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The importance of drug delivery to chemists, medicinal and otherwise, has increased since the advent of integrated drug discovery processes. Physicochemical and biological barriers, pathways for drug delivery, formulation, pharmacokinetic and pharmacodynamic issues, metabolism, and cell culture models used in studying drug delivery are just some of the topics that make drug delivery an exciting field for researchers.
Find all articles on drug delivery in Wiley Online Library...
Liang Gao, Jinbo Fei, Jie Zhao, Wei Cui, Yue Cui, Junbai Li
pH and Redox-Responsive Polysaccharide-Based Microcapsules with Autofluorescence for Biomedical Applications [Full Paper]
Responsive carriers: Autofluorescent microcapsules were assembled by covalent cross-linking of polysaccharide derivative alginate dialdehyde (ADA) and cystamine dihydrochloride (CM) through a layer-by-layer technique. The formulated Schiff base and disulfide bonds render capsules with pH and redox-responsive properties for pinpointed intracellular delivery.
Chem. Eur. J., February 16, 2012, DOI: 10.1002/chem.201103584
Sergio Sánchez-Muñoz, Santiago Gómez-Ruiz, Damián Pérez-Quintanilla, Sonia Morante-Zarcero, Isabel Sierra, Sanjiv Prashar, Reinhard Paschke, Goran N. Kaluđerović
Preliminary Study of the Anticancer Applications of Mesoporous Materials Functionalized with the Natural Product Betulinic Acid [Full Paper]
The perfect combination: The combination of functionalized mesoporous materials such as MCM-41 with betulinic acid, a potent anticancer drug, led to novel drug delivery systems which may be useful in the future as adjuvant agents to avoid the recurrence of bone tumors on local implantations.
Ming Zhou, Nandi Zhou, Filiz Kuralay, Joshua R. Windmiller, Serguey Parkhomovsky, Gabriela Valdés-Ramírez, Evgeny Katz, Joseph Wang
A Self-Powered “Sense-Act-Treat” System that is Based on a Biofuel Cell and Controlled by Boolean Logic [Communication]
Bio-logic-al: An autonomous, integrated “sense-act-treat” system that is based on an enzymatic biofuel cell has been developed. The system couples a biocomputing logic-detection method with a drug-release system to provide a logic-activated therapeutic intervention in response to a simulated abnormal physiological state, without the need for an external power source, control electronics, or microelectromechanical actuators.
Angew. Chem. Int. Ed., January 3, 2012, DOI: 10.1002/anie.201107068
Zhijun Ma, Huijiao Ji, Dezhi Tan, Guoping Dong, Yu Teng, Jiajia Zhou, Jianrong Qiu
Porous YAG:Nd3+ Fibers with Excitation and Emission in the Human “NIR Optical Window” as Luminescent Drug Carriers [Full Paper]
Fruit and fibers: Porous YAG:Nd3+ fibers are suitable as luminescent drug carriers for in vivo applications owing to their huge specific surface area, large pore volume, affording both excitation and emission in the human “NIR optical window”, and their ability to monitor the release of drugs.
Sanjib Bhattacharyya, Raman Deep Singh, Richard Pagano, J. David Robertson, Resham Bhattacharya, Priyabrata Mukherjee
Switching the Targeting Pathways of a Therapeutic Antibody by Nanodesign [Communication]
On the right path: The mechanisms of endocytosis of cetuximab (C225) and its nanoconjugates have been elucidated in a pancreatic cancer cell line. By using gold nanoparticles as a scaffold, it is possible to switch the pathway for endocytosis from a Dyn-2-dependent caveolar mechanism to Cdc42-dependent pinocytosis/phagocytosis. Tailoring endocytotic mechanisms may enable specific intracellular pathways to be targeted.
Kristin L. Horton, Mark P. Pereira, Kelly M. Stewart, Sonali B. Fonseca, Shana O. Kelley
Tuning the Activity of Mitochondria-Penetrating Peptides for Delivery or Disruption [Full Paper]
Decommissioning the powerhouse: Mitochondrial-targeting agents have the capacity to be both vehicles for the delivery of bioactive agents and mitochondrial disrupters and show promise for the treatment of various diseases. Here, we assess the physicochemical properties governing mitochondrial matrix accumulation or membrane disruption caused by mitochondria-penetrating peptides (see graphic).
Noufal Kandoth, Elisa Vittorino, Maria Teresa Sciortino, Tiziana Parisi, Ivana Colao, Antonino Mazzaglia, Salvatore Sortino
A Cyclodextrin-Based Nanoassembly with Bimodal Photodynamic Action [Full Paper]
Bimodal anticancer therapy: A supramolecular nanoassembly based on cationic amphiphilic cyclodextrins incorporating two suitable photoactive units permits effective photogeneration of 1O2 and NO in cancer cells (see figure) and induces a remarkable level of cell mortality through bimodal photodynamic actions, as well as displaying imaging capacities.
Charlotte C. Williams, San H. Thang, Tina Hantke, Uwe Vogel, Peter H. Seeberger, John Tsanaktsidis, Bernd Lepenies
RAFT-Derived Polymer–Drug Conjugates: Poly(hydroxypropyl methacrylamide) (HPMA)–7-Ethyl-10-hydroxycamptothecin (SN-38) Conjugates [Full Paper]
A life RAFT! A series of well-defined polymer–drug conjugates have been prepared to increase the bioavailability of the known cytotoxic drug 7-ethyl-10-hydroxycamptothecin (SN-38). Reversible addition–fragmentation chain transfer (RAFT) polymerisation was used to covalently and site-specifically append an N-(2-hydroxypropyl)methacrylamide (HPMA) polymer to SN-38. The poly-HPMA–SN-38 conjugates displayed excellent aqueous solubility, cytotoxic activity, and specificity for cancer cells.
Nathan P. Gabrielson, Hua Lu, Lichen Yin, Dong Li, Fei Wang, Jianjun Cheng
Reactive and Bioactive Cationic α-Helical Polypeptide Template for Nonviral Gene Delivery [Communication]
At every turn: Poly(γ-(4-vinylbenzyl)-L-glutamate) (PVBLG) is a bioactive and reactive template for a library of cationic α-helical polypeptides (PVBLGn-X) for gene delivery. The top-performing PVBLGn-X outperformed polyethyleneimine (PEI) by 12-fold. Preliminary data indicate that the helicity of the polypeptides is essential for their performance, and enhanced membrane disruption is a likely source of their transfection efficiency. RLU=relative light unit.
Maïté Marguet, Lise Edembe, Sébastien Lecommandoux
Polymersomes in Polymersomes: Multiple Loading and Permeability Control [Communication]
Capsules in capsules: An emulsion–centrifugation method allows polymersomes in polymersomes “PiPs” (see picture) or polymer vesosomes to be prepared. This simple approach to generate biomimetic compartmentalized structures offers a way to encapsulate several different and even mutually incompatible active substances, thereby opening avenues in combinatory drug release and providing exquisite control of permeation properties.
Gonçalo J. L. Bernardes, Giulio Casi, Sabrina Trüssel, Isabelle Hartmann, Kathrin Schwager, Jörg Scheuermann, Dario Neri
A Traceless Vascular-Targeting Antibody–Drug Conjugate for Cancer Therapy [Communication]
Right on target: A chemically defined vascular-targeting antibody–drug conjugate (ADC) that offers comprehensive tumor coverage has been developed. When injected intravenously, this ADC potently inhibited tumor growth in a syngeneic immunocompetent model of murine cancer which cannot be cured by conventional cytotoxic agents.
Nikola Ž. Knežević, Igor I. Slowing, Victor S.-Y. Lin
Tuning the Release of Anticancer Drugs from Magnetic Iron Oxide/Mesoporous Silica Core/Shell Nanoparticles [Full Paper]
A series of core/shell magnetic mesoporous silica nanoparticle (MMSN) materials were prepared. The loading and release of anticancer drugs, 9-aminoacridine (9AA) and camptothecin (CPT), as well as cytotoxic activity of drug loaded materials, is influenced by the presence of phenylethyl functionalization inside the MMSN mesopores (see figure). An externally applied magnetic field accelerates the drug release from the materials.
Edmond Gravel, Julien Ogier, Thomas Arnauld, Nicolas Mackiewicz, Frédéric Ducongé, Eric Doris
Drug Delivery and Imaging with Polydiacetylene Micelles [Concept]
Photopolymerized micelles obtained from the self-assembly of diacetylene-containing amphiphiles have been developed for biomedical applications in the fields of imaging and drug delivery (see figure).
Christian Argyo, Valentina Cauda, Hanna Engelke, Joachim Rädler, Gregor Bein, Thomas Bein
Heparin-Coated Colloidal Mesoporous Silica Nanoparticles Efficiently Bind to Antithrombin as an Anticoagulant Drug-Delivery System [Communication]
Blood ties: A novel nanoscale, injectable drug-delivery system that combines heparin, which prevents blood clotting, with multifunctional core-shell colloidal mesoporous silica nanoparticles has been designed (see figure). The anticoagulant and biocompatible properties of heparin together with the highly porous features of the nanoparticles lead to an efficient multifunctional drug-delivery system that can itself act as an anticoagulant and allows for incorporation of biologically active molecules as deliverable cargo.
Yilong Ma, Dongmei Yang, Yan Ma, Yu-Hui Zhang
Novel Cell-Penetrating Peptides Based on α-Aminoxy Acids [Full Paper]
A novel cell-penetrating peptide featuring α-aminoxy acid residues forms an efficient diffuse distribution in the cytosol; it is stable toward serum and possesses low cytotoxicity, thus making it a potential vector candidate for in vivo applications.
Xin Xia, Chunfang Zhou, Lluís Ballell, Alfonso E. Garcia-Bennett
In vivo Enhancement in Bioavailability of Atazanavir in the Presence of Proton-Pump Inhibitors using Mesoporous Materials [Communication]
Matters of the HAART! The current treatment for human immunodeficiency virus (HIV), HAART, makes use of a combination of antiretroviral drugs, which are poorly soluble in aqueous media. Enhancing the solubility of such drugs through the use of mesoporous materials could lead to improved treatment efficiency and might provide a solution to the drug–drug interaction problems associated with these types of therapeutic regimes.
Kejing Zhang, Kwame Sefah, Lili Tang, Zilong Zhao, Guizhi Zhu, Mao Ye, Weijia Sun, Steve Goodison, Weihong Tan
A Novel Aptamer Developed for Breast Cancer Cell Internalization [Full Paper]
SELEX-tive uptake: The oligonucleotide KMF2-1a is one of a panel of aptamers that specifically recognize the MCF-10AT1 breast cancer cell line, with Kd values in the nanomolar range. KMF2-1a binds specifically and very stably to target cells. Furthermore, this aptamer can bind to target cells at both 4 and 37 °C, extending its use for in vivo experimentation.
Madhab C. Das, Shengchang Xiang, Zhangjing Zhang, Banglin Chen
Functional Mixed Metal–Organic Frameworks with Metalloligands [Minireview]
Metal mixer: A novel metalloligand approach allows the rational immobilization of a variety of functional sites in mixed metal–organic frameworks (M'MOFs). This Minireview highlights some important functional M'MOFs with metalloligands for gas storage and separation, enantioselective separation, heterogeneous asymmetric catalysis, sensing, drug delivery, and biomedical imaging.
Morteza Malakoutikhah, Meritxell Teixidó, Ernest Giralt
Shuttle-Mediated Drug Delivery to the Brain [Review]
Operating a shuttle service: The use of chemical shuttles to deliver drugs to the brain is a plausible solution to overcome the obstacle posed by the blood–brain barrier. The drug is conjugated to a shuttle molecule that has the ability to permeate the blood–brain barrier (see picture).
Jillian L. Perry, Charles R. Martin, Jon D. Stewart
Drug-Delivery Strategies by Using Template-Synthesized Nanotubes [Concept]
Special order delivery! Template synthesis strategies provide excellent control over both the internal and external dimensions of nanotubes. Because these methods also allow internal and external surfaces to display disparate functional groups, template-synthesized nanotubes are very attractive starting points for drug-delivery vehicles (see graphic). Several key advances have recently been made that bring this goal closer to reality and are discussed in this Concept article.
© Wiley-VCH 2011.
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