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Gold

goldZum Golde drängt, am Golde hängt doch alles.
For gold contend, On gold depend All things.

J. W. Goethe, Faust I

The element gold has many personalities, of which the image of a noble but soft, yellow metal would first across one's mind. The recently discovered nanoparticles and nanowires containing gold are a natural extension of this aspect, as are the uses of gold in electronics and decoration. Thought to be noble, gold actually has a rich chemistry. Fascinating in its complexity for academic chemists, this chemistry has potential applications in materials science, medicine and, recently, in both heterogeneous and homogeneous catalysis. Some fresh promises are related to the optical properties of certain gold compounds or to the possibility of forming new nanostructures based on gold. The unique properties of gold are strongly influenced by relativistic effects.

[1] P. Pyykkö, Theoretical Chemistry of Gold
Angew. Chem. 2004, 116, 4512–4557; Angew. Chem. Int. Ed. 2004, 43, 4412–4456

[2] A. S. K. Hashmi, The Catalysis Gold Rush: New Claims
Angew. Chem. 2005, 117, 7150; Angew. Chem. Int. Ed. 2005, 44, 6990

[3] G. Schmid, B. Corain, Nanoparticulated Gold: Syntheses, Structures, Electronics, and Reactivities
Eur. J. Inorg. Chem. 2003, 3081

Recent Articles

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Size-Dependent Cellular Uptake of DNA Functionalized Gold Nanoparticles

Size‐Dependent Cellular Uptake of DNA Functionalized Gold Nanoparticles

Systematic variation of DNA conformation, DNA length, and nanoparticle core diameter is performed to evaluate the influence of size, surface charge, and DNA conformation on the internalization of DNA functionalized gold nanoparticles by cells. Cellular uptake is primarily dependent on size, which informs the design of gold nanoparticle probes that possess enhanced cell entry properties for imaging and therapeutic applications.

[Full Paper]
Alexis C. Wong, David W. Wright
Small, August 26, 2016, DOI: 10.1002/smll.201601697. Read article

Gold Nanomaterials in Consumer Cosmetics Nanoproducts: Analyses, Characterization, and Dermal Safety Assessment

Gold Nanomaterials in Consumer Cosmetics Nanoproducts: Analyses, Characterization, and Dermal Safety Assessment

A practical protocol including separation, characterization, and toxicity assessment of gold nanomaterials in cosmetic creams is developed. Gold nanomaterials are successfully separated from facial or eye creams and their physiochemical properties are analyzed by several state-of-the art techniques. Subsequently, the preliminary toxicity assessments indicate that they have no observable toxicity to human keratinocytes.

[Full Paper]
Mingjing Cao, Jiayang Li, Jinglong Tang, Chunying Chen, Yuliang Zhao
Small, August 26, 2016, DOI: 10.1002/smll.201601574. Read article

Gd-Hybridized Plasmonic Au-Nanocomposites Enhanced Tumor-Interior Drug Permeability in Multimodal Imaging-Guided Therapy

Gd‐Hybridized Plasmonic Au‐Nanocomposites Enhanced Tumor‐Interior Drug Permeability in Multimodal Imaging‐Guided Therapy

An original gadolinium-hybridized plasmonic gold nanocomposite is fabricated to provide an insightful and attractive strategy to overcome both the physiological and pathological barriers of tumor, and increase the transportation and permeability of imaging agents and drugs in tumor interior for achieving high-sensitive multimodal imaging and simultaneously improving the therapeutic efficacy of cancer.

[Communication]
Jing Wang, Jing Liu, Ying Liu, Liming Wang, Mingjing Cao, Yinglu Ji, Xiaochun Wu, Yingying Xu, Bing Bai, Qing Miao, Chunying Chen, Yuliang Zhao
Adv. Mater., August 26, 2016, DOI: 10.1002/adma.201603114. Read article

A Simple and Highly Stable Porous Gold-based Electrochemical Sensor for Bisphenol A Detection

A Simple and Highly Stable Porous Gold‐based Electrochemical Sensor for Bisphenol A Detection

[Full Paper]
Rodtichoti Wannapob, Panote Thavarungkul, Supaporn Dawan, Apon Numnuam, Warakorn Limbut, Proespichaya Kanatharana
Electroanalysis, August 25, 2016, DOI: 10.1002/elan.201600371. Read article

A Novel Solid-state Electrochemiluminescent Enantioselective Sensor for Ascorbic Acid and Isoascorbic Acid

A Novel Solid‐state Electrochemiluminescent Enantioselective Sensor for Ascorbic Acid and Isoascorbic Acid

[Full Paper]
Shu Zhu, Xia Lin, Qinghong Wang, Qiao Xia, Peiyao Ran, Yingzi Fu
Electroanalysis, August 25, 2016, DOI: 10.1002/elan.201600329. Read article

Subtissue Imaging and Thermal Monitoring of Gold Nanorods through Joined Encapsulation with Nd-Doped Infrared-Emitting Nanoparticles

Subtissue Imaging and Thermal Monitoring of Gold Nanorods through Joined Encapsulation with Nd‐Doped Infrared‐Emitting Nanoparticles

Encapsulation of gold nanorods together with Nd-doped fluorescent nanoparticles in a biocompatible polymer creates multifunctional nanostructures, whose infrared fluorescence allows their subcutaneous localization in biological tissues while also adding the ability to measure the temperature from the emitted light in order to better monitor the light-to-heat conversion of the gold nanorods during photothermal therapy.

[Communication]
Uéslen Rocha, Jie Hu, Emma Martín Rodríguez, Alexander S. Vanetsev, Mikhel Rähn, Väino Sammelselg, Yurii V. Orlovskii, José García Solé, Daniel Jaque, Dirk H. Ortgies
Small, August 23, 2016, DOI: 10.1002/smll.201600866. Read article

D6h-Au42 isomer: A Golden Aromatic Toroid Involving Superatomic -Orbitals Which Follows the Hückel (4n+2) rule.

Recently, it has been shown that the superatom concept is intimately connected to relevant tools of great chemical significance, such as the Lewis structure model and the VSEPR theory, which has been employed to understand hybridized and dimeric-like molecules. This suggests a potential rational construction of superatomic clusters mimicking more complex structures. Here, we extend another well-employed concept to the superatomic clusters, to construct a novel Au42 isomer with resemblance to cyclic aromatic molecules. It is shown that the Hückel (4n+2)rule is ready to be applied, predicting an aromatic behavior latterly supported by the favorable evaluation of the induced shielding cone formation. The here D6h-isomer of Au42 described here exhibits inherent characteristics mimicking aromatic hydrocarbon rings, displaying -superatomic orbitals and related properties. This new cluster is the first member of the superatomic clusters family to exhibit an aromatic -electron system.

[Article]
Alvaro Rafael Muñoz-Castro
ChemPhysChem, August 23, 2016, DOI: 10.1002/cphc.201600864. Read article

Sequential functionalization of alkynes and alkenes catalyzed by Au(I)- and Pd(II)-NHC complexes

[Full Paper]
Steven Patrick Nolan, Catherine Cazin, Fady Nahra, Alberto Gomez-Herrera, Marcel Brill
ChemCatChem, August 22, 2016, DOI: 10.1002/cctc.201600868. Read article

From the Superatom Model to a Diverse Array of Super-Elements: A Systematic Study of Dopant Influence on the Electronic Structure of Thiolate-Protected Gold Clusters

From the Superatom Model to a Diverse Array of Super‐Elements: A Systematic Study of Dopant Influence on the Electronic Structure of Thiolate‐Protected Gold Clusters

The effects of microdoping: The tunability of doped thiolate-protected gold clusters is systematically investigated by means of density functional theory. The superatomic model is evaluated for its applicability, by comparing structural distortion and electronic inhomogeneity for Pd-, Pt-, Cu- and Ag-doped clusters.

[Article]
Julia Schacht, Nicola Gaston
ChemPhysChem, August 19, 2016, DOI: 10.1002/cphc.201600684. Read article

Optical Modulation of Azobenzene-Modified Peptide for Gold Surface Binding

Optical Modulation of Azobenzene‐Modified Peptide for Gold Surface Binding

Finding the right wavelength: Optically switchable biomolecular interactions with gold surfaces via conformational changes of a photoswitch built into a peptide are discussed. Exposure to visible light increases peptide binding affinity to gold, while UV light promotes dissociation of peptides.

[Article]
Joseph M. Slocik, Zhifeng Kuang, Marc R. Knecht, Rajesh R. Naik
ChemPhysChem, August 16, 2016, DOI: 10.1002/cphc.201600670. Read article

A Simple Flow Amperometric Electrochemical Biosensor Based on Chitosan Scaffolds and Gold Nanowires Modified on a Glassy Carbon Electrode for Detection of Glutamate in Food Products

A Simple Flow Amperometric Electrochemical Biosensor Based on Chitosan Scaffolds and Gold Nanowires Modified on a Glassy Carbon Electrode for Detection of Glutamate in Food Products

[Full Paper]
Jiraporn Kitikul, Sakchai Satienperakul, Anchana Preechaworapun, Pusit Pookmanee, Tanin Tangkuaram
Electroanalysis, August 12, 2016, DOI: 10.1002/elan.201600263. Read article

Selective Detection of Dopamine in the Presence of Ascorbic and Uric Acids through its Covalent Immobilization on Gold Mercaptopropionic Acid Self-assembled Monolayer

Selective Detection of Dopamine in the Presence of Ascorbic and Uric Acids through its Covalent Immobilization on Gold Mercaptopropionic Acid Self‐assembled Monolayer

[Full Paper]
Reza Karimi Shervedani, Sonia Bahrani, Marzieh Samiei Foroushani, Fariborz Momenbeik
Electroanalysis, August 12, 2016, DOI: 10.1002/elan.201600220. Read article

Effects of Functionalized Electrodes and Gold Nanoparticle Carrier Signal Amplification on an Electrochemical DNA Sensing Strategy

Effects of Functionalized Electrodes and Gold Nanoparticle Carrier Signal Amplification on an Electrochemical DNA Sensing Strategy

Which effect is stronger? A DNA sensing strategy to analyze the effects on the electrochemical response of electrode functionalization and signal amplification is described (see figure). Four kinds of electrodes and a methyl blue labeled DNA signal probe with or without the gold nanoparticle (nanoAu) carrier amplification strategy are discussed.

[Article]
Yi Zhang, Chen Qian, Guang Ming Zeng, Lin Tang, Chang Zhang, Yuan Zhu, Chong Ling Feng, Yuan Yuan Liu
ChemElectroChem, August 11, 2016, DOI: 10.1002/celc.201600362. Read article

Evaluation of Electron Donation as a Mechanism for the Stabilisation of Chalcogenate-Protected Gold Nanoclusters

Evaluation of Electron Donation as a Mechanism for the Stabilisation of Chalcogenate‐Protected Gold Nanoclusters

A stabilization mechanism: Chalcogen-protected gold nanocluster models show unambiguously the presence of a chalcogen[RIGHTWARDS ARROW]cluster σ-donation, as supported by energy decomposition analysis coupled with natural orbitals for chemical valence (EDA-NOCV) and natural bond orbital (NBO) analyses. In all cases, the metal–ligand interactions are characterized as being more covalent than electrostatic.

[Article]
Maximiliano Segala, Felipe S. S. Schneider, Giovanni F. Caramori, Renato L. T. Parreira
ChemPhysChem, August 10, 2016, DOI: 10.1002/cphc.201600552. Read article

Tuning the Drug Loading and Release of DNA-Assembled Gold-Nanorod Superstructures

Tuning the Drug Loading and Release of DNA‐Assembled Gold‐Nanorod Superstructures

Use of DNA to assemble inorganic nanoparticles into superstructures is an emerging strategy to build non-toxic delivery vehicles for targeting diseases in the body. The impact of the core–satellite nanosystem design in mediating drug storage, drug release (via heat), and killing of HeLa cells in culture is investigated.

[Communication]
Vahid Raeesi, Leo Y. T. Chou, Warren C. W. Chan
Adv. Mater., August 09, 2016, DOI: 10.1002/adma.201600773. Read article

CO2 Reduction to CO in Water: Carbon Nanotube–Gold Nanohybrid as a Selective and Efficient Electrocatalyst

CO2 Reduction to CO in Water: Carbon Nanotube–Gold Nanohybrid as a Selective and Efficient Electrocatalyst

One gold for CO2: The activity of gold nanoparticles for CO2 electroreduction can be greatly increased when deposited on carbon nanotubes. The prepared cathode material consists of multi-walled carbon nanotubes (MWCNTs) covered by amphiphilic nitrilotriacetic–diyne lipid (DANTA), cationic poly(diallyldimethylammonium chloride) (PDADMAC), and monodispersed Au nanoparticles, which shows excellent activity in water and good faradaic yield, with CO as the major product.

[Communication]
Tran Ngoc Huan, Praveen Prakash, Philippe Simon, Gwenaëlle Rousse, X. Xu, Vincent Artero, Edmond Gravel, Eric Doris, Marc Fontecave
ChemSusChem, August 05, 2016, DOI: 10.1002/cssc.201600597. Read article

Sol–Gel Immobilized N-Heterocyclic Carbene Gold Complex as a Recyclable Catalyst for the Rearrangement of Allylic Esters and the Cycloisomerization of γ-Alkynoic Acids

Sol–Gel Immobilized N‐Heterocyclic Carbene Gold Complex as a Recyclable Catalyst for the Rearrangement of Allylic Esters and the Cycloisomerization of γ‐Alkynoic Acids

Golden gels: The first silica-supported (NHC)AuCl (NHC=N-heterocyclic carbene) complex prepared by a sol–gel process from a well-defined bis-silylated precursor is an active and recyclable catalyst for rearrangement and cycloisomerization reactions.

[Full Paper]
Meritxell Ferré, Xavier Cattoën, Michel Wong Chi Man, Roser Pleixats
ChemCatChem, August 05, 2016, DOI: 10.1002/cctc.201600632. Read article

Controlled Synthesis of Carbon-Supported Gold Clusters for Rational Catalyst Design

Controlled Synthesis of Carbon‐Supported Gold Clusters for Rational Catalyst Design

The development of metal-cluster catalysts requires a rational design principle as well as atomically precise synthetic methods. A method to precisely and independently control the size, composition, and surface modification of heterogeneous gold clusters by calcination of the ligand-protected Au clusters on carbon supports is discussed using benzyl alcohol oxidation as a test reaction.

[Personal Account]
Seiji Yamazoe, Tatchamapan Yoskamtorn, Shinjiro Takano, Sudarat Yadnum, Jumras Limtrakul, Tatsuya Tsukuda
The Chemical Record, August 04, 2016, DOI: 10.1002/tcr.201600074. Read article

Tuning Gold Nanoparticle Aggregation through the Inhibition of Acid Phosphatase Bioactivity: A Plasmonic Sensor for Light-Up Visual Detection of Arsenate (AsV)

Tuning Gold Nanoparticle Aggregation through the Inhibition of Acid Phosphatase Bioactivity: A Plasmonic Sensor for Light‐Up Visual Detection of Arsenate (AsV)

Good AsV gold: The first colorimetric sensor specifically for arsenate makes use of gold nanoparticles. The sensing rationale relies on the selective inhibition of acid phosphatase bioactivity by arsenate, leading to the reversal of solution color from blue to red.

[Communication]
Jia Zhang, Chuan-Ling Zhang, Shu-Hong Yu
ChemPlusChem, August 03, 2016, DOI: 10.1002/cplu.201600355. Read article

An Efficient Particle-Based DNA Circuit System: Catalytic Disassembly of DNA/PEG-Modified Gold Nanoparticle–Magnetic Bead Composites for Colorimetric Detection of miRNA

An Efficient Particle‐Based DNA Circuit System: Catalytic Disassembly of DNA/PEG‐Modified Gold Nanoparticle–Magnetic Bead Composites for Colorimetric Detection of miRNA

An efficient particle-based DNA circuit system for a new colorimetric miRNA assay is designed and devised based on a catalytic disassembly strategy through a target miRNA-triggered DNA circuit mechanism. The new particle-based DNA circuit system shows a rapid color change as well as significant improvement of sensitivity without need for other enzymes or instruments.

[Communication]
Motoi Oishi, Satomi Sugiyama
Small, August 02, 2016, DOI: 10.1002/smll.201601741. Read article

Au-Cu Alloy Formation on Cubic Cu2O Nanocrystals at Ambient Temperature and Their Catalytic Performance

Au‐Cu Alloy Formation on Cubic Cu2O Nanocrystals at Ambient Temperature and Their Catalytic Performance

Mixed metal arts: Au-Cu alloys were synthesized at ambient temperature via the clustering of Au and Cu atoms simultaneously produced from the galvanic replacement reaction between HAuCl4 and Cu2O and the disproportionation reaction of Cu2O in an ethanol–water mixture solution. The supported AuCu alloy particles exhibit excellent activity in catalyzing the liquid phase aerobic oxidation reaction of benzyl alcohol.

[Communication]
Zhenhua Zhang, Tian Cao, Liangfeng Luo, Rui Song, Huijuan Wang, Weixin Huang
ChemNanoMat, August 02, 2016, DOI: 10.1002/cnma.201600211. Read article

When Inert Becomes Active: A Fascinating Route for Catalyst Design

When Inert Becomes Active: A Fascinating Route for Catalyst Design

The nanoscale functionalization of catalytically inactive or completely inert materials via their size, structure, morphology, and support material represents a novel route to catalytically active systems. In particular, functionalization of hexagonal boron nitride led to its activity in a number of catalytic reactions involving oxygen activation, oxidation by molecular oxygen, and the oxygen reduction reaction.

[Personal Account]
Andrey Lyalin, Min Gao, Tetsuya Taketsugu
The Chemical Record, July 29, 2016, DOI: 10.1002/tcr.201600035. Read article

Deubiquitinases as Anticancer Targets of Gold Complexes

Deubiquitinases as Anticancer Targets of Gold Complexes

[Review]
Taotao Zou, Jing-Jing Zhang, Bei Cao, Ka-Chung Tong, Chun-Nam Lok, Chi-Ming Che
Isr. J. Chem., July 28, 2016, DOI: 10.1002/ijch.201600044. Read article

Local Geometric Effects on Stability and Energy Gap of Thiolate-Protected Gold Nanoparticles

Local Geometric Effects on Stability and Energy Gap of Thiolate‐Protected Gold Nanoparticles

Experiment meets theory: Thiolate-protected gold nanoclusters, Aum(SR)n, have potential applications in many fields due to their high stability and remarkable electronic properties. Through DFT calculations, including nonlocal many-body dispersion interactions, the geometric and electronic properties of Aum(SR)n clusters are investigated to determine the stability and HOMO–LUMO gaps of these clusters (see figure

[Article]
YiFan Bu, Ming Zhao, Yuquan He, Wang Gao, Qing Jiang
ChemPhysChem, July 21, 2016, DOI: 10.1002/cphc.201600539. Read article

Electrocatalytic Oxidation of Alcohols, Tripropylamine, and DNA with Ligand-Free Gold Nanoclusters on Nitrided Carbon

Electrocatalytic Oxidation of Alcohols, Tripropylamine, and DNA with Ligand‐Free Gold Nanoclusters on Nitrided Carbon

Good as gold: Ligand-free Au nanoclusters supported on nitrided carbon nanoparticles and assembled into layer-by-layer films of {PDDA/AuNCs@N-C}n are found to be highly active for the electrocatalytic oxidation of alcohols, an amine, and DNA.

[Article]
Huiqin Yao, Ben Liu, Islam M. Mosa, Itti Bist, Jie He, James F. Rusling
ChemElectroChem, July 20, 2016, DOI: 10.1002/celc.201600283. Read article

Electro-assisted Deposition of Binary Self-Assembled 1,2-Dithiolane Monolayers on Gold with Predictable Composition

Electro‐assisted Deposition of Binary Self‐Assembled 1,2‐Dithiolane Monolayers on Gold with Predictable Composition

SAM forecast: An electro-assisted method is applied to control and predict the chemical composition of functional binary self-assembled monolayers (SAMs) on gold surfaces. Similar ratios of adsorbate molecules in solution and in the monolayers are thus scheduled.

[Article]
Dany Capitao, Rihab Sahli, Noureddine Raouafi, Benoit Limoges, Claire Fave, Bernd Schöllhorn
ChemElectroChem, July 19, 2016, DOI: 10.1002/celc.201600260. Read article

Preparation of Triazole Gold(III) Complex as an Effective Catalyst for the Synthesis of E-α-Haloenones

Preparation of Triazole Gold(III) Complex as an Effective Catalyst for the Synthesis of E-α-Haloenones

[Communication]
Yongchun Yang, Wenkang Hu, Xiaohan Ye, Dawei Wang, Xiaodong Shi
Adv. Synth. Catal., July 12, 2016, DOI: 10.1002/adsc.201600243. Read article.

Metabolic Characteristics of 16HBE and A549 Cells Exposed to Different Surface Modified Gold Nanorods

Metabolic Characteristics of 16HBE and A549 Cells Exposed to Different Surface Modified Gold Nanorods

Gold Nanorods (AuNRs) with different surface modification induce distinct metabolic consequences to cancer and noncancer cells. PEI-AuNRs show specific cytotoxiciy to A549 cancer cells companied with large disruptions to the cell metabolisms such as energy metabolism, choline metabolism, hexosamine biosynthesis pathway, and oxidative stress to cells. Comprehensive molecular information of different surface modified AuNRs can be valuable in designing purpose-driven AuNRs.

[Full Paper]
Zhigang Liu, Liming Wang, Limin Zhang, Xiaochun Wu, Guangjun Nie, Chunying Chen, Huiru Tang, Yulan Wang
Adv. Healthcare Mater., July 08, 2016, DOI: 10.1002/adhm.201600164. Read article

Polydopamine-Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer

Polydopamine‐Functionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer

A gold nanostars (GNS) and doxorubicin (DOX) coloaded nanosized reduced graphene oxide (NRGO)-GNS@DOX platform is developed for efficient chemo- and photothermal treatment of breast cancer. The antitumor studies using a metastatic 4T1 breast tumor model demonstrate that a combination of NRGO-GNS@DOX with localized laser irradiation can simultaneously reduce the growth of the primary tumors and suppress their distant metastasis.

[Full Paper]
Fengyang Wang, Qianqian Sun, Bing Feng, Zhiai Xu, Junying Zhang, Jie Xu, Linlin Lu, Haijun Yu, Mingwei Wang, Yaping Li, Wen Zhang
Adv. Healthcare Mater., July 05, 2016, DOI: 10.1002/adhm.201600283. Read article

Advances in Gold Catalysis and Understanding the Catalytic Mechanism

Advances in Gold Catalysis and Understanding the Catalytic Mechanism

Au nanocluster catalysts exhibit remarkable catalytic activities for several reactions. The emphasis here is on our research into the development of preparation methods, their characterization, theoretical calculations, and application in catalysis. We share our insight into the interplay between them.

[Personal Account]
Tamao Ishida, Hiroaki Koga, Mitsutaka Okumura, Masatake Haruta
The Chemical Record, June 27, 2016, DOI: 10.1002/tcr.201600046. Read article

Dopamine-Directed In-Situ and One-Step Synthesis of Au@Ag Core–Shell Nanoparticles Immobilized to a Metal–Organic Framework for Synergistic Catalysis

Dopamine‐Directed In‐Situ and One‐Step Synthesis of Au@Ag Core–Shell Nanoparticles Immobilized to a Metal–Organic Framework for Synergistic Catalysis

There′s a synergy: Bimetallic core–shell Au@Ag NPs were immobilized in MOFs via one-step synthetic route at room temperature by using dopamine (DA) as a moderate reductant to reduce the bimetallic precursors step-by-step spontaneously. The as-formed Au@Ag/MOF composites show a striking synergistic effect for heterogeneous catalysis.

[Communication]
Pengcheng Huang, Wenjie Ma, Ping Yu, Lanqun Mao
Chem. Asian J., June 02, 2016, DOI: 10.1002/asia.201600469. Read article

Synthesis and Catalytic Activity of Gold Nanoparticles Supported on Dendrimeric Nanocellulose Hybrids

Synthesis and Catalytic Activity of Gold Nanoparticles Supported on Dendrimeric Nanocellulose Hybrids

Alkynyl-dendrons of the PAMAM family were covalently attached to azide-linked cellulose nanocrystals using click chemistry and then used as templates for the preparation of stable and monodispersed gold nanoparticles in aqueous media. The new materials were evaluated as catalysts for the reduction of 4-nitrophenyl and displayed enhanced activity relative to other supported AuNPs.

[Full Paper]
Ana Herreros-López, Caroline Hadad, Luis Yate, Ali A. Alshatwi, Nicola Vicentini, Tommaso Carofiglio, Maurizio Prato
Eur. J. Org. Chem., April 27, 2016, DOI: 10.1002/ejoc.201600148. Read article.

Synthesis of Gold(I) Derivatives Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane as Selective Anticancer Metallodrugs

Synthesis of Gold(I) Derivatives Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane as Selective Anticancer Metallodrugs

The preparation of new water-soluble mono- and bis-phosphanes derived from 1,3,5-triaza-7-phosphaadamantane (PTA) is described. Antiproliferative effects against colon cancer cell lines and low cytotoxicity towards differentiated cells (non-carcinogenic) have been observed for some of the gold complexes formed with these phosphanes.

[Full Paper]
Elena Atrián-Blasco, Sonia Gascón, M. Jesús Rodríguez-Yoldi, Mariano Laguna, Elena Cerrada
Eur. J. Inorg. Chem., April 24, 2016, DOI: 10.1002/ejic.201600177. Read article.

Isolable Ethylene Complexes of Copper(I), Silver(I), and Gold(I) Supported by Fluorinated Scorpionates [HB{3-(CF3),5-(CH3)Pz}3] and [HB{3-(CF3),5-(Ph)Pz}3]

Isolable Ethylene Complexes of Copper(I), Silver(I), and Gold(I) Supported by Fluorinated Scorpionates [HB{3-(CF3),5-(CH3)Pz}3]– and [HB{3-(CF3),5-(Ph)Pz}3]–

Partially fluorinated scorpionate [HB{3-(CF3),5-(CH3)Pz}3] allows the stabilization of molecules with gold(I), silver(I) and copper(I) ethylene adducts. Related adducts supported by [HB{3-(CF3),5-(CH3)Pz}3] are also included for comparisons. Notable differences exist in scorpionate modes of coordination and ethylene carbon chemical shift values.

[Communication]
Shawn G. Ridlen, Jiang Wu, Naveen V. Kulkarni, H. V. Rasika Dias
Eur. J. Inorg. Chem., February 9, 2016, DOI: 10.1002/ejic.201501365. Read article.

Detailed Investigation of the Structural, Thermal, and Electronic Properties of Gold Isocyanide Complexes with Mechano-Triggered Single-Crystal-to-Single-Crystal Phase Transitions

Detailed Investigation of the Structural, Thermal, and Electronic Properties of Gold Isocyanide Complexes with Mechano-Triggered Single-Crystal-to-Single-Crystal Phase Transitions

Mechano-induced phase transitions: A detailed investigation of two intriguing gold(I) complexes that show mechano-triggered single-crystal-to-single-crystal (SCSC) phase transitions is described, which includes face index experiments, thermal analyses, and conductivity measurements (see figure). Various hitherto unknown insights into the mechano-responsive molecular crystals have been reported.

[Full Paper]
Tomohiro Seki, Kenta Sakurada, Mai Muromoto, Shu Seki, Hajime Ito
Chem. Eur. J., January 11, 2016, DOI: 10.1002/chem.201503721. Read article.

Co-Adsorption of O2 and CO on Au2: Infrared Photodissociation Spectroscopy and Theoretical Study of [Au2O2(CO)n] (n=2–6)

Co-Adsorption of O2 and CO on Au2−: Infrared Photodissociation Spectroscopy and Theoretical Study of [Au2O2(CO)n]− (n=2–6)

Co-adsorption: The [Au2O2(CO)n] (n=2–6) complexes were prepared through a laser vaporization supersonic ion source and were studied by using infrared photodissociation spectroscopy (see figure). All complexes were characterized to have a core structure involving one CO and one O2 molecule co-adsorbed on Au2 with the other CO molecules physically tagged around.

[Full Paper]
Hao Liu, Xiaopeng Xing, Xuefeng Wang, Hui Qu, Guan-jun Wang, Ming-fei Zhou
Chem. Eur. J., January 8, 2016, DOI: 10.1002/chem.201504384. Read article.

Gold-Catalyzed Tandem Cycloisomerization–Halogenation of Chiral Homopropargyl Sulfonamides

Gold-Catalyzed Tandem Cycloisomerization–Halogenation of Chiral Homopropargyl Sulfonamides

Two new gold-catalyzed tandem cycloisomerization–halogenation reactions of chiral homopropargyl sulfonamides have been developed. Enantioenriched 3,3-diiodopyrrolidin-2-ols and 3-fluoropyrrolidin-2-ols were obtained in moderate-to-good yields with excellent enantio- and diastereocontrol (see scheme; PG=protecting group, DCE=1,2-dichloroethane, NIS=N-iodosuccinimide).

[Full Paper]
Chao Shu, Long Li, Cang-Hai Shen, Peng-Peng Ruan, Chao-Yue Liu, Long-Wu Ye 
Chem. Eur. J., January 8, 2016, DOI: 10.1002/chem.201503891. Read article.

Chemo- and Regioselective Ethynylation of Tryptophan-Containing Peptides and Proteins

Chemo- and Regioselective Ethynylation of Tryptophan-Containing Peptides and Proteins

Alkynes on a gold Tr(i)p! Various peptides and one model protein were functionalized with ethynyl moieties at their tryptophan residues using Waser’s reagent, TIPS-EBX, under gold(I) catalysis (see scheme; TIPS=triisopropylsilyl). The reaction proceeded in a regio- and chemoselective manner leading to C2 substitution at the tryptophan residues only. Subsequently, the terminal alkyne was used to label one of the model peptides with a fluorophore by means of copper-catalyzed click chemistry.

[Communication]
Morten Borre Hansen, František Hubálek, Troels Skrydstrup, Thomas Hoeg-Jensen
Chem. Eur. J., December 22, 2015, DOI: 10.1002/chem.201504462. Read article.

Activation and Transformation of Ethane by Au2VO3+ Clusters with Closed-Shell Electronic Structures

Activation and Transformation of Ethane by Au2VO3+ Clusters with Closed-Shell Electronic Structures

The crucial role of gold in the transformation of ethane to ethene and dihydrogen is observed in the reaction between C2H6 and Au2VO3+ clusters with closed-shell electronic structures. The first C-H activation is initiated by gold rather than an oxygen species. The Au-Au dimer formed during the reactions plays important roles in converting ethane into ethene and making dihydrogen energetically more favorable.

[Full Paper]
Ya-Ke Li, Zi-Yu Li, Yan-Xia Zhao, Qing-Yu Liu, Jing-Heng Meng, Sheng-Gui He
Chem. Eur. J., December 17, 2015, DOI: 10.1002/chem.201503676. Read article.

On the Mechanism of the Digold(I)–Hydroxide-Catalysed Hydrophenoxylation of Alkynes

On the Mechanism of the Digold(I)–Hydroxide-Catalysed Hydrophenoxylation of Alkynes

Gold rush! A series of in silico studies, supported by experimental work, have been carried out to further elucidate the mechanistic aspects of the hydrophenoxylation of alkynes. The results suggest that the synergic cooperation of two mono-gold species facilitates this process, although analogous mono-gold species are not capable of mediating this reaction (see figure).

[Full Paper]
Adrián Gómez-Suárez, Yoshihiro Oonishi, Anthony R. Martin, Sai V. C. Vummaleti, David J. Nelson, David B. Cordes, Alexandra M. Z. Slawin, Luigi Cavallo, Steven P. Nolan, Albert Poater
Chem. Eur. J., December 11, 2015, DOI: 10.1002/chem.201503097. Read article.

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