European Journal of Organic Chemistry http://dx.doi.org/10.1002/(ISSN)1099-0690 News and current content from the journal European Journal of Organic Chemistry en Copyright 2010, Wiley-VCH 2012-05-22T00:10:00+02:00 Wiley-VCH info@wiley-vch.de Chemistry 2001-01-01T00:00+00:00 1 daily Highly Enantioselective Thiolysis of Prochiral Cyclic Anhydrides Catalyzed by Amino Alcohol Bifunctional Organocatalysts and Its Application to the Synthesis of Pregabalin http://dx.doi.org/10.1002/ejoc.201300464 Hong-Jun Yang, Fang-Jun Xiong, Xiao-Fei Chen, Fen-Er Chen 2013-06-18T00:54+05:00 Highly Enantioselective Thiolysis of Prochiral Cyclic Anhydrides Catalyzed by Amino Alcohol Bifunctional Organocatalysts and Its Application to the Synthesis of Pregabalin

[Short Communication]
Hong-Jun Yang, Fang-Jun Xiong, Xiao-Fei Chen, Fen-Er Chen
Eur. J. Org. Chem., Jun 18, 2013, DOI: 10.1002/ejoc.201300464. Read article.

]]> Copper-Catalyzed Synthesis of a Highly Hydroxy-Functionalized Benzo[<I>e</I>]indolizidine by Intramolecular <I>N</I>-Arylation http://dx.doi.org/10.1002/ejoc.201300440 Franca M. Cordero, Bhushan B. Khairnar, Paola Bonanno, Andrea Martinelli, Alberto Brandi 2013-06-18T00:54+05:00 Copper-Catalyzed Synthesis of a Highly Hydroxy-Functionalized Benzo[e]indolizidine by Intramolecular N-Arylation

[Full Paper]
Franca M. Cordero, Bhushan B. Khairnar, Paola Bonanno, Andrea Martinelli, Alberto Brandi
Eur. J. Org. Chem., Jun 18, 2013, DOI: 10.1002/ejoc.201300440. Read article.

]]> 2,2'-Bis-azonia-Cope Rearrangements of 2,3-Homo-6<I>H</I>-1,4-diazepinium Dications http://dx.doi.org/10.1002/ejoc.201300386 Helmut Quast, Hubert-Matthias Seidenspinner, Josef Walter Stawitz 2013-06-18T00:54+05:00 2,2'-Bis-azonia-Cope Rearrangements of 2,3-Homo-6H-1,4-diazepinium Dications

[Full Paper]
Helmut Quast, Hubert-Matthias Seidenspinner, Josef Walter Stawitz
Eur. J. Org. Chem., Jun 18, 2013, DOI: 10.1002/ejoc.201300386. Read article.

]]> Bifunctional Squaramide-Catalyzed One-Pot Sequential Michael Addition/Dearomative Bromination: Convenient Access to Optically Active Brominated Pyrazol-5(4<I>H</I>)-ones with Adjacent Quaternary and Tertiary Stereocenters http://dx.doi.org/10.1002/ejoc.201300460 Huanxia Wang, Youming Wang, Haibin Song, Zhenghong Zhou, Chuchi Tang 2013-06-18T00:41+05:00 Bifunctional Squaramide-Catalyzed One-Pot Sequential Michael Addition/Dearomative Bromination: Convenient Access to Optically Active Brominated Pyrazol-5(4H)-ones with Adjacent Quaternary and Tertiary Stereocenters

[Full Paper]
Huanxia Wang, Youming Wang, Haibin Song, Zhenghong Zhou, Chuchi Tang
Eur. J. Org. Chem., Jun 18, 2013, DOI: 10.1002/ejoc.201300460. Read article.

]]> Copper-Catalyzed Synthesis of Substituted Isoindolo[2,1-<I>a</I>]quinoxalines and Isoindolo[2,1-<I>a</I>]quinoxalin-6(5<I>H</I>)-ones http://dx.doi.org/10.1002/ejoc.201300466 Subhasish Biswas, Sanjay Batra 2013-06-18T00:40+05:00 Copper-Catalyzed Synthesis of Substituted Isoindolo[2,1-a]quinoxalines and Isoindolo[2,1-a]quinoxalin-6(5H)-ones

[Full Paper]
Subhasish Biswas, Sanjay Batra
Eur. J. Org. Chem., Jun 18, 2013, DOI: 10.1002/ejoc.201300466. Read article.

]]> Organocatalytic Asymmetric Direct Aldol Reaction of Pyruvic Aldehyde Dimethyl Acetal with Isatin Derivatives http://dx.doi.org/10.1002/ejoc.201300411 Akshay Kumar, Swapandeep Singh Chimni 2013-06-18T00:40+05:00 Organocatalytic Asymmetric Direct Aldol Reaction of Pyruvic Aldehyde Dimethyl Acetal with Isatin Derivatives

[Full Paper]
Akshay Kumar, Swapandeep Singh Chimni
Eur. J. Org. Chem., Jun 18, 2013, DOI: 10.1002/ejoc.201300411. Read article.

]]> Diarylated Ethanones from Mo(CO)<sub>6</sub>-Mediated and Microwave-Assisted Palladium-Catalysed Carbonylative Negishi Cross-Couplings http://dx.doi.org/10.1002/ejoc.201300610 Hitesh V. Motwani, Mats Larhed 2013-06-18T00:39+05:00 Diarylated Ethanones from Mo(CO)6-Mediated and Microwave-Assisted Palladium-Catalysed Carbonylative Negishi Cross-Couplings

[Short Communication]
Hitesh V. Motwani, Mats Larhed
Eur. J. Org. Chem., Jun 18, 2013, DOI: 10.1002/ejoc.201300610. Read article.

]]> Catalytic Asymmetric Allylic Alkylation of 3-Arylated Piperidin-2-ones http://dx.doi.org/10.1002/ejoc.201300510 Christophe Michon, Aurélien Béthegnies, Frédéric Capet, Pascal Roussel, Arnault de Filippis, Domingo Gomez-Pardo, Janine Cossy, Francine Agbossou-Niedercorn 2013-06-18T00:33+05:00 Catalytic Asymmetric Allylic Alkylation of 3-Arylated Piperidin-2-ones

[Full Paper]
Christophe Michon, Aurélien Béthegnies, Frédéric Capet, Pascal Roussel, Arnault de Filippis, Domingo Gomez-Pardo, Janine Cossy, Francine Agbossou-Niedercorn
Eur. J. Org. Chem., Jun 18, 2013, DOI: 10.1002/ejoc.201300510. Read article.

]]> Towards Tartaric-Acid-Derived Asymmetric Organocatalysts http://dx.doi.org/10.1002/ejoc.201201675 Katharina Gratzer, Guddeangadi N. Gururaja, Mario Waser 2013-06-17T06:52+05:00 Towards Tartaric-Acid-Derived Asymmetric Organocatalysts

[Microreview]
Katharina Gratzer, Guddeangadi N. Gururaja, Mario Waser
Eur. J. Org. Chem., Jun 17, 2013, DOI: 10.1002/ejoc.201201675. Read article.

]]> Lipases in the Regioselective Preparation of Glyceric Acid Esters of Methyl Glycosides http://dx.doi.org/10.1002/ejoc.201300450 Riku Sundell, Liisa T. Kanerva 2013-06-17T06:50+05:00 Lipases in the Regioselective Preparation of Glyceric Acid Esters of Methyl Glycosides

[Full Paper]
Riku Sundell, Liisa T. Kanerva
Eur. J. Org. Chem., Jun 17, 2013, DOI: 10.1002/ejoc.201300450. Read article.

]]> Functionalized Gold Nanoparticles as an Approach to the Direct Colorimetric Detection of DCNP Nerve Agent Simulant http://dx.doi.org/10.1002/ejoc.201300339 Almudena Martí, Ana M. Costero, Pablo Gaviña, Salvador Gil, Margarita Parra, Mauro Brotons-Gisbert, Juan Francisco Sánchez-Royo 2013-06-17T06:50+05:00 Functionalized Gold Nanoparticles as an Approach to the Direct Colorimetric Detection of DCNP Nerve Agent Simulant

[Full Paper]
Almudena Martí, Ana M. Costero, Pablo Gaviña, Salvador Gil, Margarita Parra, Mauro Brotons-Gisbert, Juan Francisco Sánchez-Royo
Eur. J. Org. Chem., Jun 17, 2013, DOI: 10.1002/ejoc.201300339. Read article.

]]> Metal-Free Oxidative Carbon-Heteroatom Bond Formation Through C–H Bond Functionalization http://dx.doi.org/10.1002/ejoc.201300286 Rajarshi Samanta, Kiran Matcha, Andrey P. Antonchick 2013-06-17T06:50+05:00 Metal-Free Oxidative Carbon-Heteroatom Bond Formation Through C–H Bond Functionalization

[Microreview]
Rajarshi Samanta, Kiran Matcha, Andrey P. Antonchick
Eur. J. Org. Chem., Jun 17, 2013, DOI: 10.1002/ejoc.201300286. Read article.

]]> Fluorenylmethoxycarbonyl-<I>N</I>-methylamino Acids Synthesized in a Flow Tube-in-Tube Reactor with a Liquid–Liquid Semipermeable Membrane http://dx.doi.org/10.1002/ejoc.201300705 Annette E. Buba, Stefan Koch, Horst Kunz, Holger Löwe 2013-06-17T06:49+05:00 Fluorenylmethoxycarbonyl-N-methylamino Acids Synthesized in a Flow Tube-in-Tube Reactor with a Liquid–Liquid Semipermeable Membrane

[Short Communication]
Annette E. Buba, Stefan Koch, Horst Kunz, Holger Löwe
Eur. J. Org. Chem., Jun 17, 2013, DOI: 10.1002/ejoc.201300705. Read article.

]]> Tether-Free Immobilized Bifunctional Squaramide Organocatalysts for Batch and Flow Reactions http://dx.doi.org/10.1002/ejoc.201300626 György Kardos, Tibor Soós 2013-06-17T06:49+05:00 Tether-Free Immobilized Bifunctional Squaramide Organocatalysts for Batch and Flow Reactions

[Short Communication]
György Kardos, Tibor Soós
Eur. J. Org. Chem., Jun 17, 2013, DOI: 10.1002/ejoc.201300626. Read article.

]]> An Aerobic and Very Fast Pd/C-Catalyzed Ligand-Free and Aqueous Suzuki Reaction Under Mild Conditions http://dx.doi.org/10.1002/ejoc.201300334 Chun Liu, Xiaofeng Rao, Yixia Zhang, Xinmin Li, Jieshan Qiu, Zilin Jin 2013-06-17T06:49+05:00 An Aerobic and Very Fast Pd/C-Catalyzed Ligand-Free and Aqueous Suzuki Reaction Under Mild Conditions

[Full Paper]
Chun Liu, Xiaofeng Rao, Yixia Zhang, Xinmin Li, Jieshan Qiu, Zilin Jin
Eur. J. Org. Chem., Jun 17, 2013, DOI: 10.1002/ejoc.201300334. Read article.

]]> Bifunctional Primary Amine-Squaramide Catalyzed Enantioselective Intramolecular Michael Addition of Keto-enones: A Convenient Process to the Stereocontrolled Construction of <I>trans</I>-Dihydrobenzofuran Skeletons http://dx.doi.org/10.1002/ejoc.201300331 Yunting Liu, Aidang Lu, Keling Hu, Youming Wang, Haibin Song, Zhenghong Zhou, Chuchi Tang 2013-06-17T06:49+05:00 Bifunctional Primary Amine-Squaramide Catalyzed Enantioselective Intramolecular Michael Addition of Keto-enones: A Convenient Process to the Stereocontrolled Construction of trans-Dihydrobenzofuran Skeletons

[Full Paper]
Yunting Liu, Aidang Lu, Keling Hu, Youming Wang, Haibin Song, Zhenghong Zhou, Chuchi Tang
Eur. J. Org. Chem., Jun 17, 2013, DOI: 10.1002/ejoc.201300331. Read article.

]]> Synthesis of Highly Functionalized Enantiopure Halocyclopropanes Derived from Carbohydrates http://dx.doi.org/10.1002/ejoc.201300322 Humberto Rodríguez-Solla, Carmen Concellón, Vicente del Amo, Ainhoa Díaz-Pardo, Elena G. Blanco, Santiago García-Granda, M. Rosario Díaz, Ricardo Llavona, Raquel G. Soengas 2013-06-17T06:49+05:00 Synthesis of Highly Functionalized Enantiopure Halocyclopropanes Derived from Carbohydrates

[Full Paper]
Humberto Rodríguez-Solla, Carmen Concellón, Vicente del Amo, Ainhoa Díaz-Pardo, Elena G. Blanco, Santiago García-Granda, M. Rosario Díaz, Ricardo Llavona, Raquel G. Soengas
Eur. J. Org. Chem., Jun 17, 2013, DOI: 10.1002/ejoc.201300322. Read article.

]]> Direct Iodination of Isoindolines and Isoindoline Nitroxides as Precursors to Functionalized Nitroxides http://dx.doi.org/10.1002/ejoc.201300313 Kathryn E. Fairfull-Smith, Emmanuel A. Debele, Jesse P. Allen, Michael C. Pfrunder, John C. McMurtrie 2013-06-17T06:49+05:00 Direct Iodination of Isoindolines and Isoindoline Nitroxides as Precursors to Functionalized Nitroxides

[Full Paper]
Kathryn E. Fairfull-Smith, Emmanuel A. Debele, Jesse P. Allen, Michael C. Pfrunder, John C. McMurtrie
Eur. J. Org. Chem., Jun 17, 2013, DOI: 10.1002/ejoc.201300313. Read article.

]]> Synthesis of Nitroalkenes Involving a Cooperative Catalytic Action of Iron(III) and Piperidine: A One-Pot Synthetic Strategy to 3-Alkylindoles, 2<I>H</I>-Chromenes and <I>N</I>-Arylpyrrole http://dx.doi.org/10.1002/ejoc.201300172 Swapnadeep Jalal, Soumen Sarkar, Krishnendu Bera, Sukhendu Maiti, Umasish Jana 2013-06-17T06:49+05:00 Synthesis of Nitroalkenes Involving a Cooperative Catalytic Action of Iron(III) and Piperidine: A One-Pot Synthetic Strategy to 3-Alkylindoles, 2H-Chromenes and N-Arylpyrrole

[Full Paper]
Swapnadeep Jalal, Soumen Sarkar, Krishnendu Bera, Sukhendu Maiti, Umasish Jana
Eur. J. Org. Chem., Jun 17, 2013, DOI: 10.1002/ejoc.201300172. Read article.

]]> One-Step Stereoselective Synthesis of Trisubstituted Monofluoroalkenes from 3,3,3-Trifluoropropionates http://dx.doi.org/10.1002/ejoc.201300551 Mercedes Lecea, Adrien Grassin, Leticia Ferreiro-Mederos, Sabine Choppin, Antonio Urbano, M. Carmen Carreno, Françoise Colobert 2013-06-13T08:02+05:00 One-Step Stereoselective Synthesis of Trisubstituted Monofluoroalkenes from 3,3,3-Trifluoropropionates

[Short Communication]
Mercedes Lecea, Adrien Grassin, Leticia Ferreiro-Mederos, Sabine Choppin, Antonio Urbano, M. Carmen Carreno, Françoise Colobert
Eur. J. Org. Chem., Jun 13, 2013, DOI: 10.1002/ejoc.201300551. Read article.

]]> Total Synthesis of (+)-Strongylin A, a Rearranged Sesquiterpenoid Hydroquinone from a Marine Sponge http://dx.doi.org/10.1002/ejoc.201300438 Takaaki Kamishima, Takuya Kikuchi, Tadashi Katoh 2013-06-13T08:02+05:00 Total Synthesis of (+)-Strongylin A, a Rearranged Sesquiterpenoid Hydroquinone from a Marine Sponge

[Full Paper]
Takaaki Kamishima, Takuya Kikuchi, Tadashi Katoh
Eur. J. Org. Chem., Jun 13, 2013, DOI: 10.1002/ejoc.201300438. Read article.

]]> From Cyclopentadiene to Isoxazoline-Carbocyclic Nucleosides; Synthesis of Highly Active Inhibitors of Influenza A Virus H1N1 http://dx.doi.org/10.1002/ejoc.201300119 Paolo Quadrelli, Mariella Mella, Laura Legnani, Dalya Al-Saad 2013-06-13T08:02+05:00 From Cyclopentadiene to Isoxazoline-Carbocyclic Nucleosides; Synthesis of Highly Active Inhibitors of Influenza A Virus H1N1

[Full Paper]
Paolo Quadrelli, Mariella Mella, Laura Legnani, Dalya Al-Saad
Eur. J. Org. Chem., Jun 13, 2013, DOI: 10.1002/ejoc.201300119. Read article.

]]> Solvent-Controlled Copper-Catalyzed Oxidation of Benzylic Alcohols to Aldehydes and Esters http://dx.doi.org/10.1002/ejoc.201300668 Yefeng Zhu, Yunyang Wei 2013-06-12T03:59+05:00 Solvent-Controlled Copper-Catalyzed Oxidation of Benzylic Alcohols to Aldehydes and Esters

[Short Communication]
Yefeng Zhu, Yunyang Wei
Eur. J. Org. Chem., Jun 12, 2013, DOI: 10.1002/ejoc.201300668. Read article.

]]> Theophyllinylpyrimidine Scaffolds Undergo Intramolecular Cyclization Reactions to Form 1,3-Diazepines and Imidazopurines http://dx.doi.org/10.1002/ejoc.201300360 Iryna O. Lebedyeva, V'yacheslav M. Povstyanoy, Aleksey B. Ryabitskii, Oleksandr Panasyuk, Evgen Ivahnenko, Vera P. Lozova, Igor Markevich, Svitlana Allakhverdova, Mykhaylo V. Povstyanoy 2013-06-12T03:59+05:00 Theophyllinylpyrimidine Scaffolds Undergo Intramolecular Cyclization Reactions to Form 1,3-Diazepines and Imidazopurines

[Full Paper]
Iryna O. Lebedyeva, V'yacheslav M. Povstyanoy, Aleksey B. Ryabitskii, Oleksandr Panasyuk, Evgen Ivahnenko, Vera P. Lozova, Igor Markevich, Svitlana Allakhverdova, Mykhaylo V. Povstyanoy
Eur. J. Org. Chem., Jun 12, 2013, DOI: 10.1002/ejoc.201300360. Read article.

]]> Amine-Catalyzed Cascade Synthesis of 3,4-Diunsubstituted Coumarins http://dx.doi.org/10.1002/ejoc.201300538 Jia Wei, Pengcheng Wang, Qianfa Jia, Jiaoyao Huang, Zhiyun Du, Kun Zhang, Jian Wang 2013-06-12T03:57+05:00 Amine-Catalyzed Cascade Synthesis of 3,4-Diunsubstituted Coumarins

[Short Communication]
Jia Wei, Pengcheng Wang, Qianfa Jia, Jiaoyao Huang, Zhiyun Du, Kun Zhang, Jian Wang
Eur. J. Org. Chem., Jun 12, 2013, DOI: 10.1002/ejoc.201300538. Read article.

]]> Synthesis of Specific Solvatochromic D-π-A Dyes with Pyridinium Ring as Electron-Withdrawing Group for Dye-Sensitized Solar Cells http://dx.doi.org/10.1002/ejoc.201300465 Yousuke Ooyama, Yuichiro Oda, Tomonobu Mizumo, Yutaka Harima, Joji Ohshita 2013-06-12T03:57+05:00 Synthesis of Specific Solvatochromic D-π-A Dyes with Pyridinium Ring as Electron-Withdrawing Group for Dye-Sensitized Solar Cells

[Full Paper]
Yousuke Ooyama, Yuichiro Oda, Tomonobu Mizumo, Yutaka Harima, Joji Ohshita
Eur. J. Org. Chem., Jun 12, 2013, DOI: 10.1002/ejoc.201300465. Read article.

]]> (–)-Isosteviol as a Versatile Ex-Chiral-Pool Building Block for Organic Chemistry http://dx.doi.org/10.1002/ejoc.201300447 Christina Lohoelter, Magdalena Weckbecker, Siegfried R. Waldvogel 2013-06-12T03:57+05:00 (–)-Isosteviol as a Versatile Ex-Chiral-Pool Building Block for Organic Chemistry

[Microreview]
Christina Lohoelter, Magdalena Weckbecker, Siegfried R. Waldvogel
Eur. J. Org. Chem., Jun 12, 2013, DOI: 10.1002/ejoc.201300447. Read article.

]]> Total Synthesis of the Phenolic Glycolipid Mycoside B and the Glycosylated <I>p</I>-Hydroxybenzoic Acid Methyl Ester HBAD-I, Virulence Markers of <I>Mycobacterium tuberculosis</I> http://dx.doi.org/10.1002/ejoc.201300437 Santiago Barroso, Danny Geerdink, Bjorn ter Horst, Eva Casas-Arce, Adriaan J. Minnaard 2013-06-12T03:57+05:00 Total Synthesis of the Phenolic Glycolipid Mycoside B and the Glycosylated p-Hydroxybenzoic Acid Methyl Ester HBAD-I, Virulence Markers of Mycobacterium tuberculosis

[Full Paper]
Santiago Barroso, Danny Geerdink, Bjorn ter Horst, Eva Casas-Arce, Adriaan J. Minnaard
Eur. J. Org. Chem., Jun 12, 2013, DOI: 10.1002/ejoc.201300437. Read article.

]]> Access to Di- and Trisubstituted Oxazoles by NBS-Mediated Oxidative Cyclisation of <I>N</I>-Acyl Amino Acid Derivatives http://dx.doi.org/10.1002/ejoc.201300421 Surendar Reddy Bathula, Muktapuram Prathap Reddy, K. K. Durga Rao Viswanadham, Pochampalli Sathyanarayana, Maddi Sridhar Reddy 2013-06-12T03:57+05:00 Access to Di- and Trisubstituted Oxazoles by NBS-Mediated Oxidative Cyclisation of N-Acyl Amino Acid Derivatives

[Full Paper]
Surendar Reddy Bathula, Muktapuram Prathap Reddy, K. K. Durga Rao Viswanadham, Pochampalli Sathyanarayana, Maddi Sridhar Reddy
Eur. J. Org. Chem., Jun 12, 2013, DOI: 10.1002/ejoc.201300421. Read article.

]]> Synthesis of an Octa-<I>tert</I>-butylphthalocyanine: A Low-Aggregating and Photochemically Stable Photosensitizer http://dx.doi.org/10.1002/ejoc.201300415 Nicholas R. S. Gobo, Timothy J. Brocksom, Julio Zukerman-Schpector, Kleber T. de Oliveira 2013-06-12T03:57+05:00 Synthesis of an Octa-tert-butylphthalocyanine: A Low-Aggregating and Photochemically Stable Photosensitizer

[Short Communication]
Nicholas R. S. Gobo, Timothy J. Brocksom, Julio Zukerman-Schpector, Kleber T. de Oliveira
Eur. J. Org. Chem., Jun 12, 2013, DOI: 10.1002/ejoc.201300415. Read article.

]]> Total Synthesis of Umuravumbolide and Hyptolide Through Silicon-Tethered Ring-Closing Metathesis http://dx.doi.org/10.1002/ejoc.201300302 Partha Sarathi Chowdhury, Pradeep Kumar 2013-06-12T03:47+05:00 Total Synthesis of Umuravumbolide and Hyptolide Through Silicon-Tethered Ring-Closing Metathesis

[Full Paper]
Partha Sarathi Chowdhury, Pradeep Kumar
Eur. J. Org. Chem., Jun 12, 2013, DOI: 10.1002/ejoc.201300302. Read article.

]]> A Flexible Strategy Towards Thienyl-, Oxazolyl- and Pyridyl-Fused Fluorenones http://dx.doi.org/10.1002/ejoc.201300233 Amel Souibgui, Anne Gaucher, Jérôme Marrot, Faouzi Aloui, Florence Mahuteau-Betzer, Bechir Ben Hassine, Damien Prim 2013-06-12T03:47+05:00 A Flexible Strategy Towards Thienyl-, Oxazolyl- and Pyridyl-Fused Fluorenones

[Full Paper]
Amel Souibgui, Anne Gaucher, Jérôme Marrot, Faouzi Aloui, Florence Mahuteau-Betzer, Bechir Ben Hassine, Damien Prim
Eur. J. Org. Chem., Jun 12, 2013, DOI: 10.1002/ejoc.201300233. Read article.

]]> Facile Synthesis of Functional Tricyclic Fused Furans by Intramolecular Wittig Reactions http://dx.doi.org/10.1002/ejoc.201300426 Yi-Ling Tsai, Utpal Das, Siang-en Syu, Chia-Jui Lee, Wenwei Lin 2013-06-10T05:28+05:00 Facile Synthesis of Functional Tricyclic Fused Furans by Intramolecular Wittig Reactions

[Full Paper]
Yi-Ling Tsai, Utpal Das, Siang-en Syu, Chia-Jui Lee, Wenwei Lin
Eur. J. Org. Chem., Jun 10, 2013, DOI: 10.1002/ejoc.201300426. Read article.

]]> Three-Component Synthesis of Indanone-Fused Spirooxindole Derivatives http://dx.doi.org/10.1002/ejoc.201300376 Xue-Bing Chen, Xi-Ming Liu, Rong Huang, Sheng-Jiao Yan, Jun Lin 2013-06-10T05:28+05:00 Three-Component Synthesis of Indanone-Fused Spirooxindole Derivatives

[Full Paper]
Xue-Bing Chen, Xi-Ming Liu, Rong Huang, Sheng-Jiao Yan, Jun Lin
Eur. J. Org. Chem., Jun 10, 2013, DOI: 10.1002/ejoc.201300376. Read article.

]]> Domino Reaction of Iodoglycosides: Synthesis of Carbohydrate-Based Nitroalkenes http://dx.doi.org/10.1002/ejoc.201300362 Raquel G. Soengas, Artur M. S. Silva 2013-06-10T05:28+05:00 Domino Reaction of Iodoglycosides: Synthesis of Carbohydrate-Based Nitroalkenes

[Short Communication]
Raquel G. Soengas, Artur M. S. Silva
Eur. J. Org. Chem., Jun 10, 2013, DOI: 10.1002/ejoc.201300362. Read article.

]]> BBr<sub>3</sub>-Assisted Cleavage of Most Ethers Does Not Follow the Commonly Assumed Mechanism http://dx.doi.org/10.1002/ejoc.201300337 Carla Sousa, Pedro J. Silva 2013-06-07T06:41+05:00 BBr3-Assisted Cleavage of Most Ethers Does Not Follow the Commonly Assumed Mechanism

[Full Paper]
Carla Sousa, Pedro J. Silva
Eur. J. Org. Chem., Jun 07, 2013, DOI: 10.1002/ejoc.201300337. Read article.

]]> Asymmetric Formal Synthesis of (–)-Swainsonine by a Highly Regioselective and Diastereoselective Allylic Amination Using Chlorosulfonyl Isocyanate http://dx.doi.org/10.1002/ejoc.201300308 Qing Ri Li, Guang Ri Dong, Sook Jin Park, Yong Rae Hong, In Su Kim, Young Hoon Jung 2013-06-07T06:41+05:00 Asymmetric Formal Synthesis of (–)-Swainsonine by a Highly Regioselective and Diastereoselective Allylic Amination Using Chlorosulfonyl Isocyanate

[Full Paper]
Qing Ri Li, Guang Ri Dong, Sook Jin Park, Yong Rae Hong, In Su Kim, Young Hoon Jung
Eur. J. Org. Chem., Jun 07, 2013, DOI: 10.1002/ejoc.201300308. Read article.

]]> Can Diels–Alder Reactions Lead to <I>trans</I>-Fused Products? A Computational Study of the Competitive [4+2] and [2+4] Cycloaddition of Dienes to α-Aryl-Substituted Cyclohexenones http://dx.doi.org/10.1002/ejoc.201201754 Snezhana M. Bakalova, A. Gil Santos 2013-06-07T06:39+05:00 Can Diels–Alder Reactions Lead to trans-Fused Products? A Computational Study of the Competitive [4+2] and [2+4] Cycloaddition of Dienes to α-Aryl-Substituted Cyclohexenones

[Full Paper]
Snezhana M. Bakalova, A. Gil Santos
Eur. J. Org. Chem., Jun 07, 2013, DOI: 10.1002/ejoc.201201754. Read article.

]]> Total Synthesis of the Hypermodified tRNA Nucleoside Epoxyqueuosine http://dx.doi.org/10.1002/ejoc.201300586 Ines Thoma, Thomas Carell 2013-06-07T05:39+05:00 Total Synthesis of the Hypermodified tRNA Nucleoside Epoxyqueuosine

[Short Communication]
Ines Thoma, Thomas Carell
Eur. J. Org. Chem., Jun 07, 2013, DOI: 10.1002/ejoc.201300586. Read article.

]]> Synthesis, Chiral Resolution, and Absolute Configuration of Dissymmetric 4,12-Difunctionalized [2.2]Paracyclophanes http://dx.doi.org/10.1002/ejoc.201300412 Georg Meyer-Eppler, Elisabeth Vogelsang, Christian Benkhäuser, Andreas Schneider, Gregor Schnakenburg, Arne Lützen 2013-06-07T05:39+05:00 Synthesis, Chiral Resolution, and Absolute Configuration of Dissymmetric 4,12-Difunctionalized [2.2]Paracyclophanes

[Full Paper]
Georg Meyer-Eppler, Elisabeth Vogelsang, Christian Benkhäuser, Andreas Schneider, Gregor Schnakenburg, Arne Lützen
Eur. J. Org. Chem., Jun 07, 2013, DOI: 10.1002/ejoc.201300412. Read article.

]]> Rearrangements of Furan-, Thiophene- and <I>N</I>-Boc-Pyrrole-Derived Donor-Acceptor Cyclopropanes: Scope and Limitations http://dx.doi.org/10.1002/ejoc.201300390 Johannes Kaschel, Tobias F. Schneider, Patrick Schirmer, Christian Maaß, Dietmar Stalke, Daniel B. Werz 2013-06-07T05:39+05:00 Rearrangements of Furan-, Thiophene- and N-Boc-Pyrrole-Derived Donor-Acceptor Cyclopropanes: Scope and Limitations

[Full Paper]
Johannes Kaschel, Tobias F. Schneider, Patrick Schirmer, Christian Maaß, Dietmar Stalke, Daniel B. Werz
Eur. J. Org. Chem., Jun 07, 2013, DOI: 10.1002/ejoc.201300390. Read article.

]]> Photochemical and Thermal [2 + 2] Cycloaddition to Generate the Bicyclo[3.2.0]heptane Core of Bielschowskysin http://dx.doi.org/10.1002/ejoc.201300382 Jean-Baptiste Farcet, Martin Himmelbauer, Johann Mulzer 2013-06-07T05:39+05:00 Photochemical and Thermal [2 + 2] Cycloaddition to Generate the Bicyclo[3.2.0]heptane Core of Bielschowskysin

[Full Paper]
Jean-Baptiste Farcet, Martin Himmelbauer, Johann Mulzer
Eur. J. Org. Chem., Jun 07, 2013, DOI: 10.1002/ejoc.201300382. Read article.

]]> A Highly Regio- and Diastereoselective Phosphane-Catalyzed [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Cyclic <I>N</I>-Acyl Ketimines http://dx.doi.org/10.1002/ejoc.201300342 Li-Jun Yang, Hua Cai, Jing Nie, Jun-An Ma 2013-06-07T05:39+05:00 A Highly Regio- and Diastereoselective Phosphane-Catalyzed [3+2] Annulation of Morita–Baylis–Hillman Carbonates with Cyclic N-Acyl Ketimines

[Full Paper]
Li-Jun Yang, Hua Cai, Jing Nie, Jun-An Ma
Eur. J. Org. Chem., Jun 07, 2013, DOI: 10.1002/ejoc.201300342. Read article.

]]> Protocols for the Catalytic Oxidation of Primary Amines to Imines http://dx.doi.org/10.1002/ejoc.201300315 Martine Largeron 2013-06-07T05:39+05:00 Protocols for the Catalytic Oxidation of Primary Amines to Imines

[Microreview]
Martine Largeron
Eur. J. Org. Chem., Jun 07, 2013, DOI: 10.1002/ejoc.201300315. Read article.

]]> Regioselective 2-Imino-1,3-thiazolidine vs. 2-Imino-1,3-oxazolidine Formation from the Vicinal <I>sec</I>-Amino Alcohol of Desosamine http://dx.doi.org/10.1002/ejoc.201300266 Zorica Marušić Ištuk, Ines Vujasinović, Ana Čikoš, Goran Kragol 2013-06-07T05:39+05:00 Regioselective 2-Imino-1,3-thiazolidine vs. 2-Imino-1,3-oxazolidine Formation from the Vicinal sec-Amino Alcohol of Desosamine

[Full Paper]
Zorica Marušić Ištuk, Ines Vujasinović, Ana Čikoš, Goran Kragol
Eur. J. Org. Chem., Jun 07, 2013, DOI: 10.1002/ejoc.201300266. Read article.

]]> Concise Total Synthesis of Hydrazidomycin A, a Rare Hydrazide Metabolite of <I>Streptomyces atratus</I> http://dx.doi.org/10.1002/ejoc.201300532 Florian Meyer, Nico Ueberschaar, Christian Hertweck 2013-06-06T03:57+05:00 Concise Total Synthesis of Hydrazidomycin A, a Rare Hydrazide Metabolite of Streptomyces atratus

[Short Communication]
Florian Meyer, Nico Ueberschaar, Christian Hertweck
Eur. J. Org. Chem., Jun 06, 2013, DOI: 10.1002/ejoc.201300532. Read article.

]]> Synthesis of Substituted Oxazoles from <I>N</I>-Benzyl Propargyl Amines and Acid Chlorides http://dx.doi.org/10.1002/ejoc.201300285 Henrik v. Wachenfeldt, Filip Paulsen, Anders Sundin, Daniel Strand 2013-06-06T03:57+05:00 Synthesis of Substituted Oxazoles from N-Benzyl Propargyl Amines and Acid Chlorides

[Full Paper]
Henrik v. Wachenfeldt, Filip Paulsen, Anders Sundin, Daniel Strand
Eur. J. Org. Chem., Jun 06, 2013, DOI: 10.1002/ejoc.201300285. Read article.

]]> Silver-Catalyzed Highly Regioselective Phosphonation of Arenes Bearing Electron-Withdrawing Groups http://dx.doi.org/10.1002/ejoc.201300545 Xuerong Mao, Xiao Ma, Shuwei Zhang, Hongwen Hu, Chengjian Zhu, Yixiang Cheng 2013-06-05T05:54+05:00 Silver-Catalyzed Highly Regioselective Phosphonation of Arenes Bearing Electron-Withdrawing Groups

[Short Communication]
Xuerong Mao, Xiao Ma, Shuwei Zhang, Hongwen Hu, Chengjian Zhu, Yixiang Cheng
Eur. J. Org. Chem., Jun 05, 2013, DOI: 10.1002/ejoc.201300545. Read article.

]]> Tröger's Base Derived Phosphanes for Suzuki–Miyaura and Buchwald–Hartwig Cross-Coupling Reactions http://dx.doi.org/10.1002/ejoc.201300519 Raul Pereira, Ján Cvengroš 2013-06-05T05:54+05:00 Tröger's Base Derived Phosphanes for Suzuki–Miyaura and Buchwald–Hartwig Cross-Coupling Reactions

[Short Communication]
Raul Pereira, Ján Cvengroš
Eur. J. Org. Chem., Jun 05, 2013, DOI: 10.1002/ejoc.201300519. Read article.

]]> Selenium-Promoted Intramolecular Oxidative Amidation of 2-(Arylamino)acetophenones for the Synthesis of <I>N</I>-Arylisatins http://dx.doi.org/10.1002/ejoc.201300477 Yong Liu, Hui Chen, Xiong Hu, Wang Zhou, Guo-Jun Deng 2013-06-05T05:54+05:00 Selenium-Promoted Intramolecular Oxidative Amidation of 2-(Arylamino)acetophenones for the Synthesis of N-Arylisatins

[Short Communication]
Yong Liu, Hui Chen, Xiong Hu, Wang Zhou, Guo-Jun Deng
Eur. J. Org. Chem., Jun 05, 2013, DOI: 10.1002/ejoc.201300477. Read article.

]]> Highly Efficient Asymmetric Conjugate Hydrocyanation of Aromatic Enones by an Anionic Chiral Phosphate Catalyst http://dx.doi.org/10.1002/ejoc.201300406 Yao-Feng Wang, Wei Zeng, Muhammad Sohail, Jiyi Guo, Shaoxiang Wu, Fu-Xue Chen 2013-06-05T05:54+05:00 Highly Efficient Asymmetric Conjugate Hydrocyanation of Aromatic Enones by an Anionic Chiral Phosphate Catalyst

[Full Paper]
Yao-Feng Wang, Wei Zeng, Muhammad Sohail, Jiyi Guo, Shaoxiang Wu, Fu-Xue Chen
Eur. J. Org. Chem., Jun 05, 2013, DOI: 10.1002/ejoc.201300406. Read article.

]]> Calix[2]triazole[2]arenes; A Class of Hybrid Heterocalixarenes http://dx.doi.org/10.1002/ejoc.201300401 Jihee Cho, Seokwoo Lee, Soonho Hwang, Sang Hoon Kim, Jong Seung Kim, Sanghee Kim 2013-06-05T05:54+05:00 Calix[2]triazole[2]arenes; A Class of Hybrid Heterocalixarenes

[Full Paper]
Jihee Cho, Seokwoo Lee, Soonho Hwang, Sang Hoon Kim, Jong Seung Kim, Sanghee Kim
Eur. J. Org. Chem., Jun 05, 2013, DOI: 10.1002/ejoc.201300401. Read article.

]]> Magnetically Recoverable CuFe<sub>2</sub>O<sub>4</sub> Nanoparticles: Catalyzed Synthesis of Aryl Azides and 1,4-Diaryl-1,2,3-triazoles from Boronic Acids in Water http://dx.doi.org/10.1002/ejoc.201300343 A. Suresh Kumar, M. Amarnath Reddy, M. Knorn, O. Reiser, B. Sreedhar 2013-06-05T05:54+05:00 Magnetically Recoverable CuFe2O4 Nanoparticles: Catalyzed Synthesis of Aryl Azides and 1,4-Diaryl-1,2,3-triazoles from Boronic Acids in Water

[Full Paper]
A. Suresh Kumar, M. Amarnath Reddy, M. Knorn, O. Reiser, B. Sreedhar
Eur. J. Org. Chem., Jun 05, 2013, DOI: 10.1002/ejoc.201300343. Read article.

]]> Cu(OTf)<sub>2</sub>-Catalyzed Dehydrogenative C–H Activation under Atmospheric Oxygen: An Expedient Approach to Pyrrolo[3,2-<I>d</I>]pyrimidine Derivatives http://dx.doi.org/10.1002/ejoc.201300275 B. Roy, Somjit Hazra, Biplab Mondal, K. C. Majumdar 2013-06-05T05:54+05:00 Cu(OTf)2-Catalyzed Dehydrogenative C–H Activation under Atmospheric Oxygen: An Expedient Approach to Pyrrolo[3,2-d]pyrimidine Derivatives

[Full Paper]
B. Roy, Somjit Hazra, Biplab Mondal, K. C. Majumdar
Eur. J. Org. Chem., Jun 05, 2013, DOI: 10.1002/ejoc.201300275. Read article.

]]> Improvement in the One-Carbon Chain Extension of Esters with Dimethylsulfoxonium Methylide http://dx.doi.org/10.1002/ejoc.201300526 Hoa Luong, Eduard Luss-Lusis, Gerald J. Tanoury, William A. Nugent 2013-06-05T05:53+05:00 Improvement in the One-Carbon Chain Extension of Esters with Dimethylsulfoxonium Methylide

[Short Communication]
Hoa Luong, Eduard Luss-Lusis, Gerald J. Tanoury, William A. Nugent
Eur. J. Org. Chem., Jun 05, 2013, DOI: 10.1002/ejoc.201300526. Read article.

]]> Subtle Steric Effects in Nickel-Catalysed Kumada–Tamao–Corriu Cross-Coupling Using Resorcinarenyl-Imidazolium Salts http://dx.doi.org/10.1002/ejoc.201300347 Neslihan Şahin, David Sémeril, Eric Brenner, Dominique Matt, Ismail Özdemir, Cemal Kaya, Loïc Toupet 2013-06-04T08:33+05:00 Subtle Steric Effects in Nickel-Catalysed Kumada–Tamao–Corriu Cross-Coupling Using Resorcinarenyl-Imidazolium Salts

[Full Paper]
Neslihan Şahin, David Sémeril, Eric Brenner, Dominique Matt, Ismail Özdemir, Cemal Kaya, Loïc Toupet
Eur. J. Org. Chem., Jun 04, 2013, DOI: 10.1002/ejoc.201300347. Read article.

]]> Towards the Total Synthesis of Marineosin A: Construction of the Macrocyclic Pyrrole and an Advanced, Functionalized Spiroaminal Model http://dx.doi.org/10.1002/ejoc.201300643 Leslie N. Aldrich, Cynthia B. Berry, Brittney S. Bates, Leah C. Konkol, Miranda So, Craig W. Lindsley 2013-06-04T08:32+05:00 Towards the Total Synthesis of Marineosin A: Construction of the Macrocyclic Pyrrole and an Advanced, Functionalized Spiroaminal Model

[Short Communication]
Leslie N. Aldrich, Cynthia B. Berry, Brittney S. Bates, Leah C. Konkol, Miranda So, Craig W. Lindsley
Eur. J. Org. Chem., Jun 04, 2013, DOI: 10.1002/ejoc.201300643. Read article.

]]> Chymotrypsin-Catalyzed Peptide Synthesis in Deep Eutectic Solvents http://dx.doi.org/10.1002/ejoc.201300448 Zaira Maugeri, Walter Leitner, Pablo Domínguez de María 2013-06-04T08:32+05:00 Chymotrypsin-Catalyzed Peptide Synthesis in Deep Eutectic Solvents

[Short Communication]
Zaira Maugeri, Walter Leitner, Pablo Domínguez de María
Eur. J. Org. Chem., Jun 04, 2013, DOI: 10.1002/ejoc.201300448. Read article.

]]> Straightforward Approach to Ferrocenyl Amino Acids and Peptides by Allylic Alkylation http://dx.doi.org/10.1002/ejoc.201300346 Jan Gorges, Angelika Ullrich, Uli Kazmaier 2013-06-03T10:15+05:00 Straightforward Approach to Ferrocenyl Amino Acids and Peptides by Allylic Alkylation

[Full Paper]
Jan Gorges, Angelika Ullrich, Uli Kazmaier
Eur. J. Org. Chem., Jun 03, 2013, DOI: 10.1002/ejoc.201300346. Read article.

]]> Synthesis and Two-Photon Absorption Properties of Symmetrical Chromophores Derived from 2,3,5-Trisubstituted Quinoxaline Units http://dx.doi.org/10.1002/ejoc.201300345 Tzu-Chau Lin, Wei Chien, Che-Yu Liu, Ming-Yu Tsai, Yu-Jheng Huang 2013-06-03T09:26+05:00 Synthesis and Two-Photon Absorption Properties of Symmetrical Chromophores Derived from 2,3,5-Trisubstituted Quinoxaline Units

[Full Paper]
Tzu-Chau Lin, Wei Chien, Che-Yu Liu, Ming-Yu Tsai, Yu-Jheng Huang
Eur. J. Org. Chem., Jun 03, 2013, DOI: 10.1002/ejoc.201300345. Read article.

]]> Efficient Consecutive Four-Component Synthesis of 5-Acylpyrid-2-ones Initiated by Copper-Free Alkynylation http://dx.doi.org/10.1002/ejoc.201300235 Jan Nordmann, Natascha Breuer, Thomas J. J. Müller 2013-05-29T06:53+05:00 Efficient Consecutive Four-Component Synthesis of 5-Acylpyrid-2-ones Initiated by Copper-Free Alkynylation

[Full Paper]
Jan Nordmann, Natascha Breuer, Thomas J. J. Müller
Eur. J. Org. Chem., May 29, 2013, DOI: 10.1002/ejoc.201300235. Read article.

]]> A New Life for an Old Reagent: Fluoroalkyl Amino Reagents as Efficient Tools for the Synthesis of Diversely Fluorinated Pyrazoles http://dx.doi.org/10.1002/ejoc.201300561 Sergiy Pazenok, Florence Giornal, Grégory Landelle, Norbert Lui, Jean-Pierre Vors, Frédéric R. Leroux 2013-05-28T06:41+05:00 A New Life for an Old Reagent: Fluoroalkyl Amino Reagents as Efficient Tools for the Synthesis of Diversely Fluorinated Pyrazoles

[Short Communication]
Sergiy Pazenok, Florence Giornal, Grégory Landelle, Norbert Lui, Jean-Pierre Vors, Frédéric R. Leroux
Eur. J. Org. Chem., May 28, 2013, DOI: 10.1002/ejoc.201300561. Read article.

]]> Tandem Iminium/Copper Catalysis: Highly Enantioselective Synthesis of α,β-Disubstituted Aldehydes http://dx.doi.org/10.1002/ejoc.201300333 Ju-Hye Kim, Eun-Jin Park, Hwa-Jung Lee, Xuan-Huong Ho, Hyo-Sang Yoon, Pilsoo Kim, Hoseop Yun, Hye-Young Jang 2013-05-27T02:27+05:00 Tandem Iminium/Copper Catalysis: Highly Enantioselective Synthesis of α,β-Disubstituted Aldehydes

[Full Paper]
Ju-Hye Kim, Eun-Jin Park, Hwa-Jung Lee, Xuan-Huong Ho, Hyo-Sang Yoon, Pilsoo Kim, Hoseop Yun, Hye-Young Jang
Eur. J. Org. Chem., May 27, 2013, DOI: 10.1002/ejoc.201300333. Read article.

]]> Supramolecular Chemistry of Protoporphyrin IX and Its Derivatives http://dx.doi.org/10.1002/ejoc.201300240 Sheshanath V. Bhosale, Sidhanath V. Bhosale, Ganesh V. Shitre, Sharad R. Bobe, Akhil Gupta 2013-05-27T02:27+05:00 Supramolecular Chemistry of Protoporphyrin IX and Its Derivatives

[Microreview]
Sheshanath V. Bhosale, Sidhanath V. Bhosale, Ganesh V. Shitre, Sharad R. Bobe, Akhil Gupta
Eur. J. Org. Chem., May 27, 2013, DOI: 10.1002/ejoc.201300240. Read article.

]]> The Reactivity of Arylphosphorus Acid Amides Under Birch Reduction Conditions http://dx.doi.org/10.1002/ejoc.201300344 Marek Stankevič, Adam Włodarczyk, Damian Nieckarz 2013-05-24T07:28+05:00 The Reactivity of Arylphosphorus Acid Amides Under Birch Reduction Conditions

[Full Paper]
Marek Stankevič, Adam Włodarczyk, Damian Nieckarz
Eur. J. Org. Chem., May 24, 2013, DOI: 10.1002/ejoc.201300344. Read article.

]]> Quantification of the Nucleophilic Reactivities of Ethyl Arylacetate Anions http://dx.doi.org/10.1002/ejoc.201300265 Francisco Corral-Bautista, Herbert Mayr 2013-05-24T07:28+05:00 Quantification of the Nucleophilic Reactivities of Ethyl Arylacetate Anions

[Full Paper]
Francisco Corral-Bautista, Herbert Mayr
Eur. J. Org. Chem., May 24, 2013, DOI: 10.1002/ejoc.201300265. Read article.

]]> BODIPY Dyes Functionalized with Pendant Cyclic and Acyclic Polyamines http://dx.doi.org/10.1002/ejoc.201300414 Yulia A. Volkova, Bertrand Brizet, Pierre D. Harvey, Alexey D. Averin, Christine Goze, Franck Denat 2013-05-23T12:03+05:00 BODIPY Dyes Functionalized with Pendant Cyclic and Acyclic Polyamines

[Full Paper]
Yulia A. Volkova, Bertrand Brizet, Pierre D. Harvey, Alexey D. Averin, Christine Goze, Franck Denat
Eur. J. Org. Chem., May 23, 2013, DOI: 10.1002/ejoc.201300414. Read article.

]]> 1,2-Asymmetric Induction in Diastereoselective Zwitterionic Aza-Claisen Rearrangements: Key Steps in Optically Active Alkaloid Synthesis http://dx.doi.org/10.1002/ejoc.201300389 Carolin Heescher, Dieter Schollmeyer, Udo Nubbemeyer 2013-05-23T12:03+05:00 1,2-Asymmetric Induction in Diastereoselective Zwitterionic Aza-Claisen Rearrangements: Key Steps in Optically Active Alkaloid Synthesis

[Full Paper]
Carolin Heescher, Dieter Schollmeyer, Udo Nubbemeyer
Eur. J. Org. Chem., May 23, 2013, DOI: 10.1002/ejoc.201300389. Read article.

]]> A Concise and Efficient Total Synthesis of Oleocanthal http://dx.doi.org/10.1002/ejoc.201300324 Matteo Valli, Elena Giulia Peviani, Alessio Porta, Alessandro D'Alfonso, Giuseppe Zanoni, Giovanni Vidari 2013-05-23T12:03+05:00 A Concise and Efficient Total Synthesis of Oleocanthal

[Full Paper]
Matteo Valli, Elena Giulia Peviani, Alessio Porta, Alessandro D'Alfonso, Giuseppe Zanoni, Giovanni Vidari
Eur. J. Org. Chem., May 23, 2013, DOI: 10.1002/ejoc.201300324. Read article.

]]> Amide Formation Using In Situ Activation of Carboxylic Acids with [Et<sub>2</sub>NSF<sub>2</sub>]BF<sub>4</sub> http://dx.doi.org/10.1002/ejoc.201300289 Olivier Mahé, Justine Desroches, Jean-François Paquin 2013-05-23T12:03+05:00 Amide Formation Using In Situ Activation of Carboxylic Acids with [Et2NSF2]BF4

[Full Paper]
Olivier Mahé, Justine Desroches, Jean-François Paquin
Eur. J. Org. Chem., May 23, 2013, DOI: 10.1002/ejoc.201300289. Read article.

]]> Palladium-Catalyzed Ring-Opening Alkynylation of Cyclopropenones http://dx.doi.org/10.1002/ejoc.201300220 Takanori Matsuda, Yusuke Sakurai 2013-05-23T12:03+05:00 Palladium-Catalyzed Ring-Opening Alkynylation of Cyclopropenones

[Short Communication]
Takanori Matsuda, Yusuke Sakurai
Eur. J. Org. Chem., May 23, 2013, DOI: 10.1002/ejoc.201300220. Read article.

]]> Enantioselective Synthesis of Myrtucommulone A http://dx.doi.org/10.1002/ejoc.201300179 Maël Charpentier, Marcus Hans, Johann Jauch 2013-05-23T12:03+05:00 Enantioselective Synthesis of Myrtucommulone A

[Full Paper]
Maël Charpentier, Marcus Hans, Johann Jauch
Eur. J. Org. Chem., May 23, 2013, DOI: 10.1002/ejoc.201300179. Read article.

]]> Synthesis of Unsaturated Diesters of Primary, Secondary and Tertiary Diols Derived from Dimethyl (+)-Tartrate and Galactaric Acid http://dx.doi.org/10.1002/ejoc.201300130 Jimena Scoccia, Darío C. Gerbino, Victor F. Terraza, Adriana E. Zúñiga, Julio C. Podestá 2013-05-23T12:03+05:00 Synthesis of Unsaturated Diesters of Primary, Secondary and Tertiary Diols Derived from Dimethyl (+)-Tartrate and Galactaric Acid

[Full Paper]
Jimena Scoccia, Darío C. Gerbino, Victor F. Terraza, Adriana E. Zúñiga, Julio C. Podestá
Eur. J. Org. Chem., May 23, 2013, DOI: 10.1002/ejoc.201300130. Read article.

]]> Diastereoselective Synthesis of Isoindole-Fused Diazacyclooctaindenones from Spirochromenes through Domino Reactions with Aliphatic 1,2-Diamines http://dx.doi.org/10.1002/ejoc.201300096 Sudipta Pathak, Animesh Pramanik 2013-05-23T12:03+05:00 Diastereoselective Synthesis of Isoindole-Fused Diazacyclooctaindenones from Spirochromenes through Domino Reactions with Aliphatic 1,2-Diamines

[Full Paper]
Sudipta Pathak, Animesh Pramanik
Eur. J. Org. Chem., May 23, 2013, DOI: 10.1002/ejoc.201300096. Read article.

]]> Synthesis of 6<I>H</I>-Isoindolo[2,1-<I>a</I>]indol-6-ones Through Wittig Reaction and Tandem Reductive Cyclization–Lactamization http://dx.doi.org/10.1002/ejoc.201300047 Hari K. Kadam, Santosh G. Tilve 2013-05-23T12:03+05:00 Synthesis of 6H-Isoindolo[2,1-a]indol-6-ones Through Wittig Reaction and Tandem Reductive Cyclization–Lactamization

[Full Paper]
Hari K. Kadam, Santosh G. Tilve
Eur. J. Org. Chem., May 23, 2013, DOI: 10.1002/ejoc.201300047. Read article.

]]> Metal-Free Dioxygenation of Enecarbamates Mediated by a Hypervalent Iodine Reagent http://dx.doi.org/10.1002/ejoc.201300501 Mathieu Bekkaye, Yingpeng Su, Géraldine Masson 2013-05-21T05:29+05:00 Metal-Free Dioxygenation of Enecarbamates Mediated by a Hypervalent Iodine Reagent

[Short Communication]
Mathieu Bekkaye, Yingpeng Su, Géraldine Masson
Eur. J. Org. Chem., May 21, 2013, DOI: 10.1002/ejoc.201300501. Read article.

]]> A Modular Approach to Build Macrocyclic Diversity<I> </I>in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay http://dx.doi.org/10.1002/ejoc.201300409 Srinivas Chamakuri, Shiva Krishna Reddy Guduru, Sreedhar Pamu, Gayathri Chandrasekar, Satish Srinivas Kitambi, Prabhat Arya 2013-05-21T05:29+05:00 A Modular Approach to Build Macrocyclic Diversity in Aminoindoline Scaffolds Identifies Antiangiogenesis Agents from a Zebrafish Assay

[Short Communication]
Srinivas Chamakuri, Shiva Krishna Reddy Guduru, Sreedhar Pamu, Gayathri Chandrasekar, Satish Srinivas Kitambi, Prabhat Arya
Eur. J. Org. Chem., May 21, 2013, DOI: 10.1002/ejoc.201300409. Read article.

]]> An Intramolecular Heck Approach To Obtain 17-Membered Macrocyclic Diversity and the Identification of an Antiangiogenesis Agent from a Zebrafish Assay http://dx.doi.org/10.1002/ejoc.201300408 Madhu Aeluri, Jagan Gaddam, Devarakonda V. K. S. Trinath, Gayathri Chandrasekar, Satish Srinivas Kitambi, Prabhat Arya 2013-05-21T05:29+05:00 An Intramolecular Heck Approach To Obtain 17-Membered Macrocyclic Diversity and the Identification of an Antiangiogenesis Agent from a Zebrafish Assay

[Short Communication]
Madhu Aeluri, Jagan Gaddam, Devarakonda V. K. S. Trinath, Gayathri Chandrasekar, Satish Srinivas Kitambi, Prabhat Arya
Eur. J. Org. Chem., May 21, 2013, DOI: 10.1002/ejoc.201300408. Read article.

]]> Synthesis of Alkyl-Ynol-Ethers by “Anti-Michael Addition” of Metal Alkoxides to β-Substituted Alkynylsulfones http://dx.doi.org/10.1002/ejoc.201300395 Leyre Marzo, Alejandro Parra, María Frías, José Alemán, José Luis García Ruano 2013-05-21T05:29+05:00 Synthesis of Alkyl-Ynol-Ethers by “Anti-Michael Addition” of Metal Alkoxides to β-Substituted Alkynylsulfones

[Full Paper]
Leyre Marzo, Alejandro Parra, María Frías, José Alemán, José Luis García Ruano
Eur. J. Org. Chem., May 21, 2013, DOI: 10.1002/ejoc.201300395. Read article.

]]> Organic and Organometallic Derivatives of Propargylallene: Syntheses, Structures, Reactivity and Rearrangements http://dx.doi.org/10.1002/ejoc.201300250 Michael J. McGlinchey, Henning Hopf 2013-05-21T05:29+05:00 Organic and Organometallic Derivatives of Propargylallene: Syntheses, Structures, Reactivity and Rearrangements

[Microreview]
Michael J. McGlinchey, Henning Hopf
Eur. J. Org. Chem., May 21, 2013, DOI: 10.1002/ejoc.201300250. Read article.

]]> Optically Active Monoacylglycerols: Synthesis and Assessment of Purity http://dx.doi.org/10.1002/ejoc.201300247 Chao-Yuan Chen, Wei-Bo Han, Hui-Jun Chen, Yikang Wu, Po Gao 2013-05-21T05:29+05:00 Optically Active Monoacylglycerols: Synthesis and Assessment of Purity

[Full Paper]
Chao-Yuan Chen, Wei-Bo Han, Hui-Jun Chen, Yikang Wu, Po Gao
Eur. J. Org. Chem., May 21, 2013, DOI: 10.1002/ejoc.201300247. Read article.

]]> Bile Acid Derived <I>Tropos Vaulted</I> Binaphthylphosphites: Synthesis, Stereochemical Characterization and Complexation to Rhodium http://dx.doi.org/10.1002/ejoc.201300024 Varsha R. Jumde, Anna Iuliano 2013-05-21T05:29+05:00 Bile Acid Derived Tropos Vaulted Binaphthylphosphites: Synthesis, Stereochemical Characterization and Complexation to Rhodium

[Full Paper]
Varsha R. Jumde, Anna Iuliano
Eur. J. Org. Chem., May 21, 2013, DOI: 10.1002/ejoc.201300024. Read article.

]]> Synthetic Access to Hydrogen and Halogen Derivatives of 3-Amino-4-nitrothiophenes http://dx.doi.org/10.1002/ejoc.201300006 Eva-Janina Vogt, Viktor A. Zapol'skii, Eva Nutz, Dieter E. Kaufmann 2013-05-21T05:29+05:00 Synthetic Access to Hydrogen and Halogen Derivatives of 3-Amino-4-nitrothiophenes

[Full Paper]
Eva-Janina Vogt, Viktor A. Zapol'skii, Eva Nutz, Dieter E. Kaufmann
Eur. J. Org. Chem., May 21, 2013, DOI: 10.1002/ejoc.201300006. Read article.

]]> Potassium (1-Organo-1<I>H</I>-1,2,3-triazol-4-yl)trifluoroborates from Ethynyltrifluoroborate through a Regioselective One-Pot Cu-Catalyzed Azide–Alkyne Cycloaddition Reaction http://dx.doi.org/10.1002/ejoc.201300365 Taejung Kim, Jung Ho Song, Kyu Hyuk Jeong, Seokjoon Lee, Jungyeob Ham 2013-05-17T07:27+05:00 Potassium (1-Organo-1H-1,2,3-triazol-4-yl)trifluoroborates from Ethynyltrifluoroborate through a Regioselective One-Pot Cu-Catalyzed Azide–Alkyne Cycloaddition Reaction

[Short Communication]
Taejung Kim, Jung Ho Song, Kyu Hyuk Jeong, Seokjoon Lee, Jungyeob Ham
Eur. J. Org. Chem., May 17, 2013, DOI: 10.1002/ejoc.201300365. Read article.

]]> A Facile Synthesis of 4,6,7,8,8<I>a</I>,9-Hexahydropyrrolo[1,2-<I>a</I>][1,2,3]triazolo[1,5-<I>d</I>]pyrazines by a Three-Component Coupling Reaction Followed by Intramolecular 1,3-Dipolar Cycloaddition http://dx.doi.org/10.1002/ejoc.201300226 Attrimuni P. Dhondge, Shakil N. Afraj, Cut Nuzlia, Chinpiao Chen, Gene-Hsian Lee 2013-05-17T07:27+05:00 A Facile Synthesis of 4,6,7,8,8a,9-Hexahydropyrrolo[1,2-a][1,2,3]triazolo[1,5-d]pyrazines by a Three-Component Coupling Reaction Followed by Intramolecular 1,3-Dipolar Cycloaddition

[Full Paper]
Attrimuni P. Dhondge, Shakil N. Afraj, Cut Nuzlia, Chinpiao Chen, Gene-Hsian Lee
Eur. J. Org. Chem., May 17, 2013, DOI: 10.1002/ejoc.201300226. Read article.

]]> Catalytic Enantioconvergent Decarboxylative Allylic Alkylation of Allyl Indolenin-3-carboxylates http://dx.doi.org/10.1002/ejoc.201300515 Thomas M. Kaiser, Jiong Yang 2013-05-16T05:54+05:00 Catalytic Enantioconvergent Decarboxylative Allylic Alkylation of Allyl Indolenin-3-carboxylates

[Short Communication]
Thomas M. Kaiser, Jiong Yang
Eur. J. Org. Chem., May 16, 2013, DOI: 10.1002/ejoc.201300515. Read article.

]]> Sequential [3+2] Cycloaddition/Air Oxidation Reactions: Triazoloyl Ion Assisted Oxidative Cleavage of Alkynes http://dx.doi.org/10.1002/ejoc.201300441 Thanasekaran Ponpandian, Shanmugam Muthusubramanian, Sridharan Rajagopal 2013-05-16T05:54+05:00 Sequential [3+2] Cycloaddition/Air Oxidation Reactions: Triazoloyl Ion Assisted Oxidative Cleavage of Alkynes

[Short Communication]
Thanasekaran Ponpandian, Shanmugam Muthusubramanian, Sridharan Rajagopal
Eur. J. Org. Chem., May 16, 2013, DOI: 10.1002/ejoc.201300441. Read article.

]]> Access to Imidazo[1,2-<I>a</I>]imidazolin-2-ones and Functionalization through Suzuki–Miyaura Cross-Coupling Reactions http://dx.doi.org/10.1002/ejoc.201300268 Sandrine Grosse, Christelle Pillard, Franck Himbert, Stéphane Massip, Jean Michel Léger, Christian Jarry, Philippe Bernard, Gérald Guillaumet 2013-05-16T05:54+05:00 Access to Imidazo[1,2-a]imidazolin-2-ones and Functionalization through Suzuki–Miyaura Cross-Coupling Reactions

[Full Paper]
Sandrine Grosse, Christelle Pillard, Franck Himbert, Stéphane Massip, Jean Michel Léger, Christian Jarry, Philippe Bernard, Gérald Guillaumet
Eur. J. Org. Chem., May 16, 2013, DOI: 10.1002/ejoc.201300268. Read article.

]]> Scalable Synthesis of Enantiomerically Pure <I>cis</I>-1,2-Cyclohexanediamine Derivatives and Conformationally Rigid 7-Azabicyclo[2.2.1]heptan-2-amines http://dx.doi.org/10.1002/ejoc.201300253 Ganesh Pandey, Debasis Dey, Rushil Fernandes 2013-05-16T05:54+05:00 Scalable Synthesis of Enantiomerically Pure cis-1,2-Cyclohexanediamine Derivatives and Conformationally Rigid 7-Azabicyclo[2.2.1]heptan-2-amines

[Full Paper]
Ganesh Pandey, Debasis Dey, Rushil Fernandes
Eur. J. Org. Chem., May 16, 2013, DOI: 10.1002/ejoc.201300253. Read article.

]]> Following the Lead from Nature: Divergent Pathways in Natural Product Synthesis and Diversity-Oriented Synthesis http://dx.doi.org/10.1002/ejoc.201300201 Christelle Serba, Nicolas Winssinger 2013-05-16T05:54+05:00 Following the Lead from Nature: Divergent Pathways in Natural Product Synthesis and Diversity-Oriented Synthesis

[Microreview]
Christelle Serba, Nicolas Winssinger
Eur. J. Org. Chem., May 16, 2013, DOI: 10.1002/ejoc.201300201. Read article.

]]> One-Pot Three-Component Heteroannulation of β-Oxo Dithioesters, Amines and Hydroxylamine: Regioselective, Facile and Straightforward Entry to 5-Substituted 3-Aminoisoxazoles http://dx.doi.org/10.1002/ejoc.201300038 Subhasis Samai, Tanmoy Chanda, Hiriyakkanavar Ila, Maya Shankar Singh 2013-05-16T05:54+05:00 One-Pot Three-Component Heteroannulation of β-Oxo Dithioesters, Amines and Hydroxylamine: Regioselective, Facile and Straightforward Entry to 5-Substituted 3-Aminoisoxazoles

[Full Paper]
Subhasis Samai, Tanmoy Chanda, Hiriyakkanavar Ila, Maya Shankar Singh
Eur. J. Org. Chem., May 16, 2013, DOI: 10.1002/ejoc.201300038. Read article.

]]> Syntheses of Hydrazino Peptides and Conjugates http://dx.doi.org/10.1002/ejoc.201201731 Siva S. Panda, Claudia El-Nachef, Kiran Bajaj, Alan R. Katritzky 2013-05-16T05:54+05:00 Syntheses of Hydrazino Peptides and Conjugates

[Full Paper]
Siva S. Panda, Claudia El-Nachef, Kiran Bajaj, Alan R. Katritzky
Eur. J. Org. Chem., May 16, 2013, DOI: 10.1002/ejoc.201201731. Read article.

]]> Short Synthetic Route to Benzaldehyde-Functionalized Idose and Talose Derivatives by Acetoxonium Ion Rearrangements http://dx.doi.org/10.1002/ejoc.201201648 Sebastian Kopitzki, Joachim Thiem 2013-05-15T09:29+05:00 Short Synthetic Route to Benzaldehyde-Functionalized Idose and Talose Derivatives by Acetoxonium Ion Rearrangements

[Full Paper]
Sebastian Kopitzki, Joachim Thiem
Eur. J. Org. Chem., May 15, 2013, DOI: 10.1002/ejoc.201201648. Read article.

]]> Metal-Free Michael-Addition-Initiated Three-Component Reaction for the Regioselective Synthesis of Highly Functionalized Pyridines: Scope, Mechanistic Investigations and Applications http://dx.doi.org/10.1002/ejoc.201300246 Christophe Allais, Frédéric Liéby-Muller, Jean Rodriguez, Thierry Constantieux 2013-05-15T08:28+05:00 Metal-Free Michael-Addition-Initiated Three-Component Reaction for the Regioselective Synthesis of Highly Functionalized Pyridines: Scope, Mechanistic Investigations and Applications

[Full Paper]
Christophe Allais, Frédéric Liéby-Muller, Jean Rodriguez, Thierry Constantieux
Eur. J. Org. Chem., May 15, 2013, DOI: 10.1002/ejoc.201300246. Read article.

]]> Cuprate Addition to a 6-Substituted Pentafulvene – Preparation of <I>sec</I>-Alkyl-Substituted Titanocene Dichlorides and Their Biological Activity http://dx.doi.org/10.1002/ejoc.201300474 Melchior Cini, Tracey D. Bradshaw, William Lewis, Simon Woodward 2013-05-15T08:27+05:00 Cuprate Addition to a 6-Substituted Pentafulvene – Preparation of sec-Alkyl-Substituted Titanocene Dichlorides and Their Biological Activity

[Full Paper]
Melchior Cini, Tracey D. Bradshaw, William Lewis, Simon Woodward
Eur. J. Org. Chem., May 15, 2013, DOI: 10.1002/ejoc.201300474. Read article.

]]> A Route to 2-Alkenyl-3-(<I>tert</I>-butyldiphenylsilyl)amines and Application to the Construction of a Tricyclic Ring System http://dx.doi.org/10.1002/ejoc.201300319 Veejendra K. Yadav, Bharat D. Narhe, Kamlesh Kumar, Vijaykumar Hulikal 2013-05-15T08:27+05:00 A Route to 2-Alkenyl-3-(tert-butyldiphenylsilyl)amines and Application to the Construction of a Tricyclic Ring System

[Full Paper]
Veejendra K. Yadav, Bharat D. Narhe, Kamlesh Kumar, Vijaykumar Hulikal
Eur. J. Org. Chem., May 15, 2013, DOI: 10.1002/ejoc.201300319. Read article.

]]> Synthesis of 3-Azabicyclo[3.2.0]heptane Derivatives as γ-Aminobutyric Acid Analogues through Intermolecular [2+2] Photocycloaddition http://dx.doi.org/10.1002/ejoc.201201723 Susanne Petz, Klaus T. Wanner 2013-05-14T05:59+05:00 Synthesis of 3-Azabicyclo[3.2.0]heptane Derivatives as γ-Aminobutyric Acid Analogues through Intermolecular [2+2] Photocycloaddition

[Full Paper]
Susanne Petz, Klaus T. Wanner
Eur. J. Org. Chem., May 14, 2013, DOI: 10.1002/ejoc.201201723. Read article.

]]> A Mild Method for Regioselective Labeling of Aromatics with Radioactive Iodine http://dx.doi.org/10.1002/ejoc.201300419 Mads H. Rønnest, Felix Nissen, Palle J. Pedersen, Thomas O. Larsen, Walter Mier, Mads H. Clausen 2013-05-14T05:58+05:00 A Mild Method for Regioselective Labeling of Aromatics with Radioactive Iodine

[Short Communication]
Mads H. Rønnest, Felix Nissen, Palle J. Pedersen, Thomas O. Larsen, Walter Mier, Mads H. Clausen
Eur. J. Org. Chem., May 14, 2013, DOI: 10.1002/ejoc.201300419. Read article.

]]> The Disubstitution of Acetals to Prepare δ,δ-Bis(aryl) β-Keto Esters http://dx.doi.org/10.1002/ejoc.201300446 Daniel L. Priebbenow, Liang-Hua Zou, Peter Becker, Carsten Bolm 2013-05-13T07:27+05:00 The Disubstitution of Acetals to Prepare δ,δ-Bis(aryl) β-Keto Esters

[Short Communication]
Daniel L. Priebbenow, Liang-Hua Zou, Peter Becker, Carsten Bolm
Eur. J. Org. Chem., May 13, 2013, DOI: 10.1002/ejoc.201300446. Read article.

]]> Application of the 2-Nitrobenzyl Group in Glycosylation Reactions: A Valuable Example of an Arming Participating Group http://dx.doi.org/10.1002/ejoc.201300123 Szymon Buda, Patrycja Gołębiowska, Jacek Mlynarski 2013-05-13T07:27+05:00 Application of the 2-Nitrobenzyl Group in Glycosylation Reactions: A Valuable Example of an Arming Participating Group

[Short Communication]
Szymon Buda, Patrycja Gołębiowska, Jacek Mlynarski
Eur. J. Org. Chem., May 13, 2013, DOI: 10.1002/ejoc.201300123. Read article.

]]> Synthesis and Optical Properties of Difluorobora-<I>s</I>-diazaindacene Dyes with Trifluoromethyl <I>meso-</I>Substituents http://dx.doi.org/10.1002/ejoc.201300212 Lyubov N. Sobenina, Olga V. Petrova, Konstantin B. Petrushenko, Igor A. Ushakov, Albina I. Mikhaleva, Rachel Meallet-Renault, Boris A. Trofimov 2013-05-10T12:40+05:00 Synthesis and Optical Properties of Difluorobora-s-diazaindacene Dyes with Trifluoromethyl meso-Substituents

[Full Paper]
Lyubov N. Sobenina, Olga V. Petrova, Konstantin B. Petrushenko, Igor A. Ushakov, Albina I. Mikhaleva, Rachel Meallet-Renault, Boris A. Trofimov
Eur. J. Org. Chem., May 10, 2013, DOI: 10.1002/ejoc.201300212. Read article.

]]> Structural Studies of the <I>O</I>-Acetyl-Containing O-Antigen from a <I>Shigella flexneri</I> Serotype 6 Strain and Synthesis of Oligosaccharide Fragments Thereof http://dx.doi.org/10.1002/ejoc.201300180 Pierre Chassagne, Carolina Fontana, Catherine Guerreiro, Charles Gauthier, Armelle Phalipon, Göran Widmalm, Laurence A. Mulard 2013-05-08T07:13+05:00 Structural Studies of the O-Acetyl-Containing O-Antigen from a Shigella flexneri Serotype 6 Strain and Synthesis of Oligosaccharide Fragments Thereof

[Full Paper]
Pierre Chassagne, Carolina Fontana, Catherine Guerreiro, Charles Gauthier, Armelle Phalipon, Göran Widmalm, Laurence A. Mulard
Eur. J. Org. Chem., May 08, 2013, DOI: 10.1002/ejoc.201300180. Read article.

]]> Total Synthesis of Neo-Tanshinlactones through a Cascade Benzannulation-Lactonization as the Key Step http://dx.doi.org/10.1002/ejoc.201300102 Ketaki Ghosh, Raju Karmakar, Dipakranjan Mal 2013-05-08T07:13+05:00 Total Synthesis of Neo-Tanshinlactones through a Cascade Benzannulation-Lactonization as the Key Step

[Full Paper]
Ketaki Ghosh, Raju Karmakar, Dipakranjan Mal
Eur. J. Org. Chem., May 08, 2013, DOI: 10.1002/ejoc.201300102. Read article.

]]> A Simple Synthetic Access to Differently 4-Substituted Neu5Ac2en Glycals Combining Elements of Molecules with Anti-Neuraminidase Activity http://dx.doi.org/10.1002/ejoc.201300154 Pietro Allevi, Paola Rota, Irene Sofia Agnolin, Antonio Gregorio, Mario Anastasia 2013-05-07T02:57+05:00 A Simple Synthetic Access to Differently 4-Substituted Neu5Ac2en Glycals Combining Elements of Molecules with Anti-Neuraminidase Activity

[Full Paper]
Pietro Allevi, Paola Rota, Irene Sofia Agnolin, Antonio Gregorio, Mario Anastasia
Eur. J. Org. Chem., May 07, 2013, DOI: 10.1002/ejoc.201300154. Read article.

]]> Chemoenzymatic Asymmetric Synthesis of Serotonin Receptor Agonist (<I>R</I>)-Frovatriptan http://dx.doi.org/10.1002/ejoc.201300114 Eduardo Busto, Lía Martínez-Montero, Vicente Gotor, Vicente Gotor-Fernández 2013-05-07T02:57+05:00 Chemoenzymatic Asymmetric Synthesis of Serotonin Receptor Agonist (R)-Frovatriptan

[Full Paper]
Eduardo Busto, Lía Martínez-Montero, Vicente Gotor, Vicente Gotor-Fernández
Eur. J. Org. Chem., May 07, 2013, DOI: 10.1002/ejoc.201300114. Read article.

]]> Synthesis and Glycosidase Inhibition Studies of 5-Methyl-Substituted Tetrahydroxyindolizidines and -pyrrolizidines Related to Natural Hyacinthacines B http://dx.doi.org/10.1002/ejoc.201300103 Daniele Martella, Francesca Cardona, Camilla Parmeggiani, Francisco Franco, Juan A. Tamayo, Inmaculada Robina, Elena Moreno-Clavijo, Antonio J. Moreno-Vargas, Andrea Goti 2013-05-06T06:27+05:00 Synthesis and Glycosidase Inhibition Studies of 5-Methyl-Substituted Tetrahydroxyindolizidines and -pyrrolizidines Related to Natural Hyacinthacines B

[Full Paper]
Daniele Martella, Francesca Cardona, Camilla Parmeggiani, Francisco Franco, Juan A. Tamayo, Inmaculada Robina, Elena Moreno-Clavijo, Antonio J. Moreno-Vargas, Andrea Goti
Eur. J. Org. Chem., May 06, 2013, DOI: 10.1002/ejoc.201300103. Read article.

]]> Copper-Mediated Cyanation of Aryl Halides by Activation of Benzyl Cyanide as the Cyanide Source http://dx.doi.org/10.1002/ejoc.201300052 Qiaodong Wen, Jisong Jin, Yuncai Mei, Ping Lu, Yanguang Wang 2013-05-06T06:27+05:00 Copper-Mediated Cyanation of Aryl Halides by Activation of Benzyl Cyanide as the Cyanide Source

[Full Paper]
Qiaodong Wen, Jisong Jin, Yuncai Mei, Ping Lu, Yanguang Wang
Eur. J. Org. Chem., May 06, 2013, DOI: 10.1002/ejoc.201300052. Read article.

]]> One-Pot Synthesis of Camalexins and 3,3'-Biindoles by the Masuda Borylation–Suzuki Arylation (MBSA) Sequence http://dx.doi.org/10.1002/ejoc.201300133 Boris O. A. Tasch, Dragutin Antovic, Eugen Merkul, Thomas J. J. Müller 2013-03-19T05:49+05:00 One-Pot Synthesis of Camalexins and 3,3'-Biindoles by the Masuda Borylation–Suzuki Arylation (MBSA) Sequence

[Full Paper]
Boris O. A. Tasch, Dragutin Antovic, Eugen Merkul, Thomas J. J. Müller
Eur. J. Org. Chem., Mar 19, 2013, DOI: 10.1002/ejoc.201300133. Read article.

]]> EurBest in EurJOC: Potassium 4-Iodylbenzenesulfonate: Preparation, Structure, and Application as a Reagent for Oxidative Iodination of Arenes http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/18086.en.html 2012-10-19T00:10:00+02:00 EurBest in EurJOC: Potassium 4-Iodylbenzenesulfonate: Preparation, Structure, and Application as a Reagent for Oxidative Iodination of Arenes

A new hypervalent iodine(V) compound, potassium 4-iodylbenzenesulfonate, was prepared by oxidation of 4-iodobenzenesulfonic acid with Oxone in water. This new reagent promises many practical applications as a thermally stable, water-soluble and recyclable hypervalent iodine oxidant, particularly useful for oxidative iodination of aromatic substrates.

Mekhman S. Yusubov, Roza Y. Yusubova, Victor N. Nemykin, Andrey V. Maskaev, Margarita R. Geraskina, Andreas Kirschning and Viktor V. Zhdankin
DOI: 10.1002/ejoc.201201064
]]> EurBest in EurJOC: Tandem Aldol Condensation/Platinacycle-Catalyzed Addition Reactions of Aldehydes, Methyl Ketones, and Arylboronic Acids http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/18087.en.html 2012-10-19T00:00:00+02:00 EurBest in EurJOC: Tandem Aldol Condensation/Platinacycle-Catalyzed Addition Reactions of Aldehydes, Methyl Ketones, and Arylboronic Acids

The aldol condensation of aldehydes with methyl ketones was successfully combined with the platinacycle-catalyzed addition reactions of arylboronic acids in a tandem fashion. A variety of β-arylated ketones was obtained in good to excellent yields.

Yuan-Xi Liao and Qiao-Sheng Hu
DOI: 10.1002/ejoc.201200867
]]> EurBest in EurJOC: Phosphane-Catalyzed [4+2] Annulation of Allenoates with Ketimines: Synthesis of Sultam-Fused Tetrahydropyridines http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/18028.en.html 2012-10-10T00:10:00+02:00 EurBest in EurJOC: Phosphane-Catalyzed [4+2] Annulation of Allenoates with Ketimines: Synthesis of Sultam-Fused Tetrahydropyridines

Cyclic ketimines were successfully used as electrophiles in phosphane-catalyzed [4+2] annulation reactions with ethyl 2-methyl-2,3-butadienoate to give the corresponding highly substituted tetrahydropyridine derivatives in moderate to good yields (55–73 %), and with moderate to excellent regioselectivity.

Xiang-Yu Chen and Song Ye
DOI: 10.1002/ejoc.201200747
]]> EurBest in EurJOC: On the Reactivity and Selectivity of Galacturonic Acid Lactones http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/18029.en.html 2012-10-10T00:00:00+02:00 EurBest in EurJOC: On the Reactivity and Selectivity of Galacturonic Acid Lactones

The reactivity and stereoselectivity of a galacturonic acid 3,6-lactone thioglycosyl donor has been investigated by using thiophilic activator systems. The reactivity of the thioglycosides depends on the activator system used. The stereoselectivity arises from preactivation of the glycosylation system, giving rise to α-selective glycosylation, whereas in situ activation gives the β-product.

Alphert E. Christina, Joey A. Muns, Jeremy Q. A. Olivier, Lotte Visser, Bas Hagen, Leendert J. van den Bos, Herman S. Overkleeft, Jeroen D. C. Codée and Gijs A. van der Marel
DOI: 10.1002/ejoc.201200717
]]> EurBest in EurJOC: Lyngbyabellins K–N from Two Palmyra Atoll Collections of the Marine Cyanobacterium Moorea bouillonii http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17932.en.html 2012-09-18T00:00:00+02:00 EurBest in EurJOC: Lyngbyabellins K–N from Two Palmyra Atoll Collections of the Marine Cyanobacterium Moorea bouillonii

Two independent collections of the marine cyanobacterium Moorea bouillonii led to the isolation of five lipopeptides of the lyngbyabellin structure class. Their structures were elucidated by various spectroscopy, synthesis, and chromatography techniques. Lyngbyabellin N showed strong cytotoxic activity against the HCT116 colon cancer cell line (IC50 = 40.9 ± 3.3 nM).

Hyukjae Choi, Emily Mevers, Tara Byrum, Frederick A. Valeriote and William H. Gerwick
DOI: 10.1002/ejoc.201200691]]> EurBest in EurJOC: Arylamine-Modified Thiazoles as Donor–Acceptor Dyes: Quantum Chemical Evaluation of the Charge-Transfer Process and Testing as Ligands in Ruthenium(II) Complexes http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17931.en.html 2012-09-17T00:00:00+02:00 EurBest in EurJOC: Arylamine-Modified Thiazoles as Donor–Acceptor Dyes: Quantum Chemical Evaluation of the Charge-Transfer Process and Testing as Ligands in Ruthenium(II) Complexes

Several 4-hydroxy-1,3-thiazole-based chromophores bearing different arylamine donor and N-heterocyclic acceptor moieties were synthesized and their electronic properties were investigated experimentally and theoretically (DFT and TDDFT). The nature of the charge-transfer transition was identified. Additionally, the dyes were applied as light-harvesting ligands in heteroleptic RuII complexes.

Roberto Menzel, Stephan Kupfer, Ralf Mede, Dieter Weiß, Helmar Görls, Leticia González and Rainer Beckert
DOI: 10.1002/ejoc.201200688]]> EurBest in EurJOC: Blurring the Boundary between Bio- and Geohopanoids: Plakohopanoid, a C32 Biohopanoid Ester from Plakortis cf. lita http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17905.en.html 2012-09-11T00:10:00+02:00 EurBest in EurJOC: Blurring the Boundary between Bio- and Geohopanoids: Plakohopanoid, a C32 Biohopanoid Ester from Plakortis cf. lita

Plakohopanoid is a new type of hopanoid composed of a C32 hopanoic acid ester linked to a mannosyl-myo-inositol. It is probably produced by bacterial symbionts of Plakortis cf. lita. The existence of a biosynthetic pathway to the C32 hopanoic acid shows that this compound should not be necessarily considered to be a geohopanoid.

Valeria Costantino, Gerardo Della Sala, Alfonso Mangoni, Cristina Perinu and Roberta Teta
DOI: 10.1002/ejoc.201200676]]> EurBest in EurJOC: General and Efficient α-Oxygenation of Carbonyl Compounds by TEMPO Induced by Single-Electron-Transfer Oxidation of Their Enolates http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17906.en.html 2012-09-11T00:00:00+02:00 EurBest in EurJOC: General and Efficient α-Oxygenation of Carbonyl Compounds by TEMPO Induced by Single-Electron-Transfer Oxidation of Their Enolates

The oxygenation of enolates proves to be the most general and effective methodology for the synthesis of O-protected α-oxy carbonyl compounds and nitriles A. The scope and limitations of the electron-transfer-induced radical coupling reaction with TEMPO are presented. The reaction pathways are outlined. Methods for the deprotection to α-hydroxy carbonyl compounds B are provided and discussed.

Emanuela Dinca, Philip Hartmann, Jakub Smrček, Ina Dix, Peter G. Jones and Ullrich Jahn
DOI: 10.1002/ejoc.201200736]]> EurBest in EurJOC: Special Electronic Structure and Extended Supramolecular Oligomerization of Anionic 1,4-Dicorannulenylbenzene http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17880.en.html 2012-09-05T00:00:00+02:00 EurBest in EurJOC: Special Electronic Structure and Extended Supramolecular Oligomerization of Anionic 1,4-Dicorannulenylbenzene

The reduction of 1,4-dicorannulenylbenzene is strongly affected by the benzene spacer, yielding an unexpected triplet ground state of the dianion and an octaanion that self-assembles into highly charged supramolecular oligomers that are longer than previously observed dicorannulenyl oligomers.

David Eisenberg, Jennifer M. Quimby, Derrick Ho, Ronit Lavi, Laurent Benisvy, Lawrence T. Scott and Roy Shenhar
DOI: 10.1002/ejoc.201200714]]> EurBest in EurJOC: Sesquiterpenoids from Common Ragweed (Ambrosia artemisiifolia L.), an Invasive Biological Polluter http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17875.en.html 2012-09-04T00:00:00+02:00 EurBest in EurJOC: Sesquiterpenoids from Common Ragweed (Ambrosia artemisiifolia L.), an Invasive Biological Polluter

Eight novel sesquiterpenoids were isolated from the aerial parts of Ambrosia artemisiifolia, an invasive weed whose pollen is responsible for severe allergic reactions. α,β-Unsaturated carbonyl derivatives were present in all aerial parts of the plant, and their reaction with thiols was correlated with the activation of TRPA1, a polymodal sensor involved in airways sensory irritation.

Orazio Taglialatela-Scafati, Federica Pollastro, Alberto Minassi, Giuseppina Chianese, Luciano De Petrocellis, Vincenzo Di Marzo and Giovanni Appendino
DOI: 10.1002/ejoc.201200650]]> EurBest in EurJOC: Controllable Regioselective Construction of Both Functional α-Methylene-β- and -γ-amino Acid Derivatives Through an Organocatalyzed Tandem Allylic Alkylation and Amination http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17847.en.html 2012-08-29T00:00:00+02:00 EurBest in EurJOC: Controllable Regioselective Construction of Both Functional α-Methylene-β- and -γ-amino Acid Derivatives Through an Organocatalyzed Tandem Allylic Alkylation and Amination

A controllable regioselective allylic alkylation and amination reaction has been developed by using α-amino nitriles for the highly selective construction of β- and γ-amino acid derivatives incorporating multiple functional groups. Subsequent multicomponent tandem reactions and transformations of the densely functionalized products were shown to readily afford a range of useful building blocks.

Feng Pan, Jian-Ming Chen, Tian-You Qin, Sean Xiao-An Zhang and Wei-Wei Liao
DOI: 10.1002/ejoc.201200642
]]> EurBest in EurJOC: Synthesis of SHIP1-Activating Analogs of the Sponge Meroterpenoid Pelorol http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17807.en.html 2012-08-21T00:00:00+02:00 EurBest in EurJOC: Synthesis of SHIP1-Activating Analogs of the Sponge Meroterpenoid Pelorol

Two biomimetic routes have been used to synthesize analogs of the SHIP1-activating sponge meroterpenoid pelorol (1) in high ee. Resorcinol analog 18 is the most effective SHIP1-activating pelorol analog made to date and racemic 28•HCl, an amino analog, activates SHIP1 in vitro, and has effective antiinflammatory activity in a mouse model (ED50 ≈ 0.1 mg/kg).

Labros G. Meimetis, Matt Nodwell, Lu Yang, Xiaoxia Wang, Joyce Wu, Curtis Harwig, Grant R. Stenton, Lloyd F. Mackenzie, Thomas MacRury, Brian O. Patrick, Andrew Ming-Lum, Christopher J. Ong, Gerald Krystal, Alice L.-F. Mui and Raymond J. Andersen
DOI: 10.1002/ejoc.201200631]]> EurBest in EurJOC: The Δ2,2'-Bi(2H-1,4-benzothiazine) Structural Motif of Red Hair Pigments Revisited: Photochromism and Acidichromism in a Unique Four-State System http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17765.en.html 2012-08-14T00:00:00+02:00 EurBest in EurJOC: The Δ2,2'-Bi(2H-1,4-benzothiazine) Structural Motif of Red Hair Pigments Revisited: Photochromism and Acidichromism in a Unique Four-State System

The stable yellow form of Δ2,2'-bi(2H-1,4-benzothiazine) (BBTZ) is shown to be the Z rather than E isomer, as originally suggested. The latter configuration pertains to the red photoexcited form. A blue species produced by diprotonation of BBTZ in 2 M HCl is also disclosed. BBTZ is thus proposed as a robust bioinspired four-state chromic system.

Loredana Leone, Orlando Crescenzi, Alessandra Napolitano, Vincenzo Barone and Marco d'Ischia
DOI: 10.1002/ejoc.201200673
]]> EurBest in EurJOC: Mori–Hiyama versus Hay Coupling for Higher Polyynes http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17694.en.html 2012-08-07T00:00:00+02:00 EurBest in EurJOC: Mori–Hiyama versus Hay Coupling for Higher Polyynes

A series of diaryloctatetraynes was synthesized by Mori–Hiyama and Hay protocols. Target compounds were isolated and spectroscopically characterized. Crystalline samples were analyzed by X-ray diffraction methods and the structures were closely scrutinized to reveal potential for topochemical 1,n-polymerization.

Nurbey Gulia, Karolina Osowska, Bartłomiej Pigulski, Tadeusz Lis, Zbigniew Galewski and Sławomir Szafert
DOI: 10.1002/ejoc.201200554]]> EurBest in EurJOC: A Bifunctional β-Isocupreidine Derivative as Catalyst for the Enantioselective Morita–Baylis–Hillman Reaction and a Mechanistic Rationale for Enantioselectivity http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17644.en.html 2012-07-31T00:10:00+02:00 EurBest in EurJOC: A Bifunctional β-Isocupreidine Derivative as Catalyst for the Enantioselective Morita–Baylis–Hillman Reaction and a Mechanistic Rationale for Enantioselectivity

β-Isocupreidine derivatives were used to catalyze the asymmetric Morita–Baylis–Hillman (MBH) reaction, giving the (R)-MBH adducts in excellent optical purities and moderate to good yields. Both 2,6-dimethyl-4-nitrophenyl and hexafluoroisopropyl acrylate could be used. The rate- and selectivity-determining step was identified and the structures of the preferred transition states were computed.

Gianluca Martelli, Mario Orena and Samuele Rinaldi
DOI: 10.1002/ejoc.201200405]]> EurBest in EurJOC: Synthetic Studies Towards the Core Tricyclic Ring System of Pradimicin A http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17645.en.html 2012-07-31T00:00:00+02:00 EurBest in EurJOC: Synthetic Studies Towards the Core Tricyclic Ring System of Pradimicin A

A model study towards the synthesis of the C–D–E tricyclic core of the carbohydrate binding agent, pradimicin A, is described. Alkoxyallylboration provided the differentially protected diol unit of the central ring. Optimization of a key enyne cycloisomerization reaction led to the synthesis of the tricycle by a one-pot Pd-catalyzed cycloisomerization/Diels–Alder cycloaddition/aromatization.

Laura Zilke and Dennis G. Hall
DOI: 10.1002/ejoc.201200294]]> EurBest in EurJOC: Synthesis of α-Amino Acids through Samarium(II) Iodide Promoted Reductive Coupling of Nitrones with CO2 http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17630.en.html 2012-07-24T00:10:00+02:00 EurBest in EurJOC: Synthesis of α-Amino Acids through Samarium(II) Iodide Promoted Reductive Coupling of Nitrones with CO2

A novel approach to the synthesis of α-amino acids is disclosed, involving C-carboxylation of nitrones by gaseous CO2 under reductive coupling reaction conditions (SmI2, 0.1 M in THF) at ambient temperature and 50 bar of CO2 pressure.

Alexander Prikhod'ko, Olaf Walter, Thomas A. Zevaco, Jaime Garcia-Rodriguez, Omar Mouhtady and Sandrine Py
DOI: 10.1002/ejoc.201200440
]]> EurBest in EurJOC: Total Synthesis of Potent Antitumor Macrolide (–)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17632.en.html 2012-07-24T00:00:00+02:00 EurBest in EurJOC: Total Synthesis of Potent Antitumor Macrolide (–)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy

An enantioselective synthesis of (–)-zampanolide has been achieved. This rare marine natural product shows microtubule-stabilizing properties. It also displays potent activity against taxol-resistant cells. This synthesis will provide a convenient access to analogues for important structure–activity relationship studies and less complex anticancer agents related to zampanolide.

Arun K. Ghosh, Xu Cheng, Ruoli Bai and Ernest Hamel
DOI: 10.1002/ejoc.201200286]]> EurBest in EurJOC: Catalytic Asymmetric Addition of Alkyllithium Reagents to Aromatic Aldehydes http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17596.en.html 2012-07-17T00:10:00+02:00 EurBest in EurJOC: Catalytic Asymmetric Addition of Alkyllithium Reagents to Aromatic Aldehydes

Herein, we report the first efficient catalytic system for the asymmetric alkylation of aldehydes with organolithium reagents in the presence of titanium(IV) isopropoxide. A variety of alkyllithium reagents can be added to aromatic aldehydes in good yields with high enantioselectivities in a simple one-pot procedure under mild conditions.

Emilio Fernández-Mateos, Beatriz Maciá and Miguel Yus
DOI: 10.1002/ejoc.201200464]]> EurBest in EurJOC: Buchwald–Hartwig Amination of (Hetero)aryl Chlorides by Employing Mor-DalPhos under Aqueous and Solvent-Free Conditions http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17597.en.html 2012-07-17T00:00:00+02:00 EurBest in EurJOC: Buchwald–Hartwig Amination of (Hetero)aryl Chlorides by Employing Mor-DalPhos under Aqueous and Solvent-Free Conditions

We report on the use of [Pd(cinnamyl)Cl]2/Mor-DalPhos in the Buchwald–Hartwig amination of (hetero)aryl chlorides with primary or secondary amines under aqueous or solvent-free conditions (52examples).

Bennett J. Tardiff and Mark Stradiotto
DOI: 10.1002/ejoc.201200510]]> EurBest in EurJOC: Monitoring Fluoride Binding in DMSO: Why is a Singular Binding Behavior Observed? http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17531.en.html 2012-07-04T00:10:00+02:00 EurBest in EurJOC: Monitoring Fluoride Binding in DMSO: Why is a Singular Binding Behavior Observed?

The titration behavior for fluoride binding in DMSO can often not be ascribed to a classical 1:1 binding isotherm. The culprit can be water, which leads to the generation of other species that can interact with the molecular receptor. The plethora of equilibria to be considered makes the quantitative evaluation of fluoride binding extremely perilous.

Matthieu Goursaud, Paolo De Bernardin, Antonella Dalla Cort, Kristin Bartik and Gilles Bruylants
DOI: 10.1002/ejoc.201200165]]> EurBest in EurJOC: Heck–Matsuda Arylation as a Strategy to Access Kavalactones Isolated from Polygala sabulosa, Piper methysticum, and Analogues http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17532.en.html 2012-07-04T00:00:00+02:00 EurBest in EurJOC: Heck–Matsuda Arylation as a Strategy to Access Kavalactones Isolated from Polygala sabulosa, Piper methysticum, and Analogues

The Heck–Matsuda reaction was applied to the syntheses of three bioactive pyrones isolated from Polygala sabulosa, eight kavalactones isolated from Piper methysticum, and several kavalactone analogues.

Cristian Soldi, Angélica V. Moro, Moacir G. Pizzolatti and Carlos R. D. Correia
DOI: 10.1002/ejoc.201200308]]> EurBest in EurJOC: A Facile, Versatile, and Mild Morita–Baylis–Hillman-Type Reaction for the Modular One-Pot Synthesis of Highly Functionalized MBH Adducts http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17489.en.html 2012-06-26T00:10:00+02:00 EurBest in EurJOC: A Facile, Versatile, and Mild Morita–Baylis–Hillman-Type Reaction for the Modular One-Pot Synthesis of Highly Functionalized MBH Adducts

Here we describe a one-pot, fast, and high-yielding methodology for the synthesis of different Morita–Baylis–Hillman derivatives by a four-component cascade reaction. The cascade is based on a Michael/aldol/O-functionalization/selenoxide elimination sequence. This protocol completely avoids the manipulation of selenium species with an unpleasant odor.

Bruno A. Sousa and Alcindo A. Dos Santos
DOI: 10.1002/ejoc.201200371
]]> EurBest in EurJOC: Reaction Mechanism of Phosphane-Catalyzed [4+2] Annulations between α-Alkylallenoates and Activated Alkenes: A Computational Study http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17490.en.html 2012-06-26T00:00:00+02:00 EurBest in EurJOC: Reaction Mechanism of Phosphane-Catalyzed [4+2] Annulations between α-Alkylallenoates and Activated Alkenes: A Computational Study

This DFT study reveals that the water-aided [3+2] addition and direct [4+2] addition mechanisms are both feasible for the titled [4+2] annulations. Unlike typical [3+2] annulations, which require water as hydrogen transfer mediator, [4+2] annulation can occur without additional mediator because the carbon bearing nitrile groups can act as the hydrogen transfer mediator.

Lili Zhao, Mingwei Wen and Zhi-Xiang Wang
DOI: 10.1002/ejoc.201200121
]]> EurBest in EurJOC: C–C Coupling of Acyclic Nitronates with Silyl Ketene Acetals under Silyl Triflate Catalysis: Reactivity Umpolung of Aliphatic Nitro Compounds http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17466.en.html 2012-06-19T00:10:00+02:00 EurBest in EurJOC: C–C Coupling of Acyclic Nitronates with Silyl Ketene Acetals under Silyl Triflate Catalysis: Reactivity Umpolung of Aliphatic Nitro Compounds

A very simple approach for umpolung of the conventional reactivity of nitroalkanes through their activation by silylation offers a convenient and efficient strategy for their C–C coupling with π-nucleophiles. Both primary (8 examples) and secondary (4 examples) nitroalkanes may be involved in coupling with silyl ketene acetals (4 examples) to provide a concise route to substituted β-amino acids.

Khomutova, Vladimir A. Tartakovsky and Sema L. Ioffe
DOI: 10.1002/ejoc.201200239
]]> EurBest in EurJOC: Exploring the Ribose Sub-Pocket of the Substrate-Binding Site in Escherichia coli IspE: Structure-Based Design, Synthesis, and Biological Evaluation of Cytosines and Cytosine Analogues http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17467.en.html 2012-06-19T00:00:00+02:00 EurBest in EurJOC: Exploring the Ribose Sub-Pocket of the Substrate-Binding Site in Escherichia coli IspE: Structure-Based Design, Synthesis, and Biological Evaluation of Cytosines and Cytosine Analogues

We report the design, synthesis, and biological evaluation of new cytosine- and 2-aminopyridine-based ligands to explore the molecular recognition properties of the ribose sub-pocket of the substrate-binding site in the IspE protein of Escherichia coli, a model enzyme for P. falciparum IspE.

Andri P. Schütz, Sho Osawa, Jennifer Mathis, Anna K. H. Hirsch, Bruno Bernet, Boris Illarionov, Markus Fischer, Adelbert Bacher and François Diederich
DOI: 10.1002/ejoc.201200296
]]> EurBest in EurJOC: Straightforward Synthesis of Poly(dimethylsiloxane) Phases with Immobilized (1R)-3-(Perfluoroalkanoyl)camphorate Metal Complexes and Their Application in Enantioselective Complexation Gas Chromatography http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17438.en.html 2012-06-12T00:10:00+02:00 EurBest in EurJOC: Straightforward Synthesis of Poly(dimethylsiloxane) Phases with Immobilized (1R)-3-(Perfluoroalkanoyl)camphorate Metal Complexes and Their Application in Enantioselective Complexation Gas Chromatography

A novel synthetic approach to camphor-based chemically bonded Chirasil-Metal-OC3 [Ni, Eu, La, V(O)] stationary phases and their application in enantioselective complexation GC is presented. Immobilization and metal incorporation was studied with a range of selector concentrations using NMR and IR spectroscopy. Overall, 29 compounds with different functionalities were separated with α-values up to 1.66.

Markus J. Spallek, Golo Storch and Oliver Trapp
DOI: 10.1002/ejoc.201200075]]> EurBest in EurJOC: Total Syntheses of Dichotomines A–D and the Stereochemical Revision of Dichotomines B–D http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17439.en.html 2012-06-12T00:00:00+02:00 EurBest in EurJOC: Total Syntheses of Dichotomines A–D and the Stereochemical Revision of Dichotomines B–D

New asymmetric total syntheses of (–)-dichotomines A–D (1–4) starting from L-tryptophan methyl ester and 2,3-O-isopropylidene-D-glyceraldehyde are described. The absolute configuration of the stereogenic center of (–)-dichotomine A (1) was reconfirmed as (S), whereas the absolute configurations of the stereogenic centers of (–)-dichotomines B–D (2–4) were revised as (R).

Qiang Zhang, Jing Dong, Xiao-Xin Shi and Xia Lu
DOI: 10.1002/ejoc.201200235
]]> EurBest in EurJOC: Matrix Isolation and Spectroscopic Characterization of 2,5,6-Trifluoropyridylnitren-3-yl http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17429.en.html 2012-06-05T00:00:00+02:00 EurBest in EurJOC: Matrix Isolation and Spectroscopic Characterization of 2,5,6-Trifluoropyridylnitren-3-yl

The combination of an aryl radical with an arylnitrene results in new motives for the construction of organic high-spin molecules. Photolysis of 3-iodo-2,5,6-trifluoropyridyl azide under the conditions of matrix isolation results in the formation of a nitrene radical with a quartet ground state. The electronic structure of this nitrene radical is described best as a σ,σ,π-triradical. The nitrene radical is stable at cryogenic temperatures but, upon irradiation, rearranges to a thermodynamically more stable azirinyl radical.

Dirk Grote, Christopher Finke, Patrik Neuhaus and Wolfram Sander
DOI: 10.1002/ejoc.201101866
]]> EurBest in EurJOC: C3v-Symmetrical Tribenzotriquinacenes Bearing Six Benzylic Tentacle Groups at the Molecular Periphery http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17366.en.html 2012-05-29T00:00:00+02:00 EurBest in EurJOC: C3v-Symmetrical Tribenzotriquinacenes Bearing Six Benzylic Tentacle Groups at the Molecular Periphery

A new tribenzotriquinacene-based sixfold benzyl chloride bearing three n-propyl residues at the outer bridgehead positions was synthesized and found to be a versatile key intermediate for tentacular extensions of the C3v-symmetrical TBTQ framework by using efficient multiple Friedel–Crafts and etherification reactions.

Ehsan Ullah Mughal and Dietmar Kuck
DOI: 10.1002/ejoc.201200194]]> EurBest in EurJOC: FeCl3•6H2O and TfOH as Catalysts for Allylic Amination Reaction: A Comparative Study http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17334.en.html 2012-05-22T00:10:00+02:00 EurBest in EurJOC: FeCl3•6H2O and TfOH as Catalysts for Allylic Amination Reaction: A Comparative Study

A comparative study for the direct allylic amination employing FeCl3•6H2O and TfOH as efficient and readily available catalysts is described. From the results of this study it can be concluded that, with some exceptions, TfOH performed better with lower catalyst loading and milder reaction conditions. The stereochemical course of the reaction is also discussed concluding that depends on the stability of the final product.

Paz Trillo, Alejandro Baeza and Carmen Nájera
DOI: 10.1002/ejoc.201101844
]]> EurBest in EurJOC: Selective N-Alkylation of Arylamines with Alkyl Chloride in Ionic Liquids: Scope and Applications http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-0690/homepage/news/17335.en.html 2012-05-22T00:00:00+02:00 EurBest in EurJOC: Selective N-Alkylation of Arylamines with Alkyl Chloride in Ionic Liquids: Scope and Applications

A protocol for the selective N-alkylation of primary aromatic amines in tetraalkylammonium ionic liquids was developed. This approach complements existing strategies by broadening the scope with more challenging substrates (e.g., p-nitroaniline) and alkylating agents (chloroalkane).

Antonio Monopoli, Pietro Cotugno, Marina Cortese, Cosima Damiana Calvano, Francesco Ciminale and Angelo Nacci
DOI: 10.1002/ejoc.201200202]]>