's Fiction 31.3. Nanomedicine: A New Era in Personalized Medicine 71.4. Nanomedicine: A Promise or Reality? 91.5. A New Frontier: Multidisciplinary Challenges and Opportunities 101.6. Scope of the Book: Multidisciplinary Education, Training, and Research 122 THE HUMAN BODY 152.1. Introductory Concepts 162.2. Cellular Structure 182.3. Various Types of Cells 232.4. Biochemical Makeup of Cells 252.5. Other Important Cellular Components 292.6. Cellular Processes 302.7. Organization of Cells into Tissues 372.8. Types of Tissues and Their Functions 392.9. Various Organs and Organ Systems in the Body 402.10. Tumors and Cancers 453 NANOCARRIERS 513.1. Nanocarriers: Delivering Payloads to Needed Sites 523.2. The Various Nanoformulations for Nanomedicine 533.3. Viruses as Nanocarriers 553.4. Polymeric Nanocarriers 563.5. Lipid-Based Nanocarriers 583.6. Dendrimers 593.7. Carbon Nanostructures 613.8. Inorganic Nanoparticles 633.9. PEBBLE 653.10. Nanoclinics 663.11. Nanoplexes 683.12. New-Generation Nanocarriers 694 NANOCHEMISTRY OF NANOCARRIERS 774.1. Nanochemistry and Nanomedicine 784.2. Top-Down Approaches 784.3. Bottom-Up Approaches 834.4. Combination of Bottom-Up and Top-Down Approaches 924.5. Nanoparticle Surface Modification 934.6. Functionalization and Bioconjugation 955 MULTIFUNCTIONALITIES FOR DIAGNOSTICS AND THERAPY 1035.1. The Various Functionalities 1045.2. Optical Functionalities 1055.3. Optical Nanoprobes 1105.4. Magnetic Functionality 1165.5. Thermal Functionality 1205.6. Radioactive Functionality 1215.7. Biological Functionality 1245.8. Multifunctionality 1256 CROSSING THE BIOLOGICAL BARRIERS 1356.1. Various Delivery Pathways 1356.2. Various Biological Barriers 1376.3. Stealth Nanoparticles 1406.4. The Various In Vitro Barrier Models 1417 BIOTARGETING 1497.1. Biotargeting: Why We Need It 1497.2. Targeted Biological Sites 1507.3. Intracellular Uptake 1517.4. Targeting Strategies 1537.5. Targeting Groups 1558 MULTIMODAL BIOMEDICAL IMAGING 1638.1. Biomedical Imaging Techniques 1648.2. Optical Bioimaging 1708.3. Magnetic Resonance Imaging 1858.4. X-Ray CT Imaging 1888.5. Radio Imaging 1908.6. Ultrasound Imaging 1908.7. Photoacoustic Imaging 1918.8. Multimodal Imaging 1929 BIOSENSING 2079.1. Principles of Biosensing 2089.2. Optical Biosensors 2119.3. Magnetic Biosensors 2289.4. Electrical Biosensing 2349.5. Electrochemical Biosensing 2369.6. Electrochemiluminescence Biosensing 2389.7. In Vivo Bioelectronic Sensors 23910 HIGH-THROUGHPUT MULTIPLEXED DIAGNOSTICS 25310.1. Comprehensive Diagnostic Strategy 25410.2. Flow Cytometry 25510.3. Enzyme-Linked Immunosorbent Assay (ELISA) 26410.4. Microarrays Technology 26910.5. Suspension Bead Assay 27711 NANOPHARMACOTHERAPY 29111.1. Nanopharmacotherapy: An Overview 29211.2. Modes of Nanoformulation for Nanopharmacotherapy 29411.3. Pharmacokinetics 29611.4. Biodistribution 29711.5. Pharmacodynamics 29811.6. Controlled Release by External Activation 29912 THE HUMAN CIRCULATORY SYSTEM AND THERANOSTICS 30512.1. Blood Fluidics and Cardiovascular System 30612.2. Circulatory-System-Based Disease Profiling 30912.3. Methods to Monitor Blood Flow 31212.4. Therapeutic Approaches Utilizing Manipulation of Blood Flow 31812.5. Lymph Node Mapping 32012.6. Lymphatic Drug Delivery 32213 NANOTECHNOLOGY FOR CANCER 33113.1. Benefits of Cancer Nanotechnology 33213.2. Chemotherapy 33513.3. Cancer Gene Therapy 33913.4. Photodynamic Therapy 34013.5. Magnetic Therapy 34913.6. Photothermal Therapy 35313.7. Neutron Capture Therapy 35713.8. Circulating Tumor Cells 35913.9. NCI Alliance for Cancer Nanotechnology 36014 GENE THERAPY 37114.1. The Principles, Steps, and Impact of Gene Therapy 37214.2. Methods of Gene Delivery 37414.3. Gene Augmentation Therapy 38114.4. Gene Silencing Therapy 38114.5. Indirect Gene Therapy Modulating Innate Immune Response 38414.6. Transmucosal Gene Delivery 38515 NANOTECHNOLOGY FOR INFECTIOUS DISEASES 39315.1. Pathogen Infections and Nanoparticle-Based Approaches 39415.2. HIV 40115.3. Influenza 40815.4. Tuberculosis 41015.5. Malaria 41616 REJUVENATION THERAPY 43316.1. Rejuvenation Therapy: Fantasy or Reality? 43316.2. Free Radical Scavenging 43616.3. Chelation Therapy 43916.4. Hormone Therapy 44117 STEM CELL BIOTECHNOLOGY 44717.1. Stem Cell Biotechnology: Overview 44817.2. Cell Reprogramming 44917.3. Gene Transfection 45217.4. Somatic Cell Transdifferentiation 45317.5. Stem Cell Sorting 45417.6. Stem Cell Tracking 45418 TISSUE ENGINEERING 46118.1. Tissue Engineering: Overview 46218.2. Tissue Regeneration 46418.3. Nanotechnology in Tissue Engineering 46718.4. Nanofibers for Tissue Engineering 47218.5. Nanoparticle Delivery of Biomolecules 47318.6. Magnetically Assisted Tissue Engineering 47418.7. Tissue/Organ Printing 47518.8. Tissue Bonding 47719 NANODERMATOLOGY AND NANOCOSMETICS 48719.1. Delivery Through Skin 48719.2. Skin Care and Nanotechnology 48819.3. Various Nanoparticles for Dermatology and Cosmetics 49119.4. Nanodermatology 49219.5. Nanocosmetics 49419.6. Nanotoxicology of the Skin 49720 NANODENTISTRY 50320.1. Nanotechnology for Dental Care 50420.2. Nanoparticles for Preventive Dentistry 50720.3. Nanomaterials for Restorative Dentistry 50920.4. Regenerative Dentistry 51620.5. Nanoparticle-Enhanced Dental Imaging and Oral Diagnostics 51920.6. Nanorobotics for Dentistry 52221 NANOTOXICITY 52921.1. Toxicity of Nanoparticles 52921.2. Cytotoxicity 53321.3. In Vitro Cytotoxicity Assays 53521.4. In Vivo Toxicity 53921.5. In Vivo Toxicity Evaluation 54221.6. Nanotoxicity Studies on Selected Nanoparticles 542Highlights of the Chapter 547Exercises 550References 551INDEX 555

 




 

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