Hot TopicsWiley-VCH

AMCPHCChem Eur JAngewandte

Gold

goldZum Golde drängt, am Golde hängt doch alles.
For gold contend, On gold depend All things.

J. W. Goethe, Faust I

The element gold has many personalities, of which the image of a noble but soft, yellow metal would first across one's mind. The recently discovered nanoparticles and nanowires containing gold are a natural extension of this aspect, as are the uses of gold in electronics and decoration. Thought to be noble, gold actually has a rich chemistry. Fascinating in its complexity for academic chemists, this chemistry has potential applications in materials science, medicine and, recently, in both heterogeneous and homogeneous catalysis. Some fresh promises are related to the optical properties of certain gold compounds or to the possibility of forming new nanostructures based on gold. The unique properties of gold are strongly influenced by relativistic effects.

[1] P. Pyykkö, Theoretical Chemistry of Gold
Angew. Chem. 2004, 116, 4512–4557; Angew. Chem. Int. Ed. 2004, 43, 4412–4456

[2] A. S. K. Hashmi, The Catalysis Gold Rush: New Claims
Angew. Chem. 2005, 117, 7150; Angew. Chem. Int. Ed. 2005, 44, 6990

[3] G. Schmid, B. Corain, Nanoparticulated Gold: Syntheses, Structures, Electronics, and Reactivities
Eur. J. Inorg. Chem. 2003, 3081

Recent Articles

RSS feed

The Sterically Demanding Thiosilyl Group SSi(SiMe3)3 as a Ligand in Transition Metal Chemistry

The Sterically Demanding Thiosilyl Group SSi(SiMe3)3 as a Ligand in Transition Metal Chemistry

[Article]
Matthias Kotsch, Christian Gienger, Claudio Schrenk, Andreas Schnepf
Z. anorg. allg. Chem., May 27, 2016, DOI: 10.1002/zaac.201600137. Read article

Metallosupramolecular Structures Derived from a Series of Diphosphine-bridged Digold(I) Metalloligands with Terminal D-Penicillamine

Metallosupramolecular Structures Derived from a Series of Diphosphine‐bridged Digold(I) Metalloligands with Terminal D‐Penicillamine

A new family of chiral heteroleptic digold(I) metalloligands, with mixed diphosphine and d-penicillaminate (d-pen), [Au2(PPh2(CH2)nPPh2)(d-pen-S)2]2–, and their application for the construction of chiral multinuclear and metallosupramolecular structures, is described.

[Personal Account]
Nobuto Yoshinari, Takumi Konno
The Chemical Record, May 27, 2016, DOI: 10.1002/tcr.201600026. Read article

Efficient Oxygen Reduction Electrocatalysts Based on Gold Nanocluster–Graphene Composites

Efficient Oxygen Reduction Electrocatalysts Based on Gold Nanocluster–Graphene Composites

Cause and effect: The porous structures in gold nanocluster–graphene composite (Au25–rGO) electrodes provide a confined space and increase the residence time of O2 on the surface, facilitating the sluggish oxygen reduction reaction (ORR). The ORR at the Au25–rGO electrode proceeds by an efficient four-electron transfer pathway to form H2O, whereas the two-electron pathway to H2O2 is favored at a Au25-modified electrode.

[Article]
Kyuju Kwak, Uday Pratap Azad, Woojun Choi, Kyunglim Pyo, Mi Jang, Dongil Lee
ChemElectroChem, May 25, 2016, DOI: 10.1002/celc.201600154. Read article

Electrochemical Behavior of Gold–Silver Alloy Nanoparticles

Electrochemical Behavior of Gold–Silver Alloy Nanoparticles

Alter ego: Gold–silver alloy nanoparticles are investigated in chloride-containing media. A significantly altered electrochemical behavior is seen relative to pure gold and pure silver nanoparticles, and restructuring of the alloy nanoparticles is evident on cycling.

[Communication]
Blake J. Plowman, Boopathi Sidhureddy, Stanislav V. Sokolov, Neil P. Young, Aicheng Chen, Richard G. Compton
ChemElectroChem, May 20, 2016, DOI: 10.1002/celc.201600212. Read article

Spectroscopic Investigation of Titania-Supported Gold Nanoparticles Prepared by a Modified Deposition/Precipitation Method for the Oxidation of CO

Spectroscopic Investigation of Titania‐Supported Gold Nanoparticles Prepared by a Modified Deposition/Precipitation Method for the Oxidation of CO

Gold nanoparticles on titania: Diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), coupled with CO adsorption, was used to investigate a modified deposition/precipitation method (DP-UC) for the preparation of supported gold nanoparticles with very low metal loading (0.1–0.5 wt %). This promising synthetic route involves the use of urea as basic agent and NaBH4 as chemical reductant in contrast to the traditional high-temperature reduction step.

[Full Paper]
Matteo Compagnoni, Simon A. Kondrat, Carine E. Chan-Thaw, David J. Morgan, Di Wang, Laura Prati, Alberto Villa, Nikolaos Dimitratos, Ilenia Rossetti
ChemCatChem, May 20, 2016, DOI: 10.1002/cctc.201600072. Read article

From Sugars to Wheels: The Conversion of Ethanol to 1,3-Butadiene over Metal-Promoted Magnesia-Silicate Catalysts

From Sugars to Wheels: The Conversion of Ethanol to 1,3‐Butadiene over Metal‐Promoted Magnesia‐Silicate Catalysts

Step up in one step: A new catalyst and process for the one-step conversion of ethanol to 1,3-butadiene (1,3-BD), a high-value chemical intermediate, is investigated. The catalyst is prepared by the impregnation of magnesium oxide onto a silica support followed by the deposition of Au nanoparticles by deposition–precipitation. The production of 1,3-BD by this process can reduce greenhouse gas emissions by as much as 155 % relative to the conventional petroleum-based production of 1,3-BD.

[Full Paper]
Sankaranarayanapillai Shylesh, Amit A. Gokhale, Corinne D. Scown, Daeyoup Kim, Christopher R. Ho, Alexis T. Bell
ChemSusChem, May 19, 2016, DOI: 10.1002/cssc.201600195. Read article

SEM and ECIS Investigation of Cells Cultured on Nanopillar Modified Interdigitated Impedance Electrodes for Analysis of Cell Growth and Cytotoxicity of Potential Anticancer Drugs

SEM and ECIS Investigation of Cells Cultured on Nanopillar Modified Interdigitated Impedance Electrodes for Analysis of Cell Growth and Cytotoxicity of Potential Anticancer Drugs

[Full Paper]
Walter Messina, Michelle Fitzgerald, Eric Moore
Electroanalysis, May 17, 2016, DOI: 10.1002/elan.201600025. Read article

Bimetallic Au@Pd-Au Tadpole-Shaped Asymmetric Nanostructures by a Combination of Precursor Reduction and Ostwald Ripening

Bimetallic Au@Pd‐Au Tadpole‐Shaped Asymmetric Nanostructures by a Combination of Precursor Reduction and Ostwald Ripening

Two-sided: A simple strategy is reported to generate asymmetric Au@Pd-Au tadpoles that can be described as having a tail of a single Au nanorod and a spherical head composed of core@shell Au@Pd decorated with small Au NPs. Their formation is based on a combination of Au deposition and Ostwald ripening at the surface of Au@Pd nanoparticle templates.

[Communication]
Liliam K. Yamada, Anderson G. M. da Silva, Thenner S. Rodrigues, Sarah J. Haigh, Pedro H. C. Camargo
ChemNanoMat, May 17, 2016, DOI: 10.1002/cnma.201600049. Read article

Identification of Individual Exosome-Like Vesicles by Surface Enhanced Raman Spectroscopy

Identification of Individual Exosome‐Like Vesicles by Surface Enhanced Raman Spectroscopy

A method is used to obtain a surface enhanced Raman spectrum of a single, nanosized exosome-like vesicle (ELV) while maintaining individual ELVs in suspension. Based on these spectra, ELVs derived from different cell types can be distinguished, hence allowing the identification and quantification of specific (cancerous) ELVs in a mixture.

[Full Paper]
Stephan Stremersch, Monica Marro, Bat-El Pinchasik, Pieter Baatsen, An Hendrix, Stefaan C. De Smedt, Pablo Loza-Alvarez, Andre G. Skirtach, Koen Raemdonck, Kevin Braeckmans
Small, May 12, 2016, DOI: 10.1002/smll.201600393. Read article

Electrochemical Fabrication of Cobalt Oxides/Nanoporous Gold Composite Electrode and its Nonenzymatic Glucose Sensing Performance

Electrochemical Fabrication of Cobalt Oxides/Nanoporous Gold Composite Electrode and its Nonenzymatic Glucose Sensing Performance

[Full Paper]
Chaohui Zhou, Xueyong Tang, Yue Xia, Zelin Li
Electroanalysis, May 12, 2016, DOI: 10.1002/elan.201501177. Read article

Non-Invasive Imaging Serum Amyloid A Activation through the NF-κB Signal Pathway upon Gold Nanostructure Exposure

Non‐Invasive Imaging Serum Amyloid A Activation through the NF‐κB Signal Pathway upon Gold Nanostructure Exposure

A highly sensitive serum amyloid A (SAA) reporter mice model is demonstrated, which is expected to have vast application prospects in evaluating nanoparticle-induced acute inflammatory reactions. Based on the mice model, the sequentially reactions to gold nanoparticles (GNPs) among macrophages, inflammatory mediators, and SAA-synthetizing hepatocytes are investigated, which shed light on the complex acute effects of GNPs on natural body.

[Full Paper]
Yulong Zhang, Qianqian Zhou, Shaoduo Yan, Ning Zhang, Man Zhao, Cong Ma, Chulin He, Qiuxia Fu, Tao Wu, Xiaohui Wang, Linsheng Zhan
Small, May 11, 2016, DOI: 10.1002/smll.201600019. Read article

Dopamine-Directed In-Situ and One-Step Synthesis of Au@Ag Core-Shell Nanoparticles Confined in Metal-Organic Framework for Synergistic Catalysis

We report a facile and general approach to formation of bimetallic core-shell Au@Ag nanoparticles (NPs) immobilized in metal-organic frameworks (MOFs) via one-step synthetic route at room temperature. Dopamine (DA) is used as a moderate reductant, which can bind to negatively charged groups of MOFs through electrostatic interaction and subsequently Au@Ag core-shell NPs are formed by in-situ reduction of the bimetallic Au and Ag precursors step-by-step spontaneously without the pre-synthesized seeds. The as-formed Au@Ag core-shell NPs confined in MOFs exhibit excellent catalytic activity for the model reaction of the reduction of 4-nitrophenol (4-NPh) by NaBH4 to 4-aminophenol (4-APh) due to the synergistic effect with a high stability after cycles.

[Communication]
Pengcheng Huang, Wenjie Ma, Ping Yu, Lanqun Mao
Chem. Asian J., May 11, 2016, DOI: 10.1002/asia.201600469. Read article

Dispersive Plasmon Damping in Single Gold Nanorods by Platinum Adsorbates

Dispersive Plasmon Damping in Single Gold Nanorods by Platinum Adsorbates

Single particle dark-field spectroscopy was employed to measure exactly the same gold nanorod before and after the Pt adsorption. The Pt-induced plasmon damping in terms of linewidth increase is found dependent on the resonance wavelength of the measured nanorod, which is dispersive in nature.

[Full Paper]
Pengyu Xu, Xuxing Lu, Song Han, Weihui Ou, Yue Li, Sheng Chen, Junfei Xue, Yaping Ding, Weihai Ni
Small, May 09, 2016, DOI: 10.1002/smll.201600533. Read article

Pre-Incubation of Auric Acid with DNA Is Unnecessary for the Formation of DNA-Templated Gold Nanoclusters

Pre‐Incubation of Auric Acid with DNA Is Unnecessary for the Formation of DNA‐Templated Gold Nanoclusters

Feel so different: Pre-incubation of HAuCl4 and a poly-adenine template is demonstrated to be unfavorable for the preparation of fluorescent DNA-templated gold nanoclusters by citrate reduction, which is distinctly different from the formation process for the corresponding silver nanoclusters.

[Communication]
Yang Chen, Guangyu Tao, Ruoyun Lin, Xiaojing Pei, Feng Liu, Na Li
Chem. Asian J., May 02, 2016, DOI: 10.1002/asia.201600285. Read article

Chirality-Selective Photoluminescence Enhancement of ssDNA-Wrapped Single-Walled Carbon Nanotubes Modified with Gold Nanoparticles

Chirality‐Selective Photoluminescence Enhancement of ssDNA‐Wrapped Single‐Walled Carbon Nanotubes Modified with Gold Nanoparticles

Selective photoluminescence enhancement for (7,5) tubes over all other chiralities is observed by dispersing single-walled carbon nanotube mixtures in single-stranded DNA (ssDNA) (ATT)4AT solution and modification with gold nanoparticles. This ssDNA sequence (ATT)4AT is reported to recognize and enable chromatographic purification of the (7,5) tubes.

[Full Paper]
Juan Yang, Qinghua Zhao, Min Lyu, Zhenyu Zhang, Xiao Wang, Meng Wang, Zhou Gao, Yan Li
Small, April 29, 2016, DOI: 10.1002/smll.201503883. Read article

Reduction of Anthelmintic Drug (Methyl [1]carbamate-albendazole) on Gold Electrodes in Aprotic Solvent: Analysis of Chromatographic Reduction Products

Reduction of Anthelmintic Drug (Methyl [1]carbamate‐albendazole) on Gold Electrodes in Aprotic Solvent: Analysis of Chromatographic Reduction Products

[Full Paper]
Geoffrey N. Kamau, Zahilis Mazzochette, Helen K. Kahi, Amos Mugweru
Electroanalysis, April 28, 2016, DOI: 10.1002/elan.201600140. Read article

Synthesis and Catalytic Activity of Gold Nanoparticles Supported on Dendrimeric Nanocellulose Hybrids

Synthesis and Catalytic Activity of Gold Nanoparticles Supported on Dendrimeric Nanocellulose Hybrids

Alkynyl-dendrons of the PAMAM family were covalently attached to azide-linked cellulose nanocrystals using click chemistry and then used as templates for the preparation of stable and monodispersed gold nanoparticles in aqueous media. The new materials were evaluated as catalysts for the reduction of 4-nitrophenyl and displayed enhanced activity relative to other supported AuNPs.

[Full Paper]
Ana Herreros-López, Caroline Hadad, Luis Yate, Ali A. Alshatwi, Nicola Vicentini, Tommaso Carofiglio, Maurizio Prato
Eur. J. Org. Chem., April 27, 2016, DOI: 10.1002/ejoc.201600148. Read article.

Synthesis of Gold(I) Derivatives Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane as Selective Anticancer Metallodrugs

Synthesis of Gold(I) Derivatives Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane as Selective Anticancer Metallodrugs

The preparation of new water-soluble mono- and bis-phosphanes derived from 1,3,5-triaza-7-phosphaadamantane (PTA) is described. Antiproliferative effects against colon cancer cell lines and low cytotoxicity towards differentiated cells (non-carcinogenic) have been observed for some of the gold complexes formed with these phosphanes.

[Full Paper]
Elena Atrián-Blasco, Sonia Gascón, M. Jesús Rodríguez-Yoldi, Mariano Laguna, Elena Cerrada
Eur. J. Inorg. Chem., April 24, 2016, DOI: 10.1002/ejic.201600177. Read article.

Exploiting Metallophilicity for the Assembly of Inorganic Nanocrystals and Conjugated Organic Molecules

Exploiting Metallophilicity for the Assembly of Inorganic Nanocrystals and Conjugated Organic Molecules

Interface design: A new source of interface interaction based on metal–metal bonds is presented. An organometallic gelator is used for the formation of hydrogel-like nanocomposites (NCPs) embedding inorganic nanoparticles and conjugated organic molecules. The establishment of metallophilic interactions at the interface between the two moieties greatly enhances the interparticle coupling, as evidenced in the case of plasmonic nanoparticles. Au-OLAm NPs: oleylamine-capped Au nanoparticles.

[Article]
Mariona Dalmases, Elisabet Aguiló, Jordi Llorca, Laura Rodríguez, Albert Figuerola
ChemPhysChem, April 20, 2016, DOI: 10.1002/cphc.201600239. Read article

Nanosecond Time-Resolution Study of Gold Nanorod Rotation at the Liquid–Solid Interface

Nanosecond Time‐Resolution Study of Gold Nanorod Rotation at the Liquid–Solid Interface

In a spin: A nanosecond time-resolution study yields new insights into the rotational motion of anchored rod-like nanoparticles at the liquid–solid interface. The continuous rotation observed under low temporal resolution is found to be comprised of numerous fast, intermittent transitions between a limited number of weakly immobilized states.

[Article]
Bhanu Neupane, Fang Chen, Yanli Wei, Ning Fang, Frances S. Ligler, Gufeng Wang
ChemPhysChem, April 20, 2016, DOI: 10.1002/cphc.201600174. Read article

Self-assembled Ultrathin Gold Nanowires as Highly Transparent, Conductive and Stretchable Supercapacitor

Self‐assembled Ultrathin Gold Nanowires as Highly Transparent, Conductive and Stretchable Supercapacitor

[Full Paper]
Shu Gong, Yunmeng Zhao, Qianqian Shi, Yan Wang, Lim Wei Yap, Wenlong Cheng
Electroanalysis, April 15, 2016, DOI: 10.1002/elan.201600081. Read article

Ultrafine Au and Ag Nanoparticles Synthesized from Self-Assembled Peptide Fibers and Their Excellent Catalytic Activity

Ultrafine Au and Ag Nanoparticles Synthesized from Self‐Assembled Peptide Fibers and Their Excellent Catalytic Activity

Feeling fine: Three nanomaterials are prepared by using the peptide Ac-FFACD-OH. Induced by Ag+, the peptide can self-assemble to form fibers. Ultrafine AgNPs (NPs=nanoparticles) are reduced in situ by these fibers, so the peptide acts as a stabilizer, reductant, and directing template agent. Ultrafine AgNPs and AuNPs are synthesized by adding NaBH4. All materials show excellent catalytic activity toward 4-nitrophenol (4-NP; see figure) and selective catalytic activity toward dyes.

[Article]
Wenlong Xu, Yue Hong, Yuanyuan Hu, Jingcheng Hao, Aixin Song
ChemPhysChem, April 13, 2016, DOI: 10.1002/cphc.201600182. Read article

Biomedical Applications of DNA-Conjugated Gold Nanoparticles

Biomedical Applications of DNA‐Conjugated Gold Nanoparticles

Glittering like gold: Gold nanoparticles are useful for diagnostic and biomedical applications but lack specificity for targets. DNA aptamers have therapeutic and target-recognizing properties but lack stability in vivo. However, DNA aptamer-functionalized gold nanoparticles have potential as anticoagulant, anticancer, antibacterial, and antiviral drugs.

[Review]
Chun-Chi Wang, Shou-Mei Wu, Hung-Wen Li, Huan-Tsung Chang
ChemBioChem, April 08, 2016, DOI: 10.1002/cbic.201600014. Read article

Cytochrome c-Capped Fluorescent Gold Nanoclusters: Imaging of Live Cells and Delivery of Cytochrome c

Cytochrome c‐Capped Fluorescent Gold Nanoclusters: Imaging of Live Cells and Delivery of Cytochrome c

Please remove your cap! In this study, mitochondrial imaging of live cells, using Au nanoclusters (Au-NCs) capped by cytochrome c that is labeled with Alexa Fluor 594, involves FRET from the Au-NCs to the Alexa dye. The cytochrome c-capped Au-NCs localize in the mitochondria of a live cell, where it interacts with glutathione leading to release of the cytochrome c inside the cell, thus switching off the FRET signal.

[Article]
Shyamtanu Chattoraj, Md. Asif Amin, Kankan Bhattacharyya
ChemPhysChem, April 06, 2016, DOI: 10.1002/cphc.201501163. Read article

Nanoplatforms for Plasmon-Induced Heating and Thermometry

Nanoplatforms for Plasmon‐Induced Heating and Thermometry

Gold nanorod heaters and (Gd,Yb,Er)2O3 nanorod thermometers join together to form nanoplatforms for efficient plasmon-induced optical heating and accurate upconversion temperature sensing, upon 980 nm laser excitation, at low power densities. These nanoplatforms are imaged within osteoblast-like cells by hyperspectral microscopy, and they are biocompatible, with potential applications in hyperthermia.

[Communication]
Mengistie L. Debasu, Carlos D. S. Brites, Sangeetha Balabhadra, Helena Oliveira, João Rocha, Luís D. Carlos
ChemNanoMat, March 29, 2016, DOI: 10.1002/cnma.201600061. Read article

Orthogonal Sensing of Small Molecules Using a Modular Nanoparticle-Based Assay

Orthogonal Sensing of Small Molecules Using a Modular Nanoparticle‐Based Assay

Feel free to choose: A modular sensing assay is described that is able to detect small molecules under competitive conditions. The selectivity of the assay can be simply tuned by changing the macrocyclic receptors bound to the surface of a monolayer-protected gold nanoparticle.

[Communication]
Simona Neri, Roberta Pinalli, Enrico Dalcanale, Leonard J. Prins
ChemNanoMat, March 24, 2016, DOI: 10.1002/cnma.201600075. Read article

Isolable Ethylene Complexes of Copper(I), Silver(I), and Gold(I) Supported by Fluorinated Scorpionates [HB{3-(CF3),5-(CH3)Pz}3] and [HB{3-(CF3),5-(Ph)Pz}3]

Isolable Ethylene Complexes of Copper(I), Silver(I), and Gold(I) Supported by Fluorinated Scorpionates [HB{3-(CF3),5-(CH3)Pz}3]– and [HB{3-(CF3),5-(Ph)Pz}3]–

Partially fluorinated scorpionate [HB{3-(CF3),5-(CH3)Pz}3] allows the stabilization of molecules with gold(I), silver(I) and copper(I) ethylene adducts. Related adducts supported by [HB{3-(CF3),5-(CH3)Pz}3] are also included for comparisons. Notable differences exist in scorpionate modes of coordination and ethylene carbon chemical shift values.

[Communication]
Shawn G. Ridlen, Jiang Wu, Naveen V. Kulkarni, H. V. Rasika Dias
Eur. J. Inorg. Chem., February 9, 2016, DOI: 10.1002/ejic.201501365. Read article.

Detailed Investigation of the Structural, Thermal, and Electronic Properties of Gold Isocyanide Complexes with Mechano-Triggered Single-Crystal-to-Single-Crystal Phase Transitions

Detailed Investigation of the Structural, Thermal, and Electronic Properties of Gold Isocyanide Complexes with Mechano-Triggered Single-Crystal-to-Single-Crystal Phase Transitions

Mechano-induced phase transitions: A detailed investigation of two intriguing gold(I) complexes that show mechano-triggered single-crystal-to-single-crystal (SCSC) phase transitions is described, which includes face index experiments, thermal analyses, and conductivity measurements (see figure). Various hitherto unknown insights into the mechano-responsive molecular crystals have been reported.

[Full Paper]
Tomohiro Seki, Kenta Sakurada, Mai Muromoto, Shu Seki, Hajime Ito
Chem. Eur. J., January 11, 2016, DOI: 10.1002/chem.201503721. Read article.

Co-Adsorption of O2 and CO on Au2: Infrared Photodissociation Spectroscopy and Theoretical Study of [Au2O2(CO)n] (n=2–6)

Co-Adsorption of O2 and CO on Au2−: Infrared Photodissociation Spectroscopy and Theoretical Study of [Au2O2(CO)n]− (n=2–6)

Co-adsorption: The [Au2O2(CO)n] (n=2–6) complexes were prepared through a laser vaporization supersonic ion source and were studied by using infrared photodissociation spectroscopy (see figure). All complexes were characterized to have a core structure involving one CO and one O2 molecule co-adsorbed on Au2 with the other CO molecules physically tagged around.

[Full Paper]
Hao Liu, Xiaopeng Xing, Xuefeng Wang, Hui Qu, Guan-jun Wang, Ming-fei Zhou
Chem. Eur. J., January 8, 2016, DOI: 10.1002/chem.201504384. Read article.

Gold-Catalyzed Tandem Cycloisomerization–Halogenation of Chiral Homopropargyl Sulfonamides

Gold-Catalyzed Tandem Cycloisomerization–Halogenation of Chiral Homopropargyl Sulfonamides

Two new gold-catalyzed tandem cycloisomerization–halogenation reactions of chiral homopropargyl sulfonamides have been developed. Enantioenriched 3,3-diiodopyrrolidin-2-ols and 3-fluoropyrrolidin-2-ols were obtained in moderate-to-good yields with excellent enantio- and diastereocontrol (see scheme; PG=protecting group, DCE=1,2-dichloroethane, NIS=N-iodosuccinimide).

[Full Paper]
Chao Shu, Long Li, Cang-Hai Shen, Peng-Peng Ruan, Chao-Yue Liu, Long-Wu Ye 
Chem. Eur. J., January 8, 2016, DOI: 10.1002/chem.201503891. Read article.

Chemo- and Regioselective Ethynylation of Tryptophan-Containing Peptides and Proteins

Chemo- and Regioselective Ethynylation of Tryptophan-Containing Peptides and Proteins

Alkynes on a gold Tr(i)p! Various peptides and one model protein were functionalized with ethynyl moieties at their tryptophan residues using Waser’s reagent, TIPS-EBX, under gold(I) catalysis (see scheme; TIPS=triisopropylsilyl). The reaction proceeded in a regio- and chemoselective manner leading to C2 substitution at the tryptophan residues only. Subsequently, the terminal alkyne was used to label one of the model peptides with a fluorophore by means of copper-catalyzed click chemistry.

[Communication]
Morten Borre Hansen, František Hubálek, Troels Skrydstrup, Thomas Hoeg-Jensen
Chem. Eur. J., December 22, 2015, DOI: 10.1002/chem.201504462. Read article.

Activation and Transformation of Ethane by Au2VO3+ Clusters with Closed-Shell Electronic Structures

Activation and Transformation of Ethane by Au2VO3+ Clusters with Closed-Shell Electronic Structures

The crucial role of gold in the transformation of ethane to ethene and dihydrogen is observed in the reaction between C2H6 and Au2VO3+ clusters with closed-shell electronic structures. The first C-H activation is initiated by gold rather than an oxygen species. The Au-Au dimer formed during the reactions plays important roles in converting ethane into ethene and making dihydrogen energetically more favorable.

[Full Paper]
Ya-Ke Li, Zi-Yu Li, Yan-Xia Zhao, Qing-Yu Liu, Jing-Heng Meng, Sheng-Gui He
Chem. Eur. J., December 17, 2015, DOI: 10.1002/chem.201503676. Read article.

On the Mechanism of the Digold(I)–Hydroxide-Catalysed Hydrophenoxylation of Alkynes

On the Mechanism of the Digold(I)–Hydroxide-Catalysed Hydrophenoxylation of Alkynes

Gold rush! A series of in silico studies, supported by experimental work, have been carried out to further elucidate the mechanistic aspects of the hydrophenoxylation of alkynes. The results suggest that the synergic cooperation of two mono-gold species facilitates this process, although analogous mono-gold species are not capable of mediating this reaction (see figure).

[Full Paper]
Adrián Gómez-Suárez, Yoshihiro Oonishi, Anthony R. Martin, Sai V. C. Vummaleti, David J. Nelson, David B. Cordes, Alexandra M. Z. Slawin, Luigi Cavallo, Steven P. Nolan, Albert Poater
Chem. Eur. J., December 11, 2015, DOI: 10.1002/chem.201503097. Read article.

© Wiley-VCH 2015.