EurBest in EurJOC: Three-Component Coupling of Aldehydes, Amines, and Alkynes Catalyzed by Oxidized Copper Nanoparticles on Titania
A3 coupling catalyzed by ultrafine copper nanoparticles on titania under solvent-free conditions is described. Some examples of KA2 coupling are also reported. The catalyst is reusable and exhibited better performance than commercially available copper catalysts. The participation of copper(I) acetylides in a heterogeneous process has been demonstrated.
María José Albaladejo, Francisco Alonso, Yanina Moglie and Miguel Yus