Mission Statement

ChemPubSoc Europe is an organization of 16 European chemical societies, founded in the late 1990s as a consequence of the amalgamation of many chemical journals owned by national chemical societies into a number of high-quality European journals.

ChemPubSoc Europe's journals, all published with Wiley-VCH, are: Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemBioChem, ChemPhysChem, ChemMedChem, ChemSusChem, ChemCatChem, ChemPlusChem, ChemElectroChem, ChemistryOpen, and ChemViews, the ChemPubSoc Europe e-zine. They replaced 16 traditional national chemistry journals.

The participating societies share a commitment to scientific excellence, to publishing ethics, and to the highest standards in publication, which are the basis for the success of the ChemPubSoc Europe journals.

ChemPubSoc Europe and its Asian sister organization, the Asian Chemical Editorial Society (ACES), mutually support each other in the publication of their journals Chemistry—A European Journal, Chemistry—An Asian Journal, and ChemSusChem.

© Wiley-VCH 2009–2013

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Latest Impact Factors

The latest impact factors for the ChemPubSoc Europe journals are as follows (2013):

Chemistry A—European Journal 5.696
European Journal of Organic / Inorganic Chemistry 3.145 / 2.965
ChemPhysChem / ChemElectroChem 3.360 / n/a
ChemBioChem / ChemMedChem 3.060 / 3.046
ChemSusChem / ChemCatChem 7.117 / 5.044
ChemPlusChem / ChemistryOpen 3.242 / 2.938

 

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Enantioselective Synthesis of Spiroimines by Asymmetric Decarboxylative Alkylation/Isomerization/[3+2]-Cycloaddition Reaction of Azidoalkenes

Enantioselective Synthesis of Spiroimines by Asymmetric Decarboxylative Alkylation/Isomerization/[3+2]-Cycloaddition Reaction of Azidoalkenes

The synthesis of optically active spiroimines, one of the pharmacophores of the marine neurotoxin gymnodimine A, is described. The approach relies on a three-step sequence that includes a palladium-catalyzed asymmetric decarboxylative alkylation, an isomerization and a [3+2]-cycloaddition reaction of an azidoalkene to build the imine.

[Full Paper]
Matt Rambla, Leslie Duroure, Laurent Chabaud, Catherine Guillou
Eur. J. Org. Chem., October 24, 2014, DOI: 10.1002/ejoc.201403161. Read article.

Synthesis of Vicinal Diketoses by Using a Metathesis–Hydroxylation–Oxidation Sequence

Synthesis of Vicinal Diketoses by Using a Metathesis–Hydroxylation–Oxidation Sequence

The attempted structure elucidation and total synthesis of a naturally occurring antidiabetic drug led to the synthesis of two higher monosaccharides by using an olefination, cross-coupling, and oxidation reaction sequence. This synthetic strategy paves the way to a new class of substances that is not yet well investigated.

[Full Paper]
Melchior Menzel, Thomas Ziegler
Eur. J. Org. Chem., October 24, 2014, DOI: 10.1002/ejoc.201403140. Read article.

Role of Side-Chain Bioisosteres in Determining the Binding Affinity of Click Chemistry Derived RGD Peptidomimetics to αvβ3 Integrin

Role of Side-Chain Bioisosteres in Determining the Binding Affinity of Click Chemistry Derived RGD Peptidomimetics to αvβ3 Integrin

Click chemistry was used to build a series of nonpeptide Arg-Gly-Asp (RGD) peptidomimetics. Integrin binding assays revealed heterocyclic guanidine bioisosteres that showed binding activity and also indicated a minor role played by the aromatics on the azide fragment. Modelling showed that the triazole and 2-aminopyridine rings interact with Tyr178 of αvβ3 integrin.

[Full Paper]
Pierangelo Fabbrizzi, Gloria Menchi, Silvia Raspanti, Antonio Guarna, Andrea Trabocchi
Eur. J. Org. Chem., October 24, 2014, DOI: 10.1002/ejoc.201403129. Read article.

Synthesis of Isotopically Labelled Oligoprenyl Diphosphates and Their Application in Mechanistic Investigations of Terpene Cyclases

Synthesis of Isotopically Labelled Oligoprenyl Diphosphates and Their Application in Mechanistic Investigations of Terpene Cyclases

A synthesis of isotopically labelled oligoprenyl diphosphates was developed. This method allows for the introduction of labelling into every position or combination of positions. [14-2H]Geranylgeranyl diphosphate was used in an incubation experiment with tuberculosinyl diphosphate synthase from Mycobacterium tuberculosis, giving insight into the stereochemical course of the terpene cyclase reaction.

[Full Paper]
Christian A. Citron, Patrick Rabe, Lena Barra, Chiaki Nakano, Tsutomu Hoshino, Jeroen S. Dickschat
Eur. J. Org. Chem., October 24, 2014, DOI: 10.1002/ejoc.201403002. Read article.

Photocatalytic Acceptorless Alkane Dehydrogenation: Scope, Mechanism, and Conquering Deactivation with Carbon Dioxide

Photocatalytic Acceptorless Alkane Dehydrogenation: Scope, Mechanism, and Conquering Deactivation with Carbon Dioxide

CO2 catalysis: A CO2-influenced, improved dehydrogenation protocol is described using trans-Rh(PMe3)2(CO)Cl as a catalyst. Alkanes and liquid organic hydrogen carriers are used as substrates under benign homogeneous reaction conditions. High catalyst turnover numbers as well as high yields are obtained because of the prevention of catalyst deactivation.

[Full Paper]
Abhishek Dutta Chowdhury, Jennifer Julis, Kathleen Grabow, Bernd Hannebauer, Ursula Bentrup, Martin Adam, Robert Franke, Ralf Jackstell, Matthias Beller
ChemSusChem, October 24, 2014, DOI: 10.1002/cssc.201402850. Read article.

A Gemini Quaternary Ammonium Poly (ether ether ketone) Anion-Exchange Membrane for Alkaline Fuel Cell: Design, Synthesis, and Properties

A Gemini Quaternary Ammonium Poly (ether ether ketone) Anion-Exchange Membrane for Alkaline Fuel Cell: Design, Synthesis, and Properties

PEEK and ye shall find: To reconcile the tradeoff between conductivity and dimensional stability in anion exchange membranes, a novel Gemini quaternary ammonium poly (ether ether ketone) (GQ-PEEK) membrane was successfully synthesized. The GQ-PEEK membranes exhibited enhanced ionic conductivity and fuel cell performance while undergoing only moderate swelling.

[Full Paper]
Jiangju Si, Shanfu Lu, Xin Xu, Sikan Peng, Ruijie Xiu, Yan Xiang
ChemSusChem, October 24, 2014, DOI: 10.1002/cssc.201402664. Read article.

Screen-Printed Calcium–Birnessite Electrodes for Water Oxidation at Neutral pH and an “Electrochemical Harriman Seriesâ€

Screen-Printed Calcium–Birnessite Electrodes for Water Oxidation at Neutral pH and an “Electrochemical Harriman Series”

Ca-lling on oxides: Powders of calcium manganese oxide (Ca–birnessite) are screen printed onto conductive substrates that are used as anodes in water electrolysis. Screening of various transition-metal oxides for electrochemical water oxidation under “artificial leaf conditions” is possible and confirms the suitability of Ca–Mn-oxides for this task.

[Full Paper]
Seung Y. Lee, Diego González-Flores, Jonas Ohms, Tim Trost, Holger Dau, Ivelina Zaharieva, Philipp Kurz
ChemSusChem, October 24, 2014, DOI: 10.1002/cssc.201402533. Read article.

Facile Synthesis of Copper-Based Metal Oxide Nanoparticles with Exceptional Catalytic Activity for the Selective Oxidation of Styrenes into Benzaldehydes

Facile Synthesis of Copper-Based Metal Oxide Nanoparticles with Exceptional Catalytic Activity for the Selective Oxidation of Styrenes into Benzaldehydes

Talkin' about our generation: Copper-based metal oxide (CuO, CuO/Co3O4) nanoparticles have been synthesized from coordination-driven self-assembling aggregates and calcination treatment. They exhibited exceptional catalytic activity and stability for the selective oxidation of styrene and its derivatives to generate the corresponding aldehydes (see figure; TBHP=tert-butyl hydroperoxide).

[Full Paper]
Danhua Ge, Jiaqing Wang, Hongbo Geng, Shuanglong Lu, Dongtao Wang, Xinming Li, Xianli Zhao, Xueqin Cao, Hongwei Gu
ChemPlusChem, October 24, 2014, DOI: 10.1002/cplu.201402319. Read article.

Selenium–Selenium Bond Cleavage of Diaryl Diselenide Radical Anions During Pulse Radiolysis

Selenium–Selenium Bond Cleavage of Diaryl Diselenide Radical Anions During Pulse Radiolysis

Studying ArSe: An unpaired electron of αNpSeSeαNp. is localized in the Se-Se σ* orbital with an elongated Se-Se bond at 77 K. As the temperature increases, αNpSeSeαNp. changes to Intermediate. with an absorption at longer wavelength owing to the conformational change, in which an unpaired electron is delocalized in the interaction between the π* and σ* orbital (see scheme).

[Full Paper]
Sachiko Tojo, Mamoru Fujitsuka, Akihiko Ouchi, Tetsuro Majima
ChemPlusChem, October 24, 2014, DOI: 10.1002/cplu.201402300. Read article.

Terminal Alkenes as Versatile Chemical Reporter Groups for Metabolic Oligosaccharide Engineering

Terminal Alkenes as Versatile Chemical Reporter Groups for Metabolic Oligosaccharide Engineering

“With the manuscript having been prepared during the soccer world cup, we found in this theme an apposite analogy to our ”sugar championship“ aiming at labeling cell-surface glycans.” Read more about the story behind the cover in the Cover Profile and about the research itself on page ██ ff. (DOI: 10.1002/chem.201404716).

[Cover Profile]
Anne-Katrin Späte, Verena F. Schart, Sophie Schöllkopf, Andrea Niederwieser, Valentin Wittmann
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201405618. Read article.

Phosphinothiolates as Ligands for Polyhydrido Copper Nanoclusters

Phosphinothiolates as Ligands for Polyhydrido Copper Nanoclusters

The structure of the cluster is unusually unorganized compared to most other clusters.” Read more about the story behind the cover in the Cover Profile and about the research itself on page ██ ff. (DOI: 10.1002/chem.201404763).

[Cover Profile]
Miguel A. Huertos, Israel Cano, Nuno A. G. Bandeira, Jordi Benet-Buchholz, Carles Bo, Piet W. N. M. van Leeuwen
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201405452. Read article.

Near-IR Absorbing BODIPY Derivatives as Glutathione-Activated Photosensitizers for Selective Photodynamic Action

Near-IR Absorbing BODIPY Derivatives as Glutathione-Activated Photosensitizers for Selective Photodynamic Action

Power with a control switch: Enhanced spatiotemporal selectivity in photonic sensitization of dissolved molecular oxygen is an important target for improving the potential and practice of photodynamic therapy. Considering the high glutathione (GSH) concentrations in cancer cells, a series of BODIPY-based “caged” sensitizers have been designed and synthesized. The sensitizers can generate cytotoxic singlet oxygen only after glutathione-mediated cleavage of the electron-sink module.

[Communication]
Ilke Simsek Turan, Fatma Pir Cakmak, Deniz Cansen Yildirim, Rengul Cetin-Atalay, Engin U. Akkaya
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201405450. Read article.

A 3D 12-Ring Zeolite with Ordered 4-Ring Vacancies Occupied by (H2O)2 Dimers

A 3D 12-Ring Zeolite with Ordered 4-Ring Vacancies Occupied by (H2O)2 Dimers

Zeolite analogues: A germanate zeolite PKU-14 with a 3D 12-ring channel system was synthesized and structurally characterized by the combination of high-resolution PXRD, RED, NMR, and IR spectroscopy. Ordered Ge4O4 vacancies inside the [46.612] cage were found in PKU-14, in which a unique (H2O)2 dimer was located at the vacancies and played a structure-directing role (see scheme).

[Communication]
Jie Liang, Jie Su, Yingxia Wang, Yanping Chen, Xiaodong Zou, Fuhui Liao, Jianhua Lin, Junliang Sun
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201405449. Read article.

Foldamers to Nanotubes: Influence of Amino Acid Side Chains in the Hierarchical Assembly of α,γ4-Hybrid Peptide Helices

Foldamers to Nanotubes: Influence of Amino Acid Side Chains in the Hierarchical Assembly of α,γ4-Hybrid Peptide Helices

Silver nanowires: Single-crystal conformations of various α, γ4-hybrid peptide 12-helices incorporated with γ4-Val, γ4-Leu and γ4-Phe residues and their supramolecular assemblies are studied. Hybrid peptide 12-helices composed of alternating α- and γPhe residues displayed unique elongated nanotubes. Further, we explored the utility of these nanotubes for the fabrication of silver nanowires from silver ions (see figure).

[Full Paper]
Sandip V. Jadhav, Rajkumar Misra, Hosahudya N. Gopi
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201404961. Read article.

Enantiopure Laterally-Functionalized Alleno–Acetylenic Macrocycles: Synthesis, Chiroptical Properties, and Self-Assembly in Aqueous Media

Enantiopure Laterally-Functionalized Alleno–Acetylenic Macrocycles: Synthesis, Chiroptical Properties, and Self-Assembly in Aqueous Media

Decorating macrocycles! A family of shape-persistent alleno–acetylenic macrocycles (SPAAMs), peripherally decorated with structurally diverse pendant groups, has been synthesized in enantiomerically pure form. Their electronic circular dichroism spectra feature a strong chiroptical response, which is not reduced by large achiral peripheral substituents. The first optically active, water-soluble oligo(ethylene glycol) (OEG)-appended SPAAMs were prepared and further characterized by cryo-TEM, revealing the formation of aggregates with fibrous fine structures that correspond to tubular, macrocyclic stacks.

[Communication]
Manolis D. Tzirakis, Mariza N. Alberti, Haim Weissman, Boris Rybtchinski, François Diederich
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201404941. Read article.

Straightforward Synthesis of 1,2-Dicyanoalkanes from Nitroalkenes and Silyl Cyanide Mediated by Tetrabutylammonium Fluoride

Straightforward Synthesis of 1,2-Dicyanoalkanes from Nitroalkenes and Silyl Cyanide Mediated by Tetrabutylammonium Fluoride

Direct cyanation: A straightforward synthesis of 1,2-dicyanoalkanes by the reaction of nitroalkenes with trimethylsilyl cyanide in the presence of tetrabutylammonium fluoride (TBAF) is reported (see scheme). The method has wide substrate scope and tolerates a wide variety of functional groups. Mechanistic studies suggest that a small amount of water present in the reaction media plays a key role in the reaction.

[Full Paper]
Kensuke Kiyokawa, Takaya Nagata, Junpei Hayakawa, Satoshi Minakata
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201404780. Read article.

Enantioselective Total Synthesis of the Lignan (+)-Linoxepin

Enantioselective Total Synthesis of the Lignan (+)-Linoxepin

Smooth operation: The key feature in the enantioselective total synthesis of the lignan, (+)-linoxepin, is a Pd-catalyzed domino reaction consisting of a carbopalladation and a Mizoroki–Heck reaction using DavePhos as a bulky electron-rich ligand and an AgI salt as additive to suppress aromatization. The stereogenic center was introduced by an asymmetric regioselective hydroboration to give the natural product.

[Full Paper]
Lutz F. Tietze, Jérôme Clerc, Simon Biller, Svenia-C. Duefert, Matthias Bischoff
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201404679. Read article.

Novel λ3-Iodane-Based Functionalization of Synthetic Carbon Allotropes (SCAs)—Common Concepts and Quantification of the Degree of Addition

Novel λ3-Iodane-Based Functionalization of Synthetic Carbon Allotropes (SCAs)—Common Concepts and Quantification of the Degree of Addition

Most accurately: A new wet chemical functionalization sequence for carbon allotropes applying λ3-iodanes is presented (see figure). By coupling thermogravimetric analysis with gas-chromatographic separation and mass-spectrometric characterization an exact determination of the degree of functionalization becomes feasible.

[Full Paper]
Ferdinand Hof, Ricarda A. Schäfer, Cornelius Weiss, Frank Hauke, Andreas Hirsch
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201404662. Read article.

Reversible Reduction of Oxatriphyrin(3.1.1)—Adjusting the Coordination Abilities to the Central Ion

Reversible Reduction of Oxatriphyrin(3.1.1)—Adjusting the Coordination Abilities to the Central Ion

Adjustable complexes: The electronic properties of a nonaromatic oxatriphyrin(3.1.1) change drastically by a trigonal-to-tetrahedral rehybridization at the C3 linker (see figure). The triheterocyclic brace of a free base presets an intensive emission, strongly depending on the solvent viscosity and robustly affecting the excited-state lifetimes. A similar relationship has been observed for boron(III) complexes of phlorin-like oxatriphyrin(3.1.1)

[Full Paper]
Miłosz Pawlicki, Aneta Kędzia, Dominik Bykowski, Lechosław Latos-Grażyński
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201404570. Read article.

Sulfur-Impregnated Core–Shell Hierarchical Porous Carbon for Lithium–Sulfur Batteries

Sulfur-Impregnated Core–Shell Hierarchical Porous Carbon for Lithium–Sulfur Batteries

Safe haven for sulfur: Core–shell hierarchical porous carbon (HPC) spheres were synthesized by a facile hydrothermal method and used as host to incorporate sulfur. The resulting material turns out to be highly uniform and exhibit enhanced specific capacity, superior rate capability, and excellent cycling stability when evaluated as a cathode material for lithium–sulfur batteries.

[Full Paper]
Fei-Fei Zhang, Gang Huang, Xu-Xu Wang, Yu-Ling Qin, Xin-Chuan Du, Dong-Ming Yin, Fei Liang, Li-Min Wang
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201404439. Read article.

Aliphatic Organoimido Derivatives of Polyoxometalates Containing a Bioactive Ligand

Aliphatic Organoimido Derivatives of Polyoxometalates Containing a Bioactive Ligand

POM–drug hybrids: A systematic investigation of aliphatic organoimido derivatives of a polyoxometalate (POM) based on the drug amantadine elucidated the spectral and crystal-structural similarities and differences between monosubstituted, cis-disubstituted, and trans-disubstituted derivatives (see figure) to provide guidance for related work on imido-functionalized Lindqvist-type POMs. Furthermore, covalently grafting a biologically active molecule to a POM enhanced its applications in clinical cancer treatment.

[Full Paper]
Shan She , Shengtai Bian, Jian Hao , Jiangwei Zhang, Jin Zhang , Yongge Wei 
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201404317. Read article.

Formal Total Synthesis of (−)-Taxol through Pd-Catalyzed Eight-Membered Carbocyclic Ring Formation

Formal Total Synthesis of (−)-Taxol through Pd-Catalyzed Eight-Membered Carbocyclic Ring Formation

A less taxing route to taxol: The Pd-catalyzed intramolecular alkenylation of a methyl ketone affords a key cyclized intermediate for the synthesis of (−)-taxol in excellent yield (97 %) (see scheme; Bn=benzyl; TES=triethylsilyl). Rearrangement of an epoxy benzyl ether through a 1,5-hydride shift, generating the C3 stereogenic center and subsequently forming the C1–C2 benzylidene, was discovered during the preparation of a substrate for the Pd-catalyzed reaction.

[Full Paper]
Sho Hirai, Masayuki Utsugi, Mitsuhiro Iwamoto, Masahisa Nakada
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201404295. Read article.

Bispidines for Dual Imaging

Bispidines for Dual Imaging

Bimodal imaging probe: A new bispidine–BODIPY building block has been developed, enabling simultaneous bimodal imaging by positron emission tomography (PET; radioactive 64Cu) and optical imaging (fluorescence dye). Further functionalization with targeting vectors can be achieved using the C1 and C2 positions of the bispidine scaffold.

[Full Paper]
Holger Stephan, Martin Walther, Silke Fähnemann, Paola Ceroni, Jennifer K. Molloy, Giacomo Bergamini, Fabian Heisig, Christa E. Müller, Werner Kraus, Peter Comba
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201404086. Read article.

Poly(N-vinylpyrrolidone)-Decorated Reduced Graphene Oxide with ZnO Grown In Situ as a Cathode Buffer Layer for Polymer Solar Cells

Poly(N-vinylpyrrolidone)-Decorated Reduced Graphene Oxide with ZnO Grown In Situ as a Cathode Buffer Layer for Polymer Solar Cells

Highly decorated: Nanocomposites were prepared by in situ growth of ZnO nanocrystals on the surface of reduced graphene oxide (RGO) that was homogeneously decorated with poly(N-vinylpyrrolidone) (PVP; see figure). ZnO@RGO-PVP has higher conductivity, fewer defects and traps, and higher LUMO energy level than bare ZnO. Using ZnO@RGO-PVP as cathode buffer layer improved the power conversion efficiency of an inverted polymer solar cell to 7.5 % with long-term stability.

[Full Paper]
Ting Hu, Lie Chen , Kai Yuan, Yiwang Chen 
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201404025. Read article.

Intramolecular Anion Effect in Polyoxometalate-Based Organocatalysts: Reactivity Enhancement and Chirality Transfer by a Metal Oxide–Organic Cation Interaction

Intramolecular Anion Effect in Polyoxometalate-Based Organocatalysts: Reactivity Enhancement and Chirality Transfer by a Metal Oxide–Organic Cation Interaction

A hybrid α1-Dawson polyanion bearing a lateral side chain with a 4-aminopyridine end group catalyzes the addition of indenyl allyl silanes to cinnamoyl fluorides. The chiral polyanionic framework influences the catalytic activity, the selectivity, and the stereoselectivity of the reaction (see figure).

[Communication]
Christian Brazel, Nathalie Dupré, Max Malacria, Bernold Hasenknopf, Emmanuel Lacôte, Serge Thorimbert
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201403989. Read article.

Coumarin-3-Aldehyde as a Scaffold for the Design of Tunable PET-Modulated Fluorescent Sensors for Neurotransmitters

Coumarin-3-Aldehyde as a Scaffold for the Design of Tunable PET-Modulated Fluorescent Sensors for Neurotransmitters

Benzene- and thiophene-substituted coumarin-3-aldehyde derivatives were developed using rational design for the fluorescent sensing of primary-amine neurotransmitters (e.g., glutamate, norepinephrine, and dopamine). The degree of photoinduced electron transfer (PET) from the aryl moiety to the fluorophore and consequently the fluorescence output of the analyte-bound sensor can be predetermined solely using DFT energy-level calculations.

[Full Paper]
Kenneth S. Hettie, Timothy E. Glass
Chem. Eur. J., October 24, 2014, DOI: 10.1002/chem.201403128. Read article.

Directed Evolution of a Formate Dehydrogenase for Increased Tolerance to Ionic Liquids Reveals a New Site for Increasing the Stability

Directed Evolution of a Formate Dehydrogenase for Increased Tolerance to Ionic Liquids Reveals a New Site for Increasing the Stability

A(n ionic) liquid diet: A mutation that improves the stability of formate dehydrogenases in ionic liquids and causes a 5.8-fold enhancement of the kcat value was identified. The site is located at the monomer–monomer interface and influences the local pKa values, including an increase in the pKa of residue E163 from 4.8 to 5.5.

[Full Paper]
Julie L. L. Carter, Mourad Bekhouche, Alexandre Noiriel, Loïc J. Blum, Bastien Doumèche
ChemBioChem, October 24, 2014, DOI: 10.1002/cbic.201402501. Read article.

Bioactive Derivatives of Isopropylstilbene from Mutasynthesis and Chemical Synthesis

Bioactive Derivatives of Isopropylstilbene from Mutasynthesis and Chemical Synthesis

It's just not natural! The production of new isopropylstilbene derivatives was achieved by mutasynthesis with a Photorhabdus ASD (anthraquinone and stilbene deficient) mutant, blocked in anthraquinone and cinnamic acid biosynthesis. Chemical synthesis of selected compounds allowed for their biological evaluation, which led to compounds with better activity than the natural products.

[Communication]
Max Kronenwerth, Alexander O. Brachmann, Marcel Kaiser, Helge B. Bode
ChemBioChem, October 24, 2014, DOI: 10.1002/cbic.201402447. Read article.