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Fundamentals of Analytical Toxicology

Flanagan, Robert J. / Cuypers, Eva / Maurer, Hans H. / Whelpton, Robin


2. Auflage Juli 2020

ISBN: 978-1-119-12234-0
John Wiley & Sons

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Fundamentals of Analytical Toxicology is an integrated introduction to the analysis of drugs, poisons, and other foreign compounds in biological and related specimens. Assuming only basic knowledge of analytical chemistry, this invaluable guide helps trainee analytical toxicologists understand the principles and practical skills involved in detecting, identifying, and measuring a broad range of compounds in various biological samples. Clear, easy-to-read chapters provide detailed information on topics including sample collection and preparation, spectrophotometric and luminescence techniques, liquid and gas-liquid chromatography, and mass spectrometry including hyphenated techniques.

This new edition contains thoroughly revised content that reflects contemporary practices and advances in analytical methods. Expanding the scope of the 1995 World Health Organization (WHO) basic analytical toxicology manual, the text includes coverage of separation science, essential pharmacokinetics, xenobiotic absorption, distribution and metabolism, clinical toxicological and substance misuse testing, therapeutic drug monitoring, trace elements and toxic metals analysis, and importantly the clinical interpretation of analytical results. Written by a prominent team of experienced practitioners, this volume:
* Focuses on analytical, statistical, and pharmacokinetic principles
* Describes basic methodology, including colour tests and immunoassay and enzyme-based assays
* Outlines laboratory operations, such as method validation, quality assessment, staff training, and laboratory accreditation
* Follows IUPAC nomenclature for chemical names and recommended International Non-proprietary Name (rINN) for drugs and pesticides
* Includes discussion of 'designer drugs' (novel pharmaceutical substances NPS)

Fundamentals of Analytical Toxicology: Clinical and Forensic, 2nd Edition is an indispensable resource for advanced students and trainee analytical toxicologists across disciplines, such as clinical science, analytical chemistry, forensic science, pathology, applied biology, food safety, and pharmaceutical and pesticide development.


Health and Safety

Nomenclature, Symbols, and Conventions

Uniform Resource Locators

Amount Concentration and Mass Concentration


List of Abbreviations

Section A. The Basics

Chapter 1. Analytical Toxicology: Overview

Chapter 2. Sample Collection, Transport, and Storage

Chapter 3. Basic Laboratory Operations

Chapter 4. Aspects of Sample Preparation

Chapter 5. Colour Tests, and Spectrophotometric and Luminescence Techniques

Chapter 6. Immunoassays and Related Assays

Section B. Separation Science

Chapter 7. Separation Science: Theoretical Aspects

Chapter 8. Planar Chromatography

Chapter 9. Gas Chromatography

Chapter 10. Liquid Chromatography

Chapter 11. Supercritical Fluid Chromatography

Chapter 12. Capillary Electrophoretic Techniques

Chapter 13. Mass Spectrometry

Chapter 14. Ion Mobility Spectrometry

Section C. Essential Pharmacokinetics

Chapter 15. Absorption, Distribution, Metabolism, and Excretion of Xenobiotics

Chapter 16. Pharmacokinetics

Section D. Analytical Toxicology

Chapter 17. Toxicology Testing at the Point of Contact

Chapter 18. Laboratory Testing for Substance Misuse

Chapter 19. General Analytical Toxicology

Chapter 20. Therapeutic Drug Monitoring

Chapter 21. Trace Elements and Toxic Metals

Chapter 22. Clinical Interpretation of Analytical Results

ROBERT J. FLANAGAN, King's College Hospital NHS Foundation Trust, UK, and Specialized Chemistry and Toxicology, Specialized Chemistry and Toxicology, Sheffield Teaching Hospitals NHS Foundation Trust, UK.

EVA CUYPERS, Maastricht Multimodal Molecular Imaging Institute, University of Maastricht, The Netherlands, and KU Leuven Toxicology and Pharmacology, Belgium.

HANS H. MAURER, Department of Experimental and Clinical Toxicology, Saarland University, Germany.

ROBIN WHELPTON, Formerly School of Biological and Chemical Sciences, Queen Mary University of London, UK.

R. J. Flanagan, Medical Toxicology Unit; E. Cuypers, The London Hospital Medical College, U.K.; H. H. Maurer, University of Saarland, Homburg/Saar, Germany; R. Whelpton, The London Hospital Medical College, U.K.