|  | Lue, Neal / Autexier, Chantal
Telomerases
Chemistry, Biology and Clinical Applications
 1. Edition July 2012
109.- Euro
2012. 318 Pages, Hardcover
ISBN 978-0-470-59204-5 - John Wiley & Sons
|
Sample Chapter
| Buy now   
E-Books are also available on all known E-Book shops.
|
| Short description
This book gives biochemists, geneticists, and related investigators a comprehensive and up-to-date review and evaluation of telomerase research, a key subfield in understanding genetic function and diseases. Chapters cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics discussed include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase, and the role of telomerase in cellular senescence, aging, and cancer. The text also reviews relevant information for retrotransposons, a class of mobile genetic elements serving as telomeres in selected organisms.
From the contents
Preface vii
Contributors ix
1 The Telomerase Complex: An Overview 1
Johanna Mancini and Chantal Autexier
2 Telomerase RNA: Structure, Function, and Molecular Mechanisms 23
Yehuda Tzfati and Julian J.-L. Chen
3 TERT Structure, Function, and Molecular Mechanisms 53
Emmanuel Skordalakes and Neal Lue
4 Telomerase Biogenesis: RNA Processing, Trafficking, and Protein Interactions 79
Tara Beattie and Pascal Chartrand
5 Transcriptional Regulation of Human Telomerase 105
Antonella Farsetti and Yu-Sheng Cong
6 Telomerase Regulation and Telomere-Length Homeostasis 135
Joachim Lingner and David Shore
7 Telomere Structure in Telomerase Regulation 157
Momchil D. Vodenicharov and Raymund J. Wellinger
8 Off-Telomere Functions of Telomerase 201
Kenkichi Masutomi and William C. Hahn
9 Murine Models of Dysfunctional Telomeres and Telomerase 213
Yie Liu and Lea Harrington
10 Cellular Senescence, Telomerase, and Cancer in Human Cells 243
Phillip G. Smiraldo, Jun Tang, Jerry W. Shay, and Woodring E. Wright
11 Telomerase, Retrotransposons, and Evolution 265
Irina R. Arkhipova
Index 301
|
|
|
|
