The importance of drug delivery to chemists, medicinal and otherwise, has increased since the advent of integrated drug discovery processes. Physicochemical and biological barriers, pathways for drug delivery, formulation, pharmacokinetic and pharmacodynamic issues, metabolism, and cell culture models used in studying drug delivery are just some of the topics that make drug delivery an exciting field for researchers.
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An efficient and selective drug-delivery carrier is reported that uses hollow mesoporous silica nanoparticles as the core and well-designed multifunctional amphiphilic agents as the capping shell. The results suggest that the nanocarriers are biocompatible and are able to selectively deliver hydrophobic drugs to targeted tumor cells, followed by a controllable release of the drug payload.
Shun Yang, Dongyun Chen, Najun Li, Qingfeng Xu, Hua Li, Frank Gu, Jianping Xie, Jianmei Lu
Small, November 30, 2015, DOI: 10.1002/smll.201503121. Read article
Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active Mn2+ and L-3,4-dihydroxyphenylalanine. Complementary images are acquired with a single contrast agent, and applications toward Parkinson's disease are suggested.
Birgitte Hjelmeland McDonagh, Gurvinder Singh, Sjoerd Hak, Sulalit Bandyopadhyay, Ingrid Lovise Augestad, Davide Peddis, Ioanna Sandvig, Axel Sandvig, Wilhelm Robert Glomm
Small, November 30, 2015, DOI: 10.1002/smll.201502545. Read article
An innovative concept for the fabrication of dual-action microrobots capable of performing single-cell microsurgery along with site-directed drug delivery feature is presented. These multi-action plant-derived biocompatible “medibots” can play a pivotal role in understanding micromotor interactions at the cellular level, aiming towards the destruction of harmful cells (like cancer) among others in living systems.
Sarvesh Kumar Srivastava, Mariana Medina-Sánchez, Britta Koch, Oliver G. Schmidt
Adv. Mater., November 30, 2015, DOI: 10.1002/adma.201504327. Read article
Liposomes loaded with doxorubicin are successfully embedded into cell backpacks with retention of their structure. Liposome-loaded backpacks are attached to the surface of living monocytes, which remain viable over timescales relevant to usual drug delivery schemes. One new interesting observation suggests a potential new use of cell backpacks as vectors for the direct targeting of cancer cells.
Roberta Polak, Rosanna M. Lim, Marisa M. Beppu, Ronaldo N. M. Pitombo, Robert E. Cohen, Michael F. Rubner
Adv. Healthcare Mater., November 30, 2015, DOI: 10.1002/adhm.201500604. Read article
Given the green light: Rose bengal in conjugation with zinc oxide nanoparticles (ZnO NPs) enhances the generation of reactive oxygen species (ROS) upon green-light irradiation in comparison with the free drug. Detailed spectroscopic investigations were performed and the in vitro toxicity of the nanohybrid was confirmed using various cell lines.
Siddhi Chaudhuri, Samim Sardar, Damayanti Bagchi, Shreyasi Dutta, Sushanta Debnath, Partha Saha, Peter Lemmens, Samir Kumar Pal
ChemPhysChem, November 26, 2015, DOI: 10.1002/cphc.201500905. Read article
Superparamagnetic nanoparticles and a functional, degradable polymer matrix based on poly(ethylene glycol) are combined to enable fully degradable magnetic microdevices for minimally invasive biomedical applications. A bioinspired helical microrobot platform mimicking Escherichia coli bacteria is fabricated and actuated using weak rotating magnetic fields. Locomotion based on corkscrew propulsion, targeted drug delivery, and low-degradation-product cytotoxicity are demonstrated.
Christian Peters, Marcus Hoop, Salvador Pané, Bradley J. Nelson, Christofer Hierold
Adv. Mater., November 25, 2015, DOI: 10.1002/adma.201503112. Read article
Holey vaterite nanoparticles! Porous vaterite nanoparticles (VNs) fabricated with gelatin assistance displayed high surface area and improved stability in aqueous solution. Their application as doxorubicin containers and their therapeutic efficacy against cancer cells were investigated in vitro. The vaterite nanoparticles prove to be excellent containers for anticancer drugs after modification by folic acid.
Anhe Wang, Yang Yang, Xiaoming Zhang, Xingcen Liu, Wei Cui, Junbai Li
ChemPlusChem, November 24, 2015, DOI: 10.1002/cplu.201500515. Read article
A visible-light-triggered drug delivery system is constructed based on a double-layered stack of TiO2 nanotubes. The key for visible light drug release is a hydrophobic cap on the nanotubes containing Au nanoparticles, where SPR with the TiO2 conduction band provides the active species for chain scission. The system was tested in antibacterial experiments against E. coli.
Jingwen Xu, Xuemei Zhou, Zhida Gao, Yan-Yan Song, Patrik Schmuki
Angew. Chem. Int. Ed., November 23, 2015, DOI: 10.1002/anie.201508710. Read article
Anticancer drug Gefitinib encapsulated within human heavy chain apoferritin by diffusion allows pH-controlled sustained release of cargo. The combination of increased cellular uptake, and potent and enhanced antitumor activity against the HER2 overexpressing SKBR3 cell line compared to Gefitinib alone, makes it a promising carrier for delivery of drugs to tumor sites.
Anchala I. Kuruppu, Lei Zhang, Hilary Collins, Lyudmila Turyanska, Neil R. Thomas, Tracey D. Bradshaw
Adv. Healthcare Mater., November 23, 2015, DOI: 10.1002/adhm.201500389. Read article
Rod-shaped Trojan “Horse” DNA origami nanostructures intercalated with the anthracycline daunorubicin circumvent drug resistance in HL-60/ADR multi-drug-resistant human leukemia cells at clinically relevant drug concentrations. Proof-of-concept enhanced efficacy is evaluated through colorimetric assays, fluorescence microscopy, and flow cytometry demonstrating a versatile delivery system with controllable drug loading that can ultimately be applied to multiple types of human cancer.
Patrick D. Halley, Christopher R. Lucas, Emily M. McWilliams, Matthew J. Webber, Randy A. Patton, Comert. Kural, David M. Lucas, John C. Byrd, Carlos E. Castro
Small, November 19, 2015, DOI: 10.1002/smll.201502118. Read article
Soft supramolecular nanoparticles (SNPs) are formed by building blocks that are brought together by multiple noncovalent supramolecular interactions. SNPs are stable yet reversible three-dimensional assemblies, and can be used for a variety of applications. This review summarizes the existing approaches for the formation of soft SNPs and focuses on their potential biomedical applications.
Carmen Stoffelen, Jurriaan Huskens
Small, November 19, 2015, DOI: 10.1002/smll.201501348. Read article
Magnetite nanocrystal clusters (MNCs) are fabricated by a self-assembly strategy, the surface of the MNCs is functionalized with polydopamine (PDOPA), and the antitumor drug epirubicin is attached onto the surface. The achieved MNC@PDOPA exhibits superparamagnetic characteristics, improved magnetization behavior under external magnetic field, well-controlled loading, and pH-responsive properties.
Shaokun Song, Wanting Zhu, Chao Long, Yang Zhang, Shun Chen, Lijie Dong
Eur. J. Inorg. Chem., November 18, 2015, DOI: 10.1002/ejic.201500912. Read article.
A novel bio-inspired rod-shaped micellar system is developed as a nanoplatform for highly effectively delivering anticancer drugs. The nanoplatform has a great capacity of escaping the rapid clearance of reticuloendothelial system in blood, a high internalization rate of tumor cells, and a significant enhancement of therapeutic agent potency against artificial solid tumors.
Dan Li, Zhaomin Tang, Yuqian Gao, Huili Sun, Shaobing Zhou
Adv. Funct. Mater., November 17, 2015, DOI: 10.1002/adfm.201503664. Read article
Ploydopamine (PDA) nanoparticles as a biocompatible nanocarrier platform are developed for loading of both radionuclides and an anticancer drug to realize nuclear-imaging-guided combined radioisotope therapy and chemotherapy of cancer. Utilizing this synergistic manner, 131I-PDA-poly(ethylene glycol)/doxorubicin nanoparticles exhibited effective cancer treatment efficacy, without rendering significant toxicity to the treated animals.
Xiaoyan Zhong, Kai Yang, Zhiliang Dong, Xuan Yi, Yong Wang, Cuicui Ge, Yuliang Zhao, Zhuang Liu
Adv. Funct. Mater., November 05, 2015, DOI: 10.1002/adfm.201503587. Read article
Humidity can serve as a feasible trigger to activate the self-healing of microporous polyelectrolyte multilayer film. Based on this, a facile and versatile means is suggested to directly integrate hydrophobic drugs into the films for biomedical coatings.
Xia-Chao Chen, Ke-Feng Ren, Jia-Hui Zhang, Dan-Dan Li, Emily Zhao, Zhong Jonathon Zhao, Zhi-Kang Xu, Jian Ji
Adv. Funct. Mater., November 05, 2015, DOI: 10.1002/adfm.201503258. Read article
A 2D photosensitive coordination polymer comprising 5-aminolevulinic acid (ALA) and Zn ions is prepared to encapsulate the agarose-stabilized magnetite colloidal supraparticles (Fe3O4@ALA-ZnII). The formed core–shell microspheres allow the pH-sensitive release of prodrug ALA, enable the ALA-mediated biosynthesis of photosensitizer PpIX, and display the remarkable PDT activity against bladder cancer cells as exposed to visible light.
Jing Tan, Chuanyu Sun, Ke Xu, Changchun Wang, Jia Guo
Small, October 30, 2015, DOI: 10.1002/smll.201502131. Read article
In nature, pollen grains play a vital role for encapsulation. Many pollen species exist which are often used as human food supplements. Dynamic image particle analysis, scanning electron microscopy, and confocal microscopy analysis confirmed the size, structural uniformity, and macromolecular encapsulation in sunflower pollen, paving the way to explore natural pollen grains for the encapsulation of therapeutic molecules.
Raghavendra C. Mundargi, Michael G. Potroz, Soohyun Park, Hitomi Shirahama, Jae Ho Lee, Jeongeun Seo, Nam-Joon Cho
Small, October 30, 2015, DOI: 10.1002/smll.201500860. Read article
Peptide-based GFP complementation: Cells expressing the GFP1-10 GFP fragment (gray circle) are electroporated or penetrated with GFP-11 (gray squares) conjugated by a linker (blue line) to a cell-penetrating peptide (orange line), thereby resulting in delivery into the cytosol and GFP complementation and fluorescence (green circle).
Samuel Schmidt, Merel J. W. Adjobo-Hermans, Rike Wallbrecher, Wouter P. R. Verdurmen, Petra H. M. Bovée-Geurts, Jenny van Oostrum, Francesca Milletti, Thilo Enderle, Roland Brock
Angew. Chem. Int. Ed., October 30, 2015, DOI: 10.1002/anie.201505913. Read article
Recent developments for ZnO nanostructures are presented, highlighting great potential for biomedical applications such as biosensing, tissue regeneration, bioimaging, and drug delivery.
Ping Zhu, Zhengyang Weng, Xia Li, Xiangmei Liu, Shuilin Wu, K. W. K. Yeung, Xianbao Wang, Zhenduo Cui, Xianjin Yang, Paul. K. Chu
Adv. Mater. Interfaces, October 29, 2015, DOI: 10.1002/admi.201500494. Read article
A novel multilayered and monodisperse nanocarrier system with tunable and multimodal functionalities is designed. This new system is prepared at ambient conditions and features multiple platforms for loading two or more different molecules simultaneously. The poly-L-lysine layer controls the deposition of outermost silica layer and also modulates its charge from positive to negative by a simple strategy.
Anshuman Jakhmola, Raffaele Vecchione, Daniela Guarnieri, Valentina Belli, Dominic Calabria, Paolo A. Netti
Adv. Healthcare Mater., October 29, 2015, DOI: 10.1002/adhm.201500588. Read article
The in situ polymerized nanogels with encapsulated proteins have great promises for storage and release of cargos in a spatial, temporal, and dosage-controlled manner. The preparation method and stimuli-responsive properties of the protein nanogels are listed and explained herein.
[Talents & Trends]
Yanqi Ye, Jicheng Yu, Zhen Gu
Macromol. Chem. Phys., October 27, 2015, DOI: 10.1002/macp.201500296. Read article
A wearable drug delivery system based on a hydrogel sheet containing thermoresponsive drug carriers interfaced with a flexible heater is engineered for topical applications. The platform maintains a conformal contact with skin and enables on demand and tunable drug delivery by controlling the hydrogel temperature. The release rates of various molecules with different sizes are studied. The system paves the way toward engineering smart wound dressings.
Sara Bagherifard, Ali Tamayol, Pooria Mostafalu, Mohsen Akbari, Mattia Comotto, Nasim Annabi, Masoumeh Ghaderi, Sameer Sonkusale, Mehmet R. Dokmeci, Ali Khademhosseini
Adv. Healthcare Mater., October 26, 2015, DOI: 10.1002/adhm.201500357. Read article
The formation of polymersomes from HPMA-related amphiphilic blockcopolymers is presented. These polymers are prepared via activated ester chemistry, which allows efficient and facile modification. The vesicles formed from them exhibit high encapsulation efficiencies for hydrophilic cargo via dual centrifugation. Furthermore, they prove to be biocompatible, which makes them promising candidates as nanosized drug carriers.
Martin Scherer, Karl Fischer, Frank Depoix, Thomas Fritz, Raphael Thiermann, Kristin Mohr, Rudolf Zentel
Macromol. Rapid Commun., October 19, 2015, DOI: 10.1002/marc.201500444. Read article
Dual-targeted nanoparticles (NPs) are fabricated by nanoprecipitation method. Bearing the aggregation-induced emission characteristics (AIE), the obtained AIE NPs show bright red fluorescence and efficient reactive oxygen species' production. The NPs are able to selectively internalize into cancer cells with folate receptor overexpression, and subsequently accumulate at mitochondria, which largely improve the photodynamic therapy efficiency.
Guangxue Feng, Wei Qin, Qinglian Hu, Ben Zhong Tang, Bin Liu
Adv. Healthcare Mater., October 19, 2015, DOI: 10.1002/adhm.201500431. Read article
A multifunctional cationic lytic peptide is designed incorporating amino acid pairing, amphipathic structure, and histidine-mediated pH-sensitivity for controllable membrane lytic activity and nanostructure. The peptide can deliver small-molecule drugs in a pH-triggered manner with selectively enhanced synergetic anticancer activity, which originates from the selective lytic activity of the peptide, representing a novel therapeutic carrier strategy.
Sheng Lu, W. F. Drew Bennett, Yong Ding, Lei Zhang, Helen Y. Fan, Danyang Zhao, Tao Zheng, Ping-Kai Ouyang, Jason Li, Yan Wu, Wen Xu, Dafeng Chu, Yongfang Yuan, Heiko Heerklotz, Mikko Karttunen, P. Chen
Adv. Healthcare Mater., October 16, 2015, DOI: 10.1002/adhm.201500636. Read article
Join the DOX: Thermo/pH dual responsive mixed-shell polymeric micelles based on the complementary multiple hydrogen bonds are synthesized. The collapsed poly(N-vinylcaprolactam) (PNVCL) shell could form hydrophobic domains on the poly(ɛ-caprolactone) (PCL) core and the corona formed by the water soluble methoxy poly(ethylene glycol) (MPEG) chains was embedded into the PNVCL shell and acted as a channel and a protective barrier against aggregation of the micelles.
Qiuhua Wu, Xiuping Tang, Xue Liu, Yu Hou, He Li, Chen Yang, Jie Yi, Ximing Song, Guolin Zhang
Chem. Asian J., October 15, 2015, DOI: 10.1002/asia.201500847. Read article
Photomediated reactive oxygen species (ROS)-generable nanoparticles (SRNs) incorporated with ROS-generator and scavenger in a single delivery platform is developed. Under attenuated single light irradiation, doxorubicin loaded SRNs (D-SRNs) synergistically exhibit simultaneous triggered drug release and endo/lysosomal escape as well as photodynamic therapy for highly efficient cancer treatment.
Eun Ha Seo, Chung-Sung Lee, Kun Na
Adv. Healthcare Mater., October 09, 2015, DOI: 10.1002/adhm.201500622. Read article
The biological mechanisms of nuclear-targeting mesoporous silica nanoparticles (MSNs)-based DDSs (DOX@NT-MSNs) in overcoming multidrug resistance of cancer cells have been studied. It is interesting to find for the first time that DOX@NT-MSNs down-regulate the expression of apoptosis suppressor genes and inhibit DNA repair process by disturbing the p53 pathway.
Xiaoyu Li, Limin Pan, Jianlin Shi
Adv. Healthcare Mater., October 09, 2015, DOI: 10.1002/adhm.201500548. Read article
Nanogels are formed in the water droplets of the water-in-oil emulsion generated feasibly from the mixture of water and a solution of hyperbranched poly(BAC2-AMPD1)-PEG in chloroform; are easily loaded with neutral charged FITC-dextram with a high efficiency and show redox-responsive release.
Weiren Cheng, Guan Wang, Jatin Nitin Kumar, Ye Liu
Macromol. Rapid Commun., September 17, 2015, DOI: 10.1002/marc.201500421. Read article
The synthesis of amphiphilic block copolypept(o)ides based on bifunctional initiators is described, which allows the incorporation of stimuli-responsive chemical entities, e.g., disulfides, at the interphase between both blocks. The stimuli-responsive block copolymers form PeptoMicelles (Rh = 40 nm) in aqueous solution, which disassemble in the presence of glutathione.
Regina Holm, Kristina Klinker, Benjamin Weber, Matthias Barz
Macromol. Rapid Commun., September 07, 2015, DOI: 10.1002/marc.201500402. Read article
New inroads in theranostics: The grafting of fluorescent ZnS:Mn-doped nanocrystals and the anticancer drug doxorubicin onto graphene oxide can be used for cell labeling and drug delivery applications. The nanocomposite particles exhibit drug entrapment efficiency of 100% and cancer cell killing efficiency of 85%. The particles label the perinuclear region of HeLa cells with yellow fluorescence (see figure).
Sanghamitra Dinda, Mitali Kakran, Jialiu Zeng, Thankiah Sudhaharan, Sohail Ahmed, Debajyoti Das, Subramanian Tamil Selvan
ChemPlusChem, September 01, 2015, DOI: 10.1002/cplu.201500349. Read article
The fabrication of a carrier system capable of selectively encapsulating two therapeutics, piribedil and glial cell derived neurotrophic factor, in select compartments, and the programming of their independent release rates is investigated. The characterization of these particles, the release of each therapeutic, and the persistence of the particles within Guinea pig cochlea are assessed.
Sahar Rahmani, Astin M. Ross, Tae-Hong Park, Hakan Durmaz, Acacia F. Dishman, Diane M. Prieskorn, Nathan Jones, Richard A. Altschuler, Joerg Lahann
Adv. Healthcare Mater., July 14, 2015, DOI: 10.1002/adhm.201500141. Read article