Clostridial Diseases of Animals
2. Auflage Juni 2026
512 Seiten, Hardcover
Wiley & Sons Ltd
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Comprehensive and up-to-date coverage of clostridial diseases
The newly revised second edition of Clostridial Diseases of Animals is a timely update to the gold-standard resource for veterinary practitioners treating clostridial disease in animals. This is a comprehensive, detailed reference that emphasizes clinically relevant information on pathogenesis, pathology, microbiology, diagnostic techniques, clinical management, and treatment.
The Second Edition takes a new One Health perspective, offering brand-new chapters that cover enteric, histotoxic, and neurotoxic clostridial diseases in animals and humans. The book also explores the reclassification of C. perfringens, providing references throughout to explain the level of evidence supporting each conclusion.
Inside the book:
* A thorough treatment of clostridial diseases with accurate coverage of new information and technologies
* A reorganized gastrointestinal section reflecting the changes to the classification of C. perfringens
* Practical discussions of enteric, histotoxic, and neurotoxic clostridial diseases
* Fully cited references demonstrating the evidence base
Written for veterinary clinicians, diagnosticians, pathologists, and microbiologists, Clostridial Diseases of Animals will also benefit regulators working in government agencies with a stake in this issue, as well as veterinary students.
Preface xxiii
Part I The pathogenic clostridia 1
1 Taxonomic relationships among the clostridia 3
Paul A. Lawson
2 General physiological and virulence properties of the pathogenic clostridia 9
Julian I. Rood
3 Brief description of animal pathogenic clostridia 15
Iman Mehdizadeh Gohari
Part II Toxins produced by the pathogenic clostridia 25
4 Toxins of histotoxic clostridia: Clostridium chauvoei, Clostridium septicum, Clostridium novyi, Paraclostridium sordellii, Clostridium histolyticum 27
Michel R. Popoff
5 Toxins of Clostridium perfringens 67
James R. Theoret, Iman Mehdizadeh Gohari, and Bruce A. McClane
6 Toxins of Clostridioides difficile 83
Panagiotis Papatheodorou
7 Clostridium botulinum and Clostridium tetani neurotoxins 95
Michel R. Popoff
Part III Clostridial infections of the gastrointestinal system 163
8 Diseases produced by Clostridium perfringens type A in animals 165
Francisco A. Uzal and Mauricio A. Navarro
9 Infections by Clostridium perfringens type B 175
Francisco A. Uzal and John S. Munday
10 Diseases produced by Clostridium perfringens type C 183
Santiago S. Diab and Horst Posthaus
11 Diseases produced by Clostridium perfringens type D 199
Francisco A. Uzal, Federico Giannitti, John W. Finnie, and Jorge P. García
12 Diseases produced by Clostridium perfringens type E 219
Mauricio A. Navarro and Francisco A. Uzal
13 Clostridium perfringens type F infections of animals 223
Iman Mehdizadeh Gohari and Bruce A. McClane
14 Diseases produced by Clostridium perfringens type G 231
Kerry K. Cooper and Margarethe A. Cooper
15 Diseases produced by Clostridioides difficile 267
Santiago S. Diab and Francisco A. Uzal
16 Disease caused by Clostridium colinum: ulcerative enteritis of poultry and other avian species 291
Agustin Rebollada-Merino and Francisco A. Uzal
17 Diseases produced by Thomasclavelia spiroformis 301
Laura M. Tuomisto and Francisco A. Uzal
18 Clostridial abomasitis 309
John F. Prescott and Russell S. Fraser
Part IV Clostridial histotoxic infections 325
19 Blackleg 327
Camila C. Abreu and Francisco A. Uzal
20 Gas gangrene 345
Rodrigo O. S. Silva, Francisco A. Uzal, Carlos A. Oliveira Junior, and Francisco C. F. Lobato
21 Gangrenous dermatitis in poultry 359
Mauricio A. Navarro, Francisco A. Uzal, and H. L. Shivaprasad
22 Bacillary hemoglobinuria 369
Mauricio A. Navarro, Fernando Dutra-Quintela, and Francisco A. Uzal
23 Infectious necrotic hepatitis 381
Mauricio A. Navarro and Francisco A. Uzal
24 Tyzzer disease 387
Karina C. Fresneda, Juan A. García, and Francisco R. Carvallo-Chaigneau
Part V Clostridial neurotoxic infections 401
25 Tetanus 403
Michel R. Popoff and Francisco A. Uzal
26 Botulism 415
Caroline Le Maréchal, Fabrizio Anniballi, Luca Bano, Martin B. Dorner, Miriam Koene, Christelle Mazuet, Christian Seyboldt, and Tom Van Nieuwenhuysen
27 Diseases caused by other clostridia producing neurotoxins 451
John F. Prescott and Michel R. Popoff
Part VI Animal clostridial diseases as zoonosis and animals as reservoir of human clostridial pathogens 455
28 Clostridial infections and one health 457
Francisco A. Uzal and Michel R. Popoff
References 466
Index 475
Francisco A. Uzal, DVM, FRVC, MSc, PhD, Dipl. ACVP, is a Distinguished Professor of Diagnostic Pathology and Branch Chief of the San Bernardino Laboratory of the California Animal Health and Food Safety at the University of California at Davis in Davis, California, USA.
Bruce A. McClane, PhD, FAAM, is a Professor of Microbiology and Molecular Genetics at the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania, United States.
Iman Mehdizadeh Gohari, DVM, MSc, PhD, is a Research Assistant Professor at the Department of Microbiology and Molecular Genetics at the University of Pittsburgh School of Medicine in Pittsburgh, Pennsylvania, United States.
Mauricio A. Navarro, DVM, MSc, PhD, Dipl. ACVP, is an Assistant Professor of Veterinary Anatomic Pathology at the Universidad Austral de Chile in Valdivia, Chile.
Michel R. Popoff, DVM, PhD, is a former Associate Professor and Head of the Research Unit of Anaerobic Bacteria and Toxins and the National Reference Center for Anaerobic Bacteria and Botulism at the Institut Pasteur in Paris, France.