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Gold

goldZum Golde drängt, am Golde hängt doch alles.
For gold contend, On gold depend All things.

J. W. Goethe, Faust I

The element gold has many personalities, of which the image of a noble but soft, yellow metal would first across one's mind. The recently discovered nanoparticles and nanowires containing gold are a natural extension of this aspect, as are the uses of gold in electronics and decoration. Thought to be noble, gold actually has a rich chemistry. Fascinating in its complexity for academic chemists, this chemistry has potential applications in materials science, medicine and, recently, in both heterogeneous and homogeneous catalysis. Some fresh promises are related to the optical properties of certain gold compounds or to the possibility of forming new nanostructures based on gold. The unique properties of gold are strongly influenced by relativistic effects.

[1] P. Pyykkö, Theoretical Chemistry of Gold
Angew. Chem. 2004, 116, 4512–4557; Angew. Chem. Int. Ed. 2004, 43, 4412–4456

[2] A. S. K. Hashmi, The Catalysis Gold Rush: New Claims
Angew. Chem. 2005, 117, 7150; Angew. Chem. Int. Ed. 2005, 44, 6990

[3] G. Schmid, B. Corain, Nanoparticulated Gold: Syntheses, Structures, Electronics, and Reactivities
Eur. J. Inorg. Chem. 2003, 3081

Recent Articles

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Cover Picture: New Synthesis of Gold- and Silver-Based Nano-Tetracycline Composites (ChemistryOpen 3/2016)

Cover Picture: New Synthesis of Gold‐ and Silver‐Based Nano‐Tetracycline Composites (ChemistryOpen 3/2016)

The Front Cover picture shows new silver (Ag) and gold (Au) nanoparticle-based tetracycline (TC) nanocomposites (AuNPs@TC and AgNPs@TC). A new synthetic methodology for the preparation of water-soluble Au and Ag nanoparticles, using the antibiotic TC as co-reducing and stabilizing agent, is reported. Both colloids exhibit high water stability, with an average size of 15±5 and 25±10 nm, respectively. Both composites are tested against TC-resistant bacteria, presenting an increasing antibacterial effect in the case of AgNPs@TC. Moreover, the sensing towards metal ions is also explored by using AuNPs@TC, which is selective and reversible for aluminum(III) in water. More information can be found in the Full Paper by C. Lodeiro, J. Fernández-Lodeiro, and co-workers on page 206 in Issue 3, 2016 (DOI: 10.1002/open.201600016).

[Cover Picture]
Jamila Djafari, Catarina Marinho, Tiago Santos, Gilberto Igrejas, Carmen Torres, José Luis Capelo, Patricia Poeta, Carlos Lodeiro, Javier Fernández-Lodeiro
ChemistryOpen, June 24, 2016, DOI: 10.1002/open.201600056. Read article

Effective Targeted Photothermal Ablation of Multidrug Resistant Bacteria and Their Biofilms with NIR-Absorbing Gold Nanocrosses

Effective Targeted Photothermal Ablation of Multidrug Resistant Bacteria and Their Biofilms with NIR‐Absorbing Gold Nanocrosses

Multiple branched gold nanostructures with strong near-infrared absorption are synthesized and conjugated with primary and secondary antibodies for effective targeted photothermal ablation of multidrug-resistant bacteria, which have become increasingly difficult to be treated with clinically available antibiotics. This method improves the efficiency in eliminating bacteria/biofilms and offers flexibility by changing the corresponding primary antibodies to target other bacteria strains.

[Full Paper]
Choon Peng Teng, Tielin Zhou, Enyi Ye, Shuhua Liu, Leng Duei Koh, Michelle Low, Xian Jun Loh, Khin Yin Win, Lianhui Zhang, Ming-Yong Han
Adv. Healthcare Mater., June 23, 2016, DOI: 10.1002/adhm.201600346. Read article

Improved Hydrogen Production of Au–Pt–CdS Hetero-Nanostructures by Efficient Plasmon-Induced Multipathway Electron Transfer

Improved Hydrogen Production of Au–Pt–CdS Hetero‐Nanostructures by Efficient Plasmon‐Induced Multipathway Electron Transfer

A well-controlled synthetic strategy is developed to selectively grow Pt nanoparticles on the tips of Au nanotriangles and coat a CdS layer along the sides. The as-prepared Au–Pt–CdS hybrids combine a plasmon-enhanced local field with visible to NIR light-harvesting and an efficient multipathway electron transfer, resulting in excellent photocatalytic activity for hydrogen production.

[Full Paper]
Liang Ma, Kai Chen, Fan Nan, Jia-Hong Wang, Da-Jie Yang, Li Zhou, Qu-Quan Wang
Adv. Funct. Mater., June 22, 2016, DOI: 10.1002/adfm.201601651. Read article

Local Geometric Effects on Stability and Energy Gap of Thiolate-Protected Gold Nanoparticles

Thiolate-protected gold nanoclusters hold potential applications in many fields, due to their high stability and remarkable electronic properties. However, the controlling factors in determining the stability and HOMO-LUMO gap of thiolate-protected gold clusters remain controversial, despite decades of work on the topic. Using density functional theory including nonlocal many-body dispersion interactions (MBD), we investigate the geometric and electronic properties of thiolate-protected gold clusters. Our calculations demonstrate that the MBD interactions are essential for correctly describing the geometry and energy of the clusters. We find that the more anisotropic polarization and the more atoms distribution in the shell of the clusters lead to the more pronounced MBD interactions and the higher stability of the clusters. Furthermore, the HOMO-LUMO gap of clusters is found to strongly depend on the Au core. These results provide critical clues for understanding and designing thiolate-protected gold clusters.

[Article]
Yi Fan Bu, Ming Zhao, Yuquan He, Wang Gao, Qing Jiang
ChemPhysChem, June 21, 2016, DOI: 10.1002/cphc.201600539. Read article

A DFT Insight into Hashmi Phenol Synthesis Catalyzed by M6@Au32 (M=Ag, Cu, Pd, Pt, Ru, Rh) Core–Shell Nanoclusters

A DFT Insight into Hashmi Phenol Synthesis Catalyzed by M6@Au32 (M=Ag, Cu, Pd, Pt, Ru, Rh) Core–Shell Nanoclusters

Another heart for gold clusters: The Hashmi phenol synthesis reaction (the ω-alkynylfuran cycloisomerization) catalyzed by the M6@Au32 (M=Ag, Cu, Pd, Pt, Ru, and Rh) core–shell clusters is predicted theoretically. The catalytic activity of Au38 can be tuned by substitution of the core gold atoms.

[Full Paper]
Miao Yang, Zhongzhu Chen, Yafei Luo, Jin Zhang, Rongxing He, Wei Shen, Dianyong Tang, Ming Li
ChemCatChem, June 21, 2016, DOI: 10.1002/cctc.201600405. Read article

Superwettability Strategy: 1D Assembly of Binary Nanoparticles as Gas Sensors

Superwettability Strategy: 1D Assembly of Binary Nanoparticles as Gas Sensors

Binary 1D nanowires consisting of both SnO2 nanoparticles and Au nanorods are fabricated through a “substrate–particle solution template” assembling method, which shows highly enhanced gas sensitivity toward acetone under ambient conditions.

[Communication]
Yue Tang, Bin Su, Minsu Liu, Yuan Feng, Xuchuan Jiang, Lei Jiang, Aibing Yu
Small, June 20, 2016, DOI: 10.1002/smll.201601087. Read article

Insights into the Interface Between Electrolytic Solution and Gold Core in Molecular Au25(SR)18 Clusters

We used a large series of Au25(SCnH2n+1)180 clusters (n = 2, 3, 4, 5, 6, 8, 10, 12, 14, 16, 18) to study the effect of n and the presence of electrolytes on their redox potentials. The electrochemical results were analyzed in the framework of concentric capacitor models previously proposed to describe larger monolayer protected clusters. We found that the average dielectric constant of the monolayer εm is significantly larger than that of the ligand chains. The effective value of εm depends on n and is the result of contributions from ligands, solvent and electrolyte. When n increases, εm decreases until a virtually constant value is attained for sufficiently long ligands. The electrochemically calculated HOMO-LUMO energy gap, on the other hand, does not depend on n and, therefore, εm. This energy gap is within error the same as that obtained from the optical spectra of the same clusters.

[Article]
Sabrina Antonello, Tiziano Dainese, Marco De Nardi, Lorena Perotti, Flavio Maran
ChemElectroChem, June 20, 2016, DOI: 10.1002/celc.201600276. Read article

High-Sensitivity Floating-Gate Phototransistors Based on WS2 and MoS2

High‐Sensitivity Floating‐Gate Phototransistors Based on WS2 and MoS2

This study reports a novel float-gated memory structure phototransistor based on multilayer WS2 with gold nanoparticles embedded in the gate dielectric. The device represents excellent photodetection capabilities demonstrating that the float-gated memory is an effective configuration to achieve high-performance 2D optoelectronic devices.

[Full Paper]
Fan Gong, Wenjin Luo, Jianlu Wang, Peng Wang, Hehai Fang, Dingshan Zheng, Nan Guo, Jingli Wang, Man Luo, Johnny C. Ho, Xiaoshuang Chen, Wei Lu, Lei Liao, Weida Hu
Adv. Funct. Mater., June 20, 2016, DOI: 10.1002/adfm.201601346. Read article

Specific Electrocatalytic Oxidation of Cellulose at Carbon Electrodes Modified by Gold Nanoparticles

Specific Electrocatalytic Oxidation of Cellulose at Carbon Electrodes Modified by Gold Nanoparticles

Gold standard: The size and oxidation state of Au are dominant factors for the specific electrocatalytic oxidation of cellulose at the interface.

[Full Paper]
Yasuhito Sugano, Narendra Kumar, Markus Peurla, Jorma Roine, Atte Aho, Johan Bobacka, Jyri-Pekka Mikkola
ChemCatChem, June 17, 2016, DOI: 10.1002/cctc.201600190. Read article

N-Heterocyclic Carbene–Gold(I) Complexes Conjugated to a Leukemia-Specific DNA Aptamer for Targeted Drug Delivery

N‐Heterocyclic Carbene–Gold(I) Complexes Conjugated to a Leukemia‐Specific DNA Aptamer for Targeted Drug Delivery

Apt to enter cancer cells: N-Heterocyclic carbene (NHC)–gold(I) complexes were conjugated to the CCRF-CEM leukemia-specific aptamer sgc8c as a strategy for the selective targeting of cancer cells. Cell-viability assays in combination with other techniques indicated that the NHC–AuI–aptamer conjugate (see structure) was more cytotoxic than the NHC–gold complex alone and targeted CCRF-CEM leukemia cells selectively.

[Communication]
Weijia Niu, Xigao Chen, Weihong Tan, Adam S. Veige
Angew. Chem. Int. Ed., June 17, 2016, DOI: 10.1002/anie.201602702. Read article

An Efficient Synthesis of benzazocines by Gold (I)-Catalyzed tandem 1,2-acyl shift / [3+2] Cycloaddition Reaction of terminal 1,9-enynyl esters

An effective synthesis of structurally diverse benzazocines has been accomplished by a gold (I)-catalyzed cascade reaction in good to excellent chemical yields (55%-82%), involving tandem 1,2-acyl shift/[3+2] cycloaddition reaction of terminal 1,9-enynyl esters. The reaction proceeds under extremely mild conditions and it represents one of the relatively few transition metal catalyzed intramolecular cycloaddition reactions for benzazocines synthesis.

[Full Paper]
Shangbiao Feng, Zhengshen Wang, Weiwei Zhang, Xingang Xie, Xuegong She
Chem. Asian J., June 16, 2016, DOI: 10.1002/asia.201600593. Read article

Gold(I)-Catalyzed N-Desulfonylative Amination versus N-to-O 1,5-Sulfonyl Migration: A Versatile Approach to 1-Azabicycloalkanes

Gold(I)‐Catalyzed N‐Desulfonylative Amination versus N‐to‐O 1,5‐Sulfonyl Migration: A Versatile Approach to 1‐Azabicycloalkanes

Worth their weight in gold: The great value of sulfonamides in gold catalysis is highlighted by two hydroamination reactions that occur by migration or cleavage of sulfonyl group (see scheme). These unprecedented gold-promoted sulfonyl-transfer reactions open the way to appealing synthetic applications of these robust nitrogen-protecting groups, as demonstrated by the formation of versatile azabicycles.

[Communication]
Solène Miaskiewicz, Boris Gaillard, Nicolas Kern, Jean-Marc Weibel, Patrick Pale, Aurélien Blanc
Angew. Chem. Int. Ed., June 16, 2016, DOI: 10.1002/anie.201604329. Read article

Structural Variety of Defect Perovskite Variants M3E2X9 (M = Rb, Tl, E = Bi, Sb, X = Br, I)

Structural Variety of Defect Perovskite Variants M3E2X9 (M = Rb, Tl, E = Bi, Sb, X = Br, I)

[Article]
Jen-Hui Chang, Thomas Doert, Michael Ruck
Z. anorg. allg. Chem., June 15, 2016, DOI: 10.1002/zaac.201600179. Read article

On-Electrode Synthesis of Shape-Controlled Hierarchical Flower-Like Gold Nanostructures for Efficient Interfacial DNA Assembly and Sensitive Electrochemical Sensing of MicroRNA

On‐Electrode Synthesis of Shape‐Controlled Hierarchical Flower‐Like Gold Nanostructures for Efficient Interfacial DNA Assembly and Sensitive Electrochemical Sensing of MicroRNA

Shape-controlled gold nanostructures are easily synthesized by the electrodeposition method, which can be used as an electrochemical sensing platform for DNA and microRNA detection. This gold nanostructure-based electrochemical biosensor can detect microRNA in buffers and in real samples with high sensitivity, selectivity, repeatability, regeneration, and stability. Moreover, this biosensor can monitor the microRNA expression level of cancer cell.

[Full Paper]
Shao Su, Yan Wu, Dan Zhu, Jie Chao, Xingfen Liu, Ying Wan, Yan Su, Xiaolei Zuo, Chunhai Fan, Lianhui Wang
Small, June 15, 2016, DOI: 10.1002/smll.201601066. Read article

Side Effect of Good's Buffers on Optical Properties of Gold Nanoparticle Solutions

In search of fluorescent nanoclusters (NCs) for bioimaging, several methods of synthesis have been attempted. Particularly, formation of gold NCs (AuNCs) during synthesis of gold nanoparticles (AuNPs) using Good's buffers was reported based on the optical properties of the reactions mixtures. Here we chose the Good's buffers 2-(N-morpholino)ethanesulfonic acid (MES), 3-(N-morpholino)propanesulfonic acid (MOPS) and 4-(N-morpholino)butanesulfonic acid (MOBS) as [AuCl4]- reducing agents. Resulting AuNP solutions were subjected to electrochemical investigations along with UV-vis and fluorescence spectroscopy. Distinct absorption features at ca. 290 and 360 nm and fluorescence emission in the 408-484 nm range are observed in filtered AuNP-free solutions. Electrochemical oxidation of these buffers generates similar optical properties, suggesting that the degradation products of the buffers contribute to the optical properties of AuNP solutions. This work indicates deeper evaluation of fluorescence signals based on metal NPs or NCs is needed.

[Article]
Christian Engelbrekt, Michal Wagner, Mikkel Undall-Behrend Christiansen, Hans Erik Mølager Christensen, Xiuzhen Qian, Jens Ulstrup, Chongjun Zhao, Jingdong Zhang
ChemElectroChem, June 15, 2016, DOI: 10.1002/celc.201600135. Read article

Chemically Engineered Nanoparticle–Protein Interface for Real-Time Cellular Oxidative Stress Monitoring

Chemically Engineered Nanoparticle–Protein Interface for Real‐Time Cellular Oxidative Stress Monitoring

A co-engineered nanoparticle/protein peroxide detector is created. This system features a gold nanoparticle functionalized with a galactose headgroup (AuNP-Gal) that reacts covalently with a boronate-modified green fluorescent protein (PB-GFP). Boronate acid-saccharide complexation between PB-GFP and AuNP-Gal affords a highly stable assembly. This complex is disrupted by peroxide, allowing quantitative and selective monitoring of hydrogen peroxide production in real time.

[Communication]
Ying Jiang, Ming Wang, Joseph Hardie, Gulen Yesilbag Tonga, Moumita Ray, Qiaobing Xu, Vincent M. Rotello
Small, June 13, 2016, DOI: 10.1002/smll.201600986. Read article

Combined Near Infrared Photothermal Therapy and Chemotherapy Using Gold Nanoshells Coated Liposomes to Enhance Antitumor Effect

Combined Near Infrared Photothermal Therapy and Chemotherapy Using Gold Nanoshells Coated Liposomes to Enhance Antitumor Effect

Gold nanoshell coated oleanolic acid liposomes mediating by chitosan (GNOLs) are designed and successfully synthesized for the first time, which demonstrate the excellent near infrared (NIR) photothermal effect, pH-responsive drug controlled release, and tumor targeting property. By combining NIR photothermal therapy and chemotherapy, the smart drug delivery system exhibits a superior antitumor property in vitro and in vivo.

[Full Paper]
Liyao Luo, Yanhong Bian, Yanping Liu, Xuwu Zhang, Meili Wang, Shanshan Xing, Lei Li, Dawei Gao
Small, June 13, 2016, DOI: 10.1002/smll.201503961. Read article

Hierarchical Nanohybrids of Gold Nanorods and PGMA-Based Polycations for Multifunctional Theranostics

Hierarchical Nanohybrids of Gold Nanorods and PGMA‐Based Polycations for Multifunctional Theranostics

Novel hierarchical nanohybrids of Au nanorods and poly(glycidyl methacrylate)-based polycations are proposed for in vivo dual-modal computed tomography/photoacoustic imaging guided gene therapy/photothermal therapy with high antitumor efficacy.

[Full Paper]
Nana Zhao, Jia Li, Yiqiang Zhou, Yang Hu, Ranran Wang, Zhaoxia Ji, Fusheng Liu, Fu-Jian Xu
Adv. Funct. Mater., June 09, 2016, DOI: 10.1002/adfm.201601418. Read article

A Universal Platform for Macromolecular Deliveryinto Cells Using Gold Nanoparticle Layers via the Photoporation Effect

A Universal Platform for Macromolecular Deliveryinto Cells Using Gold Nanoparticle Layers via the Photoporation Effect

A universal platform using gold nanoparticle layer (GNPL) as the photoporation reagent for macromolecular delivery is proposed. It achieves the high-efficiency delivery of different macromolecules into various cell types, including hard-to-transfect cells. Importantly, as the gold nanoparticles (GNPs) that constitute the GNPL are firmly immobilized together, the potential cytotoxicity caused by endocytosis of GNPs is effectively avoided.

[Full Paper]
Zhonglin Lyu, Feng Zhou, Qi Liu, Hui Xue, Qian Yu, Hong Chen
Adv. Funct. Mater., June 07, 2016, DOI: 10.1002/adfm.201602036. Read article

A Robust Design for Cellular Vehicles of Gold Nanorods for Multimodal Imaging

A Robust Design for Cellular Vehicles of Gold Nanorods for Multimodal Imaging

Hybrid particles with plasmonic bands in the near infrared are engineered to undergo consistent uptake from tumor-tropic cells, without affecting their viability and chemotaxis. These cells may be recruited as Trojan horses to target tumors across all biological barriers and to enable their multimodal detection by photoacoustic imaging and X-ray computed tomography and their destruction by photothermal ablation.

[Full Paper]
Fulvio Ratto, Sonia Centi, Cinzia Avigo, Claudia Borri, Francesca Tatini, Lucia Cavigli, Claudia Kusmic, Beatrice Lelli, Sarah Lai, Stefano Colagrande, Francesco Faita, Luca Menichetti, Roberto Pini
Adv. Funct. Mater., June 06, 2016, DOI: 10.1002/adfm.201600836. Read article

New Synthesis of Gold- and Silver-Based Nano-Tetracycline Composites

New Synthesis of Gold‐ and Silver‐Based Nano‐Tetracycline Composites

All that glitters isn't gold: A new synthetic methodology of water-soluble gold and silver nanoparticles (AuNPs@TC and AgNPs@TC), using the antibiotic tetracycline (TC) as co-reducing and stabilizing agent, is reported. Both composites are tested against TC-resistant bacteria, presenting an increasing effect in the case of AgNPs@TC. The sensing towards metal ions is also explored in aqueous solution.

[Full Paper]
Jamila Djafari, Catarina Marinho, Tiago Santos, Gilberto Igrejas, Carmen Torres, José Luis Capelo, Patricia Poeta, Carlos Lodeiro, Javier Fernández-Lodeiro
ChemistryOpen, June 03, 2016, DOI: 10.1002/open.201600016. Read article

Gold Nanoparticle Cluster Arrays for High-Performance SERS Substrates Fabricated by Electro-oxidative Lithography

Gold Nanoparticle Cluster Arrays for High‐Performance SERS Substrates Fabricated by Electro‐oxidative Lithography

A high-performance SERS substrate was fabricated by combining electro-oxidative lithography and self-assembly procedures. High SERS enhancement factors of 5×106 with good reproducibility were achieved by the interparticle and the intercluster plasmon coupling of the Au nanoparticle cluster arrays.

[Communication]
He Liu, Almut M. Schwenke, Florian Kretschmer, Stephanie Hoeppener, Ulrich S. Schubert
ChemNanoMat, June 03, 2016, DOI: 10.1002/cnma.201600063. Read article

Bacterial Nanocellulose-Based Flexible Surface Enhanced Raman Scattering Substrate

Bacterial Nanocellulose‐Based Flexible Surface Enhanced Raman Scattering Substrate

A novel surface enhanced Raman scattering substrate based on bacterial nanocellulose film that offers a high density of nanostructures and low surface roughness leading to excellent uniformity is demonstrated. Owing to the flexibility of the BNC film, the novel SERS substrate can be used as a swab to collect, detect, and identify bacteria on real-world surfaces.

[Full Paper]
Limei Tian, Qisheng Jiang, Keng-Ku Liu, Jingyi Luan, Rajesh R. Naik, Srikanth Singamaneni
Adv. Mater. Interfaces, June 03, 2016, DOI: 10.1002/admi.201600214. Read article

Carbon Monoxide: A Mild and Efficient Reducing Agent towards Atomically Precise Gold Nanoclusters

Carbon Monoxide: A Mild and Efficient Reducing Agent towards Atomically Precise Gold Nanoclusters

Carbon monoxide is a mild reducing agent that could provide a good platform to synthesize gold nanoclusters with atomic precision and tunable sizes. CO could also slow down the formation of gold nanoclusters and facilitate the investigation of the formation mechanism of thiolated gold nanoclusters.

[Personal Account]
Tiankai Chen, Jianping Xie
The Chemical Record, June 02, 2016, DOI: 10.1002/tcr.201600004. Read article

Advances in Transition-Metal-Catalysed Alkyne Hydroarylations

Advances in Transition‐Metal‐Catalysed Alkyne Hydroarylations

Cheaper control: An overview of achievements in the application of late-transition-metal complexes as catalysts for the intermolecular hydroarylation of alkynes is presented herein. The usefulness of complexes of Pd, Pt, or Au with N-heterocyclic carbenes (NHCs), in which the ligand stabilizes the complex and renders the catalytic system more productive, is highlighted. Promoters and reaction media for improved catalytic activity and control of the reaction chemoselectivity are also discussed.

[Personal Account]
Andrea Biffis, Cristina Tubaro, Marco Baron
The Chemical Record, June 02, 2016, DOI: 10.1002/tcr.201500285. Read article

Dopamine-Directed In-Situ and One-Step Synthesis of Au@Ag Core–Shell Nanoparticles Immobilized to a Metal–Organic Framework for Synergistic Catalysis

Dopamine‐Directed In‐Situ and One‐Step Synthesis of Au@Ag Core–Shell Nanoparticles Immobilized to a Metal–Organic Framework for Synergistic Catalysis

There′s a synergy: Bimetallic core–shell Au@Ag NPs were immobilized in MOFs via one-step synthetic route at room temperature by using dopamine (DA) as a moderate reductant to reduce the bimetallic precursors step-by-step spontaneously. The as-formed Au@Ag/MOF composites show a striking synergistic effect for heterogeneous catalysis.

[Communication]
Pengcheng Huang, Wenjie Ma, Ping Yu, Lanqun Mao
Chem. Asian J., June 02, 2016, DOI: 10.1002/asia.201600469. Read article

Self-Assembly of DNA Functionalized Gold Nanoparticles at the Liquid-Vapor Interface

Self‐Assembly of DNA Functionalized Gold Nanoparticles at the Liquid‐Vapor Interface

Single-stranded DNA-functionalized gold nanoparticles (ssDNA-AuNPs) accumulate and crystallize at the liquid–vapor interface by adding divalent salts. X-ray scattering and spectroscopy techniques demonstrate that the ions screen the charges of ssDNA causing shrinkage of the complexed spheres. At threshold salt concentrations, the hydrophobic effect mainly arising from the hexyl-thiol overcomes DNA affinity to water, leading to interfacial self-assembly.

[Full Paper]
Honghu Zhang, Wenjie Wang, Noah Hagen, Ivan Kuzmenko, Mufit Akinc, Alex Travesset, Surya Mallapragada, David Vaknin
Adv. Mater. Interfaces, May 30, 2016, DOI: 10.1002/admi.201600180. Read article

Efficient Oxygen Reduction Electrocatalysts Based on Gold Nanocluster–Graphene Composites

Efficient Oxygen Reduction Electrocatalysts Based on Gold Nanocluster–Graphene Composites

Cause and effect: The porous structures in gold nanocluster–graphene composite (Au25–rGO) electrodes provide a confined space and increase the residence time of O2 on the surface, facilitating the sluggish oxygen reduction reaction (ORR). The ORR at the Au25–rGO electrode proceeds by an efficient four-electron transfer pathway to form H2O, whereas the two-electron pathway to H2O2 is favored at a Au25-modified electrode.

[Article]
Kyuju Kwak, Uday Pratap Azad, Woojun Choi, Kyunglim Pyo, Mi Jang, Dongil Lee
ChemElectroChem, May 25, 2016, DOI: 10.1002/celc.201600154. Read article

Electrochemical Behavior of Gold–Silver Alloy Nanoparticles

Electrochemical Behavior of Gold–Silver Alloy Nanoparticles

Alter ego: Gold–silver alloy nanoparticles are investigated in chloride-containing media. A significantly altered electrochemical behavior is seen relative to pure gold and pure silver nanoparticles, and restructuring of the alloy nanoparticles is evident on cycling.

[Communication]
Blake J. Plowman, Boopathi Sidhureddy, Stanislav V. Sokolov, Neil P. Young, Aicheng Chen, Richard G. Compton
ChemElectroChem, May 20, 2016, DOI: 10.1002/celc.201600212. Read article

SEM and ECIS Investigation of Cells Cultured on Nanopillar Modified Interdigitated Impedance Electrodes for Analysis of Cell Growth and Cytotoxicity of Potential Anticancer Drugs

SEM and ECIS Investigation of Cells Cultured on Nanopillar Modified Interdigitated Impedance Electrodes for Analysis of Cell Growth and Cytotoxicity of Potential Anticancer Drugs

[Full Paper]
Walter Messina, Michelle Fitzgerald, Eric Moore
Electroanalysis, May 17, 2016, DOI: 10.1002/elan.201600025. Read article

Electrochemical Fabrication of Cobalt Oxides/Nanoporous Gold Composite Electrode and its Nonenzymatic Glucose Sensing Performance

Electrochemical Fabrication of Cobalt Oxides/Nanoporous Gold Composite Electrode and its Nonenzymatic Glucose Sensing Performance

[Full Paper]
Chaohui Zhou, Xueyong Tang, Yue Xia, Zelin Li
Electroanalysis, May 12, 2016, DOI: 10.1002/elan.201501177. Read article

Synthesis and Catalytic Activity of Gold Nanoparticles Supported on Dendrimeric Nanocellulose Hybrids

Synthesis and Catalytic Activity of Gold Nanoparticles Supported on Dendrimeric Nanocellulose Hybrids

Alkynyl-dendrons of the PAMAM family were covalently attached to azide-linked cellulose nanocrystals using click chemistry and then used as templates for the preparation of stable and monodispersed gold nanoparticles in aqueous media. The new materials were evaluated as catalysts for the reduction of 4-nitrophenyl and displayed enhanced activity relative to other supported AuNPs.

[Full Paper]
Ana Herreros-López, Caroline Hadad, Luis Yate, Ali A. Alshatwi, Nicola Vicentini, Tommaso Carofiglio, Maurizio Prato
Eur. J. Org. Chem., April 27, 2016, DOI: 10.1002/ejoc.201600148. Read article.

Synthesis of Gold(I) Derivatives Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane as Selective Anticancer Metallodrugs

Synthesis of Gold(I) Derivatives Bearing Alkylated 1,3,5-Triaza-7-phosphaadamantane as Selective Anticancer Metallodrugs

The preparation of new water-soluble mono- and bis-phosphanes derived from 1,3,5-triaza-7-phosphaadamantane (PTA) is described. Antiproliferative effects against colon cancer cell lines and low cytotoxicity towards differentiated cells (non-carcinogenic) have been observed for some of the gold complexes formed with these phosphanes.

[Full Paper]
Elena Atrián-Blasco, Sonia Gascón, M. Jesús Rodríguez-Yoldi, Mariano Laguna, Elena Cerrada
Eur. J. Inorg. Chem., April 24, 2016, DOI: 10.1002/ejic.201600177. Read article.

Isolable Ethylene Complexes of Copper(I), Silver(I), and Gold(I) Supported by Fluorinated Scorpionates [HB{3-(CF3),5-(CH3)Pz}3] and [HB{3-(CF3),5-(Ph)Pz}3]

Isolable Ethylene Complexes of Copper(I), Silver(I), and Gold(I) Supported by Fluorinated Scorpionates [HB{3-(CF3),5-(CH3)Pz}3]– and [HB{3-(CF3),5-(Ph)Pz}3]–

Partially fluorinated scorpionate [HB{3-(CF3),5-(CH3)Pz}3] allows the stabilization of molecules with gold(I), silver(I) and copper(I) ethylene adducts. Related adducts supported by [HB{3-(CF3),5-(CH3)Pz}3] are also included for comparisons. Notable differences exist in scorpionate modes of coordination and ethylene carbon chemical shift values.

[Communication]
Shawn G. Ridlen, Jiang Wu, Naveen V. Kulkarni, H. V. Rasika Dias
Eur. J. Inorg. Chem., February 9, 2016, DOI: 10.1002/ejic.201501365. Read article.

Detailed Investigation of the Structural, Thermal, and Electronic Properties of Gold Isocyanide Complexes with Mechano-Triggered Single-Crystal-to-Single-Crystal Phase Transitions

Detailed Investigation of the Structural, Thermal, and Electronic Properties of Gold Isocyanide Complexes with Mechano-Triggered Single-Crystal-to-Single-Crystal Phase Transitions

Mechano-induced phase transitions: A detailed investigation of two intriguing gold(I) complexes that show mechano-triggered single-crystal-to-single-crystal (SCSC) phase transitions is described, which includes face index experiments, thermal analyses, and conductivity measurements (see figure). Various hitherto unknown insights into the mechano-responsive molecular crystals have been reported.

[Full Paper]
Tomohiro Seki, Kenta Sakurada, Mai Muromoto, Shu Seki, Hajime Ito
Chem. Eur. J., January 11, 2016, DOI: 10.1002/chem.201503721. Read article.

Co-Adsorption of O2 and CO on Au2: Infrared Photodissociation Spectroscopy and Theoretical Study of [Au2O2(CO)n] (n=2–6)

Co-Adsorption of O2 and CO on Au2−: Infrared Photodissociation Spectroscopy and Theoretical Study of [Au2O2(CO)n]− (n=2–6)

Co-adsorption: The [Au2O2(CO)n] (n=2–6) complexes were prepared through a laser vaporization supersonic ion source and were studied by using infrared photodissociation spectroscopy (see figure). All complexes were characterized to have a core structure involving one CO and one O2 molecule co-adsorbed on Au2 with the other CO molecules physically tagged around.

[Full Paper]
Hao Liu, Xiaopeng Xing, Xuefeng Wang, Hui Qu, Guan-jun Wang, Ming-fei Zhou
Chem. Eur. J., January 8, 2016, DOI: 10.1002/chem.201504384. Read article.

Gold-Catalyzed Tandem Cycloisomerization–Halogenation of Chiral Homopropargyl Sulfonamides

Gold-Catalyzed Tandem Cycloisomerization–Halogenation of Chiral Homopropargyl Sulfonamides

Two new gold-catalyzed tandem cycloisomerization–halogenation reactions of chiral homopropargyl sulfonamides have been developed. Enantioenriched 3,3-diiodopyrrolidin-2-ols and 3-fluoropyrrolidin-2-ols were obtained in moderate-to-good yields with excellent enantio- and diastereocontrol (see scheme; PG=protecting group, DCE=1,2-dichloroethane, NIS=N-iodosuccinimide).

[Full Paper]
Chao Shu, Long Li, Cang-Hai Shen, Peng-Peng Ruan, Chao-Yue Liu, Long-Wu Ye 
Chem. Eur. J., January 8, 2016, DOI: 10.1002/chem.201503891. Read article.

Chemo- and Regioselective Ethynylation of Tryptophan-Containing Peptides and Proteins

Chemo- and Regioselective Ethynylation of Tryptophan-Containing Peptides and Proteins

Alkynes on a gold Tr(i)p! Various peptides and one model protein were functionalized with ethynyl moieties at their tryptophan residues using Waser’s reagent, TIPS-EBX, under gold(I) catalysis (see scheme; TIPS=triisopropylsilyl). The reaction proceeded in a regio- and chemoselective manner leading to C2 substitution at the tryptophan residues only. Subsequently, the terminal alkyne was used to label one of the model peptides with a fluorophore by means of copper-catalyzed click chemistry.

[Communication]
Morten Borre Hansen, František Hubálek, Troels Skrydstrup, Thomas Hoeg-Jensen
Chem. Eur. J., December 22, 2015, DOI: 10.1002/chem.201504462. Read article.

Activation and Transformation of Ethane by Au2VO3+ Clusters with Closed-Shell Electronic Structures

Activation and Transformation of Ethane by Au2VO3+ Clusters with Closed-Shell Electronic Structures

The crucial role of gold in the transformation of ethane to ethene and dihydrogen is observed in the reaction between C2H6 and Au2VO3+ clusters with closed-shell electronic structures. The first C-H activation is initiated by gold rather than an oxygen species. The Au-Au dimer formed during the reactions plays important roles in converting ethane into ethene and making dihydrogen energetically more favorable.

[Full Paper]
Ya-Ke Li, Zi-Yu Li, Yan-Xia Zhao, Qing-Yu Liu, Jing-Heng Meng, Sheng-Gui He
Chem. Eur. J., December 17, 2015, DOI: 10.1002/chem.201503676. Read article.

On the Mechanism of the Digold(I)–Hydroxide-Catalysed Hydrophenoxylation of Alkynes

On the Mechanism of the Digold(I)–Hydroxide-Catalysed Hydrophenoxylation of Alkynes

Gold rush! A series of in silico studies, supported by experimental work, have been carried out to further elucidate the mechanistic aspects of the hydrophenoxylation of alkynes. The results suggest that the synergic cooperation of two mono-gold species facilitates this process, although analogous mono-gold species are not capable of mediating this reaction (see figure).

[Full Paper]
Adrián Gómez-Suárez, Yoshihiro Oonishi, Anthony R. Martin, Sai V. C. Vummaleti, David J. Nelson, David B. Cordes, Alexandra M. Z. Slawin, Luigi Cavallo, Steven P. Nolan, Albert Poater
Chem. Eur. J., December 11, 2015, DOI: 10.1002/chem.201503097. Read article.

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